Compounds > cephamycin c
Page last updated: 2024-09-03

cephamycin c and clavulanic acid

cephamycin c has been researched along with clavulanic acid in 19 studies

Compound Research Comparison

Studies
(cephamycin c)		Trials
(cephamycin c)		Recent Studies (post-2010)
(cephamycin c)		Studies
(clavulanic acid)		Trials
(clavulanic acid)		Recent Studies (post-2010) (clavulanic acid)
720121,801212424

Protein Interaction Comparison

ProteinTaxonomycephamycin c (IC50)clavulanic acid (IC50)
Beta-lactamase Klebsiella pneumoniae1.72
Beta-lactamase Escherichia coli0.07
Beta-lactamase Citrobacter gillenii0.009
Beta-lactamase Shouchella clausii0.085
Beta-lactamase Pseudomonas aeruginosa0.1
Beta-lactamase Pseudomonas aeruginosa0.1
Beta-lactamaseStaphylococcus aureus0.08
Beta-lactamaseEscherichia coli K-120.015
Beta-lactamase SHV-1Escherichia coli0.028
Beta-lactamase SHV-1Klebsiella pneumoniae0.17
Beta-lactamase OXA-1Escherichia coli3.2
Cytochrome P450 2B6Homo sapiens (human)0.17
Beta-lactamasePseudomonas aeruginosa PAO10.8
Beta-lactamase TEMEscherichia coli0.0933
Beta-lactamase Salmonella enterica subsp. enterica serovar Westhampton0.01
Beta-lactamase Pseudomonas aeruginosa0.1
Beta-lactamase Klebsiella pneumoniae0.02
Class D beta-lactamaseBrachyspira pilosicoli2
Beta-lactamase Pseudomonas luteola0.036
Beta-lactamase Escherichia coli8.6
Beta-lactamase Escherichia coli0.009

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (15.79)18.2507
2000's12 (63.16)29.6817
2010's4 (21.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hodgson, JE; Ward, JM1
Braña, AF; Sánchez, L1
Bezbaruah, RL; Dutta, NN; Roy, MK; Thakur, R1
Jensen, SE; Paradkar, AS; Thai, W1
Anders, C; Barton, B; Greaves, P; Griffin, A; Griffin, J; Hughes, C; Jensen, SE; Mosher, RH; Paradkar, AS1
Alexander, DC; Jensen, SE; Leskiw, BK; Trepanier, NK1
Liras, P; Martín, JF; Pérez-Redondo, R; Rodríguez-García, A; Santamarta, I1
Jin, W; Kang, SG; Kim, SK; Lee, KJ; Lee, SH; Ochi, K; Ryu, YG; Saito, N1
Alexander, DC; Jensen, SE; Kaziuk, TL; Tahlan, K; Wang, L1
Bignell, DR; Colvin, KR; Jensen, SE; Leskiw, BK; Tahlan, K1
Liras, P; Lorenzana, LM; Martín, JF; Pérez-Redondo, R; Santamarta, I1
Gomez-Escribano, JP; Liras, P; Martín, JF; Pisabarro, A1
Koekman, B; Liras, P; López-García, MT; Martín, JF; Pérez-Redondo, R; Santamarta, I1
Bibb, MJ; Gomez-Escribano, JP; Hesketh, A; Liras, P; Martín, JF1
Jensen, SE; Kim, DW; Kim, ES; Lee, KJ; Song, JY1
Liras, P; Lorenzana, LM; Martín, JF; Nárdiz, N; Santamarta, I1
Álvarez-Álvarez, R; Kurt, A; Liras, P; Özcengiz, G1
Alvarez-Álvarez, R; Liras, P; Martínez-Burgo, Y; Pérez-Redondo, R; Prieto-Domínguez, A; Rodríguez-García, A; Santamarta, I1
Araujo, ML; Baptista, AS; Cavallieri, AP; Leite, CA1

Other Studies

19 other study(ies) available for cephamycin c and clavulanic acid

ArticleYear
The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces.
    FEMS microbiology letters, 1993, Jun-15, Volume: 110, Issue:2

    Topics: Bacterial Proteins; Cephamycins; Chromosome Mapping; Chromosomes, Bacterial; Clavulanic Acid; Clavulanic Acids; Cloning, Molecular; Cosmids; DNA, Bacterial; Genes, Bacterial; Genetic Vectors; Intramolecular Transferases; Isomerases; Mixed Function Oxygenases; Multigene Family; Penicillin-Binding Proteins; Species Specificity; Streptomyces

1993
Cell density influences antibiotic biosynthesis in Streptomyces clavuligerus.
    Microbiology (Reading, England), 1996, Volume: 142 ( Pt 5)

    Topics: Amino Acids; Bacteria; Biological Factors; Cephamycins; Clavulanic Acid; Clavulanic Acids; Culture Media; Culture Media, Conditioned; Hot Temperature; Kinetics; Peptides; Spores, Bacterial; Streptomyces

1996
Coordinate production of cephamycin c and clavulanic acid by Streptomyces clavuligerus.
    Indian journal of experimental biology, 1999, Volume: 37, Issue:10

    Topics: Anti-Bacterial Agents; Cephamycins; Clavulanic Acid; Culture Media; Streptomyces

1999
Construction and analysis of ss-lactamase-inhibitory protein (BLIP) non-producer mutants of Streptomyces clavuligerus.
    Microbiology (Reading, England), 2001, Volume: 147, Issue:Pt 2

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; ATP-Binding Cassette Transporters; Bacterial Proteins; beta-Lactamase Inhibitors; Blotting, Southern; Blotting, Western; Cephamycins; Clavulanic Acid; Enzyme Inhibitors; Molecular Sequence Data; Mutation; Penicillin G; Sequence Analysis, DNA; Streptomyces

2001
Applications of gene replacement technology to Streptomyces clavuligerus strain development for clavulanic acid production.
    Applied and environmental microbiology, 2001, Volume: 67, Issue:5

    Topics: Cephamycins; Clavulanic Acid; Gene Deletion; Genes, Bacterial; Genetic Engineering; Lysine; Streptomyces; Transaminases

2001
The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant.
    Microbiology (Reading, England), 2002, Volume: 148, Issue:Pt 3

    Topics: Bacterial Proteins; Base Sequence; Cephamycins; Clavulanic Acid; Codon; Gene Expression Regulation, Bacterial; Molecular Sequence Data; Mutation; Protein Biosynthesis; RNA, Bacterial; RNA, Transfer, Leu; Sequence Analysis, DNA; Streptomyces

2002
CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus.
    Journal of bacteriology, 2002, Volume: 184, Issue:11

    Topics: Amino Acid Isomerases; Bacterial Proteins; Cephamycins; Clavulanic Acid; DNA-Binding Proteins; Genes, Bacterial; Genes, Regulator; Promoter Regions, Genetic; Recombinant Fusion Proteins; Streptomyces; Transcription Factors

2002
Two relA/spoT homologous genes are involved in the morphological and physiological differentiation of Streptomyces clavuligerus.
    Microbiology (Reading, England), 2004, Volume: 150, Issue:Pt 5

    Topics: Bacterial Proteins; Cephamycins; Clavulanic Acid; Culture Media; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Guanosine Pentaphosphate; Guanosine Tetraphosphate; Ligases; Molecular Sequence Data; Mutation; Phylogeny; Sequence Analysis, DNA; Streptomyces

2004
Transcriptional and translational analysis of the ccaR gene from Streptomyces clavuligerus.
    Microbiology (Reading, England), 2004, Volume: 150, Issue:Pt 12

    Topics: Bacterial Proteins; Base Sequence; Cephamycins; Clavulanic Acid; Escherichia coli; Gene Expression Regulation, Bacterial; Molecular Sequence Data; Mutation; Protein Biosynthesis; Streptomyces; Transcription Factors; Transcription, Genetic

2004
Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:4

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Cephamycins; Clavulanic Acid; Gene Expression Regulation, Bacterial; Molecular Sequence Data; Open Reading Frames; Repressor Proteins; Sequence Analysis, DNA; Sigma Factor; Streptomyces

2005
Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus.
    Molecular microbiology, 2005, Volume: 56, Issue:3

    Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Cephamycins; Clavulanic Acid; Cloning, Molecular; DNA-Binding Proteins; Escherichia coli; Gene Expression Regulation, Bacterial; Gene Order; Genes, Regulator; Molecular Sequence Data; Mutation; Receptors, GABA-A; Recombinant Proteins; Response Elements; Streptomyces; Transcription Factors

2005
An rplKDelta29-PALG-32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus.
    Molecular microbiology, 2006, Volume: 61, Issue:3

    Topics: Amino Acids; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Cephamycins; Clavulanic Acid; Deoxyribonucleases, Type II Site-Specific; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Genes, Regulator; Molecular Sequence Data; Mutation; Nucleotides; Open Reading Frames; Ribosomal Proteins; Streptomyces; Thiostrepton; Transcription Factors; Transcription, Genetic

2006
Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production.
    Molecular microbiology, 2007, Volume: 66, Issue:2

    Topics: Acetates; Amino Acid Sequence; Bacterial Proteins; Blotting, Southern; Cephamycins; Clavulanic Acid; Fatty Acids; Gene Deletion; Gene Expression Regulation, Bacterial; Leucine; Molecular Sequence Data; Mutation; Operon; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Streptomyces; Transcription, Genetic

2007
Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp.
    Microbiology (Reading, England), 2008, Volume: 154, Issue:Pt 3

    Topics: Base Sequence; Cephamycins; Clavulanic Acid; Cloning, Molecular; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Guanosine Pentaphosphate; Ligases; Molecular Sequence Data; Mutagenesis, Insertional; Mutation; Sequence Analysis, DNA; Spores, Bacterial; Streptomyces; Transcription Initiation Site; Transcriptional Activation

2008
A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production.
    Journal of industrial microbiology & biotechnology, 2009, Volume: 36, Issue:2

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Biotechnology; Cephamycins; Clavulanic Acid; Culture Media; Gene Expression Regulation, Bacterial; Multigene Family; Mutation; Open Reading Frames; Streptomyces

2009
A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production.
    Microbial biotechnology, 2011, Volume: 4, Issue:2

    Topics: Bacterial Proteins; Cephamycins; Clavulanic Acid; Gene Expression Regulation, Bacterial; Lactams; Membrane Transport Proteins; Mutation; Streptomyces; Thiosulfate Sulfurtransferase

2011
Role of the cmcH-ccaR intergenic region and ccaR overexpression in cephamycin C biosynthesis in Streptomyces clavuligerus.
    Applied microbiology and biotechnology, 2013, Volume: 97, Issue:13

    Topics: Biosynthetic Pathways; Cephamycins; Clavulanic Acid; DNA, Intergenic; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genes, Bacterial; Real-Time Polymerase Chain Reaction; Sequence Deletion; Streptomyces; Transcription Factors

2013
Transcriptomic analysis of Streptomyces clavuligerus ΔccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation.
    Microbial biotechnology, 2014, Volume: 7, Issue:3

    Topics: Biosynthetic Pathways; Cephamycins; Clavulanic Acid; Culture Media; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genes, Reporter; Luciferases; Multigene Family; Real-Time Polymerase Chain Reaction; Streptomyces; Transcription Factors

2014
Dissociation of cephamycin C and clavulanic acid biosynthesis by 1,3-diaminopropane in Streptomyces clavuligerus.
    FEMS microbiology letters, 2016, Volume: 363, Issue:1

    Topics: Biosynthetic Pathways; Cephamycins; Clavulanic Acid; Culture Media; Diamines; Streptomyces

2016