Page last updated: 2024-09-05

cgp 54626 and baclofen

cgp 54626 has been researched along with baclofen in 19 studies

Compound Research Comparison

Studies
(cgp 54626)
Trials
(cgp 54626)
Recent Studies (post-2010)
(cgp 54626)
Studies
(baclofen)
Trials
(baclofen)
Recent Studies (post-2010) (baclofen)
570166,0173721,535

Protein Interaction Comparison

ProteinTaxonomycgp 54626 (IC50)baclofen (IC50)
Gamma-aminobutyric acid type B receptor subunit 2Homo sapiens (human)0.05
Gamma-aminobutyric acid type B receptor subunit 2Rattus norvegicus (Norway rat)0.2762
Gamma-aminobutyric acid type B receptor subunit 1Homo sapiens (human)0.05
Gamma-aminobutyric acid type B receptor subunit 1Rattus norvegicus (Norway rat)0.2762

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.26)18.2507
2000's11 (57.89)29.6817
2010's7 (36.84)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bernasconi, R; Bittiger, H; De Barry, J; Marescaux, C; Mathivet, P1
Ferguson, SC; McFarlane, S1
Medda, BK; Sengupta, JN; Shaker, R1
Bettler, B; Bräuner-Osborne, H; Cryan, JF; Froestl, W; Kaupmann, K; Klebs, K; Mombereau, C; Mosbacher, J; Sansig, G; Schmutz, M; van der Putten, H; Waldmeier, P; Wellendorph, P1
Farb, DH; Gravielle, MC; Lyons, HR; Martin, SC; Russek, SJ; Steiger, JL1
Bourova, L; Hejnova, L; Ihnatovych, I; Novotny, J; Stöhr, J; Svoboda, P1
Kerr, DI; Marino, V; Ong, J; Parker, DA1
Priest, CA; Puche, AC1
Carai, MA; Carboni, G; Castelli, MP; Gessa, GL; Pibiri, F1
Colón, J; Luján, R; Marker, CL; Wickman, K1
Friedrich, RW; Tabor, R; Yaksi, E1
Baumann, O; Blenau, W; Rotte, C; Walz, B; Witte, J1
Balana, B; Dolev, I; Laviv, T; Riven, I; Slesinger, PA; Slutsky, I; Vertkin, I1
Bernier, BE; Clements, MA; Morikawa, H; Perra, S1
Chen, CC; Cheng, SJ; Lin, CC; Lu, HC; Min, MY; Wang, HY; Wu, Y; Yang, HW1
Berdichevsky, Y; Bettler, B; Fogel, H; Laviv, T; Riven, I; Slesinger, PA; Slutsky, I; Vertkin, I1
Lalive, AL; Luján, R; Lüscher, C; Martínez-Hernández, J; Moss, SJ; Munoz, MB; Padgett, CL; Pangalos, MN; Slesinger, PA; Tan, KR; Terunuma, M; Watanabe, M1
Martire, M; Samengo, IA; Scotti, V1
Borst, JG; Hruskova, B; Rusu, SI; Turecek, R; Wang, T1

Other Studies

19 other study(ies) available for cgp 54626 and baclofen

ArticleYear
Binding characteristics of gamma-hydroxybutyric acid as a weak but selective GABAB receptor agonist.
    European journal of pharmacology, 1997, Feb-19, Volume: 321, Issue:1

    Topics: Animals; Anticonvulsants; Baclofen; Binding, Competitive; Brain Chemistry; Ethosuximide; GABA Agonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Organophosphorus Compounds; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-B; Sodium Oxybate; Valproic Acid

1997
GABA and development of the Xenopus optic projection.
    Journal of neurobiology, 2002, Jun-15, Volume: 51, Issue:4

    Topics: Analysis of Variance; Animals; Baclofen; Blotting, Western; Culture Techniques; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Embryonic Development; Epithelial Cells; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; Muscimol; Neurites; Neurons; Organophosphorus Compounds; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Retinal Ganglion Cells; Visual Pathways; Xenopus laevis

2002
Effect of GABA(B) receptor agonist on distension-sensitive pelvic nerve afferent fibers innervating rat colon.
    American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 283, Issue:6

    Topics: Afferent Pathways; Animals; Baclofen; Biomechanical Phenomena; Colon; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; Male; Nerve Fibers; Organophosphorus Compounds; Pelvis; Physical Stimulation; Pressure; Rats; Rats, Long-Evans; Receptors, GABA-B; Spinal Nerve Roots

2002
Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice.
    The European journal of neuroscience, 2003, Volume: 18, Issue:10

    Topics: 4-Butyrolactone; Adjuvants, Anesthesia; Animals; Anticonvulsants; Autoradiography; Baclofen; Behavior, Animal; Benzocycloheptenes; Binding, Competitive; Body Weight; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Electroencephalography; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Inbred BALB C; Mice, Knockout; Motor Activity; Organophosphorus Compounds; Phenols; Radioligand Assay; Receptors, GABA-B; Sodium Oxybate; Time Factors

2003
Differential expression of gamma-aminobutyric acid type B receptor subunit mRNAs in the developing nervous system and receptor coupling to adenylyl cyclase in embryonic neurons.
    The Journal of comparative neurology, 2004, May-17, Volume: 473, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Baclofen; Binding Sites; Blotting, Western; Chlorocebus aethiops; COS Cells; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; In Situ Hybridization; Inhibitory Concentration 50; Male; Nervous System; Neurons; Organophosphorus Compounds; Phosphodiesterase Inhibitors; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Tritium

2004
Increased baclofen-stimulated G protein coupling and deactivation in rat brain cortex during development.
    Brain research. Developmental brain research, 2004, Jul-19, Volume: 151, Issue:1-2

    Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Baclofen; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Organophosphorus Compounds; Protein Binding; Proteins; Radioligand Assay; Rats; RGS Proteins; Tritium

2004
Gabapentin activates presynaptic GABAB heteroreceptors in rat cortical slices.
    European journal of pharmacology, 2004, Jul-14, Volume: 495, Issue:2-3

    Topics: Amines; Animals; Baclofen; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Morpholines; Neocortex; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Presynaptic; Tritium

2004
GABAB receptor expression and function in olfactory receptor neuron axon growth.
    Journal of neurobiology, 2004, Volume: 60, Issue:2

    Topics: Analysis of Variance; Animals; Animals, Newborn; Axons; Baclofen; Cells, Cultured; Drug Interactions; Embryo, Mammalian; Female; GABA Agonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Gene Expression Regulation; Glutamate Decarboxylase; Growth Cones; Immunohistochemistry; In Vitro Techniques; Male; Mice; Olfactory Bulb; Olfactory Mucosa; Olfactory Receptor Neurons; Organophosphorus Compounds; Pregnancy; Receptors, GABA-B; Time Factors

2004
Up-regulation of GABA(B) receptors by chronic administration of the GABA(B) receptor antagonist SCH 50,911.
    European journal of pharmacology, 2005, May-16, Volume: 515, Issue:1-3

    Topics: Animals; Baclofen; Binding, Competitive; Brain; Dose-Response Relationship, Drug; GABA Agonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred DBA; Morpholines; Organophosphorus Compounds; Receptors, GABA-B; Sulfur Radioisotopes; Tritium; Up-Regulation

2005
Distinct populations of spinal cord lamina II interneurons expressing G-protein-gated potassium channels.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Nov-22, Volume: 26, Issue:47

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Baclofen; Blotting, Western; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA Agonists; Immunohistochemistry; Immunoprecipitation; In Vitro Techniques; Interneurons; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Immunoelectron; Organophosphorus Compounds; Receptors, GABA; Receptors, Opioid, mu; Spinal Cord; Synapses

2006
Multiple functions of GABA A and GABA B receptors during pattern processing in the zebrafish olfactory bulb.
    The European journal of neuroscience, 2008, Volume: 28, Issue:1

    Topics: Animals; Baclofen; Calcium; Food; GABA Agonists; GABA Antagonists; Neural Pathways; Neurons; Odorants; Olfactory Bulb; Organophosphorus Compounds; Patch-Clamp Techniques; Pyridazines; Receptors, GABA-A; Receptors, GABA-B; Smell; Zebrafish

2008
Source, topography and excitatory effects of GABAergic innervation in cockroach salivary glands.
    The Journal of experimental biology, 2009, Volume: 212, Issue:Pt 1

    Topics: Analysis of Variance; Animals; Baclofen; Benzylamines; Electrophysiology; Fluorescent Antibody Technique; GABA Agonists; gamma-Aminobutyric Acid; Neurons; Organophosphorus Compounds; Periplaneta; Phosphinic Acids; Salivary Glands

2009
Basal GABA regulates GABA(B)R conformation and release probability at single hippocampal synapses.
    Neuron, 2010, Jul-29, Volume: 67, Issue:2

    Topics: Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Baclofen; CA1 Region, Hippocampal; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Egtazic Acid; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Agents; gamma-Aminobutyric Acid; In Vitro Techniques; Microscopy, Confocal; Neurons; Nipecotic Acids; Organophosphorus Compounds; Potassium Chloride; Presynaptic Terminals; Probability; Protein Conformation; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, GABA-B; Synapses; Tetrodotoxin

2010
In vivo ethanol experience increases D(2) autoinhibition in the ventral tegmental area.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011, Volume: 36, Issue:5

    Topics: Action Potentials; Analysis of Variance; Animals; Baclofen; Central Nervous System Depressants; Chelating Agents; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Estrenes; Ethanol; GABA Antagonists; GABA-B Receptor Agonists; In Vitro Techniques; Indoles; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Organophosphorus Compounds; Patch-Clamp Techniques; Pyrrolidinones; Receptors, Dopamine D2; Time Factors; Ventral Tegmental Area

2011
GABAB receptor-mediated tonic inhibition of noradrenergic A7 neurons in the rat.
    Journal of neurophysiology, 2011, Volume: 105, Issue:6

    Topics: Analysis of Variance; Animals; Anisoles; Baclofen; Barium; Bee Venoms; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA Antagonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; In Vitro Techniques; Lysine; Male; Morpholines; Neural Inhibition; Neurons; Nipecotic Acids; Norepinephrine; Organophosphorus Compounds; Oximes; Patch-Clamp Techniques; Pons; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; RNA, Messenger

2011
Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Aug-31, Volume: 31, Issue:35

    Topics: Analysis of Variance; Animals; Baclofen; Calcium; Calcium Channels, N-Type; Cyclic AMP; Electric Stimulation; GABA Antagonists; GABA-B Receptor Agonists; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Hippocampus; Luminescent Proteins; Mice; Mice, Inbred BALB C; Mice, Knockout; Microscopy, Confocal; Mutation; Neural Inhibition; Organophosphorus Compounds; Pertussis Toxin; Picrotoxin; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, GABA-B; Signal Transduction; Spectroscopy, Fourier Transform Infrared; Synapses; Synaptic Vesicles

2011
Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA.
    Neuron, 2012, Mar-08, Volume: 73, Issue:5

    Topics: Action Potentials; Animals; Animals, Newborn; Baclofen; Bacterial Proteins; Central Nervous System Stimulants; Channelrhodopsins; Dopamine; Dopamine Agents; Down-Regulation; Drug Interactions; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; Homeodomain Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Luminescent Proteins; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Immunoelectron; Neurons; Organophosphorus Compounds; Phosphorylation; Receptors, GABA-A; Transcription Factors; Ventral Tegmental Area

2012
Co-application of the GABAB receptor agonist, baclofen, and the mGlu receptor agonist, L-CCG-I, facilitates [(3)H]GABA release from rat cortical nerve endings.
    Journal of neural transmission (Vienna, Austria : 1996), 2013, Volume: 120, Issue:12

    Topics: Amino Acids, Dicarboxylic; Animals; Baclofen; Cerebral Cortex; Chelating Agents; Estrenes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; gamma-Aminobutyric Acid; Male; Neurons; Organophosphorus Compounds; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Wistar; Synaptosomes; Time Factors

2013
Modulation of synaptic depression of the calyx of Held synapse by GABA(B) receptors and spontaneous activity.
    The Journal of physiology, 2013, Oct-01, Volume: 591, Issue:19

    Topics: Acoustic Stimulation; Action Potentials; Age Factors; Animals; Baclofen; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Organophosphorus Compounds; Receptors, GABA-B; Synapses; Synaptic Potentials; Tegmentum Mesencephali

2013