Page last updated: 2024-09-04

centchroman and tamoxifen

centchroman has been researched along with tamoxifen in 20 studies

Compound Research Comparison

Studies
(centchroman)
Trials
(centchroman)
Recent Studies (post-2010)
(centchroman)
Studies
(tamoxifen)
Trials
(tamoxifen)
Recent Studies (post-2010) (tamoxifen)
157124720,6302,2276,256

Protein Interaction Comparison

ProteinTaxonomycentchroman (IC50)tamoxifen (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.46
Serine/threonine-protein kinase D3Homo sapiens (human)1
Bile salt export pumpHomo sapiens (human)10
Epidermal growth factor receptorHomo sapiens (human)3.553
Estrogen receptorHomo sapiens (human)0.9266
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.949
Protein kinase C gamma typeHomo sapiens (human)1
Protein kinase C beta typeHomo sapiens (human)1
Tyrosine-protein kinase LckHomo sapiens (human)8.033
Tyrosine-protein kinase FynHomo sapiens (human)1.195
Progesterone receptorHomo sapiens (human)0.1288
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.472
Muscarinic acetylcholine receptor M2Homo sapiens (human)7.793
Muscarinic acetylcholine receptor M4Homo sapiens (human)4.817
ATP-dependent translocase ABCB1Homo sapiens (human)6.4
Muscarinic acetylcholine receptor M5Homo sapiens (human)2.585
Alpha-2A adrenergic receptorHomo sapiens (human)1.935
Adenosine receptor A3Homo sapiens (human)3.701
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.829
Steroid hormone receptor ERR1Homo sapiens (human)0.2
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.967
Beta-3 adrenergic receptorHomo sapiens (human)7.703
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)3.701
Protein kinase C alpha typeHomo sapiens (human)1
Alpha-2B adrenergic receptorHomo sapiens (human)3.518
Muscarinic acetylcholine receptor M3Homo sapiens (human)2.974
Substance-K receptorHomo sapiens (human)3.67
D(1A) dopamine receptorHomo sapiens (human)8.502
Prostaglandin G/H synthase 1Homo sapiens (human)4.391
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.472
Thromboxane-A synthase Homo sapiens (human)0.916
Protein kinase C eta typeHomo sapiens (human)1
Histamine H2 receptorHomo sapiens (human)9.396
Alpha-1D adrenergic receptorHomo sapiens (human)4.982
5-hydroxytryptamine receptor 2AHomo sapiens (human)4.801
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.46
Adenosine receptor A2aHomo sapiens (human)7.099
Sodium-dependent serotonin transporterHomo sapiens (human)2.334
D(3) dopamine receptorHomo sapiens (human)1.072
5-hydroxytryptamine receptor 2BHomo sapiens (human)2.084
Protein kinase C iota typeHomo sapiens (human)1
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)3.701
5-hydroxytryptamine receptor 6Homo sapiens (human)2.679
Estrogen-related receptor gammaHomo sapiens (human)0.0622
Sodium-dependent dopamine transporter Homo sapiens (human)1.841
Protein kinase C epsilon typeHomo sapiens (human)1
Protein kinase C theta typeHomo sapiens (human)1
Protein kinase C zeta typeHomo sapiens (human)1
Protein kinase C delta typeHomo sapiens (human)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.2759
Platelet-activating factor acetylhydrolaseHomo sapiens (human)0.904
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseHomo sapiens (human)0.012
Serine/threonine-protein kinase D1Homo sapiens (human)1
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)0.967
Estrogen receptor betaHomo sapiens (human)0.7809
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.021
7-dehydrocholesterol reductaseHomo sapiens (human)0.012

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.00)18.7374
1990's10 (50.00)18.2507
2000's3 (15.00)29.6817
2010's6 (30.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kon, OL; Ng, SC; Sim, KY; Teo, CC1
Kamboj, VP; Malaviya, B; Paliwal, A1
Devi, PK1
Chauhan, SC; Dwivedi, A; Kamboj, VP; Singh, MM; Trivedi, RN1
Kamboj, VP; Singh, MM; Sreenivasulu, S1
Dwivedy, I; Katzenellenbogen, JA; O'Neil, JP; Ray, S; Tandon, A; Wilson, SR1
Chauhan, SC; Kamboj, VP; Maitra, SC; Singh, MM1
Blair, HC; Jordan, SE; McDonald, JM; McKenna, MA; Radding, W; Williams, JP1
Allag, IS; Rangari, K1
Giri, AK; Gupta, S; Mukhopadhyay, A; Ray, S2
Giri, AK; Mukhopadhyay, A; Ray, S1
Arshad, M; Ghosh, R; Sawlani, V; Sengupta, S; Sharma, S; Singh, MM1
Balapure, AK; Nigam, M; Ranjan, V; Sharma, R; Srivastava, S1
Balapure, AK; Gupta, DK; Nigam, D; Nigam, M; Ranjan, V; Sharma, R; Singh, N; Sundaram, S; Zaidi, D1
Dalela, D; Gupta, G; Jain, A; Jain, RK; Kumar, R; Maikhuri, JP; Sarswat, A; Sharma, VL; Verma, V1
Ali, MM; Jain, GK; Kohli, K; Singh, SP1
Hou, J; Li, P; Mi, M; Xiong, X; Xu, X; Zeng, J1
Bansal, A; Choudhary, D; Garg, PK; Jain, BK; Mohanty, D1
Gayen, JR; Hussain, KM; Mishra, DP; Rama Raju, KS; Singh, SK; Singh, SP; Taneja, I; Tripathi, A; Wahajuddin, M1

Reviews

1 review(s) available for centchroman and tamoxifen

ArticleYear
Antiestrogens.
    Pharmacology & therapeutics, 1981, Volume: 12, Issue:3

    Topics: Animals; Centchroman; Chemical Phenomena; Chemistry; Clomiphene; Estrogen Antagonists; Humans; Nafoxidine; Tamoxifen

1981

Trials

1 trial(s) available for centchroman and tamoxifen

ArticleYear
Centchroman vs tamoxifen for regression of mastalgia: a randomized controlled trial.
    International journal of surgery (London, England), 2015, Volume: 15

    Topics: Adult; Centchroman; Estrogen Antagonists; Female; Follow-Up Studies; Humans; Mastodynia; Pain Measurement; Tamoxifen; Time Factors; Treatment Outcome; Young Adult

2015

Other Studies

18 other study(ies) available for centchroman and tamoxifen

ArticleYear
Synthesis of 2-(p-chlorobenzyl)-3-aryl-6-methoxybenzofurans as selective ligands for antiestrogen-binding sites. Effects on cell proliferation and cholesterol synthesis.
    Journal of medicinal chemistry, 1992, Apr-17, Volume: 35, Issue:8

    Topics: Benzofurans; Binding Sites; Binding, Competitive; Cell Division; Cell Line; Cholesterol; Estrogen Antagonists; Humans; Ligands; Receptors, Estrogen; Thymidine

1992
Effect of centchroman and tamoxifen on protein patterns of fallopian tubes of rhesus monkeys, Macaca mulatta.
    Indian journal of experimental biology, 1992, Volume: 30, Issue:10

    Topics: Animals; Centchroman; Estradiol; Fallopian Tubes; Female; Macaca mulatta; Protein Biosynthesis; Proteins; Tamoxifen

1992
Time-related effects of a triphenylethylene antiestrogen on estrogen-induced changes in uterine weight, estrogen receptors, and endometrial sensitivity in rats.
    Contraception, 1995, Volume: 51, Issue:6

    Topics: Administration, Oral; Animals; Centchroman; Decidua; Dose-Response Relationship, Drug; Endometrium; Epithelium; Estradiol; Estrogen Antagonists; Female; Microscopy, Electron, Scanning; Nafoxidine; Organ Size; Ovariectomy; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Tamoxifen; Time Factors; Uterus

1995
Duration of anti-implantation action of the triphenylethylene anti-oestrogen centchroman in adult female rats.
    Journal of reproduction and fertility, 1994, Volume: 100, Issue:2

    Topics: Administration, Oral; Animals; Centchroman; Embryo Implantation; Embryo Implantation, Delayed; Female; Rats; Rats, Sprague-Dawley; Tamoxifen; Time Factors

1994
An X-ray crystallographic study of the nonsteroidal contraceptive agent centchroman.
    Journal of medicinal chemistry, 1994, Mar-04, Volume: 37, Issue:5

    Topics: Centchroman; Crystallization; Crystallography, X-Ray; Estradiol; Iodides; Methylation; Molecular Conformation; Molecular Structure; Nafoxidine; Receptors, Estrogen; Stereoisomerism; Tamoxifen

1994
Inhibition of progesterone-induced development of giant mitochondria in uterine glandular epithelial cells by an antiestrogen in rat.
    Contraception, 1996, Volume: 54, Issue:4

    Topics: Animals; Centchroman; Cohort Studies; Epithelial Cells; Epithelium; Estradiol; Estrogen Antagonists; Female; Microscopy, Electron; Mitochondria; Ovariectomy; Progesterone; Random Allocation; Rats; Rats, Sprague-Dawley; Tamoxifen; Uterus

1996
Differential effects of tamoxifen-like compounds on osteoclastic bone degradation, H(+)-ATPase activity, calmodulin-dependent cyclic nucleotide phosphodiesterase activity, and calmodulin binding.
    Journal of cellular biochemistry, 1997, Sep-01, Volume: 66, Issue:3

    Topics: Animals; Anticarcinogenic Agents; Benzopyrans; Bone Resorption; Calmodulin; Centchroman; Cyclic Nucleotide Phosphodiesterases, Type 1; Dose-Response Relationship, Drug; Female; Osteoclasts; Phosphoric Diester Hydrolases; Piperidines; Proton-Translocating ATPases; Tamoxifen; Trifluoperazine

1997
In-vitro effect of estrogen-antagonist on motility and penetration ability of human spermatozoa.
    Indian journal of experimental biology, 1997, Volume: 35, Issue:8

    Topics: Adult; Centchroman; Estradiol; Estrogen Antagonists; Female; Humans; In Vitro Techniques; Male; Sperm Motility; Sperm-Ovum Interactions; Tamoxifen

1997
Comparative antimutagenic effects of D- and L-centchroman and their comparison with tamoxifen in Salmonella assay.
    Mutation research, 1999, Sep-15, Volume: 445, Issue:1

    Topics: Animals; Antimutagenic Agents; Cell Extracts; Centchroman; Dose-Response Relationship, Drug; Liver; Male; Mutagenicity Tests; Mutagens; Rats; Salmonella; Species Specificity; Stereoisomerism; Tamoxifen

1999
Anticlastogenic effects of centchroman and its enantiomers in Swiss albino mice. I. Acute study and their comparison with tamoxifen.
    Cancer letters, 1999, Oct-01, Volume: 144, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Antineoplastic Agents; Centchroman; Chromosome Aberrations; Cyclophosphamide; Estrogen Antagonists; Female; Mice; Mice, Inbred Strains; Mutagens; Sister Chromatid Exchange; Stereoisomerism; Tamoxifen

1999
Anticlastogenic effects of d- and l-centchroman in Swiss albino mice. 2. Subacute study in vivo and comparison with tamoxifen.
    Cytobios, 2001, Volume: 106, Issue:412

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimutagenic Agents; Antineoplastic Agents; Bone Marrow Cells; Centchroman; Chromosome Aberrations; Cyclophosphamide; Female; Mice; Stereoisomerism; Tamoxifen

2001
In vitro anti-resorptive activity and prevention of ovariectomy-induced osteoporosis in female Sprague-Dawley rats by ormeloxifene, a selective estrogen receptor modulator.
    The Journal of steroid biochemistry and molecular biology, 2004, Volume: 91, Issue:1-2

    Topics: Animals; Autopsy; Benzopyrans; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Calcium; Centchroman; Chick Embryo; Densitometry; Disease Models, Animal; Epithelial Cells; Ethinyl Estradiol; Female; Femur; Osteocalcin; Osteoporosis; Ovary; Parathyroid Hormone; Piperidines; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Tamoxifen; Tibia

2004
Centchroman induces G0/G1 arrest and caspase-dependent apoptosis involving mitochondrial membrane depolarization in MCF-7 and MDA MB-231 human breast cancer cells.
    Life sciences, 2008, Mar-12, Volume: 82, Issue:11-12

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspases; Cell Line, Tumor; Cell Nucleus; Cell Shape; Cell Survival; Centchroman; Clinical Trials as Topic; DNA Fragmentation; Estrogen Antagonists; Female; G1 Phase; Humans; Membrane Potentials; Mitochondria; Resting Phase, Cell Cycle; Tamoxifen

2008
Centchroman mediated apoptosis involves cross-talk between extrinsic/intrinsic pathways and oxidative regulation.
    Life sciences, 2010, Dec-18, Volume: 87, Issue:23-26

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspases; Cell Cycle; Cell Line, Tumor; Centchroman; Cycloheximide; Dactinomycin; Down-Regulation; Estrogen Antagonists; Female; Humans; Immunoprecipitation; Oxidative Stress; Tamoxifen; Up-Regulation

2010
Selective estrogen receptor modulators regulate stromal proliferation in human benign prostatic hyperplasia by multiple beneficial mechanisms--action of two new agents.
    Investigational new drugs, 2012, Volume: 30, Issue:2

    Topics: 5-alpha Reductase Inhibitors; Animals; Apoptosis; Aromatase; Benzopyrans; Cell Proliferation; Cell Survival; Cells, Cultured; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Finasteride; Gene Expression Regulation; Humans; Male; Piperidines; Prostate; Prostatic Hyperplasia; Rats; Rats, Sprague-Dawley; Receptors, Androgen; RNA, Messenger; Selective Estrogen Receptor Modulators; Signal Transduction; Stromal Cells; Tamoxifen; Testosterone; Tissue Culture Techniques

2012
Liquid chromatography-mass spectrometry method for the quantification of tamoxifen and its metabolite 4-hydroxytamoxifen in rat plasma: application to interaction study with biochanin A (an isoflavone).
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Oct-01, Volume: 879, Issue:27

    Topics: Animals; Area Under Curve; Centchroman; Chromatography, Liquid; Drug Interactions; Female; Genistein; Rats; Rats, Sprague-Dawley; Regression Analysis; Reproducibility of Results; Sensitivity and Specificity; Tamoxifen; Tandem Mass Spectrometry

2011
[Effect of xy2004, a centchroman derivative, on proliferation of MCF-7 cells in vitro and the mechanism].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2014, Volume: 34, Issue:10

    Topics: Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Proliferation; Centchroman; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; MCF-7 Cells; Proto-Oncogene Proteins c-bcl-2; Tamoxifen

2014
Simultaneous determination of centchroman and tamoxifen along with their metabolites in rat plasma using LC-MS/MS.
    Bioanalysis, 2015, Volume: 7, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Centchroman; Chromatography, Liquid; Female; Mammary Neoplasms, Experimental; Metabolomics; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tamoxifen; Tandem Mass Spectrometry; Tissue Distribution

2015