ceratamine-a and o-iodoxybenzoic-acid

ceratamine-a has been researched along with o-iodoxybenzoic-acid* in 1 studies

Other Studies

1 other study(ies) available for ceratamine-a and o-iodoxybenzoic-acid

Article	Year
A direct and efficient total synthesis of the tubulin-binding agents ceratamine A and B; use of IBX for a remarkable heterocycle dehydrogenation. Organic letters, 2009, May-21, Volume: 11, Issue:10 The total synthesis of the tubulin-binding agents ceratamine A and B is reported, along with des-methyl analogs, via a synthetic route that is high-yielding and operationally efficient. The synthetic route involved a Beckmann rearrangement to form an azepine ring precursor, a Knoevenagel condensation to install the benzylic side chain, and an effective imidazole annulation onto an alpha-aminoketone precursor with a protected S-methylisothiourea. Final dehydrogenation proved remarkably facile using IBX. Topics: Animals; Azepines; Drug Design; Imidazoles; Iodobenzenes; Molecular Structure; Porifera; Tubulin Modulators	2009

Article

Year

A direct and efficient total synthesis of the tubulin-binding agents ceratamine A and B; use of IBX for a remarkable heterocycle dehydrogenation.

Organic letters, 2009, May-21, Volume: 11, Issue:10

The total synthesis of the tubulin-binding agents ceratamine A and B is reported, along with des-methyl analogs, via a synthetic route that is high-yielding and operationally efficient. The synthetic route involved a Beckmann rearrangement to form an azepine ring precursor, a Knoevenagel condensation to install the benzylic side chain, and an effective imidazole annulation onto an alpha-aminoketone precursor with a protected S-methylisothiourea. Final dehydrogenation proved remarkably facile using IBX.

Topics: Animals; Azepines; Drug Design; Imidazoles; Iodobenzenes; Molecular Structure; Porifera; Tubulin Modulators

2009