Page last updated: 2024-09-05

cgp 54626 and gamma-aminobutyric acid

cgp 54626 has been researched along with gamma-aminobutyric acid in 20 studies

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

Compound Research Comparison

Studies
(cgp 54626)
Trials
(cgp 54626)
Recent Studies (post-2010)
(cgp 54626)
Studies
(gamma-aminobutyric acid)
Trials
(gamma-aminobutyric acid)
Recent Studies (post-2010) (gamma-aminobutyric acid)
5701640,2151,4239,631

Protein Interaction Comparison

ProteinTaxonomycgp 54626 (IC50)gamma-aminobutyric acid (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 2Rattus norvegicus (Norway rat)0.0292
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0332
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0323
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)2.152
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0333
Sodium- and chloride-dependent GABA transporter 1Homo sapiens (human)5.2623
Sodium- and chloride-dependent taurine transporterHomo sapiens (human)354
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)2.51
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)6.349
Sodium- and chloride-dependent GABA transporter 2Mus musculus (house mouse)7.0795
Sodium- and chloride-dependent GABA transporter 3Mus musculus (house mouse)8.1283
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent betaine transporterHomo sapiens (human)6.4082
Sodium- and chloride-dependent GABA transporter 3Homo sapiens (human)3.9953
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0333
GABA theta subunitRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 1Rattus norvegicus (Norway rat)0.0292

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.00)18.2507
2000's12 (60.00)29.6817
2010's6 (30.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Angst, C; Bettler, B; Bischoff, S; Bittiger, H; Flor, PJ; Froestl, W; Heid, J; Huggel, K; Kaupmann, K; McMaster, G; Mickel, SJ1
Bray, SM; Chang, S; He, C; Jin, P; Li, Z; Warren, ST; Zarnescu, DC1
Bernasconi, R; Bittiger, H; De Barry, J; Marescaux, C; Mathivet, P1
Mezler, M; Müller, T; Raming, K1
Ferguson, SC; McFarlane, S1
Bettler, B; Bräuner-Osborne, H; Cryan, JF; Froestl, W; Kaupmann, K; Klebs, K; Mombereau, C; Mosbacher, J; Sansig, G; Schmutz, M; van der Putten, H; Waldmeier, P; Wellendorph, P1
Farb, DH; Gravielle, MC; Lyons, HR; Martin, SC; Russek, SJ; Steiger, JL1
Kerr, DI; Marino, V; Ong, J; Parker, DA1
Akaike, A; Katsuki, H1
Hamasaka, Y; Nässel, DR; Wegener, C1
Laurent, G; Wilson, RI1
Asay, MJ; Boyd, SK1
Cirule, H; Dambrova, M; Kalvinsh, I; Liepinsh, E; Veinberg, G; Zharkova, O; Zvejniece, L1
Baumann, O; Blenau, W; Rotte, C; Walz, B; Witte, J1
Brański, P; Dybala, M; Nowak, G; Pilc, A; Siwek, A; Wierońska, JM1
Balana, B; Dolev, I; Laviv, T; Riven, I; Slesinger, PA; Slutsky, I; Vertkin, I1
Chen, CC; Cheng, SJ; Lin, CC; Lu, HC; Min, MY; Wang, HY; Wu, Y; Yang, HW1
Lalive, AL; Luján, R; Lüscher, C; Martínez-Hernández, J; Moss, SJ; Munoz, MB; Padgett, CL; Pangalos, MN; Slesinger, PA; Tan, KR; Terunuma, M; Watanabe, M1
Martire, M; Samengo, IA; Scotti, V1
Barz, M; Bettler, B; Bischofberger, J; Gassmann, M; Giachino, C; Taylor, V; Tchorz, JS; Tome, M1

Other Studies

20 other study(ies) available for cgp 54626 and gamma-aminobutyric acid

ArticleYear
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
    Nature, 1997, Mar-20, Volume: 386, Issue:6622

    Topics: Adenylyl Cyclases; Affinity Labels; Amino Acid Sequence; Animals; Azides; Benzoates; Cell Line; Central Nervous System; Cloning, Molecular; COS Cells; DNA, Complementary; Escherichia coli; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; In Situ Hybridization; Ligands; Molecular Sequence Data; Organophosphorus Compounds; Radioligand Assay; Rats; Receptors, GABA; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Recombinant Proteins; RNA, Messenger; Sequence Alignment

1997
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.
    Nature chemical biology, 2008, Volume: 4, Issue:4

    Topics: Animals; Disease Models, Animal; Drosophila; Drosophila Proteins; Drug Evaluation, Preclinical; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; gamma-Aminobutyric Acid; Glutamic Acid; Male; Molecular Weight; Mutation; Phenotype; Pyridines; RNA, Messenger; Small Molecule Libraries

2008
Binding characteristics of gamma-hydroxybutyric acid as a weak but selective GABAB receptor agonist.
    European journal of pharmacology, 1997, Feb-19, Volume: 321, Issue:1

    Topics: Animals; Anticonvulsants; Baclofen; Binding, Competitive; Brain Chemistry; Ethosuximide; GABA Agonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Organophosphorus Compounds; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-B; Sodium Oxybate; Valproic Acid

1997
Cloning and functional expression of GABA(B) receptors from Drosophila.
    The European journal of neuroscience, 2001, Volume: 13, Issue:3

    Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Central Nervous System; Cloning, Molecular; Cyclic AMP; Drosophila melanogaster; GABA Antagonists; gamma-Aminobutyric Acid; Ganglia, Invertebrate; Gene Expression Regulation, Developmental; GTP-Binding Proteins; Humans; Insect Proteins; Kidney; Molecular Sequence Data; Oocytes; Organophosphorus Compounds; Phosphinic Acids; Phylogeny; Potassium Channels; Potassium Channels, Inwardly Rectifying; Propanolamines; Receptors, GABA-B; Sequence Homology, Amino Acid; Xenopus

2001
GABA and development of the Xenopus optic projection.
    Journal of neurobiology, 2002, Jun-15, Volume: 51, Issue:4

    Topics: Analysis of Variance; Animals; Baclofen; Blotting, Western; Culture Techniques; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Embryonic Development; Epithelial Cells; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; Muscimol; Neurites; Neurons; Organophosphorus Compounds; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Retinal Ganglion Cells; Visual Pathways; Xenopus laevis

2002
Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice.
    The European journal of neuroscience, 2003, Volume: 18, Issue:10

    Topics: 4-Butyrolactone; Adjuvants, Anesthesia; Animals; Anticonvulsants; Autoradiography; Baclofen; Behavior, Animal; Benzocycloheptenes; Binding, Competitive; Body Weight; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Electroencephalography; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Inbred BALB C; Mice, Knockout; Motor Activity; Organophosphorus Compounds; Phenols; Radioligand Assay; Receptors, GABA-B; Sodium Oxybate; Time Factors

2003
Differential expression of gamma-aminobutyric acid type B receptor subunit mRNAs in the developing nervous system and receptor coupling to adenylyl cyclase in embryonic neurons.
    The Journal of comparative neurology, 2004, May-17, Volume: 473, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Baclofen; Binding Sites; Blotting, Western; Chlorocebus aethiops; COS Cells; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; In Situ Hybridization; Inhibitory Concentration 50; Male; Nervous System; Neurons; Organophosphorus Compounds; Phosphodiesterase Inhibitors; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Tritium

2004
Gabapentin activates presynaptic GABAB heteroreceptors in rat cortical slices.
    European journal of pharmacology, 2004, Jul-14, Volume: 495, Issue:2-3

    Topics: Amines; Animals; Baclofen; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Morpholines; Neocortex; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Presynaptic; Tritium

2004
Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation.
    Neuroreport, 2005, Aug-01, Volume: 16, Issue:11

    Topics: Animals; Animals, Newborn; Bicuculline; Cell Count; Citalopram; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hypothalamus; Immunohistochemistry; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Magnesium; Neurons; Neuropeptides; Nipecotic Acids; Norepinephrine; Orexin Receptors; Orexins; Organophosphorus Compounds; Picrotoxin; Quinolinic Acid; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide; Selective Serotonin Reuptake Inhibitors; Serotonin

2005
GABA modulates Drosophila circadian clock neurons via GABAB receptors and decreases in calcium.
    Journal of neurobiology, 2005, Volume: 65, Issue:3

    Topics: Animals; Animals, Genetically Modified; Blotting, Western; Calcium; Cell Count; Cells, Cultured; Circadian Rhythm; Diagnostic Imaging; Dose-Response Relationship, Drug; Drosophila; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Green Fluorescent Proteins; Immunohistochemistry; Isoenzymes; Larva; Neurons; Organophosphorus Compounds; Picrotoxin; Receptors, GABA-A; Serotonin

2005
Role of GABAergic inhibition in shaping odor-evoked spatiotemporal patterns in the Drosophila antennal lobe.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Oct-05, Volume: 25, Issue:40

    Topics: Animals; Animals, Genetically Modified; CD8 Antigens; Cell Count; Drosophila; Drosophila Proteins; Fushi Tarazu Transcription Factors; gamma-Aminobutyric Acid; Green Fluorescent Proteins; Immunohistochemistry; Membrane Potentials; Neural Inhibition; Odorants; Olfactory Bulb; Olfactory Receptor Neurons; Organophosphorus Compounds; Patch-Clamp Techniques; Recombinant Fusion Proteins; Sense Organs; Synaptic Transmission

2005
Characterization of the binding of [3H]CGP54626 to GABAB receptors in the male bullfrog (Rana catesbeiana).
    Brain research, 2006, Jun-13, Volume: 1094, Issue:1

    Topics: Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Drug Interactions; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Male; Neural Inhibition; Neurons; Organophosphorus Compounds; Radioligand Assay; Rana catesbeiana; Receptors, GABA-B; Subcellular Fractions; Taurine; Temperature; Time Factors; Tritium

2006
Comparative pharmacological activity of optical isomers of phenibut.
    European journal of pharmacology, 2008, Mar-31, Volume: 583, Issue:1

    Topics: Analgesics; Animals; Antidepressive Agents; Conflict, Psychological; Depression; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hot Temperature; Male; Mice; Mice, Inbred CBA; Mice, Inbred ICR; Motor Activity; Muscle Strength; Organophosphorus Compounds; Pain Measurement; Postural Balance; Psychomotor Performance; Psychotropic Drugs; Reaction Time; Receptors, GABA-B; Stereoisomerism; Swimming

2008
Source, topography and excitatory effects of GABAergic innervation in cockroach salivary glands.
    The Journal of experimental biology, 2009, Volume: 212, Issue:Pt 1

    Topics: Analysis of Variance; Animals; Baclofen; Benzylamines; Electrophysiology; Fluorescent Antibody Technique; GABA Agonists; gamma-Aminobutyric Acid; Neurons; Organophosphorus Compounds; Periplaneta; Phosphinic Acids; Salivary Glands

2009
GABAergic dysfunction in mGlu7 receptor-deficient mice as reflected by decreased levels of glutamic acid decarboxylase 65 and 67kDa and increased reelin proteins in the hippocampus.
    Brain research, 2010, Jun-02, Volume: 1334

    Topics: Analysis of Variance; Animals; Cell Adhesion Molecules, Neuronal; Extracellular Matrix Proteins; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurons; Organophosphorus Compounds; Protein Binding; Receptors, Metabotropic Glutamate; Reelin Protein; RNA, Messenger; Serine Endopeptidases; Tritium

2010
Basal GABA regulates GABA(B)R conformation and release probability at single hippocampal synapses.
    Neuron, 2010, Jul-29, Volume: 67, Issue:2

    Topics: Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Baclofen; CA1 Region, Hippocampal; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Egtazic Acid; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Agents; gamma-Aminobutyric Acid; In Vitro Techniques; Microscopy, Confocal; Neurons; Nipecotic Acids; Organophosphorus Compounds; Potassium Chloride; Presynaptic Terminals; Probability; Protein Conformation; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, GABA-B; Synapses; Tetrodotoxin

2010
GABAB receptor-mediated tonic inhibition of noradrenergic A7 neurons in the rat.
    Journal of neurophysiology, 2011, Volume: 105, Issue:6

    Topics: Analysis of Variance; Animals; Anisoles; Baclofen; Barium; Bee Venoms; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA Antagonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; In Vitro Techniques; Lysine; Male; Morpholines; Neural Inhibition; Neurons; Nipecotic Acids; Norepinephrine; Organophosphorus Compounds; Oximes; Patch-Clamp Techniques; Pons; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; RNA, Messenger

2011
Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA.
    Neuron, 2012, Mar-08, Volume: 73, Issue:5

    Topics: Action Potentials; Animals; Animals, Newborn; Baclofen; Bacterial Proteins; Central Nervous System Stimulants; Channelrhodopsins; Dopamine; Dopamine Agents; Down-Regulation; Drug Interactions; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; Homeodomain Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Luminescent Proteins; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Immunoelectron; Neurons; Organophosphorus Compounds; Phosphorylation; Receptors, GABA-A; Transcription Factors; Ventral Tegmental Area

2012
Co-application of the GABAB receptor agonist, baclofen, and the mGlu receptor agonist, L-CCG-I, facilitates [(3)H]GABA release from rat cortical nerve endings.
    Journal of neural transmission (Vienna, Austria : 1996), 2013, Volume: 120, Issue:12

    Topics: Amino Acids, Dicarboxylic; Animals; Baclofen; Cerebral Cortex; Chelating Agents; Estrenes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; gamma-Aminobutyric Acid; Male; Neurons; Organophosphorus Compounds; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Wistar; Synaptosomes; Time Factors

2013
GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors.
    Development (Cambridge, England), 2014, Volume: 141, Issue:1

    Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Mice; Mice, Knockout; Neural Stem Cells; Neurogenesis; Neurons; Organophosphorus Compounds; Receptors, GABA-A; Receptors, GABA-B; Signal Transduction

2014