chelerythrine and kn 62

chelerythrine has been researched along with kn 62 in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (40.00)18.2507
2000's3 (30.00)29.6817
2010's3 (30.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Conigrave, AD; Shemon, AN; Sluyter, R; Wiley, JS1
Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Glembotski, CC; McDonough, PM; Stella, SL1
Maurer, JA; McKay, DB; Wenger, BW1
Krnjević, K; Liu, PL; McArdle, JJ; Ren, J; Ye, JH1
Hiruma, H; Hoka, S; Katakura, T; Kawakami, T; Maruyama, H; Nishida, S; Simada, ZB; Takenaka, T1
Caivano, M; Cohen, P; Davies, SP; Reddy, H1
Blanquet, PR; Derer, P; Mariani, J1
Balezina, OP; Bogatcheva, PO; Ezhova, EV1

Other Studies

10 other study(ies) available for chelerythrine and kn 62

ArticleYear
Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor.
    British journal of pharmacology, 2004, Volume: 142, Issue:6

    Topics: Adenosine Triphosphate; Alkaloids; B-Lymphocytes; Benzophenanthridines; Berberine; Enzyme Activation; Enzyme Inhibitors; Humans; Isoquinolines; Kinetics; Phenanthridines; Phospholipase D; Protein Kinase C; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Rubidium Radioisotopes; Tetradecanoylphorbol Acetate; Time Factors

2004
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
    The Biochemical journal, 2013, Apr-15, Volume: 451, Issue:2

    Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

2013
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Involvement of cytoplasmic calcium and protein kinases in the regulation of atrial natriuretic factor secretion by contraction rate and endothelin.
    The Journal of biological chemistry, 1994, Apr-01, Volume: 269, Issue:13

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Analysis of Variance; Animals; Animals, Newborn; Atrial Natriuretic Factor; Benzophenanthridines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cytoplasm; Endothelins; Fluorescent Dyes; Heart; Heart Atria; Indoles; Isoquinolines; Kinetics; Myocardial Contraction; Myocardium; Phenanthridines; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Phosphoproteins; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence

1994
Effects of protein kinase inhibitors on morphology and function of cultured bovine adrenal chromaffin cells: KN-62 inhibits secretory function by blocking stimulated Ca2+ entry.
    Journal of neurochemistry, 1996, Volume: 66, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Benzophenanthridines; Biological Transport; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Catecholamines; Cattle; Cells, Cultured; Enzyme Inhibitors; Indole Alkaloids; Isoquinolines; Phenanthridines; Piperazines; Protein Kinase C; Staurosporine; Substrate Specificity

1996
Cocaine decreases the glycine-induced Cl- current of acutely dissociated rat hippocampal neurons.
    European journal of pharmacology, 1999, Feb-12, Volume: 367, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anesthetics, Local; Animals; Benzophenanthridines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Chloride Channels; Cocaine; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glycine; Glycine Agents; Hippocampus; Isoquinolines; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenanthridines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Strychnine; Sulfonamides; Tetrodotoxin

1999
Axonal transport is inhibited by a protein kinase C inhibitor in cultured isolated mouse dorsal root ganglion cells.
    Brain research, 1999, Apr-24, Volume: 826, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Axonal Transport; Benzophenanthridines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Ganglia, Spinal; Male; Mice; Mice, Inbred C57BL; Neurites; Neurons, Afferent; Phenanthridines; Protein Kinase C

1999
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

2000
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.
    Neuroscience, 2003, Volume: 118, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin

2003
Mechanism of inhibition of acetylcholine secretion in newly formed mouse synapses involving Ca2+-dependent kinases and voltage-gated K+-channels.
    Bulletin of experimental biology and medicine, 2010, Volume: 149, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Acetylcholine; Animals; Benzophenanthridines; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinases; Excitatory Postsynaptic Potentials; Imidazoles; Indoles; Maleimides; Mice; Muscle, Skeletal; Nifedipine; Potassium Channels, Voltage-Gated; Protein Kinase C; Synapses

2010