Page last updated: 2024-08-21

chenodeoxycholic acid and cyclosporine

chenodeoxycholic acid has been researched along with cyclosporine in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (30.43)18.2507
2000's4 (17.39)29.6817
2010's11 (47.83)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Craddock, AL; Daniel, RW; Dawson, PA; Kirby, LC; Love, MW; Walters, HC; Wong, MH1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Ericzon, BG1
Budai, K; Javitt, NB; Levy, J1
Bernard, B; Bouvier, E; Cabrol, A; Cadranel, JF; Dorent, R; Gandjbakhch, I; Gerhardt, M; Ghoussoub, JJ; Lunel, F; Myara, A; Opolon, P; Trivin, F1
Angelico, M; Baiocchi, L; Casciani, CU; Iaria, G; Negrini, S; Nistri, A; Pisani, F; Romagnoli, J; Tisone, G1
Angelin, B; Duraj, F; Einarsson, K; Ericzon, BG; Eusufzai, S; Söderdahl, G1
Fujimura, A; Hashizume, K; Kawarasaki, H; Kobayashi, E; Mizuta, K; Uchida, H1
Moreno, AJ; Oliveira, PJ; Palmeira, CM; Rolo, AP1
Hishikawa, S; Kawarasaki, H; Kobayashi, E; Mizuta, K; Uchida, H1
Gäbel, G; Honscha, KU; Honscha, W; Kneuer, C1
Abe, T; Goto, J; Hishinuma, T; Mano, N; Mikkaichi, T; Okada, M; Shimada, M; Sugie, M; Toyohara, T; Yamaguchi, H1
Gao, E; He, B; Koch, W; Lau, WB; Ma, XL; Pu, J; Shan, P; Wang, X; Wang, Y; Yuan, A1
Wang, L; Zhang, FC; Zhang, X1
Davidson, BR; Eusebi, LH; Gurusamy, KS; Saffioti, F; Thorburn, D; Tsochatzis, E1
Fukagai, M; Ito, K; Oizumi, K; Sekine, S; Susukida, T1
Darrer, R; Enright, EF; Gahan, CGM; Govindarajan, K; Joyce, SA; MacSharry, J1
Kowdley, KV; Shah, RA1

Reviews

4 review(s) available for chenodeoxycholic acid and cyclosporine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Therapeutic advances for primary biliary cholangitis: the old and the new.
    European journal of gastroenterology & hepatology, 2016, Volume: 28, Issue:6

    Topics: Abatacept; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Chenodeoxycholic Acid; Cholagogues and Choleretics; Cyclosporine; Enzyme Inhibitors; Fibric Acids; Glucocorticoids; Humans; Immunosuppressive Agents; Indoles; Liver Cirrhosis, Biliary; Mesenchymal Stem Cell Transplantation; Methotrexate; Mycophenolic Acid; Pyridones; Rituximab; Tacrolimus; Ursodeoxycholic Acid; Ustekinumab

2016
Pharmacological interventions for primary biliary cholangitis: an attempted network meta-analysis.
    The Cochrane database of systematic reviews, 2017, 03-28, Volume: 3

    Topics: Azathioprine; Chenodeoxycholic Acid; Cholagogues and Choleretics; Cholangitis; Chronic Disease; Colchicine; Cyclosporine; Humans; Immunosuppressive Agents; Methotrexate; Mitochondria; Network Meta-Analysis; Penicillamine; Quality of Life; Randomized Controlled Trials as Topic; Ursodeoxycholic Acid

2017
Current and potential treatments for primary biliary cholangitis.
    The lancet. Gastroenterology & hepatology, 2020, Volume: 5, Issue:3

    Topics: Benzothiazoles; Bezafibrate; Bile Acids and Salts; Budesonide; Case-Control Studies; Chenodeoxycholic Acid; Cholagogues and Choleretics; Clinical Trials as Topic; Cyclosporine; Disease Progression; Glucocorticoids; Homeostasis; Humans; Immunologic Factors; Immunosuppressive Agents; Isoxazoles; Liver Cirrhosis, Biliary; Liver Transplantation; Peroxisome Proliferator-Activated Receptors; Receptors, Cytoplasmic and Nuclear; Rituximab; Treatment Outcome; United States; United States Food and Drug Administration; Ursodeoxycholic Acid

2020

Trials

2 trial(s) available for chenodeoxycholic acid and cyclosporine

ArticleYear
Qualitative patterns of biliary bile acids affect cyclosporine intestinal absorption in liver transplant recipients.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Adult; Analysis of Variance; Bile Acids and Salts; Chenodeoxycholic Acid; Cholic Acid; Cholic Acids; Cyclosporine; Female; Humans; Immunosuppressive Agents; Intestinal Absorption; Liver Transplantation; Male; Regression Analysis; Time Factors

1996
Secretion and composition of bile after human liver transplantation: studies on the effects of cyclosporine and tacrolimus.
    Transplantation, 1997, Jan-15, Volume: 63, Issue:1

    Topics: Adult; Bile; Chenodeoxycholic Acid; Cholic Acid; Cholic Acids; Cyclosporine; Female; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Middle Aged; Muromonab-CD3; Prospective Studies; Tacrolimus

1997

Other Studies

17 other study(ies) available for chenodeoxycholic acid and cyclosporine

ArticleYear
Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter.
    The American journal of physiology, 1998, Volume: 274, Issue:1

    Topics: Amino Acid Sequence; Animals; Anions; Base Sequence; Bile Acids and Salts; Biological Transport; Carrier Proteins; Cations, Monovalent; CHO Cells; Cloning, Molecular; COS Cells; Cricetinae; DNA, Complementary; Humans; Ileum; Kidney; Kinetics; Molecular Sequence Data; Organic Anion Transporters, Sodium-Dependent; Recombinant Proteins; RNA, Messenger; Sodium; Symporters; Taurocholic Acid; Transcription, Genetic; Transfection

1998
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
    Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index

2014
Early graft function in liver transplantation patients.
    Transplantation proceedings, 1994, Volume: 26, Issue:6

    Topics: Bile; Bile Acids and Salts; Bilirubin; Chenodeoxycholic Acid; Cyclosporine; Graft Rejection; Humans; Liver Transplantation; Tacrolimus; Time Factors

1994
Bile acid synthesis in HepG2 cells: effect of cyclosporin.
    Journal of lipid research, 1994, Volume: 35, Issue:10

    Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Cholic Acid; Cholic Acids; Cyclosporine; Humans; Sterols; Tumor Cells, Cultured

1994
Cyclosporin A-mediated cholestasis in patients with chronic hepatitis after heart transplantation.
    European journal of gastroenterology & hepatology, 1996, Volume: 8, Issue:3

    Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Bile Acids and Salts; Bilirubin; Chenodeoxycholic Acid; Cholestasis; Cholic Acid; Cholic Acids; Chromatography, High Pressure Liquid; Cyclosporine; Fasting; Female; Glycocholic Acid; Heart Transplantation; Hepatitis, Chronic; Humans; Immunosuppressive Agents; Lithocholic Acid; Male; Middle Aged; Spectrophotometry, Ultraviolet; Taurocholic Acid; Ursodeoxycholic Acid

1996
Dose-dependent reduction of bile secretion in cyclosporine-treated rats.
    Transplantation, 1998, Mar-15, Volume: 65, Issue:5

    Topics: Animals; Bile; Chenodeoxycholic Acid; Cyclosporine; Dose-Response Relationship, Drug; Male; Rats; Rats, Wistar; Secretory Rate

1998
Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria.
    Bioscience reports, 2001, Volume: 21, Issue:1

    Topics: Animals; Calcium; Chenodeoxycholic Acid; Cholestasis; Cyclosporine; Enzyme Inhibitors; Gastrointestinal Agents; Indicators and Reagents; Liver; Male; Membrane Potentials; Mitochondria, Liver; Osmosis; Permeability; Rats; Rats, Wistar; Ruthenium Red; Subcellular Fractions

2001
Increase of bile acid production by tacrolimus in the rat liver.
    Transplantation proceedings, 2003, Volume: 35, Issue:1

    Topics: Animals; Bile; Bile Acids and Salts; Chenodeoxycholic Acid; Cholic Acid; Cyclosporine; Immunosuppressive Agents; Liver; Male; Rats; Rats, Wistar; Tacrolimus; Ursodeoxycholic Acid

2003
Adaptive response to increased bile acids: induction of MDR1 gene expression and P-glycoprotein activity in renal epithelial cells.
    Pflugers Archiv : European journal of physiology, 2007, Volume: 454, Issue:4

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Acids and Salts; Cell Line; Chenodeoxycholic Acid; Cholagogues and Choleretics; Cholic Acid; Cyclosporine; Deoxycholic Acid; Dogs; Enzyme Inhibitors; Epithelial Cells; Gastrointestinal Agents; Gene Expression Regulation; Kidney; Paclitaxel; Rhodamine 123; Taurocholic Acid

2007
Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1.
    Drug metabolism and pharmacokinetics, 2010, Volume: 25, Issue:3

    Topics: Animals; Binding, Competitive; Biological Transport; Cell Line; Chenodeoxycholic Acid; Cyclosporine; Digoxin; Dogs; Epithelial Cells; Estrone; Humans; Kidney; Organic Anion Transporters; Ouabain; Pharmacokinetics; Sulfobromophthalein; Triiodothyronine

2010
Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury.
    European heart journal, 2013, Volume: 34, Issue:24

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Survival; Chenodeoxycholic Acid; Cyclosporine; Cytochromes c; Enzyme Inhibitors; Isoxazoles; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocytes, Cardiac; Pregnenediones; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering

2013
Identification of Bile Acids Responsible for Inhibiting the Bile Salt Export Pump, Leading to Bile Acid Accumulation and Cell Toxicity in Rat Hepatocytes.
    Journal of pharmaceutical sciences, 2017, Volume: 106, Issue:9

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Cell Death; Cells, Cultured; Chenodeoxycholic Acid; Cyclosporine; Deoxycholic Acid; Hepatocytes; Rats; Rats, Sprague-Dawley

2017
Gut Microbiota-Mediated Bile Acid Transformations Alter the Cellular Response to Multidrug Resistant Transporter Substrates in Vitro: Focus on P-glycoprotein.
    Molecular pharmaceutics, 2018, 12-03, Volume: 15, Issue:12

    Topics: ATP Binding Cassette Transporter, Subfamily B; Biological Variation, Population; Caco-2 Cells; Cell Survival; Chenodeoxycholic Acid; Cyclosporine; Deoxycholic Acid; Drug Resistance, Multiple; Gastrointestinal Microbiome; Glycine; HT29 Cells; Humans; Intestinal Mucosa; RNA, Messenger; Taurine; Toxicity Tests

2018