ceritinib has been researched along with piperidine* in 1 studies
1 other study(ies) available for ceritinib and piperidine
| Article | Year |
|---|---|
Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R.
The piperidine fragment in ceritinib was replaced with diverse aliphatic amines to improve inherent resistance issues of ceritinib. While most of the prepared compounds exhibit as similar in vitro activities as ceritinib, compound 10 shows encouraging activities against wild-type ALK as well as crizotinib-resistant mutants including extremely resistant G1202R mutant with an IC Topics: Amines; Anaplastic Lymphoma Kinase; Animals; Crizotinib; Drug Resistance, Neoplasm; Heterografts; Humans; Mice; Mutation; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Receptor Protein-Tyrosine Kinases; Sulfones | 2017 |