cercosporin and phorbol

cercosporin has been researched along with phorbol* in 1 studies

Other Studies

1 other study(ies) available for cercosporin and phorbol

ArticleYear
Structural investigation of protein kinase C inhibitors.
    Journal of molecular structure, 1991, Volume: 230

    The phospholipid and Ca2+ dependent protein kinase (PKC) plays an essential role in a variety of cellular events. Inhibition of PKC was shown to arrest growth in tumor cell cultures making it a target for possible antitumor therapy. Calphostins are potent inhibitors of PKC with high affinity for the enzyme regulatory site. Structural characteristics of calphostins, which confer the inhibitory activity, are investigated by comparing their optimized structures with the existing models for PKC activation. The resulting model of inhibitory activity assumes interaction with two out of the three electrostatic interaction sites postulated for activators. The model shows two sites of hydrophobic interaction and enables the inhibitory activity of gossypol to be accounted for.

    Topics: Gossypol; Lyngbya Toxins; Models, Molecular; Naphthalenes; Perylene; Phorbols; Protein Conformation; Protein Kinase C

1991