chiniofon and acetylacetone

Understanding the excited-state dynamics in conjugated systems can lead to their better utilization in optical sensors, organic photovoltaics (OPVs), and organic light-emitting diodes (OLEDs). We present the synthesis of self-assembled coordination polymers comprising two types of fluorescent moieties: discrete fluorene oligomers of a well-defined length (n = 1-9) connected via aluminum(III) bis(8-quinolinolate)acetylacetone joints. Due to their well-defined structure, these materials allowed for a detailed study of energy migration processes within the materials. Thus, femtosecond transient spectroscopy was used to study the ultrafast energy transfer from the oligofluorene to the quinolinolate moieties, which was found to proceed at a rate of 10(11) s(-1). The experimental results were found to be in agreement with the behavior predicted according to the Beljonne's improved Forster model of energy transfer. In addition, the solid-state and semiconductor properties of these coordination polymers allowed for the fabrication of OLEDs. Preliminary experiments with simple two- and three-layer devices fabricated by spin-coating yield bright yellow electroluminescence with maximum brightness of 6000 cd/m(2), with a turn-on voltage of approximately 6 V and a maximum external quantum efficiency of up to 1.2%, suggesting their potential for use in PLED applications.

Topics: Aluminum; Fluorenes; Hydroxyquinolines; Organometallic Compounds; Pentanones; Polymers; Spectrophotometry, Ultraviolet; Thermodynamics

Topics: Blood Platelets; Humans; Hydroxyquinolines; Indium; Occupational Diseases; Organometallic Compounds; Oxyquinoline; Pentanones; Radiation Protection; Radiodermatitis; Radioisotopes; Radionuclide Imaging

Tropolone forms a lipophilic complex with indium-111 which is capable of mediating the labelling of polymorphonuclear leucocytes (PMNs) by this isotope; labelling efficiencies are comparable with the best achieved using 8-hydroxyquinoline and acetylacetone. However, in terms of PMN chemotaxis and phagocytosis, tropolone is significantly less toxic than either of te other ligands. 8-Hydroxyquinoline was found to reduce PMN chemotaxis and phagocytosis to approximately 70% of the control values at a concentration of 20 micro M. Tropolone may prove a superior labelling reagent.

Topics: Chemotaxis, Leukocyte; Cycloheptanes; Humans; Hydroxyquinolines; Indium; Ketones; Ligands; Neutrophils; Oxyquinoline; Pentanones; Phagocytosis; Radioisotopes; Tropolone

Topics: Aged; Diagnosis, Differential; Humans; Hydroxyquinolines; Indium; Inflammation; Ketones; Leukocytes; Organometallic Compounds; Oxyquinoline; Pentanones; Radioisotopes; Radionuclide Imaging

The labelling of HeLa S3 cells with 111In acetylacetone (111In-acac) was studied together with cell damage, measured by the reduction in colony-forming ability of labelled cells. Using 2 X 10(5) cells/ml in Hepes saline buffer at pH 7.6 incubated with 7.4-185 kBq (0.2-5.0 microCi)/ml 111In-acac, containing 0.19% acetylacetone for 15 minutes at room temperature, 60-80% 111In was bound to the cells. The cell binding was linear with activity and resulted in an exponential reduction in colony forming ability and a D0 of 26 kBq (0.7 microCi)/2 X 10(5) cells. Radiation was shown to be the major cause of cell damage. It is concluded that 111In-acac is preferable to 111In oxine because it is soluble in physiological buffers, which eliminates the use of ethanol; it is quick and easy to prepare; and compared with previous results using HeLa S3 cells labelled with 111In oxine, 111In-acac gives much more reproducible results and is no more toxic. Clinically 111In-acac was shown to give similar results to 111In oxine.

Topics: Cell Survival; HeLa Cells; Humans; Hydroxyquinolines; Indium; Isotope Labeling; Ketones; Oxyquinoline; Pentanones; Radioisotopes

Topics: Animals; Cattle; Erythrocytes; Hydroxyquinolines; Indium; Isotope Labeling; Ketones; Oxyquinoline; Pentanones; Radioisotopes