cgs 26303 has been researched along with thiorphan in 2 studies
*Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. [MeSH]
*Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. [MeSH]
| Studies (cgs 26303) | Trials (cgs 26303) | Recent Studies (post-2010) (cgs 26303) | Studies (thiorphan) | Trials (thiorphan) | Recent Studies (post-2010) (thiorphan) |
|---|---|---|---|---|---|
| 33 | 0 | 2 | 665 | 50 | 82 |
| Protein | Taxonomy | cgs 26303 (IC50) | thiorphan (IC50) |
|---|---|---|---|
| Thermolysin | Bacillus thermoproteolyticus | 9.5 | |
| Neprilysin | Rattus norvegicus (Norway rat) | 0.0058 | |
| Neprilysin | Oryctolagus cuniculus (rabbit) | 0.0085 | |
| Neprilysin | Homo sapiens (human) | 0.0024 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.2281 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 0.42 | |
| Neprilysin | Sus scrofa (pig) | 0.0062 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blanchard, L; Chou, M; De Lombaert, S; Fitt, J; Hoyer, D; Jeng, AY; Marcopoulos, N; Moliterni, J; Satoh, Y; Savage, P; Simonsbergen, D; Stamford, LB; Tan, J; Trapani, AJ; Wallace, EM | 1 |
| Held, HD; Raschak, M; Uhlig, S | 1 |
2 other study(ies) available for cgs 26303 and thiorphan
| Article | Year |
|---|---|
Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
Topics: Animals; Aspartic Acid Endopeptidases; Benzofurans; Blood Pressure; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Enzyme Inhibitors; Humans; Male; Metalloendopeptidases; Organophosphonates; Protein Precursors; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Tetrazoles | 2000 |
Rat big endothelin-1-induced bronchoconstriction and vasoconstriction in the isolated perfused rat lung: role of endothelin converting enzyme and neutral endopeptidase 24.11.
Topics: Airway Resistance; Analysis of Variance; Animals; Aspartic Acid Endopeptidases; Bronchoconstriction; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Female; Glycopeptides; Lung; Metalloendopeptidases; Neprilysin; Organophosphonates; Perfusion; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Tetrazoles; Thiorphan; Vascular Resistance; Vasoconstriction | 1997 |