Page last updated: 2024-08-21

chenodeoxycholic acid and gw 4064

chenodeoxycholic acid has been researched along with gw 4064 in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	21 (34.43)	29.6817
2010's	35 (57.38)	24.3611
2020's	5 (8.20)	2.80

Authors

Authors	Studies
Chandra, G; Creech, KL; Fivush, AM; Haffner, CD; Jones, SA; Lewis, MC; Maloney, PR; Moore, LB; Parks, DJ; Plunket, KD; Willson, TM; Wilson, JG	1
Anisfeld, AM; Edwards, PA; Goodwin, B; Jones, SA; Kast, HR; Kliewer, S; Stoltz, CM; Tarr, PT; Tontonoz, P; Willson, TM	1
Camaioni, E; Clerici, C; Costantino, G; Fiorucci, S; Maloney, PR; Morelli, A; Parks, DJ; Pellicciari, R; Willson, TM	1
Camaioni, E; Clerici, C; Costantino, G; Entrena, A; Fiorucci, S; Gioiello, A; Pellicciari, R; Sadeghpour, BM; Willson, TM	1
Costantino, G; Fiorucci, S; Pellicciari, R	1
Hashimoto, Y; Kainuma, M; Makishima, M; Miyachi, H	1
Covey, DF; Cummins, CL; Ferguson, AD; Katona, BW; Li, T; Mangelsdorf, DJ; Schmidt, DR	1
Hashimoto, Y; Hayashi, H; Misawa, T; Sugiyama, Y	1
Hashimoto, Y; Hayashi, H; Makishima, M; Misawa, T; Sugiyama, Y	1
Ahmad, K; Carrasco Gomez, R; Lamers, C; Merk, D; Schneider, G; Schubert-Zsilavecz, M; Steinhilber, D	1
Flesch, D; Gabler, M; Gomez, RC; Lill, A; Merk, D; Schneider, G; Schubert-Zsilavecz, M; Stark, H; Steri, R	1
Andrali, SS; Forman, BM; Huang, W; Li, H; Lin, M; Yu, DD	1
Cheung, SY; Flesch, D; Gabler, M; Hartmann, M; Heering, J; Heitel, P; Kaiser, A; Kramer, J; Lamers, C; Lindner, M; Lüddens, H; Lüddens-Dämgen, K; Merk, D; Proschak, E; Schmidt, J; Schubert-Zsilavecz, M; Wurglics, M	1
Angioni, C; Geisslinger, G; Goebel, T; Heering, J; Kahnt, A; Kaiser, A; Merk, D; Paulke, A; Proschak, E; Rotter, M; Schmidt, J; Steinhilber, D; Weiser, T; Weizel, L; Wittmann, S; Wurglics, M	1
Li, H; Li, X; Luo, G; Qiu, R; Xiang, H; You, Q; Zhang, J; Zheng, F	1
Baronissi, G; Biagioli, M; Carino, A; Cassiano, C; Del Gaudio, F; Di Leva, FS; Finamore, C; Fiorucci, C; Fiorucci, S; Limongelli, V; Marchianò, S; Monti, MC; Novellino, E; Sepe, V; Zampella, A	1
Fenaux, M; Halcomb, RL; Jones, CT; Romero, FA; Xu, Y	1
Helmstädter, M; Kaiser, A; Merk, D; Schierle, S; Schmidt, J; Sommer, J; Vietor, J; Willems, S	1
Claudel, T; Duval, C; Fruchart, JC; Kosykh, V; Pineda Torra, I; Staels, B	1
Blevins, RA; Cui, J; de Pedro, N; Hrywna, Y; Huang, L; Lew, JL; Peláez, F; Thompson, JR; Wright, SD; Yu, J; Zhang, T; Zhao, A	1
Billin, AN; Bisi, J; Donahee, M; Goodwin, B; Holt, JA; Jones, SA; Kliewer, SA; Kozarsky, KF; Luo, G; Mansfield, TA; McNeill, YY; Wang, DY	1
Brozek, J; Claudel, T; Darteil, R; Fruchart, JC; Hum, DW; Kosykh, V; Martin, G; Sirvent, A; Staels, B	1
Barbu, V; Chignard, N; Finzi, L; Housset, C; Mergey, M; Paul, A; Tiret, E	1
Eloranta, JJ; Kullak-Ublick, GA; Landrier, JF; Vavricka, SR	1
Edwards, PA; Kast-Woelbern, HR; Lusis, AJ; Shih, DM; Wong, J; Xia, YR	1
Auwerx, J; Cummins, CL; Houten, SM; Mangelsdorf, DJ; Volle, DH	1
Billiar, TR; Gao, X; He, F; Kuruba, R; Li, J; Li, S; Pitt, BR; Wilson, A; Xie, W; Zhang, Q	1
Bishop-Bailey, D; Li, YT; Swales, KE; Thomas, GJ; Warner, TD	1
Cariou, B; Caron, S; Costet, P; Kourimate, S; Krempf, M; Langhi, C; Le May, C; Staels, B	1
Chen, WD; Forman, BM; Huang, W; Huang, X; Lai, L; Wang, YD; Yang, F	1
Chiang, JY; Li, T; Owsley, E; Song, KH; Strom, S	1
Los, EL; Lukovac, S; Rings, EH; Stellaard, F; Verkade, HJ	1
Andò, S; Bonofiglio, D; Catalano, S; Giordano, C; Gu, G; Lanzino, M; Malivindi, R; Panno, ML; Panza, S; Sisci, D	1
Chiang, JY; Li, T; Owsley, E; Song, KH	1
Andò, S; Barone, I; Bonofiglio, D; Catalano, S; Fuqua, SA; Gelsomino, L; Giordano, C; Panza, S; Rizza, P; Vizza, D	1
Kim, SG; Kim, YM; Kim, YW; Noh, K	1
Baldelli, F; Cipriani, S; D'Amore, C; Distrutti, E; Fiorucci, S; Mencarelli, A; Palladino, G; Renga, B	1
Chang, KO; Kim, Y	1
Araya, JJ; Chen, T; Guo, GL; Li, G; Lin, W; Timmermann, BN	1
Gao, E; He, B; Koch, W; Lau, WB; Ma, XL; Pu, J; Shan, P; Wang, X; Wang, Y; Yuan, A	1
Gong, W; He, F; Huang, G; Xu, Z; Zeng, Y; Zhao, Y; Zhou, P	1
Fu, J; Li, WH; Liu, GX; Tang, Y; Zheng, MY	1
Cai, K; Sewer, MB	1
Haro, D; Langhi, C; Marrero, PF; Pedraz-Cuesta, E; Rodríguez, JC	1
Dong, J; Guo, D; Jiang, Y; Li, L; Liu, H; Liu, X; Peng, J; Wang, Y; Zhang, Y	1
Broderick, D; Hsu, V; Jiang, Y; Maier, CS; Yang, L	1
Eigner, K; Fruhwürth, S; Röhrl, C; Stangl, H	1
Alcorn, JL; Batra, S; Blackburn, MR; Fallon, MB; Hu, B; Wu, W; Yang, W; Zhang, J	1
Drews, G; Düfer, M; Kähny, V; Krippeit-Drews, P; Peter, A; Schittenhelm, B; Wagner, R	1
Chang, S; Choi, HS; Choi, SM; Lee, MO; Lee, S; Moon, Y; Park, B; Park, H	1
Alasmael, N; Meira, LB; Mohan, R; Plant, NJ; Swales, KE	1
Chen, W; Chu, H; Hou, Z; Huang, Q; Li, Q; Man, M; Wang, J; Wang, W; Zhan, M	1
Fu, X; Guan, M; Liu, Q; Liu, R; Pan, H; Sun, C; Wong, CW; Yang, M	1
Alawad, AS; Levy, C	1
Ali, MS; Bishop-Bailey, D; Bye, AP; Dombrowicz, D; Dorchies, E; Flora, GD; Gibbins, JM; Kriek, N; Molendi-Coste, O; Moraes, LA; Sage, T; Sasikumar, P; Staels, B; Unsworth, AJ; Vaiyapuri, S	1
Guo, L; Lu, D; Wang, S; Wu, B; Xie, Q	1
Guo, L; Lu, D; Wang, S; Wu, B; Yuan, X	1
Kainuma, M; Makishima, M; Sano, K; Takada, I	1
Brunst, S; Ebert, R; Helmstädter, M; Kramer, JS; Merk, D; Proschak, E; Schierle, S; Steinhilber, D	1
Cao, S; Chen, X; Jiang, L; Li, Y; Meng, X; Sun, L; Xuan, H	1
Bertolini, A; Bloks, VW; Chen, S; de Wit, S; Havinga, R; Jašprová, J; Jonker, JW; Mennillo, E; Rettenmeier, E; Schreuder, AB; Struik, D; Tukey, RH; Valášková, P; van der Schoor, LWE; Verkade, HJ; Vítek, L; Weber, AA	1

Reviews

4 review(s) available for chenodeoxycholic acid and gw 4064

Article	Year
Farnesoid X receptor: from structure to potential clinical applications. Journal of medicinal chemistry, 2005, Aug-25, Volume: 48, Issue:17 Topics: Animals; Bile Acids and Salts; Binding Sites; Cardiovascular Diseases; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Humans; Insulin Resistance; Ligands; Models, Molecular; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Transcription Factors	2005
The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. Journal of medicinal chemistry, 2020, 05-28, Volume: 63, Issue:10 Topics: Animals; Anticholesteremic Agents; Drug Delivery Systems; Drug Development; Humans; Hypoglycemic Agents; Lipid Metabolism; Metabolic Syndrome; Non-alcoholic Fatty Liver Disease; Obesity; PPAR gamma; Protein Structure, Tertiary	2020
[Progress in the ligands and their complex structures of farnesoid X receptor]. Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:6 Topics: Animals; Anticholesteremic Agents; Azepines; Benzene Derivatives; Chenodeoxycholic Acid; Crystallization; Humans; Indoles; Isoxazoles; Ligands; Molecular Structure; Multienzyme Complexes; Pregnenediones; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship	2012
FXR Agonists: From Bench to Bedside, a Guide for Clinicians. Digestive diseases and sciences, 2016, Volume: 61, Issue:12 Topics: Animals; Azepines; Chenodeoxycholic Acid; Cholagogues and Choleretics; Cholestasis; Drug Evaluation, Preclinical; Gastrointestinal Agents; Hepatitis, Autoimmune; Humans; Hypertension, Portal; Indoles; Isoxazoles; Liver Cirrhosis, Alcoholic; Liver Cirrhosis, Biliary; Liver Diseases; Metabolic Syndrome; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear; Ursodeoxycholic Acid	2016

Other Studies

57 other study(ies) available for chenodeoxycholic acid and gw 4064

Article	Year
Identification of a chemical tool for the orphan nuclear receptor FXR. Journal of medicinal chemistry, 2000, Aug-10, Volume: 43, Issue:16 Topics: Animals; Biological Availability; Cell Line; Cell-Free System; Combinatorial Chemistry Techniques; DNA-Binding Proteins; Humans; Isoxazoles; Mice; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transfection; Triglycerides	2000
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. The Journal of biological chemistry, 2002, Jan-25, Volume: 277, Issue:4 Topics: Animals; Base Sequence; Bile Acids and Salts; Blotting, Northern; Cell Line; Cell Nucleus; Cells, Cultured; Constitutive Androstane Receptor; DNA-Binding Proteins; Drug Resistance, Multiple; Genes, Reporter; Hepatocytes; Humans; Isoxazoles; Ligands; Liver; Membrane Transport Proteins; Mice; Models, Biological; Molecular Sequence Data; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Nucleic Acid Hybridization; Phenobarbital; Pregnane X Receptor; Promoter Regions, Genetic; Protein Binding; Protein Transport; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptional Activation	2002
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. Journal of medicinal chemistry, 2002, Aug-15, Volume: 45, Issue:17 Topics: Animals; Anticholesteremic Agents; Cell Line; Chenodeoxycholic Acid; Cholestasis; DNA-Binding Proteins; Humans; Ligands; Liver; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Transcription Factors	2002
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid. Journal of medicinal chemistry, 2004, Aug-26, Volume: 47, Issue:18 Topics: Bile Acids and Salts; Chenodeoxycholic Acid; DNA-Binding Proteins; Humans; Ligands; Protein Binding; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Transcription Factors	2004
Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist. Bioorganic & medicinal chemistry, 2007, Apr-01, Volume: 15, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Design; Humans; Indicators and Reagents; Isoxazoles; Ligands; Magnetic Resonance Spectroscopy; Plasmids; Progesterone; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transcriptional Activation; Transfection	2007
Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. Journal of medicinal chemistry, 2007, Nov-29, Volume: 50, Issue:24 Topics: Cell Line; Chenodeoxycholic Acid; DNA-Binding Proteins; Humans; Lithocholic Acid; Micelles; Models, Molecular; Pregnane X Receptor; Receptors, Calcitriol; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; Receptors, Steroid; Stereoisomerism; Transcription Factors	2007
Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2. Bioorganic & medicinal chemistry, 2012, May-01, Volume: 20, Issue:9 Topics: Amino Acid Substitution; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Biological Transport; Cell Line; Cholestasis, Intrahepatic; Dogs; Drug Evaluation, Preclinical; Endoplasmic Reticulum; Gene Expression; Isoxazoles; Mutation; Phenylbutyrates; Structure-Activity Relationship	2012
E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: structural development study and separation from farnesoid X receptor-agonistic activity. Bioorganic & medicinal chemistry letters, 2012, Jun-15, Volume: 22, Issue:12 Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Biological Transport; Cell Line; Dogs; Dose-Response Relationship, Drug; Humans; Isoxazoles; Mutation; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship	2012
Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist. Journal of medicinal chemistry, 2014, Oct-09, Volume: 57, Issue:19 Topics: Animals; Drug Discovery; Hep G2 Cells; Humans; Molecular Docking Simulation; ortho-Aminobenzoates; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship	2014
Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties. Bioorganic & medicinal chemistry, 2015, Jul-01, Volume: 23, Issue:13 Topics: Cell Survival; Crystallography, X-Ray; Gene Expression; HeLa Cells; Hep G2 Cells; Humans; Hydrolysis; Isoxazoles; Ligands; Molecular Docking Simulation; Plasmids; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Transfection	2015
Novel FXR (farnesoid X receptor) modulators: Potential therapies for cholesterol gallstone disease. Bioorganic & medicinal chemistry, 2016, 09-15, Volume: 24, Issue:18 Topics: Animals; Cells, Cultured; Drug Discovery; Gallstones; Hep G2 Cells; Hepatocytes; Humans; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Targeted Therapy; Protein Binding; Receptors, Cytoplasmic and Nuclear; Ursodeoxycholic Acid	2016
Nonacidic Farnesoid X Receptor Modulators. Journal of medicinal chemistry, 2017, 08-24, Volume: 60, Issue:16 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Cholesterol 7-alpha-Hydroxylase; Drug Stability; HEK293 Cells; HeLa Cells; Hep G2 Cells; Humans; Imidazoles; Male; Membrane Transport Proteins; Molecular Docking Simulation; PPAR alpha; Pyridines; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sterol Regulatory Element Binding Protein 1; Structure-Activity Relationship; Zolpidem	2017
A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis. Journal of medicinal chemistry, 2017, 09-28, Volume: 60, Issue:18 Topics: Animals; Anti-Inflammatory Agents; Drug Discovery; Enzyme Inhibitors; Epoxide Hydrolases; HeLa Cells; Hep G2 Cells; Humans; Liver; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship	2017
Lipid accumulation inhibitory activities of novel isoxazole-based chenodeoxycholic acids: Design, synthesis and preliminary mechanism study. Bioorganic & medicinal chemistry letters, 2018, 09-15, Volume: 28, Issue:17 Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Survival; Chenodeoxycholic Acid; Dose-Response Relationship, Drug; Drug Design; Hep G2 Cells; Humans; Isoxazoles; Lipids; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship	2018
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury. ACS medicinal chemistry letters, 2019, Apr-11, Volume: 10, Issue:4 Topics:	2019
A New FXR Ligand Chemotype with Agonist/Antagonist Switch. ACS medicinal chemistry letters, 2021, Feb-11, Volume: 12, Issue:2 Topics:	2021
Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. Molecular endocrinology (Baltimore, Md.), 2003, Volume: 17, Issue:2 Topics: Animals; Base Sequence; Bile Acids and Salts; Cells, Cultured; Chenodeoxycholic Acid; DNA-Binding Proteins; Gene Expression Regulation; Hepatocytes; Humans; Isoxazoles; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Promoter Regions, Genetic; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Response Elements; Retinoid X Receptors; RNA, Messenger; Species Specificity; Taurocholic Acid; Transcription Factors; Tumor Cells, Cultured	2003
Human kininogen gene is transactivated by the farnesoid X receptor. The Journal of biological chemistry, 2003, Aug-01, Volume: 278, Issue:31 Topics: Binding Sites; Blotting, Northern; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; DNA; DNA-Binding Proteins; Gene Deletion; Gene Expression Regulation; Hepatocytes; Humans; Isoxazoles; Kininogens; Liver Neoplasms; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Repetitive Sequences, Nucleic Acid; Retinoid X Receptors; RNA, Messenger; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured	2003
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes & development, 2003, Jul-01, Volume: 17, Issue:13 Topics: Animals; Anthracenes; Bile Acids and Salts; Cell Line; Cells, Cultured; Chenodeoxycholic Acid; Cholesterol 7-alpha-Hydroxylase; DNA-Binding Proteins; Enzyme Repression; Fibroblast Growth Factors; Gene Expression Regulation; Hepatocytes; Humans; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-jun; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Response Elements; Signal Transduction; Transcription Factors; Transfection	2003
The farnesoid X receptor induces very low density lipoprotein receptor gene expression. FEBS letters, 2004, May-21, Volume: 566, Issue:1-3 Topics: Animals; Bile Acids and Salts; Cell Line, Tumor; Chenodeoxycholic Acid; DNA-Binding Proteins; Hepatocytes; Humans; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; RNA, Small Interfering; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Up-Regulation	2004
VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium. Hepatology (Baltimore, Md.), 2005, Volume: 42, Issue:3 Topics: Base Sequence; Cells, Cultured; Chenodeoxycholic Acid; DNA Primers; DNA-Binding Proteins; Epithelial Cells; Gallbladder; Gene Expression Regulation; Humans; Isoxazoles; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Vasoactive Intestinal Polypeptide, Type I; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors	2005
The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. American journal of physiology. Gastrointestinal and liver physiology, 2006, Volume: 290, Issue:3 Topics: Base Sequence; Bile Acids and Salts; Cell Line, Tumor; Chenodeoxycholic Acid; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Humans; Ileum; Isoxazoles; Membrane Transport Proteins; Molecular Sequence Data; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Repetitive Sequences, Nucleic Acid; Retinoid X Receptor alpha; Transcription Factors	2006
A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. Journal of lipid research, 2006, Volume: 47, Issue:2 Topics: Administration, Oral; Animals; Anthracenes; Aryldialkylphosphatase; Bile Acids and Salts; Cell Line, Tumor; Chenodeoxycholic Acid; Cholesterol 7-alpha-Hydroxylase; Cholesterol, Dietary; Cholic Acid; Dietary Fats; DNA-Binding Proteins; Enzyme Inhibitors; Female; Fibroblast Growth Factors; Gene Expression; Humans; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phospholipid Transfer Proteins; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Sterol Regulatory Element Binding Protein 1; Transcription Factors	2006
In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue. Molecular endocrinology (Baltimore, Md.), 2007, Volume: 21, Issue:6 Topics: Adrenal Glands; Animals; Bile Acids and Salts; Chenodeoxycholic Acid; DNA-Binding Proteins; Genes, Reporter; Ileum; Isoxazoles; Kidney; Ligands; Liver; Luciferases; Mice; Mice, Transgenic; Models, Animal; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Transcription Factors	2007
FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells. Cardiovascular research, 2008, Feb-01, Volume: 77, Issue:3 Topics: Angiotensin II; Animals; Cells, Cultured; Chenodeoxycholic Acid; DNA-Binding Proteins; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Isoxazoles; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Promoter Regions, Genetic; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptors, Cytoplasmic and Nuclear; Transcription Factors	2008
Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration. Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:12 Topics: Animals; Anti-Inflammatory Agents; Becaplermin; Cell Line; Cell Movement; Cell Survival; Cells, Cultured; Chenodeoxycholic Acid; Cyclooxygenase 2; DNA-Binding Proteins; Dose-Response Relationship, Drug; Genes, Reporter; Humans; Inflammation; Interleukin-1beta; Isoxazoles; Ligands; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Nitric Oxide Synthase Type II; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Receptors, Cytoplasmic and Nuclear; RNA Interference; RNA, Messenger; RNA, Small Interfering; Transcription Factors; Transcription, Genetic; Transfection	2007
Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes. FEBS letters, 2008, Mar-19, Volume: 582, Issue:6 Topics: Chenodeoxycholic Acid; DNA-Binding Proteins; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoxazoles; Pravastatin; Proprotein Convertase 9; Proprotein Convertases; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; RNA, Messenger; Serine Endopeptidases; Transcription Factors; Transcription, Genetic	2008
Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo. Molecular endocrinology (Baltimore, Md.), 2008, Volume: 22, Issue:7 Topics: Animals; Apoptosis; Cell Communication; Cell Line; Chenodeoxycholic Acid; DNA-Binding Proteins; Hepatocytes; Humans; Isoxazoles; Ligands; Liver; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Receptors, Cytoplasmic and Nuclear; Transcription Factors	2008
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology (Baltimore, Md.), 2009, Volume: 49, Issue:1 Topics: Butadienes; Carcinoma, Hepatocellular; Cell Line, Tumor; Chenodeoxycholic Acid; Cholesterol 7-alpha-Hydroxylase; DNA-Binding Proteins; Fibroblast Growth Factors; Gene Expression; Hepatocytes; Humans; Isoxazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Receptor, Fibroblast Growth Factor, Type 4; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Transcription Factors	2009
Effects of essential fatty acid deficiency on enterohepatic circulation of bile salts in mice. American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:3 Topics: Animals; Bile; Bile Acids and Salts; Caco-2 Cells; Chenodeoxycholic Acid; Cholesterol 7-alpha-Hydroxylase; Enterohepatic Circulation; Fatty Acids, Essential; Feedback, Physiological; Fibroblast Growth Factors; Humans; Intestinal Absorption; Intestine, Small; Isoxazoles; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; RNA, Messenger	2009
Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells. The Journal of biological chemistry, 2010, Feb-19, Volume: 285, Issue:8 Topics: Animals; Aromatase; Cathartics; Chenodeoxycholic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HeLa Cells; Hep G2 Cells; Humans; Isoxazoles; Leydig Cell Tumor; Leydig Cells; Male; Mice; Neoplasm Proteins; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Response Elements; Steroidogenic Factor 1	2010
A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes. Journal of lipid research, 2010, Volume: 51, Issue:8 Topics: 3' Untranslated Regions; Base Sequence; Chenodeoxycholic Acid; Cholesterol 7-alpha-Hydroxylase; Fibroblast Growth Factors; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatocytes; Humans; Isoxazoles; MicroRNAs; Oligonucleotide Array Sequence Analysis; RNA Processing, Post-Transcriptional; Transcription, Genetic	2010
Farnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expression. Oncogene, 2011, Sep-29, Volume: 30, Issue:39 Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chenodeoxycholic Acid; Chromatin Immunoprecipitation; Down-Regulation; Drug Resistance, Neoplasm; Electrophoretic Mobility Shift Assay; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Mitogen-Activated Protein Kinase 3; NF-kappa B; Promoter Regions, Genetic; Receptor, ErbB-2; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tamoxifen	2011
Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylation of CCAAT/enhancer binding protein β. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:8 Topics: AMP-Activated Protein Kinases; Animals; CCAAT-Enhancer-Binding Protein-beta; Chenodeoxycholic Acid; Hep G2 Cells; Hepatocytes; Humans; Immunoblotting; Inactivation, Metabolic; Isoxazoles; Ligands; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Transfection; Xenobiotics	2011
FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicity. Nutrition, metabolism, and cardiovascular diseases : NMCD, 2013, Volume: 23, Issue:2 Topics: Acyl-CoA Oxidase; Animals; Apoptosis; Bile Acids and Salts; Blood Glucose; Cardiovascular Diseases; Chenodeoxycholic Acid; Dyslipidemias; Fibrosis; Hyperinsulinism; Hyperlipidemias; Insulin Resistance; Isoxazoles; Lipid Metabolism; Liver; Myocardium; Obesity; PPAR alpha; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Risk Factors; RNA, Messenger; Triglycerides	2013
Inhibitory effects of bile acids and synthetic farnesoid X receptor agonists on rotavirus replication. Journal of virology, 2011, Volume: 85, Issue:23 Topics: Animals; Blotting, Western; Caco-2 Cells; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Female; Gastrointestinal Agents; Humans; Isoxazoles; Liver Neoplasms; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger; Rotavirus; Rotavirus Infections; Triglycerides; Tumor Cells, Cultured; Virus Replication	2011
A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor. Toxicology and applied pharmacology, 2012, Jan-15, Volume: 258, Issue:2 Topics: Animals; Catechin; Cells, Cultured; Chenodeoxycholic Acid; Dose-Response Relationship, Drug; Gene Expression Regulation; Hep G2 Cells; Humans; Inhibitory Concentration 50; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Receptor Coactivator 2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tea	2012
Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury. European heart journal, 2013, Volume: 34, Issue:24 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Survival; Chenodeoxycholic Acid; Cyclosporine; Cytochromes c; Enzyme Inhibitors; Isoxazoles; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocytes, Cardiac; Pregnenediones; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering	2013
Activation of farnesoid X receptor increases the expression of cytokine inducible SH2-containing protein in HepG2 cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2012, Volume: 32, Issue:11 Topics: Animals; Chenodeoxycholic Acid; Cytokines; Hep G2 Cells; Hepatocytes; Humans; Interleukin-6; Isoxazoles; Janus Kinase 2; Liver; Mice; Mice, Inbred C57BL; Phosphorylation; Protein Biosynthesis; Receptors, Cytoplasmic and Nuclear; Signal Transduction; STAT5 Transcription Factor; Suppressor of Cytokine Signaling Proteins; Transcription, Genetic; Transcriptional Activation; Up-Regulation	2012
Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes. The Biochemical journal, 2013, Sep-01, Volume: 454, Issue:2 Topics: Cells, Cultured; Chenodeoxycholic Acid; Diacylglycerol Kinase; Gene Expression Regulation; Gene Silencing; Genes, Reporter; Glucose; Hep G2 Cells; Hepatocytes; Humans; Isoenzymes; Isoxazoles; Mechanistic Target of Rapamycin Complex 2; Multiprotein Complexes; Mutation; Phosphatidic Acids; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Signal Transduction; TOR Serine-Threonine Kinases	2013
Regulation of human class I alcohol dehydrogenases by bile acids. Journal of lipid research, 2013, Volume: 54, Issue:9 Topics: Alcohol Dehydrogenase; Alcohols; Animals; Base Sequence; Chenodeoxycholic Acid; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatocytes; Humans; Isoxazoles; Ligands; Male; Mice; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Repetitive Sequences, Nucleic Acid; Response Elements; RNA, Messenger; Signal Transduction	2013
Farnesoid X receptor up-regulates expression of lipid transfer inhibitor protein in liver cells and mice. Biochemical and biophysical research communications, 2013, Nov-29, Volume: 441, Issue:4 Topics: Animals; Apolipoproteins; Chenodeoxycholic Acid; Gene Expression Regulation; Hep G2 Cells; Humans; Isoxazoles; Liver; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Up-Regulation	2013
Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone. Biochimica et biophysica acta, 2014, Volume: 1844, Issue:9 Topics: Amino Acid Sequence; Chenodeoxycholic Acid; Deuterium Exchange Measurement; Escherichia coli; Humans; Hypolipidemic Agents; Isoxazoles; Ligands; Mass Spectrometry; Molecular Docking Simulation; Molecular Sequence Data; Pregnenediones; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins	2014
Bile acids reduce endocytosis of high-density lipoprotein (HDL) in HepG2 cells. PloS one, 2014, Volume: 9, Issue:7 Topics: Bile Acids and Salts; CD36 Antigens; Chenodeoxycholic Acid; Endocytosis; Hep G2 Cells; Humans; Isoxazoles; Lipoproteins, HDL; Receptors, Cytoplasmic and Nuclear; Scavenger Receptors, Class B; Taurocholic Acid; Transferrin	2014
Alveolar type II epithelial cell dysfunction in rat experimental hepatopulmonary syndrome (HPS). PloS one, 2014, Volume: 9, Issue:11 Topics: Animals; Apoptosis; Bile Acids and Salts; Blotting, Western; Cell Line; Chenodeoxycholic Acid; Common Bile Duct; Epithelial Cells; Gene Expression; Hepatopulmonary Syndrome; Isoxazoles; Male; Microscopy, Fluorescence; Pulmonary Alveoli; Pulmonary Surfactant-Associated Proteins; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha	2014
Role of FXR in β-cells of lean and obese mice. Endocrinology, 2015, Volume: 156, Issue:4 Topics: Animals; Chenodeoxycholic Acid; Female; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Isoxazoles; Male; Mice; Mice, Knockout; Mice, Obese; Obesity; Receptors, Cytoplasmic and Nuclear; Taurochenodeoxycholic Acid	2015
Chenodeoxycholic Acid Reduces Hypoxia Inducible Factor-1α Protein and Its Target Genes. PloS one, 2015, Volume: 10, Issue:6 Topics: Blotting, Western; Cell Hypoxia; Chenodeoxycholic Acid; DNA Primers; Gene Expression Regulation; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoxazoles; Leupeptins; Pregnenediones; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction	2015
Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential. Cancer letters, 2016, Jan-28, Volume: 370, Issue:2 Topics: Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chenodeoxycholic Acid; Female; Humans; Isoxazoles; Receptors, Cytoplasmic and Nuclear	2016
FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression. Oncotarget, 2016, Jun-07, Volume: 7, Issue:23 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; bcl-X Protein; Biliary Tract; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chenodeoxycholic Acid; Cholangiocarcinoma; Cisplatin; Down-Regulation; Drug Synergism; Frataxin; Gallbladder Neoplasms; Humans; Iron-Binding Proteins; Isoxazoles; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; STAT3 Transcription Factor	2016
Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression. Molecular and cellular endocrinology, 2016, 11-15, Volume: 436 Topics: Animals; Chenodeoxycholic Acid; Diet, High-Fat; Gene Expression Regulation; Group X Phospholipases A2; Hep G2 Cells; Humans; Hyperlipidemias; Isoxazoles; Ligands; Lipid Metabolism; Lipoproteins, VLDL; Male; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Triglycerides	2016
Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets. Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:12 Topics: Animals; Blood Platelets; Calcium Signaling; Chenodeoxycholic Acid; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinogen; Genotype; Hemostasis; Humans; Isoxazoles; Ligands; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Cytoplasmic and Nuclear; Thrombosis; Time Factors	2016
Transcriptional Regulation of Human UDP-Glucuronosyltransferase 2B10 by Farnesoid X Receptor in Human Hepatoma HepG2 Cells. Molecular pharmaceutics, 2017, 09-05, Volume: 14, Issue:9 Topics: Binding Sites; Blotting, Western; Chenodeoxycholic Acid; Chromatin Immunoprecipitation; Electrophoretic Mobility Shift Assay; Glucuronosyltransferase; Hep G2 Cells; Humans; Isoxazoles; Models, Biological; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors	2017
Farnesoid X receptor regulates SULT1E1 expression through inhibition of PGC1α binding to HNF4α. Biochemical pharmacology, 2017, 12-01, Volume: 145 Topics: Chenodeoxycholic Acid; Gene Expression Regulation; Hep G2 Cells; Hepatocyte Nuclear Factor 4; Humans; Isoxazoles; Molecular Structure; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Receptors, Cytoplasmic and Nuclear; Sulfotransferases	2017
Farnesoid X Receptor Activation Enhances Transforming Growth Factor β-Induced Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells. International journal of molecular sciences, 2018, 06-28, Volume: 19, Issue:7 Topics: Bile Acids and Salts; Cadherins; Carcinoma, Hepatocellular; Cell Line, Tumor; Chenodeoxycholic Acid; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Liver; Liver Neoplasms; Receptors, Cytoplasmic and Nuclear; Transforming Growth Factor beta1	2018
Development and in vitro Profiling of Dual FXR/LTA4H Modulators. ChemMedChem, 2021, 08-05, Volume: 16, Issue:15 Topics: Chenodeoxycholic Acid; Drug Development; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Isoxazoles; Molecular Structure; Receptors, Cytoplasmic and Nuclear	2021
Bile Acids Elevated in Chronic Periaortitis Could Activate Farnesoid-X-Receptor to Suppress IL-6 Production by Macrophages. Frontiers in immunology, 2021, Volume: 12 Topics: Aged; Animals; Bile Acids and Salts; Cell Nucleus; Chenodeoxycholic Acid; Female; Gene Expression Profiling; Humans; Interleukin-6; Isoxazoles; Leukocytes, Mononuclear; Macrophages; Male; Mice; Middle Aged; Promoter Regions, Genetic; RAW 264.7 Cells; Receptors, Cytoplasmic and Nuclear; Retroperitoneal Fibrosis; Signal Transduction	2021
Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia. Scientific reports, 2021, 05-27, Volume: 11, Issue:1 Topics: Animals; Bile Acids and Salts; Bilirubin; Chenodeoxycholic Acid; Hyperbilirubinemia, Neonatal; Ileum; Isoxazoles; Liver; Mice; Rats, Gunn; Receptors, Cytoplasmic and Nuclear; Treatment Outcome; Ursodeoxycholic Acid	2021