cgp 36742 has been researched along with baclofen in 18 studies
| Studies (cgp 36742) | Trials (cgp 36742) | Recent Studies (post-2010) (cgp 36742) | Studies (baclofen) | Trials (baclofen) | Recent Studies (post-2010) (baclofen) |
|---|---|---|---|---|---|
| 63 | 3 | 2 | 6,017 | 372 | 1,535 |
| Protein | Taxonomy | cgp 36742 (IC50) | baclofen (IC50) |
|---|---|---|---|
| Gamma-aminobutyric acid type B receptor subunit 2 | Homo sapiens (human) | 0.05 | |
| Gamma-aminobutyric acid type B receptor subunit 2 | Rattus norvegicus (Norway rat) | 0.2762 | |
| Gamma-aminobutyric acid type B receptor subunit 1 | Homo sapiens (human) | 0.05 | |
| Gamma-aminobutyric acid type B receptor subunit 1 | Rattus norvegicus (Norway rat) | 0.2762 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (77.78) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Smart, TG; Xie, X | 1 |
| Bowery, NG; Constanti, A; Libri, V; Malcangio, M; Teoh, H | 1 |
| Moshé, SL; Ortíz, J; Ptachewich, Y; Shinnar, S; Velísek, L; Velísková, J | 1 |
| Bowery, NG; Malcangio, M | 2 |
| Bowery, NG; Da Silva, H; Malcangio, M | 1 |
| Bon, C; Galvan, M | 1 |
| Bowery, NG; Malcangio, M; Teoh, H | 1 |
| Kombian, SB; Pittman, QJ; Zidichouski, JA | 1 |
| Nakagawa, Y; Takashima, T | 1 |
| Cheng, GJ; Hu, BR; Yu, ZF | 1 |
| Nakagawa, Y; Sasaki, A; Takashima, T | 1 |
| Antonsson, M; Bremner-Danielsen, M; Flärdh, M; Hansson-Brändén, L; Kärrberg, L; Lehmann, A | 1 |
| Bonanno, G; Carità, F; Cavazzani, P; Munari, C; Raiteri, M | 1 |
| Bettler, B; Kuhn, R; Lacampagne, A; Lorente, P; Malitschek, B; Pouzeratte, Y; Richards, S; Vassort, G | 1 |
| Lindström, S; Magnusson, AK; Tham, R | 1 |
| Anum, E; Lichtman, AH; Niyuhire, F; Varvel, SA; Wise, LE | 1 |
| Bowery, NG | 1 |
1 review(s) available for cgp 36742 and baclofen
| Article | Year |
|---|---|
GABAB receptor: a site of therapeutic benefit.
Topics: Animals; Baclofen; Brain; Clinical Trials as Topic; Cognition; Drug Evaluation, Preclinical; Epilepsy, Absence; GABA Agonists; GABA Antagonists; Humans; Muscle Spasticity; Organophosphorus Compounds; Pain; Receptors, GABA-B; Substance-Related Disorders | 2006 |
17 other study(ies) available for cgp 36742 and baclofen
| Article | Year |
|---|---|
gamma-Hydroxybutyrate depresses monosynaptic excitatory and inhibitory postsynaptic potentials in rat hippocampal slices.
Topics: Animals; Baclofen; Bicuculline; Hippocampus; Membrane Potentials; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, GABA-A; Sodium Oxybate; Synapses | 1992 |
Chronic (-)baclofen or CGP 36742 alters GABAB receptor sensitivity in rat brain and spinal cord.
Topics: Amino Acids; Analysis of Variance; Animals; Baclofen; Evoked Potentials; Immunohistochemistry; In Vitro Techniques; Male; Membrane Potentials; Neuronal Plasticity; Olfactory Pathways; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, GABA-B; Spinal Cord; Substance P | 1995 |
Age-dependent effects of gamma-aminobutyric acid agents on flurothyl seizures.
Topics: Age Factors; Animals; Anticonvulsants; Baclofen; Convulsants; Flurothyl; GABA Agents; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Male; Organophosphorus Compounds; Phenobarbital; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Seizures; Vigabatrin | 1995 |
Gamma-aminobutyric acidB, but not gamma-aminobutyric acidA receptor activation, inhibits electrically evoked substance P-like immunoreactivity release from the rat spinal cord in vitro.
Topics: Animals; Baclofen; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Neurotransmitter Uptake Inhibitors; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, GABA-A; Spinal Cord; Substance P | 1993 |
Plasticity of GABAB receptor in rat spinal cord detected by autoradiography.
Topics: Animals; Autoradiography; Baclofen; Binding Sites; gamma-Aminobutyric Acid; Organophosphorus Compounds; Phosphinic Acids; Rats; Receptors, GABA-B; Spinal Cord; Up-Regulation | 1993 |
GABAB receptor-mediated inhibition of forskolin-stimulated cyclic AMP accumulation in rat spinal cord.
Topics: Analgesics; Animals; Animals, Newborn; Baclofen; Capsaicin; Colforsin; Cyclic AMP; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Norepinephrine; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, GABA-B; Spinal Cord | 1993 |
Electrophysiological actions of GABAB agonists and antagonists in rat dorso-lateral septal neurones in vitro.
Topics: Analysis of Variance; Animals; Baclofen; Benzylamines; Dose-Response Relationship, Drug; Electrophysiology; GABA Agonists; GABA Antagonists; GABA-B Receptor Antagonists; In Vitro Techniques; Male; Membrane Potentials; Organophosphorus Compounds; Phosphinic Acids; Propanolamines; Rats; Receptors, GABA-B; Septal Nuclei | 1996 |
GABA, glutamate and substance P-like immunoreactivity release: effects of novel GABAB antagonists.
Topics: Animals; Baclofen; Benzoates; Benzylamines; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Isonicotinic Acids; Male; Organophosphorus Compounds; Phosphinic Acids; Propanolamines; Rats; Rats, Wistar; Receptors, GABA-B; Spinal Nerve Roots; Stereoisomerism; Substance P | 1996 |
GABAB receptors presynaptically modulate excitatory synaptic transmission in the rat supraoptic nucleus in vitro.
Topics: Animals; Baclofen; Excitatory Postsynaptic Potentials; GABA Agonists; GABA Antagonists; In Vitro Techniques; Neurons; Organophosphorus Compounds; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Glutamate; Supraoptic Nucleus; Synaptic Transmission | 1996 |
The GABA(B) receptor antagonist CGP36742 attenuates the baclofen- and scopolamine-induced deficit in Morris water maze task in rats.
Topics: Animals; Baclofen; Cholinergic Fibers; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Maze Learning; Memory; Movement; Muscarinic Antagonists; Organophosphorus Compounds; Rats; Rats, Wistar; Scopolamine; Spatial Behavior | 1997 |
[Improvement of learning and memory functions by GABAB receptor antagonists in mice].
Topics: Animals; Baclofen; Female; GABA Antagonists; Learning; Male; Memory; Mice; Organophosphorus Compounds | 1996 |
The GABA(B) receptor antagonist CGP36742 improves learned helplessness in rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Baclofen; Behavior, Animal; Biguanides; Dose-Response Relationship, Drug; Escape Reaction; GABA Agonists; GABA Antagonists; GABA-B Receptor Antagonists; Helplessness, Learned; Imipramine; Indoles; Male; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, GABA-B; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Serotonin Receptor Agonists; Tropisetron | 1999 |
Activation of the GABA(B) receptor inhibits transient lower esophageal sphincter relaxations in dogs.
Topics: Animals; Baclofen; Dogs; Esophagogastric Junction; Female; GABA Agonists; GABA Antagonists; GABA-B Receptor Antagonists; Male; Muscle Relaxation; Organophosphorus Compounds; Peristalsis; Pressure; Receptors, GABA-B; Stereoisomerism; Stomach; Time Factors | 1999 |
Selective block of rat and human neocortex GABA(B) receptors regulating somatostatin release by a GABA(B) antagonist endowed with cognition enhancing activity.
Topics: Adult; Animals; Baclofen; Female; GABA Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Neocortex; Nootropic Agents; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Somatostatin; Synaptosomes | 1999 |
gamma-aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes.
Topics: Adjuvants, Anesthesia; Animals; Baclofen; Cells, Cultured; Electrophysiology; GABA Agonists; GABA Antagonists; Gene Expression; Heart Ventricles; Mammals; Myocardium; Organophosphorus Compounds; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, GABA-B; RNA, Messenger; Sodium Oxybate | 2000 |
GABA(B) receptors contribute to vestibular compensation after unilateral labyrinthectomy in pigmented rats.
Topics: Adaptation, Physiological; Animals; Baclofen; Female; GABA Agonists; GABA Antagonists; Male; Organophosphorus Compounds; Posture; Rats; Rats, Inbred Strains; Receptors, GABA-B; Reflex, Vestibulo-Ocular; Sensory Deprivation; Skin Pigmentation; Stimulation, Chemical; Time Factors; Vestibule, Labyrinth | 2000 |
Delta(9)-THC-induced cognitive deficits in mice are reversed by the GABA(A) antagonist bicuculline.
Topics: Animals; Baclofen; Bicuculline; Brain; Dronabinol; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Marijuana Abuse; Maze Learning; Memory, Short-Term; Mental Recall; Mice; Mice, Inbred C57BL; Muscimol; Organophosphorus Compounds; Phenotype; Receptor, Cannabinoid, CB1 | 2005 |