cgs 25462 has been researched along with thiorphan in 1 studies
*Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. [MeSH]
*Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. [MeSH]
| Studies (cgs 25462) | Trials (cgs 25462) | Recent Studies (post-2010) (cgs 25462) | Studies (thiorphan) | Trials (thiorphan) | Recent Studies (post-2010) (thiorphan) |
|---|---|---|---|---|---|
| 7 | 0 | 0 | 665 | 50 | 82 |
| Protein | Taxonomy | cgs 25462 (IC50) | thiorphan (IC50) |
|---|---|---|---|
| Thermolysin | Bacillus thermoproteolyticus | 9.5 | |
| Neprilysin | Rattus norvegicus (Norway rat) | 0.0058 | |
| Neprilysin | Oryctolagus cuniculus (rabbit) | 0.0085 | |
| Neprilysin | Homo sapiens (human) | 0.0024 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.2281 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 0.42 | |
| Neprilysin | Sus scrofa (pig) | 0.0062 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berry, C; Blanchard, L; De Lombaert, S; el-Chehabi, L; Erion, MD; Ghai, RD; Sakane, Y; Tan, J; Trapani, AJ | 1 |
1 other study(ies) available for cgs 25462 and thiorphan
| Article | Year |
|---|---|
N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors.
Topics: Animals; Antihypertensive Agents; Biological Availability; Biphenyl Compounds; Blood Pressure; Half-Life; Neprilysin; Organophosphonates; Phenylalanine; Phosphopeptides; Prodrugs; Rats; Structure-Activity Relationship | 1994 |