chelerythrine and pd 98059

Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

Topics: Alkaloids; Benzophenanthridines; Butyrates; Butyric Acid; Calcitriol; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cycloheximide; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Mitogen-Activated Protein Kinase Kinases; Osteopontin; Phenanthridines; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Sialoglycoproteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tretinoin

Topics: 4-Aminopyridine; Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-Antagonists; Alkaloids; Animals; Benzophenanthridines; Bumetanide; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Enzyme Inhibitors; Flavonoids; In Vitro Techniques; Kinetics; Male; Myocardium; Phenanthridines; Phenylephrine; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Rubidium Radioisotopes; Sodium-Potassium-Chloride Symporters; Staurosporine; Timolol

Topics: Alkaloids; Benzophenanthridines; Calcium-Calmodulin-Dependent Protein Kinases; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation; Genes, fos; Glioma; Oligopeptides; Phenanthridines; Phosphorylation; Pyrrolidinones; RNA, Messenger; Tumor Cells, Cultured

Topics: Alkaloids; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Benzophenanthridines; Biological Transport; Carrier Proteins; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Flavonoids; Gene Expression Regulation, Neoplastic; Glioma; Glutamate Plasma Membrane Transport Proteins; Hypertonic Solutions; Imidazoles; Kinetics; Mitogen-Activated Protein Kinases; Phenanthridines; Phosphorylation; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Symporters; Transcription, Genetic; Tumor Cells, Cultured

Topics: Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Cell Hypoxia; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Imidazoles; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase Kinases; Myocardium; Oxidative Phosphorylation; Phenanthridines; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Rats; Receptors, Estrogen; RNA, Messenger; Signal Transduction; Tyrphostins

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

Topics: 3T3 Cells; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Blotting, Western; Calcineurin; Cell Adhesion; Cell Line; Culture Media; Cyclosporine; Down-Regulation; Enzyme Inhibitors; Flavonoids; Indoles; Isoenzymes; MAP Kinase Signaling System; Marine Toxins; Methionine; Mice; Models, Biological; Okadaic Acid; Oxazoles; Phenanthridines; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-epsilon; Protein Structure, Tertiary; Serine; Signal Transduction; Sirolimus; Tacrolimus; Transfection

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Benzophenanthridines; Calcitriol; Capsaicin; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; Maleimides; Phenanthridines; Protein Kinase C; Signal Transduction; Tretinoin

Topics: Alkaloids; Animals; Benzophenanthridines; Benzopyrans; Carbazoles; Cell Adhesion Molecules; Cell Line, Transformed; Cysteine Proteinase Inhibitors; Endothelium; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Gene Expression; Genistein; Imidazoles; Immunoglobulins; In Vitro Techniques; Indoles; Inflammatory Bowel Diseases; Intestinal Mucosa; Isoquinolines; Leupeptins; MAP Kinase Signaling System; Mice; Mucoproteins; NF-kappa B; Phenanthridines; Pyridines; RNA, Messenger; Tumor Necrosis Factor-alpha

Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Amino Acid Motifs; Benzophenanthridines; Bucladesine; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Fetal Blood; Flavonoids; Follicular Fluid; Humans; Isoquinolines; Male; MAP Kinase Kinase Kinase 1; Phenanthridines; Phosphorylation; Progesterone; Protein Kinase C; Protein Serine-Threonine Kinases; Seminal Plasma Proteins; Signal Transduction; Sperm Capacitation; Sulfonamides; Tyrosine; Tyrphostins

Topics: Alkaloids; Animals; Base Sequence; Benzophenanthridines; Breast Neoplasms; Diethylstilbestrol; DNA Primers; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinases; Nuclear Proteins; PC12 Cells; Phenanthridines; Phorbol 12,13-Dibutyrate; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tamoxifen; Tumor Cells, Cultured

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin

Topics: Alkaloids; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Benzophenanthridines; Cell Movement; Cells, Cultured; Cysteine-Rich Protein 61; Flavonoids; Gene Expression Regulation; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Interleukin-6; Leukemia Inhibitory Factor; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Myocytes, Smooth Muscle; Naphthalenes; Neovascularization, Physiologic; Norepinephrine; Paracrine Communication; Phenanthridines; Phenylephrine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; RNA, Messenger; Stress, Mechanical; Telmisartan; Tumor Necrosis Factor-alpha

Topics: Adenosine Triphosphate; Alkaloids; Aminoimidazole Carboxamide; Animals; Antimycin A; Benzophenanthridines; Brefeldin A; Carbazoles; Cell Hypoxia; Cells, Cultured; Connexin 43; Cycloheximide; Deoxyglucose; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Myocardial Contraction; Myocytes, Cardiac; Okadaic Acid; Ouabain; Phenanthridines; Phosphorylation; Potassium Cyanide; Protein Processing, Post-Translational; Pyridines; Pyrroles; Rats; Recombinant Fusion Proteins; Ribonucleotides; Staurosporine; Tacrolimus; Tetradecanoylphorbol Acetate

Topics: Alkaloids; Benzophenanthridines; Bosentan; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Flavonoids; Glucose; Humans; Microscopy, Confocal; Phenanthridines; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Umbilical Veins; Up-Regulation

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Androstadienes; Antineoplastic Agents, Phytogenic; Benzophenanthridines; Cell Differentiation; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HL-60 Cells; Humans; Indoles; Lactones; Maleimides; Models, Biological; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Wortmannin

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Amphetamine; Animals; Benzophenanthridines; Brain; Cell Survival; Dopamine; Dopamine Agents; Drugs, Chinese Herbal; Enzyme Inhibitors; Flavonoids; Inhibitory Concentration 50; Male; Organic Chemicals; PC12 Cells; Phenanthridines; Plant Extracts; Plant Stems; Potassium; Rats; Salvia miltiorrhiza; Thionucleotides; Time Factors; Water

Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Benzophenanthridines; Enzyme Inhibitors; Flavonoids; Ischemic Preconditioning; Liver; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tetradecanoylphorbol Acetate

Topics: Alkaloids; Animals; Benzophenanthridines; Cell Survival; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutathione Peroxidase; HSP70 Heat-Shock Proteins; In Vitro Techniques; L-Lactate Dehydrogenase; Malondialdehyde; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protein Kinase C; Pyrazines; Rats; Superoxide Dismutase; Vasodilator Agents

Topics: Animals; Benzophenanthridines; Cardiotonic Agents; Cell Survival; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glyburide; Hydrogen Sulfide; Ischemic Preconditioning, Myocardial; KATP Channels; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium Channel Blockers; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfides; Time Factors

Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Benzophenanthridines; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Immunoblotting; Microtubule-Associated Proteins; Microtubules; Models, Biological; Neurites; Nocodazole; PC12 Cells; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Rats; Receptors, Adrenergic, alpha-2; Serine; Yohimbine

Topics: Anthracenes; Anti-Inflammatory Agents; Benzophenanthridines; Cell Line; Curcumin; Enzyme Activation; Epithelial Cells; Esophagus; Flavonoids; Humans; Hydrogen-Ion Concentration; Imidazoles; Interleukin-6; Interleukin-8; Mitogen-Activated Protein Kinases; Mucous Membrane; NF-kappa B; Peptides; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Telomerase; Time Factors; Transcription, Genetic; Up-Regulation

Topics: Animals; Apoptosis; Benzophenanthridines; Cell Movement; Cell Proliferation; Culture Media, Conditioned; DNA; Endothelial Cells; Estradiol; Female; Flavonoids; Indomethacin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Progesterone; Rats; Rats, Wistar; Time Factors

Topics: Acidosis; Alkalosis; Animals; Azepines; Benzophenanthridines; Dose-Response Relationship, Drug; Flavonoids; Guanidines; Guinea Pigs; Heart Ventricles; Hydrogen-Ion Concentration; Indoles; Ion Transport; Maleimides; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Kinase Inhibitors; Receptors, G-Protein-Coupled; Signal Transduction; Sodium; Sodium-Hydrogen Exchangers; Spectrometry, Fluorescence; Sulfones; Time Factors; Triazoles

Topics: Androgens; Animals; Benzophenanthridines; Calcium Channel Blockers; Cells, Cultured; Endothelial Cells; Flavonoids; Nitric Oxide; Platelet Aggregation; Rats; Testosterone; Verapamil

Topics: Animals; Benzophenanthridines; Calcium; Cell Membrane; Chlorides; Enzyme Activation; Epithelium; Female; Flavonoids; Focal Adhesion Kinase 2; Gene Expression Regulation; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Kidney Tubules, Proximal; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Kinase Inhibitors; Protein Kinases; Proton-Translocating ATPases; Receptors, G-Protein-Coupled; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Transfection; Zinc Compounds

Topics: Animals; Anthracenes; Benzophenanthridines; Cells, Cultured; Chromones; Colon; Flavonoids; Genistein; Imidazoles; Interstitial Cells of Cajal; Intestine, Small; Membrane Potentials; Mice; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Protein-Tyrosine Kinases; Pyridines; Rifabutin