chalcomycin has been researched along with desosamine* in 1 studies
1 other study(ies) available for chalcomycin and desosamine
| Article | Year |
|---|---|
Novel desosaminyl derivatives of dihydrochalcomycin from a genetically engineered strain of Streptomyces sp.
Dihydrochalcomycin from Streptomyces sp. KCTC 0041BP is a 16-membered macrolide antibiotic containing two deoxysugars (D-chalcose and D-mycinose) that are O-glycosylated at the C-5 and C-20 positions, respectively. The desosamine sugar cassette was constructed from pikromycin-deoxysugar biosynthetic genes and transformed into Streptomyces sp. GerSM1, which was engineered for deletion of the genes related to TDP-D-chalcose biosynthesis (gerB, gerN and gerMI). Novel 16-membered macrolides (5-O-desosaminyl derivatives of dihydrochalcomycin) were detected by ESI-MS, LC/MS, and MS/MS thereby demonstrating combinatorial biosynthesis of the deoxysugar in 16-membered macrolide antibiotics. Topics: Amino Sugars; Chromatography, Liquid; Computational Biology; Gene Silencing; Genes, Bacterial; Genetic Engineering; Glycosylation; Macrolides; Mass Spectrometry; Nucleoside Diphosphate Sugars; Streptomyces; Thymine Nucleotides | 2009 |