cerulenin and 1-oleoyl-2-acetylglycerol

cerulenin has been researched along with 1-oleoyl-2-acetylglycerol* in 1 studies

Other Studies

1 other study(ies) available for cerulenin and 1-oleoyl-2-acetylglycerol

Article	Year
Inhibitory effect of antibiotic cerulenin on the respiratory burst in phagocytes. II. Inhibition by cerulenin of intracellular calcium mobilization in human neutrophils. The Journal of antibiotics, 1989, Volume: 42, Issue:7 Generation of superoxide anion (O2-) and mobilization of intracellular Ca2+ in human neutrophils upon exposure to stimuli such as N-formylmethionylleucylphenylalanine (fMLP) were inhibited by the antibiotic cerulenin, which inhibits fatty acid and cholesterol biosynthesis. The inhibition of O2- generation and Ca2+-mobilization required certain periods of incubation with cerulenin and both abilities of the cells were gradually lost following a similar time-course. In contrast, significant Ca2+-influx from the medium was observed in cerulenin-treated cells as well as untreated cells. The results suggest that an event which coincides with the Ca2+-mobilization and not Ca2+ per se is important for the induction of O2- generation in the fMLP-stimulated cells and that this step is blocked in cerulenin-treated cells. Phorbol myristate acetate or synthetic 1-oleoyl-2-acetylglycerol were able to bypass the block and induced O2- generation in cerulenin-treated cells. Topics: Antifungal Agents; Bacterial Toxins; Calcimycin; Calcium; Cerulenin; Diglycerides; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen; Phagocytes; Phagocytosis; Sodium Fluoride; Superoxides; Tetradecanoylphorbol Acetate	1989

Article

Year

Inhibitory effect of antibiotic cerulenin on the respiratory burst in phagocytes. II. Inhibition by cerulenin of intracellular calcium mobilization in human neutrophils.

The Journal of antibiotics, 1989, Volume: 42, Issue:7

Generation of superoxide anion (O2-) and mobilization of intracellular Ca2+ in human neutrophils upon exposure to stimuli such as N-formylmethionylleucylphenylalanine (fMLP) were inhibited by the antibiotic cerulenin, which inhibits fatty acid and cholesterol biosynthesis. The inhibition of O2- generation and Ca2+-mobilization required certain periods of incubation with cerulenin and both abilities of the cells were gradually lost following a similar time-course. In contrast, significant Ca2+-influx from the medium was observed in cerulenin-treated cells as well as untreated cells. The results suggest that an event which coincides with the Ca2+-mobilization and not Ca2+ per se is important for the induction of O2- generation in the fMLP-stimulated cells and that this step is blocked in cerulenin-treated cells. Phorbol myristate acetate or synthetic 1-oleoyl-2-acetylglycerol were able to bypass the block and induced O2- generation in cerulenin-treated cells.

Topics: Antifungal Agents; Bacterial Toxins; Calcimycin; Calcium; Cerulenin; Diglycerides; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen; Phagocytes; Phagocytosis; Sodium Fluoride; Superoxides; Tetradecanoylphorbol Acetate

1989