chicoric-acid and catechol

chicoric-acid has been researched along with catechol* in 1 studies

Other Studies

1 other study(ies) available for chicoric-acid and catechol

Article	Year
Caffeoylglycolic and caffeoylamino acid derivatives, halfmers of L-chicoric acid, as new HIV-1 integrase inhibitors. European journal of medicinal chemistry, 2007, Volume: 42, Issue:10 Human immunodeficiency virus (HIV) integrase (IN) catalyzes the integration of HIV DNA copy into the host cell DNA. L-Chicoric acid (1) has been found to be one of the most potent HIV-1 integrase inhibitor. Caffeoylglycolic and caffeoylamino acid derivatives' halfmeric structures of L-chicoric acid 2 were synthesized for the purpose of simplifying the structure of L-chicoric acid. Among synthesized, compounds 2c and 3f showed HIV-1 IN inhibitory activities with IC(50) values of 10.5 and 12.0 microM, respectively, comparable to that of parent compound L-chicoric acid (IC(50)=15.7 microM). Topics: Amino Acids; Caffeic Acids; Catechols; Drug Design; HIV Integrase Inhibitors; Inhibitory Concentration 50; Molecular Structure; Structure-Activity Relationship; Succinates	2007

Article

Year

Caffeoylglycolic and caffeoylamino acid derivatives, halfmers of L-chicoric acid, as new HIV-1 integrase inhibitors.

European journal of medicinal chemistry, 2007, Volume: 42, Issue:10

Human immunodeficiency virus (HIV) integrase (IN) catalyzes the integration of HIV DNA copy into the host cell DNA. L-Chicoric acid (1) has been found to be one of the most potent HIV-1 integrase inhibitor. Caffeoylglycolic and caffeoylamino acid derivatives' halfmeric structures of L-chicoric acid 2 were synthesized for the purpose of simplifying the structure of L-chicoric acid. Among synthesized, compounds 2c and 3f showed HIV-1 IN inhibitory activities with IC(50) values of 10.5 and 12.0 microM, respectively, comparable to that of parent compound L-chicoric acid (IC(50)=15.7 microM).

Topics: Amino Acids; Caffeic Acids; Catechols; Drug Design; HIV Integrase Inhibitors; Inhibitory Concentration 50; Molecular Structure; Structure-Activity Relationship; Succinates

2007