chenodeoxycholic acid has been researched along with pregna-4,17-diene-3,16-dione in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 12 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carotti, A; Ciaccioli, G; Gioiello, A; Passeri, D; Pellicciari, R; Pittol, JMR; van Mil, SWC | 1 |
| Dodds, DT; Gonzalez, FJ; Heyman, RA; Liverman, AB; Mangelsdorf, DJ; Moore, DD; Ordentlich, P; Silva, FV; Urizar, NL; Yan, Y | 1 |
| Chiang, JY; Owsley, E | 1 |
| Bhat, A; Evans, MJ; Hartman, HB; Lai, K; Moy, FJ; Wang, S | 1 |
| Boyer, JL; Cai, SY; He, H; Mennone, A; Nguyen, T | 1 |
| Gao, E; He, B; Koch, W; Lau, WB; Ma, XL; Pu, J; Shan, P; Wang, X; Wang, Y; Yuan, A | 1 |
| Fu, J; Li, WH; Liu, GX; Tang, Y; Zheng, MY | 1 |
| Broderick, D; Hsu, V; Jiang, Y; Maier, CS; Yang, L | 1 |
| Chang, S; Choi, HS; Choi, SM; Lee, MO; Lee, S; Moon, Y; Park, B; Park, H | 1 |
| Hou, X; Huang, Y; Lu, Y; Nie, L; Tian, Y; Wang, J; Wu, W; Yin, Y | 1 |
| Hsu, CW; Xia, M; Zhao, J | 1 |
| Duan, XP; Huo, XK; Liu, KX; Liu, ZH; Meng, Q; Peng, JY; Sun, HJ; Sun, PY; Wang, CY | 1 |
| Lu, C; Shao, J; Xu, W; Yao, S; Zhang, F; Zheng, S | 1 |
| Ali, AA; Attia, YM; Elmazar, MM; Tawfiq, RA | 1 |
| Eda, H; Fukui, H; Horikawa, T; Kitayama, Y; Kondo, T; Kono, T; Li, M; Miwa, H; Nakamura, K; Ogawa, T; Okugawa, T; Oshima, T; Tamura, A; Tomita, T; Tozawa, K; Watari, J; Yamasaki, T | 1 |
1 review(s) available for chenodeoxycholic acid and pregna-4,17-diene-3,16-dione
| Article | Year |
|---|---|
[Progress in the ligands and their complex structures of farnesoid X receptor].
Topics: Animals; Anticholesteremic Agents; Azepines; Benzene Derivatives; Chenodeoxycholic Acid; Crystallization; Humans; Indoles; Isoxazoles; Ligands; Molecular Structure; Multienzyme Complexes; Pregnenediones; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship | 2012 |
14 other study(ies) available for chenodeoxycholic acid and pregna-4,17-diene-3,16-dione
| Article | Year |
|---|---|
Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool.
Topics: | 2019 |
A natural product that lowers cholesterol as an antagonist ligand for FXR.
Topics: Animals; Binding Sites; Caco-2 Cells; Carrier Proteins; Cells, Cultured; Chenodeoxycholic Acid; Cholesterol; Cholesterol, Dietary; DNA; DNA-Binding Proteins; Hepatocytes; Histone Acetyltransferases; Humans; Hydroxysteroid Dehydrogenases; Hypolipidemic Agents; Ligands; Liver; Membrane Glycoproteins; Mice; Nuclear Receptor Coactivator 1; Pregnane X Receptor; Pregnenediones; Promoter Regions, Genetic; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2002 |
Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Cell Line; Chenodeoxycholic Acid; Cholesterol 7-alpha-Hydroxylase; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Pregnane X Receptor; Pregnenediones; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Transcription Factors; Transcriptional Activation | 2003 |
The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone.
Topics: Amino Acid Sequence; Androsterone; Animals; Cell Line; Chenodeoxycholic Acid; Crystallization; DNA-Binding Proteins; Embryo, Mammalian; Gene Expression; Hepatocytes; Histone Acetyltransferases; Humans; Kidney; Ligands; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Receptor Coactivator 1; Orchiectomy; Pregnenediones; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship; Testosterone; Transcription Factors | 2006 |
Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.
Topics: Animals; Chenodeoxycholic Acid; Cholesterol 7-alpha-Hydroxylase; Gene Expression Regulation, Enzymologic; Gene Knockdown Techniques; Genes, Reporter; Hep G2 Cells; Hepatocytes; Humans; Mice; Mutation; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pregnenediones; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptor alpha; RNA, Messenger; Trans-Activators; Transcription Factors; Transfection; Tretinoin | 2010 |
Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Survival; Chenodeoxycholic Acid; Cyclosporine; Cytochromes c; Enzyme Inhibitors; Isoxazoles; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocytes, Cardiac; Pregnenediones; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering | 2013 |
Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.
Topics: Amino Acid Sequence; Chenodeoxycholic Acid; Deuterium Exchange Measurement; Escherichia coli; Humans; Hypolipidemic Agents; Isoxazoles; Ligands; Mass Spectrometry; Molecular Docking Simulation; Molecular Sequence Data; Pregnenediones; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins | 2014 |
Chenodeoxycholic Acid Reduces Hypoxia Inducible Factor-1α Protein and Its Target Genes.
Topics: Blotting, Western; Cell Hypoxia; Chenodeoxycholic Acid; DNA Primers; Gene Expression Regulation; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoxazoles; Leupeptins; Pregnenediones; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction | 2015 |
Morphologic Damage of Rat Alveolar Epithelial Type II Cells Induced by Bile Acids Could Be Ameliorated by Farnesoid X Receptor Inhibitor Z-Guggulsterone In Vitro.
Topics: Alveolar Epithelial Cells; Animals; Cell Shape; Cells, Cultured; Chenodeoxycholic Acid; Cytoplasm; Fluorescent Antibody Technique; Male; Pregnenediones; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear | 2016 |
Transactivation and Coactivator Recruitment Assays for Measuring Farnesoid X Receptor Activity.
Topics: beta-Lactamases; Chenodeoxycholic Acid; Fluorescence Resonance Energy Transfer; Genes, Reporter; HEK293 Cells; High-Throughput Screening Assays; Humans; Pregnenediones; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Small Molecule Libraries; Structure-Activity Relationship; Transcriptional Activation | 2016 |
Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
Topics: Animals; Chenodeoxycholic Acid; Cholestenones; Choline Deficiency; Dose-Response Relationship, Drug; Fibrosis; Gene Expression; Hepatocytes; Lipid Metabolism; Lipogenesis; Liver; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Pregnenediones; Primary Cell Culture; Protective Agents; Receptors, Cytoplasmic and Nuclear | 2017 |
Dihydroartemisinin counteracts fibrotic portal hypertension via farnesoid X receptor-dependent inhibition of hepatic stellate cell contraction.
Topics: Animals; Artemisinins; Carbon Tetrachloride; Cell Death; Chenodeoxycholic Acid; Gene Expression; Hepatic Stellate Cells; Hepatocytes; Humans; Hypertension, Portal; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred ICR; Mice, Transgenic; Portal Vein; Pregnenediones; Protective Agents; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear | 2017 |
The FXR Agonist, Obeticholic Acid, Suppresses HCC Proliferation & Metastasis: Role of IL-6/STAT3 Signalling Pathway.
Topics: Antineoplastic Agents, Phytogenic; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chenodeoxycholic Acid; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Hepatocytes; Humans; Interleukin-1beta; Interleukin-6; Janus Kinase 2; Pregnenediones; Receptors, Cytoplasmic and Nuclear; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein | 2017 |
Chenodeoxycholic Acid Releases Proinflammatory Cytokines from Small Intestinal Epithelial Cells Through the Farnesoid X Receptor.
Topics: Adult; Aged; Biopsy; Caco-2 Cells; Case-Control Studies; Chenodeoxycholic Acid; Enterocytes; Female; Healthy Volunteers; Humans; Ileum; Interleukin-6; Interleukin-8; Irritable Bowel Syndrome; Male; Middle Aged; Permeability; Pregnenediones; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tumor Necrosis Factor-alpha | 2019 |