cellulase and cetraxate

cellulase has been researched along with cetraxate* in 1 studies

Other Studies

1 other study(ies) available for cellulase and cetraxate

ArticleYear
[The synthesis of 4'-(2-carboxyethyl)phenyl trans-4-aminomethyl cyclohexane carboxylate hydrochloride (cetraxate hydrochloride) by means of enzymatic debenzylation].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1989, Volume: 109, Issue:3

    Cetraxate hydrochloride (1) (antiulcer agent) has been industrially produced by the chemical protective method of p-hydroxy propionic acid derivatives. Screening of enzymes which quantitatively hydrolyzed cetraxate benzyl ester hydrochloride (2) into 1 was undertaken to establish a novel enzymatic method of production of 1. It was found that the enzyme activity for debenzylation of 2 is contained in cellulase enzymes originated from Aspergillus sp. Lower alkyl groups or phenyl groups of p-hydroxy propionic acid derivatives are likewise selectively hydrolyzed by the cellulase enzyme. This enzymatic synthetic method is very useful for the industrial preparation of 1.

    Topics: Anti-Ulcer Agents; Aspergillus; Cellulase; Cyclohexanecarboxylic Acids; Methods; Tranexamic Acid

1989