chiniofon and 2-aminophenol

Based on the dramatic accelerating effect of 2-aminophenol, three ligands derived from 2-aminophenol were developed. Copper-catalyzed coupling reaction of nitrogen-containing nucleophiles with aryl bromides was efficiently carried out under mild conditions using 1,2,3,4-tetrahydro-8-hydroxyquinoline as a novel, simple, and versatile ligand.

Topics: Aminophenols; Benzene Derivatives; Catalysis; Copper; Cross-Linking Reagents; Hydrocarbons, Brominated; Hydroxyquinolines; Nitrogen