cetirizine and astemizole

cetirizine has been researched along with astemizole in 46 studies

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.17)	18.7374
1990's	26 (56.52)	18.2507
2000's	12 (26.09)	29.6817
2010's	6 (13.04)	24.3611
2020's	1 (2.17)	2.80

Authors

Authors	Studies
Carrupt, PA; Jolliet, P; Morin, C; Morin, D; Pagliara, A; Rihoux, JP; Testa, B; Tillement, JP; Urien, S	1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B	1
Keserü, GM	1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Jia, L; Sun, H	1
Sen, S; Sinha, N	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA	1
Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C	1
Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR	1
Kabir, M; Kerns, E; Neyra, J; Nguyen, K; Nguyễn, ÐT; Shah, P; Siramshetty, VB; Southall, N; Williams, J; Xu, X; Yu, KR	1
Fletcher, MP; Ryhal, BT	1
Soter, NA	1
Gillardin, JM; Gommeren, W; Janssen, PA; Janssen, PF; Leysen, JE; Sanz, G; Schotte, A	1
Humphreys, F; Hunter, JA	1
McMillan, JL; Simons, FE; Simons, KJ	1
Woodward, JK	1
Coulie, P; Lobaton, P; Moreno, F	1
Kaiser, HB	1
Simons, FE	1
Chung, M; Simons, FE; Simons, KJ; Yeh, J	1
Breneman, D; Bronsky, EA; Bruce, S; Kalivas, JT; Klein, GL; Roth, HL; Soter, N; Tharp, MD; Treger, C	1
de Mol, NJ; Fischer, MJ; Horbach, DA; Janssen, LH; Paulussen, JJ; Roelofsen, EP; van Miltenburg, JC	1
Arron, RJ; Bogdanovic, RP; Brandes, LJ; Fang, W; LaBella, FS; Queen, GM; Stein, DA; Tong, J; Warrington, RC; Zaborniak, CL	1
Dowd, PM; Goldsmith, P	1
Berkowitz, RB; Dockhorn, R; Findlay, S; Howland, WC; Lockey, R; Mitchell, DQ; Woehler, T	1
Woosley, RL	1
Clark, S	1
Edwards, IR; Lindquist, M	1
Briscoe, MP; Clark, RH; Day, JH; Ellis, AK; Gervais, P	1
Delgado, LF; Naspitz, CK; Pferferman, A; Solé, D	1
Estes, KS; González, MA	1
Annunziato, L; Castaldo, P; Genovese, A; Giorgio, G; January, CT; Marone, G; Pannaccione, A; Taglialatela, M; Zhou, Z	1
de Abajo, FJ; Rodríguez, LA	1
Mattila, MJ; Paakkari, I	1
Cheymol, G; Jaillon, P; Noyer, M; Weissenburger, J	1
Collart, P; Nicolas, JM; Roba, J; Whomsley, R	1
Cahill, SA; Gilbert, JD; Gross, GJ; Lukas, A; McCartney, DG	1
Benedetto, SR; Duncan, BS; Sloan, AS	1
Annunziato, L; Cataldi, M; Di Renzo, G; Giorgio, G; Secondo, A; Taglialatela, M; Valore, M	1
Annunziato, L; Castaldo, P; Fresi, A; Giorgio, G; Pannaccione, A; Rosati, B; Secondo, A; Taglialatela, M; Wanke, E	1
Paakkari, I	1
Moeller, ML; Nahata, MC; Phan, H	1
Bengtsson, E; Blomgren, B; Danielsson, BR; Danielsson, C; Johansson, A; Khan, KM; Kultima, K; Nilsson, MF; Sköld, AC; Webster, WS; Wilson, J	1

Reviews

8 review(s) available for cetirizine and astemizole

Article	Year
The second-generation antihistamines. What makes them different? Postgraduate medicine, 1991, May-01, Volume: 89, Issue:6 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Blood-Brain Barrier; Brain; Cetirizine; Cyproheptadine; Education, Medical, Continuing; Histamine H1 Antagonists; Humans; Hydroxyzine; Hypersensitivity; Loratadine; Terfenadine	1991
H1-receptor antagonist treatment of seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Clemastine; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Ketotifen; Loratadine; Rhinitis, Allergic, Seasonal; Terfenadine	1990
Recent advances in H1-receptor antagonist treatment. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Receptors, Histamine H1; Rhinitis, Allergic, Perennial; Terfenadine; Urticaria	1990
The new H1 antihistamines. Treatment of urticaria and other clinical problems. Dermatologic clinics, 1993, Volume: 11, Issue:1 Topics: Astemizole; Cetirizine; Dermatitis, Atopic; Histamine H1 Antagonists; Humans; Loratadine; Terfenadine; Triprolidine; Urticaria	1993
Cardiac actions of antihistamines. Annual review of pharmacology and toxicology, 1996, Volume: 36 Topics: Animals; Astemizole; Cetirizine; Diphenhydramine; Drug Interactions; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Terfenadine; Torsades de Pointes	1996
Pharmacokinetic overview of oral second-generation H1 antihistamines. International journal of clinical pharmacology and therapeutics, 1998, Volume: 36, Issue:5 Topics: Astemizole; Blood-Brain Barrier; Cetirizine; Histamine H1 Antagonists; Humans; Loratadine; Structure-Activity Relationship; Terfenadine; Therapeutic Equivalency; Torsades de Pointes	1998
Variations among non-sedating antihistamines: are there real differences? European journal of clinical pharmacology, 1999, Volume: 55, Issue:2 Topics: Astemizole; Benzimidazoles; Butyrophenones; Central Nervous System; Cetirizine; Drug Interactions; Heart; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Piperidines; Potassium Channel Blockers; Terfenadine; Triprolidine	1999
Cardiotoxicity of new antihistamines and cisapride. Toxicology letters, 2002, Feb-28, Volume: 127, Issue:1-3 Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Diseases; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Serotonin Receptor Agonists; Terfenadine; Triprolidine	2002

Trials

7 trial(s) available for cetirizine and astemizole

Article	Year
The effects of astemizole, cetirizine and loratadine on the time course of weal and flare reactions to histamine, codeine and antigen. The British journal of dermatology, 1991, Volume: 125, Issue:4 Topics: Adult; Animals; Antigens; Astemizole; Cetirizine; Codeine; Cyproheptadine; Dermatitis, Contact; Dust; Female; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Male; Middle Aged; Mites; Skin; Time Factors	1991
A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:4 Pt 1 Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Cyproheptadine; Double-Blind Method; Histamine; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Male; Placebos; Skin Tests; Terfenadine; Time Factors; Urticaria	1990
Comparison of cetirizine with astemizole in the treatment of perennial allergic rhinitis and study of the concomitant effect on histamine and allergen-induced wheal responses. Annals of allergy, 1990, Volume: 65, Issue:5 Topics: Adult; Astemizole; Benzimidazoles; Cetirizine; Double-Blind Method; Histamine H1 Antagonists; Humans; Hydroxyzine; Rhinitis, Allergic, Perennial; Skin Tests; Urticaria	1990
Cetirizine and astemizole therapy for chronic idiopathic urticaria: a double-blind, placebo-controlled, comparative trial. Journal of the American Academy of Dermatology, 1995, Volume: 33, Issue:2 Pt 1 Topics: Adult; Astemizole; Cetirizine; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Time Factors; Urticaria	1995
Comparison of efficacy, safety, and skin test inhibition of cetirizine and astemizole. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1996, Volume: 76, Issue:4 Topics: Adolescent; Adult; Aged; Analysis of Variance; Anti-Allergic Agents; Astemizole; Cetirizine; Child; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Intradermal Tests; Male; Middle Aged; Rhinitis, Allergic, Seasonal	1996
Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 79, Issue:2 Topics: Adolescent; Adult; Anti-Allergic Agents; Astemizole; Cetirizine; Double-Blind Method; Environmental Exposure; Female; Humans; Loratadine; Male; Middle Aged; Pruritus; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sneezing; Terfenadine; Treatment Outcome	1997
Evaluation of the potential cardiotoxicity of the antihistamines terfenadine, astemizole, loratadine, and cetirizine in atopic children. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1998, Volume: 80, Issue:4 Topics: Anti-Allergic Agents; Anti-Bacterial Agents; Astemizole; Cetirizine; Child; Child, Preschool; Drug Interactions; Electrocardiography; Erythromycin; Female; Heart; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Loratadine; Male; Terfenadine	1998

Other Studies

31 other study(ies) available for cetirizine and astemizole

Article	Year
Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist. Journal of medicinal chemistry, 1998, Mar-12, Volume: 41, Issue:6 Topics: Alkanes; Animals; Biological Transport; Blood Proteins; Brain; Cetirizine; Histamine H1 Antagonists; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydroxyzine; Isomerism; Models, Molecular; Molecular Conformation; Octanols; Rats; Water	1998
Predicting blood-brain barrier permeation from three-dimensional molecular structure. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs	2013
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells). Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4 Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles	2013
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity. Bioorganic & medicinal chemistry, 2019, 07-15, Volume: 27, Issue:14 Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility	2019
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models. Scientific reports, 2020, 11-26, Volume: 10, Issue:1 Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States	2020
Treatment of urticaria and angioedema: low-sedating H1-type antihistamines. Journal of the American Academy of Dermatology, 1991, Volume: 24, Issue:6 Pt 2 Topics: Angioedema; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Terfenadine; Urticaria	1991
[Non-sedative antihistaminics and binding to central and peripheral H1 histamine receptors]. Allergie et immunologie, 1991, Volume: 23, Issue:2 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cerebellum; Cetirizine; Cyproheptadine; Histamine H1 Antagonists; Hydroxyzine; Kinetics; Loratadine; Lung; Organ Specificity; Protein Binding; Receptors, Histamine H1; Terfenadine	1991
Pharmacology of antihistamines. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:4 Pt 2 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Cyproheptadine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Terfenadine; Time Factors	1990
The comparative pharmacokinetics of H1-receptor antagonists. Annals of allergy, 1987, Volume: 59, Issue:6 Pt 2 Topics: Adult; Age Factors; Astemizole; Benzhydryl Compounds; Benzimidazoles; Brompheniramine; Cetirizine; Child; Chlorpheniramine; Dose-Response Relationship, Drug; Half-Life; Histamine H1 Antagonists; Humans; Hydroxyzine; Terfenadine	1987
Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: relation to lipophilicity and membrane effects. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44, Issue:2 Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Antigens; Astemizole; beta-N-Acetylhexosaminidases; Calorimetry, Differential Scanning; Cell Membrane; Cetirizine; Histamine H1 Antagonists; Hydroxyzine; Leukemia, Basophilic, Acute; Mast Cells; Meclizine; Piperazines; Rats; Receptors, IgE; Signal Transduction; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured	1995
Enhanced cancer growth in mice administered daily human-equivalent doses of some H1-antihistamines: predictive in vitro correlates. Journal of the National Cancer Institute, 1994, May-18, Volume: 86, Issue:10 Topics: Animals; Astemizole; Carcinogens; Cetirizine; Doxylamine; Female; Histamine H1 Antagonists; Hydroxyzine; Loratadine; Melanoma, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley	1994
Dangers of non-sedating antihistamines. Lancet (London, England), 1997, May-03, Volume: 349, Issue:9061 Topics: Arrhythmias, Cardiac; Astemizole; Cetirizine; Heart Diseases; Histamine H1 Antagonists; Humans; Legislation, Drug; Liver Diseases; Loratadine; Terfenadine; United Kingdom	1997
Risks of non-sedating antihistamines. Lancet (London, England), 1997, May-03, Volume: 349, Issue:9061 Topics: Adverse Drug Reaction Reporting Systems; Astemizole; Cetirizine; Histamine H1 Antagonists; Humans; Loratadine; Terfenadine; Triprolidine	1997
Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines. Molecular pharmacology, 1998, Volume: 54, Issue:1 Topics: Animals; Astemizole; Cation Transport Proteins; Cetirizine; DNA-Binding Proteins; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart; Histamine H1 Antagonists; Humans; Loratadine; Oocytes; Potassium Channels; Potassium Channels, Voltage-Gated; Receptors, Histamine H1; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Transfection; Tumor Cells, Cultured; Xenopus laevis	1998
Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs. British journal of clinical pharmacology, 1999, Volume: 47, Issue:3 Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Case-Control Studies; Cetirizine; Child; Child, Preschool; Cohort Studies; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Female; Histamine H1 Antagonists; Humans; Infant; Infant, Newborn; Information Systems; Loratadine; Male; Middle Aged; Risk Factors; Tachycardia, Ventricular; Terfenadine; Triprolidine	1999
Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1999, Volume: 29 Suppl 3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Astemizole; Cetirizine; Dogs; Dose-Response Relationship, Drug; Female; Histamine H1 Antagonists; Long QT Syndrome; Sotalol	1999
In vitro inhibition of human liver drug metabolizing enzymes by second generation antihistamines. Chemico-biological interactions, 1999, Nov-15, Volume: 123, Issue:1 Topics: Astemizole; Benzimidazoles; Cetirizine; Cytochrome P-450 Enzyme Inhibitors; Dimethyl Sulfoxide; Enzyme Inhibitors; Glucuronosyltransferase; Histamine H1 Antagonists; Humans; Isoenzymes; Kinetics; Loratadine; Microsomes, Liver; Terfenadine	1999
Predictors of torsades de pointes in rabbit ventricles perfused with sedating and nonsedating histamine H1-receptor antagonists. Canadian journal of physiology and pharmacology, 2000, Volume: 78, Issue:5 Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Astemizole; Cetirizine; Electrocardiography; Heart; Heart Ventricles; Histamine H1 Antagonists; Hydroxyzine; Hypnotics and Sedatives; In Vitro Techniques; Male; Perfusion; Rabbits; Torsades de Pointes	2000
Impact of interventions designed to increase market share and prescribing of fexofenadine at HMOs. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2000, Oct-01, Volume: 57, Issue:19 Topics: Analysis of Variance; Astemizole; Cetirizine; Cost Savings; Drug Costs; Drug Utilization; Health Maintenance Organizations; Histamine H1 Antagonists; Humans; Loratadine; Marketing of Health Services; Practice Patterns, Physicians'; Retrospective Studies; Terfenadine; United States	2000
Pharmacological blockade of ERG K(+) channels and Ca(2+) influx through store-operated channels exerts opposite effects on intracellular Ca(2+) oscillations in pituitary GH(3) cells. Molecular pharmacology, 2000, Volume: 58, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Astemizole; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cation Transport Proteins; Cells, Cultured; Cetirizine; Electrophysiology; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Hydroxyzine; Large-Conductance Calcium-Activated Potassium Channels; Nimodipine; Phenethylamines; Pituitary Gland; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Voltage-Gated; Rats; Small-Conductance Calcium-Activated Potassium Channels; Sulfonamides; Terfenadine	2000
Inhibition of depolarization-induced [3H]noradrenaline release from SH-SY5Y human neuroblastoma cells by some second-generation H(1) receptor antagonists through blockade of store-operated Ca(2+) channels (SOCs). Biochemical pharmacology, 2001, Nov-01, Volume: 62, Issue:9 Topics: Astemizole; Calcium; Calcium Channel Blockers; Calcium Channels; Cation Transport Proteins; Cetirizine; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Neuroblastoma; Norepinephrine; Potassium Channels; Potassium Channels, Voltage-Gated; Receptors, Histamine H1; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Tritium; Tumor Cells, Cultured	2001
Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast. Drugs, 2009, Volume: 69, Issue:18 Topics: Acetates; Administration, Oral; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Astemizole; Cetirizine; Child; Cyclopropanes; Drug Administration Schedule; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; Ketotifen; Leukotriene Antagonists; Loratadine; Piperazines; Quinolines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Safety; Sulfides; Tablets; Terfenadine; Treatment Outcome	2009
Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs. Reproductive toxicology (Elmsford, N.Y.), 2010, Volume: 29, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Astemizole; Cetirizine; Drug Evaluation, Preclinical; Embryo Culture Techniques; Embryo, Mammalian; Embryonic Development; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart Rate; Histamine H1 Antagonists, Non-Sedating; Hypoxia; Image Processing, Computer-Assisted; Maternal Exposure; Nitroimidazoles; Potassium Channels, Inwardly Rectifying; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens	2010