cetrorelix has been researched along with antarelix* in 2 studies
2 other study(ies) available for cetrorelix and antarelix
| Article | Year |
|---|---|
Fluorescence spectroscopic determination of the critical aggregation concentration of the GnRH antagonists Cetrorelix, Teverelix and Ozarelix.
The fluorescence spectroscopic behavior of three 2-naphthylalanine containing Gonadotropin-releasing hormone (GnRH) antagonists Cetrorelix, Teverelix and Ozarelix has been investigated concerning their aggregation process in comparison to the non-aggregating peptide D-Phe(6)-GnRH. The aim of the present investigation consisted in developing a method to determine the critical aggregation concentration for these decapeptides. This was achieved by monitoring the incorporation of the fluorescent probe 1-anilino-8-naphthalene sulfonate (ANS) into aggregates and utilizing the modification of band shape and intensity of the intrinsic peptide fluorescence emission depending on the analyzed peptide concentrations. Finally an approach for the explanation of the observed band characteristics is presented analyzing the fluorescence of fragments Cetrorelix(1-4) and Cetrorelix(1-6). Topics: Anilino Naphthalenesulfonates; Fluorescent Dyes; Gonadotropin-Releasing Hormone; Molecular Conformation; Oligopeptides; Spectrometry, Fluorescence; Stereoisomerism | 2010 |
Stability of several LHRH antagonists against proteolytic enzymes and identification of degradation products by mass spectrometry.
In this study stabilities of several LHRH antagonists against proteolytic enzymes are compared. For the enzymatic tests 15 proteases which differ in both substrate specificity and pH optimum were selected. The cyclic and two linear antagonists proved to be extraordinarily stable against the enzymes used over an incubation time of 50 h. Some degradation products were identified by high-performance liquid chromatography combined with mass spectrometry. Topics: Chromatography, Liquid; Endopeptidases; Gonadotropin-Releasing Hormone; Hormone Antagonists; Hydrogen-Ion Concentration; Mass Spectrometry; Oligopeptides; Substrate Specificity | 2001 |