Page last updated: 2024-09-04

cgs 26303 and organophosphonates

cgs 26303 has been researched along with organophosphonates in 30 studies

Compound Research Comparison

Studies
(cgs 26303)
Trials
(cgs 26303)
Recent Studies (post-2010)
(cgs 26303)
Studies
(organophosphonates)
Trials
(organophosphonates)
Recent Studies (post-2010) (organophosphonates)
33029,9688803,596

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (33.33)18.2507
2000's18 (60.00)29.6817
2010's2 (6.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
De Lombaert, S; Ghai, RD; Jeng, AY; Trapani, AJ; Webb, RL1
Arthur, A; Caner, HH; Jeng, AY; Kassell, NF; Kwan, AL; Lappe, RW; Lee, KS1
Held, HD; Raschak, M; Uhlig, S1
Bavbek, M; Jeng, AY; Kassell, NF; Kwan, AL; Lappe, RW; Lee, KS; Maniara, W; Toyoda, T1
Battistini, B; Jeng, AY; Pelletier, S; Sirois, P1
Bavbek, M; Jeng, AY; Kassell, NF; Kwan, AL; Lee, KS; Toyoda, T1
deWit, D; Emoto, N; Télémaque, S; Yanagisawa, M1
Hoang, MV; Sansom, CE; Turner, AJ1
Barker, S; Mitchell, JA; Rees, GM; Walcot, NR; Warner, TD; Wood, EG; Woods, M1
Carr, MJ; Goldie, RG; Henry, PJ; Jeng, AY1
Battistini, B; McKay, KO; Yap, EY1
Battistini, B; Cloutier, R; Fournier, L; Jean, S; Jeng, AY; Kavanagh, M; Kluth, D; Major, D1
Chang, CZ; Howng, SL; Jeng, AY; Kwan, AL; Lin, CL; Winardi, D; Yen, CP1
Chou, M; Feldman, DL; Jeng, AY; Mogelesky, TC1
Battistini, B; Escher, E; Jeng, AY; Pham, D; Sirois, P1
Battistini, B; Jeng, AY; Wright, JL1
Chang, CZ; Hwong, SL; Jeng, AY; Kwan, AL; Lee, KS; Lin, CL; Wu, HJ1
Allen, TJ; Burrell, LM; Cao, Z; Casley, D; Cooper, ME; Davis, BJ; Johnston, CI; Lassila, M; Tikkanen, I; Tikkanen, T1
Chang, CZ; Howng, SL; Jeng, AY; Kassell, NF; Kwan, AL; Lee, KS; Lin, CL; Savage, P; Winardi, D; Wu, SC; Yen, CP1
Barbier, S; Henry, JP; Jeng, AY; Monteil, C; Mulder, P; Renet, S; Thuillez, C1
Emoto, N1
Nakayama, Y; Tomita, K1
Goto, K1
Chang, CY; Chen, SC; Jeng, AY; Kassell, NF; Kwan, AL; Lin, TK; Lue, SI; Wu, SC; Yen, CP1
Chang, CZ; Howng, SL; Jeng, AY; Kassell, NF; Kwan, AL; Lin, TK; Winadi, D; Wu, SC; Yen, CP1
Adiarto, S; Emoto, N; Isaka, D; Jeng, AY; Masuda, S; Raharjo, SB; Yokoyama, M1
Dumont, AS; Huang, CS; Jeng, AY; Kassell, NF; Kuo, CL; Kwan, AL; Lin, CL; Liu, CS; Su, YF; Wang, CJ; Wu, SC1
Arribas-Gomez, I; Lopez-Ongil, S; Martinez-Miguel, P; Raoch, V; Rodriguez-Puyol, D; Rodriguez-Puyol, M1
Chung, CL; Kassell, NF; Kwan, AL; Lee, PY; Loh, JK; Tsai, HP; Wang, CJ; Wu, BN; Wu, SC1
Chang, LL; Cheng, KI; Chou, CW; Kwan, AL; Wang, HC1

Reviews

3 review(s) available for cgs 26303 and organophosphonates

ArticleYear
[Physiological and pathophysiological roles of the endothelin converting enzymes].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 9

    Topics: Animals; Aspartic Acid Endopeptidases; Benzazepines; Benzofurans; Drug Design; Endothelin-Converting Enzymes; Glycopeptides; Heart Failure; Humans; Hypertension; Metalloendopeptidases; Mice; Mice, Knockout; Myocardial Infarction; Organophosphonates; Phenylalanine; Tetracyclines; Tetrazoles

2004
[Endothelin and kidney disease].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 9

    Topics: Animals; Aspartic Acid Endopeptidases; Autocrine Communication; Cell Division; Cyclosporine; Drug Design; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Gene Expression; Glomerular Mesangium; Humans; Kidney Diseases; Metalloendopeptidases; Organophosphonates; Tetrazoles; Vasoconstriction

2004
[Prospects for endothelin-related drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 9

    Topics: Animals; Aspartic Acid Endopeptidases; Bosentan; Cardiovascular Diseases; Drug Design; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Hemodynamics; Humans; Metalloendopeptidases; Organophosphonates; Peptides, Cyclic; Quinazolines; Receptors, Endothelin; Sulfonamides; Sulfonylurea Compounds; Tetracyclines; Tetrazoles

2004

Other Studies

27 other study(ies) available for cgs 26303 and organophosphonates

ArticleYear
Pharmacological profile of a non-peptidic dual inhibitor of neutral endopeptidase 24.11 and endothelin-converting enzyme.
    Biochemical and biophysical research communications, 1994, Oct-14, Volume: 204, Issue:1

    Topics: Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Atrial Natriuretic Factor; Blood Pressure; Cell Membrane; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Kidney Cortex; Kinetics; Male; Metalloendopeptidases; Molecular Sequence Data; Neprilysin; Oligopeptides; Organophosphonates; Phenylalanine; Protein Precursors; Rats; Rats, Inbred SHR; Substrate Specificity; Tetrazoles

1994
Systemic administration of an inhibitor of endothelin-converting enzyme for attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage.
    Journal of neurosurgery, 1996, Volume: 85, Issue:5

    Topics: Animals; Disease Models, Animal; Endothelin-1; Endothelins; Ischemic Attack, Transient; Organophosphonates; Protease Inhibitors; Protein Precursors; Rabbits; Subarachnoid Hemorrhage; Tetrazoles; Time Factors

1996
Rat big endothelin-1-induced bronchoconstriction and vasoconstriction in the isolated perfused rat lung: role of endothelin converting enzyme and neutral endopeptidase 24.11.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:5

    Topics: Airway Resistance; Analysis of Variance; Animals; Aspartic Acid Endopeptidases; Bronchoconstriction; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Female; Glycopeptides; Lung; Metalloendopeptidases; Neprilysin; Organophosphonates; Perfusion; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Tetrazoles; Thiorphan; Vascular Resistance; Vasoconstriction

1997
Prevention and reversal of cerebral vasospasm by an endothelin-converting enzyme inhibitor, CGS 26303, in an experimental model of subarachnoid hemorrhage.
    Journal of neurosurgery, 1997, Volume: 87, Issue:2

    Topics: Animals; Disease Models, Animal; Ischemic Attack, Transient; Male; Organophosphonates; Protease Inhibitors; Rabbits; Subarachnoid Hemorrhage; Tetrazoles

1997
Effects of dual endothelin-converting enzyme/neutral endopeptidase inhibitors, CGS 26303 and CGS 26393, on lipopolysaccharide or interleukin-1 beta-stimulated release of endothelin from guinea pig tracheal epithelial cells.
    Journal of cardiovascular pharmacology, 1998, Volume: 31 Suppl 1

    Topics: Animals; Aspartic Acid Endopeptidases; Cells, Cultured; Endothelin-1; Endothelin-Converting Enzymes; Epithelial Cells; Guinea Pigs; Interleukin-1; Lipopolysaccharides; Male; Metalloendopeptidases; Organophosphonates; Phenylalanine; Protease Inhibitors; Tetrazoles; Trachea

1998
Attenuation of experimental subarachnoid hemorrhage-induced cerebral vasospasm by CGS 26303, an endothelin-converting enzyme inhibitor.
    Journal of cardiovascular pharmacology, 1998, Volume: 31 Suppl 1

    Topics: Animals; Aspartic Acid Endopeptidases; Dose-Response Relationship, Drug; Endothelin-Converting Enzymes; Ischemic Attack, Transient; Metalloendopeptidases; Organophosphonates; Protease Inhibitors; Rabbits; Subarachnoid Hemorrhage; Tetrazoles

1998
In vivo role of endothelin-converting enzyme-1 as examined by adenovirus-mediated overexpression in rats.
    Journal of cardiovascular pharmacology, 1998, Volume: 31 Suppl 1

    Topics: Adenoviridae Infections; Animals; Aspartic Acid Endopeptidases; Azepines; Blood Pressure; Cattle; DNA, Complementary; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Humans; Hypertension; Indoles; Male; Metalloendopeptidases; Organophosphonates; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptor, Endothelin A; Tetrazoles

1998
Molecular modelling and site-directed mutagenesis of the active site of endothelin-converting enzyme.
    Protein engineering, 1998, Volume: 11, Issue:12

    Topics: Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Binding Sites; CHO Cells; Conserved Sequence; Cricetinae; Endothelin-Converting Enzymes; Gene Expression; Glycopeptides; Humans; Metalloendopeptidases; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Neprilysin; Organophosphonates; Protease Inhibitors; Rats; Recombinant Proteins; Sequence Alignment; Tetrazoles; Thermolysin

1998
Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme.
    Molecular pharmacology, 1999, Volume: 55, Issue:5

    Topics: Aspartic Acid Endopeptidases; Cells, Cultured; Cytokines; Drug Interactions; Endothelin-1; Endothelin-Converting Enzymes; Glycopeptides; Humans; Interferon-gamma; Mammary Arteries; Metalloendopeptidases; Muscle, Smooth, Vascular; Organophosphonates; Phenylalanine; Protease Inhibitors; RNA, Messenger; Saphenous Vein; Tetrazoles; Tumor Necrosis Factor-alpha

1999
The role of endothelin in mediating virus-induced changes in endothelinB receptor density in mouse airways.
    The European respiratory journal, 1999, Volume: 14, Issue:1

    Topics: Animals; Autoradiography; Disease Models, Animal; Down-Regulation; Endothelin-1; Influenza A virus; Lung; Male; Mice; Mice, Inbred CBA; Muscle, Smooth; Neprilysin; Organ Size; Organophosphonates; Orthomyxoviridae Infections; Protease Inhibitors; Receptor, Endothelin B; Receptors, Endothelin; Tetrazoles; Trachea

1999
Contraction to big endothelin-1, big endothelin-2 and big endothelin-3, and endothelin-converting enzyme inhibition in human isolated bronchi.
    British journal of pharmacology, 2000, Volume: 129, Issue:1

    Topics: Aspartic Acid Endopeptidases; Bronchi; Endothelin-1; Endothelin-2; Endothelin-3; Endothelin-Converting Enzymes; Endothelins; Enzyme Inhibitors; Glycopeptides; Humans; In Vitro Techniques; Lung; Metalloendopeptidases; Organophosphonates; Protease Inhibitors; Protein Precursors; Tetrazoles

2000
Effect of CGS 26303, an endothelin-converting enzyme-neutral endopeptidase inhibitor, on nitrofen-induced congenital diaphragmatic hernia in the rat.
    Journal of pediatric surgery, 2000, Volume: 35, Issue:5

    Topics: Animals; Animals, Newborn; Aspartic Acid Endopeptidases; Body Weight; Disease Models, Animal; Endothelin-Converting Enzymes; Female; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Injections, Subcutaneous; Linear Models; Liver; Lung; Metalloendopeptidases; Organ Size; Organophosphonates; Phenyl Ethers; Pregnancy; Proportional Hazards Models; Protease Inhibitors; Rats; Reference Values; Survival Analysis; Tetrazoles

2000
Effects of endothelin-converting enzyme inhibitors on hemolysate-induced morphological changes and production of endothelin-1 in bovine cerebrovascular endothelial cells.
    Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:5 Suppl 1

    Topics: Animals; Aspartic Acid Endopeptidases; Cattle; Cells, Cultured; Cerebral Arteries; Dose-Response Relationship, Drug; Endothelin-1; Endothelin-Converting Enzymes; Endothelium, Vascular; Metalloendopeptidases; Organophosphonates; Protease Inhibitors; Tetrazoles

2000
Attenuation of puromycin aminonucleoside-induced glomerular lesions in rats by CGS 26303, a dual neutral endopeptidase/endothelin-converting enzyme inhibitor.
    Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:5 Suppl 1

    Topics: Animals; Aspartic Acid Endopeptidases; Blotting, Northern; Endothelin-Converting Enzymes; Kidney Glomerulus; Male; Metalloendopeptidases; Neprilysin; Organophosphonates; Protease Inhibitors; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; RNA, Messenger; Tetrazoles

2000
Effects of a selective neutral endopeptidase and a nonselective neutral endopeptidase/endothelin-converting enzyme inhibitor on lipopolysaccharide-induced endotoxaemia in anaesthetized Sprague-Dawley rats.
    Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:5 Suppl 1

    Topics: Acid-Base Equilibrium; Animals; Aspartic Acid Endopeptidases; Blood Cell Count; Endothelin-Converting Enzymes; Endotoxemia; Hemodynamics; Lipopolysaccharides; Male; Metalloendopeptidases; Neprilysin; Organophosphonates; Phenylalanine; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Tetrazoles

2000
Effect of ECE and NEP inhibition on cigarette smoke-induced cell proliferation in the rat lung.
    Inhalation toxicology, 2001, Volume: 13, Issue:6

    Topics: Administration, Inhalation; Animals; Bromodeoxyuridine; Bronchi; Cell Division; Drug Interactions; Endothelium, Vascular; Glycopeptides; Male; Metalloendopeptidases; Neprilysin; Organophosphonates; Phenylalanine; Protease Inhibitors; Pulmonary Alveoli; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Respiratory Mucosa; Smoking; Tetrazoles

2001
Continuous intravenous infusion of CGS 26303, an endothelin-converting enzyme inhibitor, prevents and reverses cerebral vasospasm after experimental subarachnoid hemorrhage.
    Neurosurgery, 2001, Volume: 49, Issue:2

    Topics: Animals; Aspartic Acid Endopeptidases; Endothelin-Converting Enzymes; Infusions, Intravenous; Male; Metalloendopeptidases; Organophosphonates; Protease Inhibitors; Rabbits; Subarachnoid Hemorrhage; Tetrazoles; Vasospasm, Intracranial

2001
Combined inhibition of neutral endopeptidase with angiotensin converting enzyme or endothelin converting enzyme in experimental diabetes.
    Journal of hypertension, 2002, Volume: 20, Issue:4

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartic Acid Endopeptidases; Atrial Natriuretic Factor; Blood Pressure; Bosentan; Diabetes Mellitus, Experimental; Drug Interactions; Endothelin Receptor Antagonists; Endothelin-Converting Enzymes; Heart; Kidney; Male; Metalloendopeptidases; Myocardium; Neprilysin; Organ Size; Organophosphonates; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Renin; Sulfonamides; Tetrazoles

2002
Oral administration of an inhibitor of endothelin-converting enzyme attenuates cerebral vasospasm following experimental subarachnoid haemorrhage in rabbits.
    Clinical science (London, England : 1979), 2002, Volume: 103 Suppl 48

    Topics: Administration, Oral; Animals; Aspartic Acid Endopeptidases; Basilar Artery; Dose-Response Relationship, Drug; Endothelin-Converting Enzymes; Enzyme Inhibitors; Metalloendopeptidases; Organophosphonates; Rabbits; Subarachnoid Hemorrhage; Tetrazoles; Vasospasm, Intracranial

2002
Sustained improvement of cardiac function and prevention of cardiac remodeling after long-term dual ECE-NEP inhibition in rats with congestive heart failure.
    Journal of cardiovascular pharmacology, 2004, Volume: 43, Issue:4

    Topics: Animals; Aspartic Acid Endopeptidases; Blood Pressure; Cardiac Output; Endothelin-Converting Enzymes; Heart Failure; Heart Rate; Male; Metalloendopeptidases; Neprilysin; Organophosphonates; Phenylalanine; Rats; Rats, Wistar; Tetrazoles; Ventricular Remodeling

2004
CGS 26303 upregulates mRNA expression of heme oxygenase-1 in brain tissue of rats subjected to experimental subarachnoid hemorrhage.
    Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1

    Topics: Animals; Aspartic Acid Endopeptidases; Brain; Disease Models, Animal; Endothelin-Converting Enzymes; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); HSP70 Heat-Shock Proteins; Male; Metalloendopeptidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organophosphonates; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Subarachnoid Hemorrhage; Tetrazoles; Up-Regulation; Vasospasm, Intracranial

2004
Neuroprotective effect of CGS 26303, an endothelin-converting enzyme inhibitor, on transient middle cerebral artery occlusion in rats.
    Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1

    Topics: Animals; Aspartic Acid Endopeptidases; Behavior, Animal; Brain; Brain Edema; Disease Models, Animal; Drug Administration Schedule; Endothelin-Converting Enzymes; Infarction, Middle Cerebral Artery; Injections, Intravenous; Male; Metalloendopeptidases; Neuroprotective Agents; Organophosphonates; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Tetrazoles

2004
Dual ECE/NEP inhibition on cardiac and neurohumoral function during the transition from hypertrophy to heart failure in rats.
    Hypertension (Dallas, Tex. : 1979), 2005, Volume: 45, Issue:6

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartic Acid Endopeptidases; Atrial Natriuretic Factor; Cardiac Output, Low; Cardiomegaly; Collagen; Echocardiography; Endothelin-1; Endothelin-Converting Enzymes; Enzyme Inhibitors; Fibrosis; Heart; Male; Metalloendopeptidases; Myocardium; Neprilysin; Neurotransmitter Agents; Organophosphonates; Phenylalanine; Rats; Rats, Inbred Dahl; RNA, Messenger; Tetrazoles; Thiazepines

2005
Attenuation of experimental subarachnoid hemorrhage-induced increases in circulating intercellular adhesion molecule-1 and cerebral vasospasm by the endothelin-converting enzyme inhibitor CGS 26303.
    Journal of neurosurgery, 2007, Volume: 106, Issue:3

    Topics: Animals; Aspartic Acid Endopeptidases; Disease Models, Animal; E-Selectin; Endothelin-Converting Enzymes; Intercellular Adhesion Molecule-1; Male; Metalloendopeptidases; Organophosphonates; Rabbits; Subarachnoid Hemorrhage; Tetrazoles; Vascular Cell Adhesion Molecule-1; Vasospasm, Intracranial

2007
The peptidase inhibitor CGS-26303 increases endothelin converting enzyme-1 expression in endothelial cells through accumulation of big endothelin-1.
    British journal of pharmacology, 2007, Volume: 152, Issue:3

    Topics: Animals; Aorta, Thoracic; Aspartic Acid Endopeptidases; Blotting, Northern; Blotting, Western; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Endothelin-Converting Enzymes; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Humans; Metalloendopeptidases; Methyltransferases; Neprilysin; Organophosphonates; Promoter Regions, Genetic; Protease Inhibitors; Tetrazoles; Transfection

2007
Alteration of basilar artery rho-kinase and soluble guanylyl cyclase protein expression in a rat model of cerebral vasospasm following subarachnoid hemorrhage.
    BioMed research international, 2014, Volume: 2014

    Topics: Animals; Basilar Artery; Behavior, Animal; Cyclic AMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Endothelin-1; Guanylate Cyclase; Male; Organ Specificity; Organophosphonates; Protein Kinase C-delta; Protein Kinase Inhibitors; Protein Transport; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; rho-Associated Kinases; Signal Transduction; Soluble Guanylyl Cyclase; Subarachnoid Hemorrhage; Tetrazoles; Vasospasm, Intracranial

2014
Intrathecal CGS-26303 Pretreatment Attenuates Spinal Nerve Ligation-Induced Neuropathic Pain in the Spinal Cord.
    World neurosurgery, 2016, Volume: 91

    Topics: Analgesics; Animals; Down-Regulation; Injections, Spinal; Ligation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neuralgia; Organophosphonates; Rats, Sprague-Dawley; Spinal Nerves; Tetrazoles

2016