cephalosporin c has been researched along with 7-aminocephalosporanic acid in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (13.04) | 18.7374 |
| 1990's | 16 (23.19) | 18.2507 |
| 2000's | 20 (28.99) | 29.6817 |
| 2010's | 21 (30.43) | 24.3611 |
| 2020's | 3 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Aramori, I; Fukagawa, M; Imanaka, H; Isogai, T; Iwami, M; Kohsaka, M; Kojo, H; Ono, T; Ueda, Y | 1 |
| Adams, PA; Sikakana, CN | 1 |
| Grabarnik, MS; Iakhkind, MI; Kocherezhko, NA | 1 |
| Good, RC; Shepard, CC; Van Landingham, RM; Walker, LL | 1 |
| Engel, GL; Indelicato, JM; Occolowitz, JL | 1 |
| Navashin, SM; Rozenfel'd, GS | 1 |
| Frère, JM; Ghuysen, JM; Kelly, JA; Klein, D | 1 |
| Sosnovskaya, IN; Yatsimirskaya, NT; Yatsimirsky, AK | 1 |
| Kurochkina, VB; Larina, EV; Libinson, GS; Nys, PS | 1 |
| Battistel, E; Franzosi, G; Gagliardi, I; Van der Goes, W | 1 |
| Matsumoto, K | 1 |
| Crucq, AS; Hickel, B; Tilquin, BL | 1 |
| Binder, R; Brown, J; Romancik, G | 1 |
| Barredo, JL; Díez, B; Fouces, R; Mellado, E; Rodríguez, M | 1 |
| Abraham, EP; Whiteman, PA | 1 |
| Lorenz, WW; Wiegel, J | 1 |
| Jeon, YJ; Kim, CG; Kim, JH; Lee, JH; Won, JI | 1 |
| Conder, MJ; Crawford, L; McAda, PC; Rambosek, JA; Reeves, CD; Stepan, AM; Vinci, VA | 1 |
| González, R; Hoogmartens, J; Nuevas, L; Rodríguez, JC | 1 |
| Balsamo, A; Barontini, S; Calvani, F; Di Modugno, E; Felici, A; Gentili, D; Macchia, M; Rossello, A | 1 |
| Baldaro, E; Carrea, G; Frare, G; Monti, D; Riva, S | 1 |
| Aretz, W; Fritz-Wolf, K; Kabsch, W; Koller, KP; Lange, G; Liesum, A; Sauber, K; Schreuder, H | 1 |
| Arndt, PA; Garratty, G | 1 |
| Hong, SI; Kim, SW; Lee, JW; Park, SW | 1 |
| Fini, A; González, M; Hernández, R; López, MA; Rodríguez, JC; Rodríguez, Z; Tolón, B; Valdés, B; Velez, H | 1 |
| Brans, A; Duval, V; Franssen, C; Frère, JM; Granier, B; Joris, B; Lepage, S; Swinnen, M | 1 |
| ABRAHAM, EP; LODER, B; NEWTON, GG | 1 |
| ABRAHAM, EP; CRAWFORD, K; CROMPTON, B; JAGO, M; NEWTON, GG | 1 |
| HUANG, HT; SETO, TA; SHULL, GM | 1 |
| BRIER, G; GODZESKI, CW; PAVEY, DE | 1 |
| JAGO, M | 1 |
| Andre, M | 1 |
| Mitsushima, K; Takakura, T; Takimoto, A; Tani, H; Yagi, S | 1 |
| Choi, JH; Jang, AS; Kim, KU; Lee, JH; Lee, YM; Park, CS; Park, HS; Park, SW | 1 |
| Li, Q; Luo, H; Shen, Z; Yu, H | 1 |
| Barber, MS; Giesecke, U; Minas, W; Reichert, A | 1 |
| Ghosh, P; Kundu, S; Nigam, VK | 2 |
| Fischer, L; Patett, F | 1 |
| Dib, I; Nidetzky, B; Riethorst, W; Slavica, A | 1 |
| Chen, J; Jiang, W; Yang, S; Yang, Y; Zhao, G; Zhao, Y; Zheng, H; Zhu, T | 1 |
| Kóczián, K; Kökösi, J; Noszál, B; Szakács, Z | 1 |
| García-Carmona, F; Lozada-Ramírez, JD; Martínez-Martínez, I; Montoro-García, S; Sánchez-Ferrer, A | 1 |
| Gaurav, K; Kundu, K; Kundu, S | 1 |
| Bai, J; Sun, SQ; Zou, JF | 1 |
| Fong, WP; Tsang, PW; Wong, KS | 1 |
| Gong, G; Hu, Y; Liu, Y; Zhu, B; Zhu, C | 1 |
| Fukuyama, K; Ishihara, S; Kijima, K; Kumagai, H; Suzuki, H; Wada, K; Yamada, C | 1 |
| Andre, M; Huck, CW; Karner, M; Märk, J | 1 |
| Chen, P; Duan, E; Li, Z; Liu, Y; Ren, X; Wang, Y; Yang, J; Zuo, J | 1 |
| Luo, H; Shen, Z; Wang, Y; Yu, H; Zhang, J | 1 |
| Bolivar, JM; Boniello, C; Mayr, T; Nidetzky, B | 1 |
| Anandan, A; Flematti, G; Golden, E; Molla, G; Paterson, R; Pollegioni, L; Rosini, E; Tie, WJ; Vrielink, A | 1 |
| Molla, G; Pollegioni, L; Rosini, E | 1 |
| Huang, H; Jiang, L; Li, S; Song, P; Tian, Q | 1 |
| Alpay-Karaoglu, S; Basoglu, S; Demirbas, A; Demirbas, N; Ulker, S | 1 |
| Huang, X; Li, Q; Zhu, Y | 1 |
| Chen, ZB; Cui, YB; He, ZW; Hu, DX; Ren, NQ; Tang, CC; Wang, AJ; Yan, LL; Zhang, Y | 1 |
| Chen, G; Huo, X; Lin, Z; Ouyang, P; Qian, Y; Xiao, Y; Zhang, Y | 1 |
| Kim, SB; Kim, SW; Park, C | 1 |
| Abdelaleem, EA; Hussein, EA; Naguib, IA; Zaazaa, HE | 1 |
| Ding, JM; Han, NY; Huang, ZX; Li, JJ; Tang, HZ; Tang, XH; Xu, B; Yang, YJ; Yu, JL; Yu, TT; Zhou, JP | 1 |
| Chen, J; Guo, R; Torres, OL; Wang, Z; Yu, Y; Zhou, Y | 1 |
| Han, Y; Hu, C; Zhang, J | 1 |
| Chen, Y; Liao, W; Liu, Y; Luo, X; Qiu, J; Tan, Q; Yuan, J; Zhang, Y | 1 |
| De Rosa, M; Hernández-Martínez, MÁ; Marabotti, A; Soriente, A; Verdino, A; Zollo, F | 1 |
| Deng, M; Ding, J; Gao, Y; Huang, Z; Yang, Y; Zhou, Y; Zhu, H | 1 |
| Arruebo, M; Chen, Y; Jacobs, LMC; Kowalczyk, A; Kowalski, K; Lewandowski, EM; Mendoza, G; Stączek, P; Szczupak, Ł | 1 |
| Chu, H; Dang, Y; Li, P; Xing, M; Xu, X; Xue, H; Zhang, N; Zhang, W; Zheng, Z; Zhou, C | 1 |
5 review(s) available for cephalosporin c and 7-aminocephalosporanic acid
| Article | Year |
|---|---|
[Achievements in the field of obtaining and studying new semisynthetic cephalosporin antibiotics. Research in the field of directed cephalosporin synthesis].
Topics: Acylation; Cefotaxime; Cephalosporins; Cephamycins; Chemical Phenomena; Chemistry; Heterocyclic Compounds; Methods; Research; Structure-Activity Relationship | 1981 |
Production of 6-APA, 7-ACA, and 7-ADCA by immobilized penicillin and cephalosporin amidases.
Topics: Bacillus megaterium; Cephalosporinase; Cephalosporins; Enzymes, Immobilized; Industrial Microbiology; Penicillanic Acid; Penicillin Amidase | 1993 |
Recombinant Acremonium chrysogenum strains for the industrial production of cephalosporin.
Topics: Acetyltransferases; Acremonium; Bacterial Proteins; Cephalosporins; DNA, Fungal; DNA, Recombinant; Drug Industry; Fungal Proteins; Genes, Fungal; Hemoglobins; Industrial Microbiology; Intramolecular Transferases; Isomerases; Oxygenases; Penicillin G; Penicillin-Binding Proteins; Penicillins; Recombinant Fusion Proteins; Truncated Hemoglobins | 1996 |
Industrial enzymatic production of cephalosporin-based beta-lactams.
Topics: Acremonium; Anti-Bacterial Agents; beta-Lactams; Bioreactors; Cell Culture Techniques; Cephalosporins; Drug Industry; Enzymes; Fungal Proteins; Gene Expression Regulation, Fungal; Industrial Microbiology | 2004 |
Cephalosporin C acylase: dream and(/or) reality.
Topics: Anti-Bacterial Agents; Cephalosporins; Penicillin Amidase; Protein Engineering | 2013 |
64 other study(ies) available for cephalosporin c and 7-aminocephalosporanic acid
| Article | Year |
|---|---|
Construction of a 7-aminocephalosporanic acid (7ACA) biosynthetic operon and direct production of 7ACA in Acremonium chrysogenum.
Topics: Acremonium; Base Sequence; Blotting, Southern; Cephalosporins; Cloning, Molecular; D-Amino-Acid Oxidase; DNA, Bacterial; DNA, Fungal; Fusarium; Molecular Sequence Data; Operon; Penicillin Amidase; Pseudomonas; Serine Endopeptidases; Transformation, Bacterial | 1991 |
1-Chloro-2,4-dinitrobenzene-mediated irreversible inactivation of acidic glutathione S-transferases. Inactivation mechanism--a saturation-type or simple second-order kinetic process?
Topics: Cephalosporins; Dinitrochlorobenzene; Enzyme Activation; Glutathione Transferase; Humans; Hydrogen-Ion Concentration; Kinetics; Placenta | 1992 |
[Structure-activity relationship in cephalosporin antibiotics. I. Impact of nitrogen functions on biological activity of cephalosporins--7-aminocephalosporanic acid derivatives].
Topics: Cephalosporins; Nitrogen; Structure-Activity Relationship | 1991 |
Activity of selected beta-lactam antibiotics against Mycobacterium leprae.
Topics: Animals; Anti-Bacterial Agents; Cefoxitin; Cefuroxime; Cephalosporins; Female; Leprosy; Mezlocillin; Mice; Mycobacterium leprae; Penicillins | 1987 |
Cephalothin: hydrolysis of the C-3'-acetoxy moiety of a 7-aminocephalosporanic acid; observation of both acyl-oxygen bond cleavage and reversible alkyl-oxygen bond cleavage.
Topics: Cephalosporins; Cephalothin; Chemical Phenomena; Chemistry; Crystallization; Dealkylation; Hydrolysis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxygen; Oxygen Radioisotopes | 1985 |
Interaction between non-classical beta-lactam compounds and the Zn2+-containing G and serine R61 and R39 D-alanyl-D-alanine peptidases.
Topics: Actinomycetaceae; Amdinocillin; beta-Lactams; Carboxypeptidases; Cefoxitin; Cephalosporins; Clavulanic Acid; Drug Interactions; Endopeptidases; Enzyme Inhibitors; Imipenem; Kinetics; Penicillanic Acid; Penicillins; Quinoxalines; Serine-Type D-Ala-D-Ala Carboxypeptidase; Streptomyces; Zinc | 1981 |
Spectrophotometric determination of 6-aminopenicillanic and 7-aminocephalosporanic acids as the Schiff bases with para-dimethylaminobenzaldehyde in the presence of sodium dodecyl sulfate micelles.
Topics: Benzaldehydes; Cephalosporins; Indicators and Reagents; Kinetics; Micelles; Microcomputers; Penicillanic Acid; Schiff Bases; Sensitivity and Specificity; Sodium Dodecyl Sulfate; Spectrophotometry; Time Factors | 1995 |
[Kinetics of 7-aminocephalosporanic acid in aqueous solutions].
Topics: Biotransformation; Catalysis; Cephalosporins; Drug Stability; Hydrogen-Ion Concentration; Solutions; Temperature; Water | 1995 |
Screening and characterization of microorganisms with glutaryl-7ADCA acylase activity.
Topics: Amidohydrolases; Bacteria; Cephalosporins; Fermentation; Glutarates; Hydrogen-Ion Concentration | 1995 |
Radical mechanisms of cephalosporins: a pulse radiolysis study.
Topics: Azides; Bromine; Cefotaxime; Ceftazidime; Cefuroxime; Cephalosporins; Free Radicals; Hydroxyl Radical; Kinetics; Oxygen; Pulse Radiolysis; Superoxides | 1995 |
Biochemical characterization of a glutaryl-7-aminocephalosporanic acid acylase from Pseudomonas strain BL072.
Topics: Amidohydrolases; Cephalosporins; Pseudomonas | 1994 |
Phenoxymethylpenicillin amidohydrolases from Penicillium chrysogenum.
Topics: Cephalosporins; Chromatography, Gel; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Enzyme Stability; Hydrogen-Ion Concentration; Molecular Structure; Molecular Weight; Penicillanic Acid; Penicillin Amidase; Penicillin V; Penicillium chrysogenum; Substrate Specificity; Temperature | 1996 |
Isolation, analysis, and expression of two genes from Thermoanaerobacterium sp. strain JW/SL YS485: a beta-xylosidase and a novel acetyl xylan esterase with cephalosporin C deacetylase activity.
Topics: Acetylesterase; Amino Acid Sequence; Bacteria, Anaerobic; Carboxylic Ester Hydrolases; Cephalosporins; Cloning, Molecular; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Bacterial; Hydrogen-Ion Concentration; Molecular Sequence Data; Molecular Weight; Recombinant Fusion Proteins; Restriction Mapping; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Substrate Specificity; Temperature; Xylosidases | 1997 |
The effect of 2-mercapto-5-methyl-1,3,4-thiadiazole on enzymatic synthesis of cefazolin.
Topics: Catalysis; Cefazolin; Cephalosporins; Enzymes, Immobilized; Hydrolysis; Penicillin Amidase; Thiadiazoles | 1998 |
Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity.
Topics: Acetyltransferases; Adipates; Cephalosporins; Culture Media; Gene Expression; Gene Transfer Techniques; Intramolecular Transferases; Oxygenases; Penicillin-Binding Proteins; Penicillium chrysogenum; Plasmids; Recombinant Proteins | 1995 |
Derivative spectrophotometric determination of the triethylammonium salt of cefotaxime in presence of related compounds from the synthesis.
Topics: Cefotaxime; Cephalosporins; Chromatography, High Pressure Liquid; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Atomic | 1998 |
New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity.
Topics: Anti-Bacterial Agents; Cephalosporins; Microbial Sensitivity Tests; Staphylococcus aureus; Streptococcus pneumoniae; Streptococcus pyogenes; Structure-Activity Relationship | 1999 |
Characterization of an industrial biocatalyst: immobilized glutaryl-7-ACA acylase.
Topics: Amidohydrolases; Biotechnology; Catalysis; Cephalosporins; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enzyme Stability; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Penicillin Amidase; Phosphates; Temperature | 2000 |
Structure-based prediction of modifications in glutarylamidase to allow single-step enzymatic production of 7-aminocephalosporanic acid from cephalosporin C.
Topics: Amidohydrolases; Amino Acid Sequence; Anti-Bacterial Agents; Catalysis; Cephalosporins; Crystallography, X-Ray; Dimerization; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutation; Penicillin Amidase; Protein Binding | 2002 |
Cross-reactivity of cefotetan and ceftriaxone antibodies, associated with hemolytic anemia, with other: cephalosporins and penicillin.
Topics: Anemia, Hemolytic; Antibodies; Cefamandole; Cefoperazone; Cefotaxime; Cefotetan; Cefoxitin; Ceftriaxone; Cells, Cultured; Cephalosporins; Cephalothin; Cross Reactions; Humans; Models, Chemical; Penicillins | 2002 |
Immobilization of glutaryl-7-aminocephalosporanic acid acylase on silica gel and enhancement of its stability.
Topics: Borohydrides; Cephalosporins; Enzyme Activation; Enzyme Stability; Enzymes, Immobilized; Ethanolamine; Hydrogen-Ion Concentration; Models, Chemical; Penicillin Amidase; Quality Control; Silica Gel; Silicon Dioxide; Temperature | 2003 |
An improved method for preparation of cefpodoxime proxetil.
Topics: Acetates; Acylation; Administration, Oral; Anti-Bacterial Agents; Benzothiazoles; Cefpodoxime Proxetil; Ceftizoxime; Cephalosporins; Chemistry, Pharmaceutical; Drug Compounding; Thiazoles | 2003 |
The kinetic properties of the carboxy terminal domain of the Bacillus licheniformis 749/I BlaR penicillin-receptor shed a new light on the derepression of beta-lactamase synthesis.
Topics: Acylation; Bacillus; Bacterial Proteins; beta-Lactamases; beta-Lactams; Carrier Proteins; Cephalosporins; Gene Expression Regulation, Bacterial; Kinetics; Penicillin-Binding Proteins; Penicillins | 2003 |
The cephalosporin C nucleus (7-aminocephalosporanic acid) and some of its derivatives.
Topics: Anti-Bacterial Agents; Cell Nucleus; Cephalosporins | 1961 |
Behaviour of some derivatives of 7-aminocephalosporanic acid and 6-aminopenicillanic acidas substrates, inhibitors and inducers of penicillinases.
Topics: Anti-Bacterial Agents; Cephalosporins; Penicillinase; Penicillins | 1962 |
Distribution and substrate specificity of benzylpenicillin acylase.
Topics: Cephalosporins; Esterases; Nocardia; Penicillanic Acid; Penicillin Amidase; Penicillin G; Penicillins; Proteus; Substrate Specificity | 1963 |
Cephalothin, a new cephalosporin with a broad antibacterial spectrum. I. In vitro studies employing the gradient plate technique.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Cephalosporins; Cephalothin; Drug Resistance, Microbial; Humans; In Vitro Techniques; Penicillinase; Staphylococcus | 1963 |
ANTIBACTERIAL ACTIVITY OF SOME DERIVATIVES OF 7-AMINOCEPHALOSPORANIC ACID AGAINST STAPHYLOCOCCUS AUREUS AND SYNERGISM BETWEEN THESE AND OTHER ANTIBIOTICS.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Cephalosporins; Coagulase; Drug Resistance; Drug Resistance, Microbial; Fusidic Acid; Methicillin; Mice; Penicillanic Acid; Penicillin G; Penicillinase; Pharmacology; Research; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus | 1964 |
Multivariate analysis and classification of the chemical quality of 7-aminocephalosporanic acid using near-infrared reflectance spectroscopy.
Topics: Algorithms; Cephalosporins; Multivariate Analysis; Principal Component Analysis; Software; Spectroscopy, Near-Infrared | 2003 |
Batch production of deacetyl 7-aminocephalosporanic acid by immobilized cephalosporin-C deacetylase.
Topics: Bacillus subtilis; Bioreactors; Biotechnology; Carboxylic Ester Hydrolases; Cephalosporins; Enzyme Stability; Enzymes, Immobilized; Escherichia coli; Hot Temperature; Hydrogen-Ion Concentration; Kinetics | 2004 |
Occupational asthma and IgE sensitization to 7-aminocephalosporanic acid.
Topics: Asthma; Cephalosporins; Drug Industry; Humans; Immunization; Immunoglobulin E; Occupational Diseases | 2004 |
Construction and application of fusion proteins of D-amino acid oxidase and glutaryl-7-aminocephalosporanic acid acylase for direct bioconversion of cephalosporin C to 7-aminocephalosporanic acid.
Topics: Cephalosporins; D-Amino-Acid Oxidase; Escherichia coli; Penicillin Amidase; Protein Engineering; Recombinant Fusion Proteins | 2004 |
Single-step conversion of cephalosporin-C to 7-aminocephalosporanic acid by free and immobilized cells of Pseudomonas diminuta.
Topics: Cell Culture Techniques; Cells, Immobilized; Cephalosporins; Enzyme Activation; Hydrogen-Ion Concentration; Penicillin Amidase; Pseudomonas; Species Specificity; Temperature | 2005 |
Spectrophotometric assay for quantitative determination of 7-aminocephalosporanic acid from direct hydrolysis of cephalosporin C.
Topics: Benzaldehydes; Cephalosporins; Penicillin Amidase; Spectrophotometry | 2006 |
Thermal inactivation of D-amino acid oxidase from Trigonopsis variabilis occurs via three parallel paths of irreversible denaturation.
Topics: Cephalosporins; D-Amino-Acid Oxidase; Enzyme Stability; Hot Temperature; Kinetics; Models, Molecular; Protein Conformation; Protein Denaturation; Saccharomycetales; Thermodynamics | 2006 |
Construction of recombinant Escherichia coli D11/pMSTO and its use in enzymatic preparation of 7-aminocephalosporanic acid in one pot.
Topics: beta-Lactamases; Biotechnology; Catalase; Cephalosporins; Chromatography, High Pressure Liquid; DNA, Recombinant; Escherichia coli; Escherichia coli Proteins; Mutation; Plasmids; Transduction, Genetic | 2007 |
Site-specific protonation microequilibria of penicillin and cephalosporin beta-lactam core molecules.
Topics: beta-Lactams; Cephalosporins; Hydrogen-Ion Concentration; Ions; Magnetic Resonance Spectroscopy; Osmolar Concentration; Penicillanic Acid; Penicillins; Potentiometry; Protons | 2007 |
Reusability of entrapped cells of Pseudomonas diminuta for production of 7-aminocephalosporanic acid.
Topics: Bioreactors; Cell Culture Techniques; Cell Proliferation; Cell Survival; Cephalosporins; Pseudomonas | 2007 |
A colorimetric assay for the determination of acetyl xylan esterase or cephalosporin C acetyl esterase activities using 7-amino cephalosporanic acid, cephalosporin C, or acetylated xylan as substrate.
Topics: Acetylation; Acetylesterase; Bacillus; Biological Assay; Cephalosporins; Chromatography, High Pressure Liquid; Colorimetry; Escherichia coli; Hydrogen-Ion Concentration; Reproducibility of Results; Sensitivity and Specificity; Substrate Specificity; Xylans | 2007 |
Microbial production of 7-amino-cephalosporanic acid and new generation cephalosporins (cephalothin) by different processing strategies.
Topics: Bioreactors; Biotechnology; Cephalosporins; Cephalothin; Enzyme Activation; Kinetics; Models, Biological; Penicillin Amidase; Pseudomonas; Regression Analysis | 2007 |
[7-aminocephalosporanic acid induced bronchial asthma in two patients].
Topics: Asthma; Cephalosporins; Humans; Male; Middle Aged; Occupational Exposure; Young Adult | 2007 |
A single Phe54Tyr substitution improves the catalytic activity and thermostability of Trigonopsis variabilis D-amino acid oxidase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Catalysis; Cephalosporins; D-Amino-Acid Oxidase; Enzyme Stability; Fungal Proteins; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Protein Structure, Tertiary; Saccharomycetales; Sequence Alignment; Temperature; Tyrosine | 2010 |
Environmentally safe production of 7-ACA by recombinant Acremonium chrysogenum.
Topics: Acremonium; Blotting, Southern; Carboxylic Ester Hydrolases; Cephalosporins; Cloning, Molecular; Culture Media; Escherichia coli; Gene Expression; Genetic Vectors; Organisms, Genetically Modified; Plasmids; Protoplasts; Reverse Transcriptase Polymerase Chain Reaction; Transformation, Genetic | 2010 |
Enhancement of glutaryl-7-aminocephalosporanic acid acylase activity of gamma-glutamyltranspeptidase of Bacillus subtilis.
Topics: Amidohydrolases; Amino Acid Sequence; Bacillus subtilis; Bacterial Proteins; Cephalosporins; Escherichia coli; gamma-Glutamyltransferase; Industrial Microbiology; Kinetics; Metabolic Networks and Pathways; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Sequence Alignment | 2010 |
Prospects for multivariate classification of a pharmaceutical intermediate with near-infrared spectroscopy as a process analytical technology (PAT) production control supplement.
Topics: Calibration; Cephalosporins; Chemistry, Pharmaceutical; Models, Chemical; Multivariate Analysis; Quality Control; Spectroscopy, Near-Infrared; Technology, Pharmaceutical | 2010 |
Struvite precipitation for ammonia nitrogen removal in 7-aminocephalosporanic acid wastewater.
Topics: Ammonia; Cephalosporins; Chemical Precipitation; Hydrogen-Ion Concentration; Magnesium Compounds; Nitrogen; Phosphates; Struvite; Waste Disposal, Fluid; Water Pollutants, Chemical | 2012 |
Double knockout of β-lactamase and cephalosporin acetyl esterase genes from Escherichia coli reduces cephalosporin C decomposition.
Topics: beta-Lactamases; Carboxylic Ester Hydrolases; Cephalosporins; Escherichia coli; Gene Knockout Techniques; Maltose-Binding Proteins; Recombinant Proteins | 2012 |
Dual-lifetime referencing (DLR): a powerful method for on-line measurement of internal pH in carrier-bound immobilized biocatalysts.
Topics: 2-Aminoadipic Acid; Bioreactors; Biosensing Techniques; Cephalosporinase; Cephalosporins; Enzymes, Immobilized; Fluorescein; Fluorescent Dyes; Hydrogen-Ion Concentration; Hydrolysis; Organometallic Compounds; Phenanthrolines; Photobleaching | 2012 |
Structure of a class III engineered cephalosporin acylase: comparisons with class I acylase and implications for differences in substrate specificity and catalytic activity.
Topics: Amidohydrolases; Catalysis; Catalytic Domain; Cephalosporins; Crystallography, X-Ray; Kinetics; Mutation; Penicillin Amidase; Protein Conformation; Pseudomonas; Recombinant Proteins; Serine; Substrate Specificity | 2013 |
A novel cephalosporin deacetylating acetyl xylan esterase from Bacillus subtilis with high activity toward cephalosporin C and 7-aminocephalosporanic acid.
Topics: Acetylesterase; Bacillus subtilis; Cephalosporins; Cloning, Molecular; DNA, Bacterial; Enzyme Stability; Escherichia coli; Hydrogen-Ion Concentration; Molecular Sequence Data; Molecular Weight; Open Reading Frames; Protein Multimerization; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Substrate Specificity; Temperature | 2014 |
Design, synthesis and biological activities of some 7-aminocephalosporanic acid derivatives.
Topics: Anti-Bacterial Agents; Antifungal Agents; Bacteria; Canavalia; Cephalosporins; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Molecular Structure; Saccharomyces cerevisiae; Structure-Activity Relationship; Urease | 2013 |
Evaluation of active designs of cephalosporin C acylase by molecular dynamics simulation and molecular docking.
Topics: Binding Sites; Catalysis; Catalytic Domain; Cephalosporins; Computer-Aided Design; Genotype; Hydrogen Bonding; Hydrolysis; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Penicillin Amidase; Phenotype; Protein Binding; Protein Conformation; Reproducibility of Results; Structure-Activity Relationship | 2014 |
Performance and model of a novel multi-sparger multi-stage airlift loop membrane bioreactor to treat high-strength 7-ACA pharmaceutical wastewater: effect of hydraulic retention time, temperature and pH.
Topics: Biodegradation, Environmental; Bioreactors; Cephalosporins; Hydrogen-Ion Concentration; Membranes, Artificial; Models, Theoretical; Pharmaceutical Preparations; Temperature; Time Factors; Wastewater; Water Purification | 2014 |
Engineering of a CPC acylase using a facile pH indicator assay.
Topics: Catalytic Domain; Cephalosporins; Enzyme Assays; Hydrogen-Ion Concentration; Models, Molecular; Mutagenesis, Site-Directed; Penicillin Amidase; Protein Engineering; Pseudomonas | 2014 |
Process design and evaluation of production of bioethanol and β-lactam antibiotic from lignocellulosic biomass.
Topics: Acremonium; Biofuels; Biomass; Cephalosporins; Computer Simulation; Ethanol; Lignin; Saccharomyces cerevisiae | 2014 |
Development and Validation of HPLC and HPTLC Methods for Determination of Cefoperazone and Its Related Impurities.
Topics: Cefoperazone; Cephalosporins; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Drug Contamination | 2016 |
Identification and Characterization of a New 7-Aminocephalosporanic Acid Deacetylase from Thermophilic Bacterium Alicyclobacillus tengchongensis.
Topics: Alicyclobacillus; Amino Acid Sequence; Cephalosporins; Cloning, Molecular; Esterases; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Molecular Sequence Data; Phylogeny | 2016 |
Investigation of the removal mechanism of antibiotic ceftazidime by green algae and subsequent microbic impact assessment.
Topics: Animals; Anti-Bacterial Agents; Biodegradation, Environmental; Ceftazidime; Cephalosporins; Chlorophyta; Metabolomics; Microbial Sensitivity Tests; Rotifera; Toxicity Tests, Acute | 2017 |
A systematic toxicity evaluation of cephalosporins via transcriptomics in zebrafish and in silico ADMET studies.
Topics: Animals; Anti-Bacterial Agents; Biomarkers; Cephalosporins; Computer Simulation; Cyclins; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Embryonic Development; Gene Expression; Hyaluronan Synthases; Ligands; Magnesium; Molecular Docking Simulation; Muscle Contraction; Real-Time Polymerase Chain Reaction; Tissue Distribution; Toxicity Tests; Transcriptome; Zebrafish | 2018 |
Progress in One-pot Bioconversion of Cephalosporin C to 7-Aminocephalosporanic Acid.
Topics: Amidohydrolases; Anti-Bacterial Agents; Cephalosporins; Chemistry, Pharmaceutical; D-Amino-Acid Oxidase; Penicillin Amidase; Protein Structure, Secondary | 2018 |
Computational analysis of the interactions of a novel cephalosporin derivative with β-lactamases.
Topics: beta-Lactamases; Catalytic Domain; Cephalosporins; Molecular Docking Simulation; Protein Binding | 2018 |
Characterization of EstZY: A new acetylesterase with 7-aminocephalosporanic acid deacetylase activity from Alicyclobacillus tengchongensis.
Topics: Acetylesterase; Alicyclobacillus; Amino Acid Sequence; Cephalosporins; Cloning, Molecular; Esterases; Hydrogen-Ion Concentration; Kinetics; Molecular Docking Simulation; Sequence Alignment; Substrate Specificity | 2020 |
Metallocenyl 7-ACA Conjugates: Antibacterial Activity Studies and Atomic-Resolution X-ray Crystal Structure with CTX-M β-Lactamase.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; beta-Lactamases; Cephalosporins; Crystallography, X-Ray; HeLa Cells; Humans; Microbial Sensitivity Tests; Models, Molecular; Protein Conformation | 2020 |
7-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis.
Topics: Animals; Anti-Bacterial Agents; Cephalosporins; Diet, High-Fat; Lipogenesis; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Triglycerides | 2022 |