cgp 39551 has been researched along with cgp 37849 in 20 studies
| Studies (cgp 39551) | Trials (cgp 39551) | Recent Studies (post-2010) (cgp 39551) | Studies (cgp 37849) | Trials (cgp 37849) | Recent Studies (post-2010) (cgp 37849) |
|---|---|---|---|---|---|
| 75 | 0 | 4 | 176 | 0 | 9 |
| Protein | Taxonomy | cgp 39551 (IC50) | cgp 37849 (IC50) |
|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | 0.1275 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 20 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kretschmer, BD; Schmidt, WJ; Volz, L; Volz, TL; Zadow, B | 1 |
| Bradford, HF; Cotterell, KL; Croucher, MJ | 2 |
| Bischoff, C; Tiedtke, PI | 1 |
| Hönack, D; Löscher, W | 1 |
| Baud, J; Baumann, P; Bittiger, H; Fagg, GE; Olpe, HR; Portet, C; Pozza, MF; Schmutz, M; Steinmann, M; Thedinga, K | 1 |
| Brugger, F; Fagg, GE; Olpe, HR; Pozza, MF | 1 |
| Allgeier, H; Fagg, GE; Heckendorn, R; Jeker, A; Klebs, K; Olpe, HR; Portet, C; Schmutz, M; van Riezen, H; Vassout, A | 1 |
| Allgeier, H; Angst, C; Bittiger, H; Brundish, D; Fagg, GE; Heckendorn, R; Olpe, HR; Pozza, MF; Schmutz, M; van Riezen, H | 1 |
| Fagg, GE; Massieu, L; McVey, M; Thedinga, KH | 1 |
| Little, HJ; Rabbani, M; Wright, EJ | 1 |
| Hartikainen, T; Koivisto, E; Pitkänen, M; Riekkinen, PJ; Sirviö, J; Sivenius, J; Ylinen, A | 1 |
| Annies, R; Hönack, D; Löscher, W | 1 |
| Czechowska, G; Czuczwar, SJ; Dziki, M; Kleinrok, Z; Pietrasiewicz, T; Turski, WA | 2 |
| Butterworth, AR; Little, HJ; Rabbani, M; Wright, J; Zhou, Q | 1 |
| Maj, J; Rogóz, Z; Skuza, G | 1 |
| Ammendola, D; De Sarro, A; De Sarro, G; Patel, S | 1 |
| D'Hooge, R; De Deyn, PP; Hiramatsu, M; Mori, A; Raes, A; Van Bogaert, PP | 1 |
| D'Hooge, R; De Deyn, PP; Raes, A; Van Bogaert, PP; Van de Vijver, G | 1 |
1 review(s) available for cgp 39551 and cgp 37849
| Article | Year |
|---|---|
CGP 37849 and CGP 39551: novel competitive N-methyl-D-aspartate receptor antagonists with potent oral anticonvulsant activity.
Topics: 2-Amino-5-phosphonovalerate; Administration, Oral; Animals; Anticonvulsants; Binding, Competitive; Kinetics; Rats; Receptors, N-Methyl-D-Aspartate | 1990 |
19 other study(ies) available for cgp 39551 and cgp 37849
| Article | Year |
|---|---|
The contribution of the different binding sites of the N-methyl-D-aspartate (NMDA) receptor to the expression of behavior.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding Sites; Catalepsy; Cycloserine; Dizocilpine Maleate; Haloperidol; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Weak anticonvulsant activity of CGP 37849 and CGP 39551 against kindled seizures following systemic administration.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Injections, Intraperitoneal; Injections, Intravenous; Kindling, Neurologic; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Seizures | 1992 |
Competitive and non-competitive NMDA receptor antagonists in spatial learning tasks.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Learning; Male; Memory; Motor Activity; Orientation; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Competitive NMDA receptor antagonists raise electrically kindled generalized seizure thresholds.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Binding, Competitive; Electric Stimulation; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Seizures | 1992 |
Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Dizocilpine Maleate; Female; Kindling, Neurologic; Motor Activity; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Binding, Competitive; Electrophysiology; Electroshock; Glutamates; Hippocampus; In Vitro Techniques; Kinetics; Male; Neurotransmitter Agents; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Valine | 1990 |
Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Electrophysiology; Hippocampus; Iontophoresis; Male; Oxadiazoles; Piperazines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Substantia Nigra; Valine | 1990 |
The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Electroshock; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Postural Balance; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biomarkers; Cell Death; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Drug Administration Schedule; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Injections; Injections, Intraperitoneal; Kainic Acid; Male; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Pipecolic Acids; Piperazines; Quinolinic Acid; Rats; Receptors, N-Methyl-D-Aspartate | 1993 |
Tolerance to competitive NMDA antagonists, but no crosstolerance with barbiturates.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ataxia; Behavior, Animal; Dizocilpine Maleate; Drug Tolerance; Hypnotics and Sedatives; Male; Mice; Motor Activity; N-Methylaspartate; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1995 |
The effects of NMDA receptor antagonists at anticonvulsive doses on the performance of rats in the water maze task.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Dizocilpine Maleate; Electroshock; Learning; Male; Memory; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Swimming | 1995 |
Comparison of competitive and uncompetitive NMDA receptor antagonists with regard to monoaminergic neuronal activity and behavioural effects in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Biogenic Monoamines; Brain; Dizocilpine Maleate; Female; Motor Activity; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior | 1993 |
Competitive NMDA receptor antagonists enhance the antielectroshock activity of various antiepileptics.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Carbamazepine; Drug Synergism; Electroshock; Male; Memory; Mice; Motor Activity; Phenobarbital; Phenytoin; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependence.
Topics: 2-Amino-5-phosphonovalerate; Animals; Barbital; Bicuculline; Cerebral Cortex; Dizocilpine Maleate; Hippocampus; Male; Mice; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1994 |
Competitive antagonists of NMDA receptors, CGP 37849 and CGP 39551, enhance the anticonvulsant activity of valproate against electroconvulsions in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Male; Mice; Receptors, N-Methyl-D-Aspartate; Seizures; Valproic Acid | 1993 |
Some central effects of CGP 37849 and CGP 39551, the competitive NMDA receptor antagonists: potential antiparkinsonian activity.
Topics: 2-Amino-5-phosphonovalerate; alpha-Methyltyrosine; Animals; Antiparkinson Agents; Antipsychotic Agents; Biogenic Monoamines; Catalepsy; Central Nervous System Agents; Clonidine; Levodopa; Male; Methyltyrosines; Motor Activity; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reserpine; Tyrosine 3-Monooxygenase | 1993 |
Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Drug Administration Schedule; Drug Tolerance; Epilepsy; Excitatory Amino Acid Antagonists; Genetic Predisposition to Disease; Male; Motor Activity; Rats; Rats, Sprague-Dawley | 1996 |
Effects of the competitive N-methyl-D-aspartate antagonist CGP 37849 and its ethylester CGP 39551 on N-methyl-D-aspartate-evoked whole-cell currents in cultured spinal neurones and on vestibular stimulation-induced seizures in EL mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Avoidance Learning; Cells, Cultured; Electric Stimulation; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Postural Balance; Receptors, N-Methyl-D-Aspartate; Seizures; Spinal Cord; Vestibule, Labyrinth | 1998 |
Effects of competitive NMDA receptor antagonists on excitatory amino acid-evoked currents in mouse spinal cord neurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |