Page last updated: 2024-09-04

cgs 26303 and thiorphan

cgs 26303 has been researched along with thiorphan in 2 studies

*Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. [MeSH]

*Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. [MeSH]

Compound Research Comparison

Studies
(cgs 26303)
Trials
(cgs 26303)
Recent Studies (post-2010)
(cgs 26303)
Studies
(thiorphan)
Trials
(thiorphan)
Recent Studies (post-2010) (thiorphan)
33026655082

Protein Interaction Comparison

ProteinTaxonomycgs 26303 (IC50)thiorphan (IC50)
ThermolysinBacillus thermoproteolyticus9.5
NeprilysinRattus norvegicus (Norway rat)0.0058
NeprilysinOryctolagus cuniculus (rabbit)0.0085
NeprilysinHomo sapiens (human)0.0024
Angiotensin-converting enzyme Homo sapiens (human)0.2281
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.42
NeprilysinSus scrofa (pig)0.0062

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Blanchard, L; Chou, M; De Lombaert, S; Fitt, J; Hoyer, D; Jeng, AY; Marcopoulos, N; Moliterni, J; Satoh, Y; Savage, P; Simonsbergen, D; Stamford, LB; Tan, J; Trapani, AJ; Wallace, EM1
Held, HD; Raschak, M; Uhlig, S1

Other Studies

2 other study(ies) available for cgs 26303 and thiorphan

ArticleYear
Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
    Journal of medicinal chemistry, 2000, Feb-10, Volume: 43, Issue:3

    Topics: Animals; Aspartic Acid Endopeptidases; Benzofurans; Blood Pressure; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Enzyme Inhibitors; Humans; Male; Metalloendopeptidases; Organophosphonates; Protein Precursors; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Tetrazoles

2000
Rat big endothelin-1-induced bronchoconstriction and vasoconstriction in the isolated perfused rat lung: role of endothelin converting enzyme and neutral endopeptidase 24.11.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:5

    Topics: Airway Resistance; Analysis of Variance; Animals; Aspartic Acid Endopeptidases; Bronchoconstriction; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Female; Glycopeptides; Lung; Metalloendopeptidases; Neprilysin; Organophosphonates; Perfusion; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Tetrazoles; Thiorphan; Vascular Resistance; Vasoconstriction

1997