celecoxib has been researched along with indomethacin in 299 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (3.01) | 18.2507 |
| 2000's | 130 (43.48) | 29.6817 |
| 2010's | 135 (45.15) | 24.3611 |
| 2020's | 25 (8.36) | 2.80 |
| Authors | Studies |
|---|---|
| Bertenshaw, SR; Burton, EG; Carter, JS; Cogburn, JN; Collins, PW; Docter, S; Graneto, MJ; Gregory, SA; Isakson, PC; Koboldt, CM; Lee, LF; Malecha, JW; Miyashiro, JM; Penning, TD; Perkins, WE; Rogers, RS; Rogier, DJ; Seibert, K; Talley, JJ; Veenhuizen, AW; Yu, SS; Zhang, YY | 1 |
| Brideau, C; Chan, CC; Charleson, S; Cromlish, W; Ethier, D; Evans, JF; Ford-Hutchinson, AW; Gauthier, JY; Gordon, R; Gresser, M; Guay, J; Kargman, S; Kennedy, B; Leblanc, Y; Léger, S; Mancini, J; O'Neill, GP; Ouellet, M; Percival, MD; Perrier, H; Prasit, P; Riendeau, D; Rodger, I; Wang, Z; Zamboni, R | 1 |
| Boyce, S; Brideau, C; Chan, CC; Charleson, S; Gordon, R; Grimm, E; Guay, J; Leblanc, Y; Léger, S; Li, CS; Prasit, P; Riendeau, D; Roy, P; Visco, D; Wang, Z; Webb, J; Xu, LJ | 1 |
| Black, WC; Brideau, C; Chan, CC; Charleson, S; Claveau, D; Cromlish, WA; Gauthier, JY; Gordon, R; Greig, G; Grimm, E; Guay, J; Lau, CK; Li, CS; Prasit, P; Riendeau, D; Thérien, M; Visco, DM; Wong, E; Xu, L | 1 |
| Brideau, C; Chan, CC; Charleson, S; Cromlish, WA; Ethier, D; Gauthier, JY; Gordon, R; Guay, J; Kargman, S; Lau, CK; Li, CS; Prasit, P; Riendeau, D; Thérien, M; Visco, DM; Xu, L | 1 |
| Beleta, J; Cardelús, I; Crespo, MI; Feixas, J; Godessart, N; Heredia, A; Huerta, JM; Ibarzo, J; Jiménez, JM; López, M; Miralpeix, M; Palacios, JM; Puig, C; Puig, J; Ryder, H; Segarra, V; Soca, L | 1 |
| Arimura, A; Hori, Y; Inagaki, M; Jyoyama, H; Kakudo, S; Kato, M; Kawai, S; Kobayashi, M; Koizumi, K; Matsumoto, S; Ohno, K; Ono, T; Suzuki, R; Tsuri, T; Yamada, K; Yasui, K | 1 |
| Bosch, J; Catena, JL; Farrerons, C; Fernández, AG; Fernández-Serrat, A; Lagunas, C; Llorens, O; Miquel, I; Pérez, JJ; Roca, T | 1 |
| Bonnet, J; Pastoureau, P; Portevin, B; Tordjman, C | 1 |
| Byun, YJ; Choi, JK; Chung, S; Ha, JY; Kim, JK; Kim, JY; Lee, CH; Lim, KM; Noh, MS; Shin, SS | 1 |
| Almansa, C; Cavalcanti, FL; de Arriba, AF; Forn, J; García-Rafanell, J; Gómez, LA; Merlos, M; Miralles, A | 1 |
| Crespo, MI; Feixas, J; Godessart, N; Jiménez, JM; Puig, C; Soca, L | 1 |
| Cabré, F; Campos, J; Entrena, A; Espinosa, A; Gallo, MA; García, L; Mauleón, D; Palomer, A; Pascual, J; Trujillo, MA | 1 |
| Haruta, J; Hashimoto, H; Imamura, K; Wakitani, K | 1 |
| Borst, P; de Haas, M; Kuil, A; Reid, G; van der Heijden, I; Wielinga, P; Wijnholds, J; Zelcer, N | 1 |
| Alfón, J; Almansa, C; Bartrolí, J; Carceller, E; Cavalcanti, FL; de Arriba, AF; Escamilla, I; García-Rafanell, J; Gómez, LA; Merlos, M; Miralles, A; Soliva, R | 1 |
| Casturi, SR; Gopalakrishnan, B; Kalleda, S; Madan, M; Malde, A; Mamidi, NV; Mullangi, R; Padakanti, S; Pal, M; Pattabiraman, VR; Vanguri, A; Yeleswarapu, KR | 1 |
| Byun, Y; Choi, JK; Choi, YH; Chung, S; Jeong, YS; Kim, JK; Kim, JY; Koh, HJ; Lee, KW; Lim, KM; Moh, JH; Noh, MS; Oh, YI; Park, YH; Shin, SS | 1 |
| Akhila, V; Casturi, SR; Krishnamraju, A; Rajjak, SA; Rao, YK; Shivaramakrishna, S; Singh, SK; Vobbalareddy, S | 1 |
| Chung, S; Ha, JY; Hyup Joo, Y; Kang, SH; Kwan Kim, J; Kyu Choi, J; Lim, KM; Noh, MS | 1 |
| Anzini, M; Biava, M; Botta, M; Cappelli, A; Makovec, F; Manetti, F; Porretta, GC; Rossi, A; Sautebin, L; Vomero, S | 1 |
| Chiou, WF; Lin, LC; Lin, SJ; Shiao, YJ; Teng, CM; Tsai, WJ; Wu, TS; Yang, LM; Yang, TH | 1 |
| Abdel Ghany, YS; Ashour, HM; Baraka, A; Bekhit, AA; Bekhit, Ael-D | 1 |
| Augustyniak, ME; Cochran, ED; Ellis, JL; Fang, X; Garvey, DS; Janero, DR; Letts, LG; Martino, AM; Melim, TL; Murty, MG; Richardson, SK; Schroeder, JD; Selig, WM; Trocha, AM; Wexler, RS; Wey, SJ; Young, DV; Zemtseva, IS; Zifcak, BM | 1 |
| Fischer, J; Gyires, K; Kis-Varga, A; Szabó, G | 1 |
| Abouzid, K; Bekhit, SA | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Abdel-Rahman, HM; Ashour, HM; Bekhit, AA; Bekhit, Ael-D; Bekhit, SA | 1 |
| Greiner, C; Koeberle, A; Schubert-Zsilavecz, M; Werz, O; Wurglics, M; Zettl, H | 1 |
| Barreiro, EJ; Cardozo, SV; de Miranda, AL; Fraga, CA; Leite, RD; Lima, LM; Romeiro, NC | 1 |
| Balazy, M; Cardile, V; Granata, G; Lombardo, L; Perdicaro, A; Santagati, A | 1 |
| Dehm, F; Haberl, EM; Koeberle, A; Northoff, H; Pergola, C; Rossi, A; Sautebin, L; Troschuetz, R; Werz, O | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| El-Ashmawy, IM; Klegeris, A; Villanueva, EB; White, MS; Youssef, AM | 1 |
| Bridoux, A; Henichart, JP; Millet, R; Pommery, J; Pommery, N | 1 |
| Alexandre-Moreira, MS; Augusto, CV; Barreiro, EJ; da Silva, YK; de Albuquerque Melo, GM; de Castro Barbosa, ML; de Lima Matos Freire Dias, T; de Queiroz, AC; Júnior, WB; Lima, LM | 1 |
| Abd-El-Aziz, AS; El-Ashmawy, IM; Klegeris, A; Neeland, EG; Patrick, B; Villanueva, EB; White, MS; Youssef, AM | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Bekhit, AA; El-Din A Bekhit, A; Fahmy, HT; Rostom, SA | 1 |
| Cao, H; Chen, YG; Choi, Y; Fong, HH; Huang, R; Jermihov, KC; Kondratyuk, TP; Liu, Y; Marler, LE; Mesecar, AD; Pezzuto, JM; Qiu, X; Sturdy, M; van Breemen, RB; Wang, LQ; Yang, JH; Yu, R; Zhang, HJ | 1 |
| Gautam, R; Jachak, SM; Kumar, V; Mohan, CG | 1 |
| Dong, H; Hammock, BD; Hwang, SH; Liu, JY; Morisseau, C; Wagner, KM; Wecksler, AT | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Dittrich, M; Greiner, C; Hieke, M; Reisen, F; Schneider, G; Schubert-Zsilavecz, M; Werz, O | 1 |
| Chaturvedi, SC; Manivannan, E | 2 |
| Chaudhaery, SS; Eleftheriou, P; Filimonov, D; Filz, O; Geronikaki, A; Hadjipavlou-Litina, D; Poroikov, V; Roy, KK; Saxena, AK; Vicini, P | 1 |
| Blobaum, AL; Crews, BC; Daniel, CM; Ghebreselasie, K; Kingsley, PJ; Liedtke, AJ; Marnett, LJ | 1 |
| Alam, MM; Alam, MS; Kalle, AM; Mulakayala, C; Mulakayala, N; Pallu, R; Shafi, S; Vanaja, G | 1 |
| Bhardwaj, A; Huang, Z; Kaur, J; Knaus, EE | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Dannhardt, G; Geffken, D; Hansen, FK; Khankischpur, M; Mesaros, R; Tolaymat, I | 1 |
| Cabrita, EJ; Carvalho, LC; Erhardt, S; Estevão, MS; Fernandes, E; Freitas, M; Gomes, A; Manso, J; Marques, MM; Viegas, A | 1 |
| Hanna, MM | 1 |
| Kalle, AM; Kumar, CS; Kumar, GP; Kumar, KR; Mulakayala, C; Mulakayala, N; Oruganti, S; Pal, M; Rambabu, D; Rao, MV | 1 |
| Chandna, N; Gupta, GK; Jachak, SM; Kapoor, JK; Kaushik, D; Kaushik, P; Kumar, S; Roy, SK; Sharma, PK | 1 |
| Bairwa, K; Grover, J; Jachak, SM; Roy, SK; Singh, IN; Srivastava, A | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Barz, D; Dehm, F; Hanke, T; Kaiser, A; Kunze, J; Lämmerhofer, M; Liening, S; Maczewsky, J; Pillong, M; Popella, SD; Sautebin, L; Schneider, G; Schubert-Zsilavecz, M; Weinigel, C; Werz, O; Wurglics, M | 1 |
| Alam, A; Alam, MS; Ali, Y; Haider, S; Hamid, H; Kalle, AM; Kharbanda, C; Mahajan, P; Nargotra, A; Nazreen, S; Panda, AK; Shafi, S | 1 |
| Bhatti, R; Sharma, S; Singh, P | 1 |
| Amini, M; Assadieskandar, A; Irannejad, H; Kebriaieezadeh, A; Montazer-Sadegh, F; Shafiee, A; Zarghi, A | 1 |
| Lavecchia, A; Malerba, P; Perrone, MG; Scilimati, A; Vitale, P | 1 |
| Abdel-Aziz, M; Abdel-Rahman, IM; Aly, OM; Beshr, EA; Ozadali, K; Tan, OU | 1 |
| Bhatti, R; Kaur, M; Sharma, S; Singh, A; Singh, P | 1 |
| Choi, TJ; Chung, HJ; Hong, JY; Kang, SS; Kim, JS; Lee, SK; Park, HJ; Pyee, Y | 1 |
| Bairwa, K; Grover, J; Jachak, SM; Kumar, V; Singh, V; Sobhia, ME | 1 |
| Jauch, J; Noha, SM; Paul, M; Schuster, D; Seitz, S; Verhoff, M; Werz, O | 1 |
| Barz, D; Bruno, F; de Caprariis, P; De Rosa, M; Dehm, F; Filosa, R; Krauth, V; Massa, A; Peduto, A; Weinigel, C; Werz, O | 1 |
| Abdel-Aziz, M; Abuo-Rahma, Gel-D; Farag, NA; Kaoud, TS | 1 |
| Gavalas, A; Geronikaki, A; Hammock, B; Hwang, SH; Iurchenko, V; Ivanenkov, Y; Krasavin, M; Morisseau, C; Mujumdar, P; Sarnpitak, P; Zozulya, S | 1 |
| Grover, J; Jachak, SM; Kumar, V; Sobhia, ME | 1 |
| Alagawadi, KR; Alegaon, SG; Hirpara, MB; Hullatti, KK; Kashniyal, K | 1 |
| Bhatti, R; Dhillon, P; Prasher, P; Singh, P | 1 |
| Arai, J; Hisa, T; Maeda, M; Mukai, T; Ohkubo, Y; Ohshima, T; Saito, Y; Yamamoto, F; Yamamoto, Y | 1 |
| Abdelgawad, MA; Abdellatif, KR; Labib, MB; Zidan, TH | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bhatti, R; Kaur, J; Kaur, S; Singh, G; Singh, P | 1 |
| Ali, WAM; Bazgier, V; Lamie, PF; Rárová, L | 1 |
| Banerjee, AG; Das, N; Sharma, PA; Shengule, SA; Shrivastava, SK; Srivastava, RS | 1 |
| Cao, Z; Hammock, BD; Hwang, SH; Lee, KS; Li, X; Morisseau, C; Wagner, K; Xu, J; Yang, J | 1 |
| Abdelall, EKA; Ali, WAM; Azouz, AA; Elshemy, HAH; Moawad, A; Safwat, NM | 1 |
| Fathi, S; Janeira, E; Komatsu, K; Kornacki, JR; Li, JD; Mrksich, M; Oyelere, AK; Raji, I; Szymczak, L; Yadudu, F | 1 |
| Alam, MS; Ali, Y; Bano, S; Dhulap, A; Hamid, H; Husain, A; Kharbanda, C | 1 |
| Bansal, R; Kumar, A; Saini, V; Singh, J | 1 |
| Guan, LP; Jin, QH; Liu, BY; Wang, SH; Xia, YN | 1 |
| Abdelall, EKA; Abdelhamid, AO; Azouz, AA | 1 |
| Bonanni, D; Boschi, D; Carnovale, IM; Cena, C; Costale, A; Giraudo, A; Lolli, ML; Marini, E; Oliaro-Bosso, S; Pippione, AC; Pors, K; Sadiq, M; Zonari, D | 1 |
| Bernardino, AMR; Boechat, N; Dos Santos, MS; Faria, JV; Miguita, AGC; Vegi, PF | 1 |
| Abdalla, MM; Ali, HI; Kassab, SE; Khedr, MA | 1 |
| Abdel-Ghany, YS; Alaaeddine, R; Alaeddine, LM; Belal, ASF; El-Yazbi, AF; Hazzaa, A; Ismail, A; Moussa, G; Nassra, R | 1 |
| Boixareu, N; Campanera, JM; Navarro, L; Pors, K; Pouplana, R; Pujol, MD; Rosell, G; Sánchez, S | 1 |
| Ibrar, A; Khan, I; Saeed, F; Shehzadi, SA | 1 |
| Bhatti, M; Bhatti, R; Kaur, B; Kaur, M; Kaur, S; Kumari, P; Singh, G; Singh, P | 1 |
| Almeida, SMV; Amorim, CADC; Jacob, ÍTT; Lima, MDCA; Melo, CML; Miranda, MDS; Moraes, ADTO; Moreira, DRM; Moura, RO; Oliveira, JF; Silva, SÂSD; Silva, TGD; Soares, MBP; Souza, TRCL | 1 |
| Abonia, R; Marín-Ocampo, L; Sepúlveda-Arias, JC; Veloza, LA | 1 |
| Abu-Serie, MM; AlFadly, ED; Bakkar, NZ; Bartolini, M; Belal, ASF; El-Yazbi, AF; Elkazaz, S; Elzahhar, PA; Ghareeb, DA; Iriepa, I; Janockova, J; Kobeissy, F; Moraleda, I; Rafeh, RW; Saudi, MNS; Shaltout, H; Soukup, O; Tramarin, A | 1 |
| Alaaeddine, R; Belal, ASF; Bruning, JB; Chua, BSK; El-Yazbi, AF; Elzahhar, PA; Frkic, RL; Ibrahim, TM; Ismail, A; Knape, T; Labib, H; Nassra, R; von Knethen, A; Wallner, N | 1 |
| Ahmed, EM; El-Malah, AA; Hassan, MSA; Kassab, AE | 1 |
| Al-Mahmoudy, AMM; El-Sabbagh, OI; Fares, M; Ibrahim, TS; Orabi, KY; Radwan, AF; Taher, ES | 1 |
| Fu, ZY; Guan, LP; Jin, QH; Qu, YL | 1 |
| Narang, RK; Pathania, S; Rawal, RK | 1 |
| Banerjee, UC; Chakraborti, AK; Dave, K; Dubey, S; Garg, SK; Goyal, R; Kumar, R; Meena, VS; Purohit, P; Saha, N; Seth, K; Sharma, SS | 1 |
| Arafa, RK; El-Sayed, NA; Nour, MS; Salem, MA | 1 |
| Abid, OU; Ahmad, A; Ahmad, S; Ayaz, M; Hussain, F; Jan, MS; Mahmood, F; Rashid, U; Sadiq, A; Ullah, F | 1 |
| Alkamali, OM; Harras, MF; Sabour, R | 1 |
| Bhatti, R; Kaur, J; Kaur, S; Kumari, P; Singh, P | 1 |
| El Kerdawy, AM; Gedawy, EM; Kassab, AE | 1 |
| Abdel-Moty, SG; Abou-Ghadir, OMF; Ali, AY; Maghraby, MT; Salem, OIA | 1 |
| Bai, XQ; Cui, MY; Li, CS; Liang, CW; Song, ZW; Wang, HY; Zhang, TY; Zheng, XJ | 1 |
| Abd El Wahab, SM; Alaaeddine, R; Allam, RM; Angeli, A; Belal, ASF; Daabees, H; Eid, AH; El-Hawash, SA; El-Yazbi, AF; Elagawany, M; Elzahhar, PA; Hegazy, RR; Helmy, MW; Supuran, CT | 1 |
| Alarcón-Aguilar, FJ; Almanza-Pérez, JC; Gomez-Quiroz, LE; Jiménez-Estrada, M; Mora-Ramiro, B; Rosiles-Alanis, W; Ventura-Gallegos, JL; Zentella-Dehesa, A | 1 |
| Guan, LP; He, LY; Peng, DX; Wang, SH; Zhang, SS | 1 |
| Guo, YH; Huang, C; Ji, YR; Li, J; Li, Z; Shi, W; Sun, GP; Zhang, YL; Zheng, Y | 1 |
| Neha, K; Wakode, S | 1 |
| Bhatti, R; Kaur, J; Kumari, P; Singh, P | 1 |
| Georgey, HH; Mohammed, ER; Said, MF | 1 |
| France, S; Guerra Faura, G; Oyelere, AK; Wu, B | 1 |
| Cui, E; Du, L; Du, S; Jiang, X; Li, J; Ma, X; Qian, S; Wang, H | 1 |
| Isakson, PC; Koboldt, CM; Masferrer, JL; Muhammad, J; Seibert, K; Shaffer, A; Smith, CJ; Talley, JJ; Zhang, Y; Zweifel, BS | 1 |
| Gierse, JK; Isakson, PC; Koboldt, CM; Seibert, K; Walker, MC | 1 |
| Conti, CJ; Fischer, SM; Gordon, GB; Kelloff, G; Lo, HH; Lubet, RA; Seibert, K | 1 |
| Wallace, JL | 1 |
| Chemtob, S; Clyman, RI; Heymann, MA; Lin, E; Roman, C; Takahashi, Y; Tse, MM | 1 |
| Ajuebor, MN; Singh, A; Wallace, JL | 1 |
| Aramberry, LJ; Cesolari, JA; Esnarriaga, JM; Laudanno, OM; Maglione, CB; Piombo, G; Rista, L; Sambrano, JS | 1 |
| Bjarnason, I; Foster, R; Sigthorsson, G; Tibble, JA | 1 |
| Levine, L | 3 |
| Bai, JC; Mauriño, E; Meddings, J; Niveloni, S; Pedreira, S; Smecuol, E; Sugai, E; Vazquez, H | 1 |
| Browning, RA; Burgess, FW | 1 |
| Bjarnason, I; Caldwell, C; Palmer, RH; Sigthorsson, G; Tibble, J | 1 |
| Akiguchi, I; Kawasaki, T; Miyake, S; Miyamoto, K; Oka, N; Yamamura, T | 1 |
| Nozaki-Taguchi, N; Yamamoto, T | 1 |
| Kawano, S; Tsuji, S | 1 |
| Salam, OM | 1 |
| Pulbutr, P; Sookvanichsilp, N | 1 |
| Peres, MF; Silberstein, SD | 1 |
| Malhotra, S; Pandhi, P; Shafiq, N | 2 |
| Bernhard, LM; Gerber, S; Gross, GA; Leguizamon, G; Levy, R; Mathur, A; Nelson, DM; Sadovsky, Y; Stika, CS | 1 |
| Kuklo, T; Lewis, S; Long, J; Riew, KD; Zhu, Y | 1 |
| Arakawa, T; Kanatsu, K; Kato, S; Ogawa, Y; Okayama, M; Takeuchi, K; Watanabe, T | 1 |
| Bakhle, YS; Chaves, CT; Ferreira-Alves, DL; Francischi, JN; Lima, AS; Moura, AC; Rocha, OA | 1 |
| Calixto, JB; Pinheiro, RM | 1 |
| Abdel-Salam, OM; Arbid, MS; Baiuomy, AR; El-Shenawy, SM | 1 |
| Ob ukhova, OA; Preobrazhenskiĭ, DV; Tsurko, VV | 1 |
| Brum-Fernandes, AJ; Peters, RR; Ribeiro-do-Valle, RM; Siqueira-Junior, JM | 1 |
| Aspenberg, P; Bylander, B; Forslund, C | 1 |
| Hayashi, N; Hori, M; Horimoto, M; Irie, T; Kakiuchi, Y; Kawai, N; Kawano, S; Kimura, A; Komori, M; Murata, H; Nishida, T; Sasaki, Y; Tsuji, S; Tsujii, M; Yasumaru, M | 1 |
| Chau, M; Gilbert, R; Jordan, RC; Lim, MS; Lim, S; Mäkitie, AA; Viani, MA | 1 |
| Boulet, J; Gottshall, S; Harrison, J; Mark, L; Pearson, M; Walker, K; Whiteside, GT | 1 |
| Abdel-Salam, OM; Arbid, MS; Baiuomy, AR | 1 |
| Brown, KM; Donahue, HJ; Kirsch, T; Reid, JS; Saunders, MM | 1 |
| Duci, D; Mazza, M; Meani, E; Romanò, CL; Romanò, D | 1 |
| Bai, AH; Hu, PJ; Leung, WK; Lin, HL; Sung, JJ; Tang, BD; Yu, J; Zeng, ZR | 1 |
| Blumenthal, M; Chen, TC; Kardosh, A; Schönthal, AH; Wang, WJ | 1 |
| Chichorro, JG; Lorenzetti, BB; Zampronio, AR | 1 |
| Coppelli, G; Coruzzi, G; Guaita, E; Spaggiari, S | 1 |
| Gotoh, T; Hoshino, T; Hwang, HJ; Mima, S; Mizushima, T; Mori, M; Takenaka, H; Tomisato, W; Tsuchiya, T; Tsutsumi, S | 1 |
| Aglas, F; Böhmova, J; Bröll, H; Bucsi, L; Hawel, R; Keszthelyi, B; Leeb, BF; Mayrhofer, F; Singer, F; Valesova, M | 1 |
| Jain, NK; Kulkarni, SK; Patil, CS; Singh, VP | 1 |
| Davis, DW; Ellis, LM; Khanbolooki, S; Lashinger, LM; McConkey, DJ; Nawrocki, S; Raut, CP; Xiong, H | 1 |
| Cristofoletti, R; Fabricio, AS; Navarra, P; Souza, GE; Veiga, FH | 1 |
| Abraham, P; Bouyé, P; Durand, S; Gallois, Y; Koïtka, A; Saumet, JL; Tartas, M | 1 |
| Bai, AH; Go, MY; Hu, PJ; Leung, WK; Ma, PK; Sung, JJ; Tang, BD; To, KF; Yu, J; Zeng, ZR | 1 |
| Farber, JL; Fong, LY; Jiang, Y; Zhang, L | 1 |
| Bjorling, DE; Calamon-Dixon, JL; Jerde, TJ; Nakada, SY | 1 |
| Kim, KH; Roh, JL; Sung, MW | 1 |
| Boulet, JM; Bunton, T; Gottshall, SL; Phillips, S; Pomonis, JD; Sellers, R; Walker, K | 1 |
| Khosrovani, S; Naghdi, N; Ostad, SN; Roghani, A; Sharifzadeh, K; Sharifzadeh, M | 1 |
| Almeida, Sde S; de Aguiar Corrêa, FM; de Bortoli, VC; de Oliveira, AM; Zangrossi Júnior, H | 1 |
| Abraham, P; Assous, S; Humeau, A; L'Huillier, JP; Tartas, M | 1 |
| Baker, J; Bell, ML; Cotter, JD; Gerrard, DF; Walker, RJ | 1 |
| Fulton, AM; Kundu, N; Ma, X; Walser, TC | 1 |
| Malhotra, S; Nada, R; Pandhi, P; Shafiq, N | 1 |
| Li, MH; Shen, JK; Yin, LL; Zhang, WY; Zhu, XZ | 1 |
| Cakir, N; Pamuk, ON | 1 |
| Cohen, DB; Ehteshami, JR; Kawamura, S; Rodeo, SA | 1 |
| Hénichart, JP; Pommery, J; Pommery, N | 1 |
| Frölich, JC; Gutzki, FM; Marhauer, V; Stichtenoth, DO; Tsikas, D | 1 |
| Adami, M; Coppelli, G; Coruzzi, G; Giovannini, E; Guaita, E; Menozzi, A; Pozzoli, C | 1 |
| Bishop-Bailey, D; Mitchell, JA; Vojnovic, I; Warner, TD | 1 |
| Matsuda, K; Matsushita, T; Nakamura, S | 1 |
| Baraliakos, X; Bohl-Bühler, MH; Braun, J; Feldtkeller, E; Zochling, J | 1 |
| Chichorro, JG; Rae, GA; Souza, GE; Zampronio, AR | 1 |
| Anning, PB; Coles, B; Dey, SK; Marnett, LJ; Morrow, JD; Morton, J; O'Donnell, VB; Uddin, J; Wang, H | 1 |
| Caraccio, N; Dardano, A; Ferrannini, E; Ghiadoni, L; Monzani, F; Salvetti, A; Taddei, S; Versari, D; Virdis, A | 1 |
| Amini, M; Eghtesad, E; Ghahremani, MH; Sharifzadeh, M; Tahsili-Fahadan, P; Tootian, Z | 1 |
| de Francischi, JN; de Menezes, GB; dos Reis, WG; Duarte, ID; Santos, JM | 1 |
| Bertini, S; Bonardi, S; Coruzzi, G; Giovannini, E; Grandi, D; Menozzi, A; Pozzoli, C; Solenghi, E; Vasina, V | 1 |
| Green, C; Hewlett, E; Hughes, M; Padgett, D; Schwartz, L; Tessier, J; Zhao, W | 1 |
| Macedo, GM; Medeiros, BA; Nobre-e-Souza, MA; Palheta-Junior, RC; Santos, AA; Santos, CL; Souza, MH; Troncon, LE | 1 |
| Cai, KQ; Hamilton, TC; Klein-Szanto, A; Smedberg, JL; Smith, ER; Xu, XX; Yang, WL | 1 |
| Hudson, M; Pilote, L; Rahme, E; Richard, H | 1 |
| Aoi, Y; Hayashi, S; Kato, S; Nishio, H; Okayama, M; Takeuchi, K | 1 |
| Hu, Q; Qiu, XW; Wang, ZR; Xu, ZQ; Zhang, J | 1 |
| Hashimoto, J; Kawai, S; Matsui, Y; Nampei, A; Ochi, T; Tsuboi, H; Yoshikawa, H | 1 |
| Nikitakis, NG; Sauk, JJ; Scheper, MA | 1 |
| Andrade, C; Nagaraja, N; Sanjay Kumar Rao, N; Singh, NM; Suresh Chandra, J; Thyagarajan, S | 1 |
| Altun, A; Bagcivan, I; Durmus, N; Guney, C; Karadas, B; Kaya, T; Koyluoglu, G | 1 |
| Adams, JA; Aria, J; Bassuk, J; Kurlansky, P; Lamas, GA; Lozano, H; Wu, D | 1 |
| Fromm, RE; Varon, J | 1 |
| Kazi, JU; Li, H; Soh, JW; Thompson, WJ; Weinstein, IB | 1 |
| Carlsson, T; Karlsson, JO; Petersen, A; Zetterberg, M | 1 |
| Andersson, M; Arvidsson, A; Brevinge, H; Lagerstedt, K; Lönnroth, C; Lundholm, K; Nordgren, S | 1 |
| El Masry, MA; Gamie, Z; Macfarlane, RJ; Ng, BH; Schizas, C; Tsiridis, E; Velonis, S | 1 |
| Jin, UH; Kim, CH; Kim, KS; Kwon, DY; Park, SD; Suh, SJ | 1 |
| Germann, B; Hofer-Warbinek, R; Neuhaus, W; Noe, CR | 1 |
| Bertini, S; Dacasto, M; Giantin, M; Gobbetti, T; Lopparelli, RM; Menozzi, A; Passeri, B; Poli, E; Pozzoli, C; Zullian, C | 1 |
| Buyse, M; Farinotti, R; Zrieki, A | 1 |
| Chen, B; Li, L; Liu, H; Qin, J; Qin, R; Qin, W; Wang, H; Wu, K; Yuan, J | 1 |
| Ahn, DW; Cho, SJ; Jung, HC; Kim, CH; Kim, JS; Kim, N; Lee, KS; Lee, MK; Park, JH; Song, IS | 1 |
| Cara, DC; Francischi, JN; Klein, A; Menezes, GB; Pereira-Silva, PE; Rezende, RM | 1 |
| Bijlsma, JW; de Boer, TN; Huisman, AM; Lafeber, FJ; Mastbergen, SC; Niehoff, AG; Polak, AA; Saris, D; van Rinsum, AC | 1 |
| Bagcivan, I; Durmus, N; Karadas, B; Kaya, T; Parlak, A; Toker, M; Topalkara, A | 1 |
| Antunes, E; Desouza, IA; Ferreira, T; Macedo, ML; Mariano, NS; Mello, GC | 1 |
| Fujikawa, Y; Itonaga, I; Kawashima, M; Takita, C; Tsumura, H | 1 |
| Caliari, MV; Duarte, ID; Francischi, JN; Maltos, KL; Pacheco, CM; Queiroz-Junior, CM | 1 |
| Lee, SP; See, TT | 1 |
| Al-Asmar, B; Chidiac, JJ; Jabbur, SJ; Rifai, K; Saadé, NE | 1 |
| Clapper, ML; Foreman, JE; Gonzalez, FJ; McGinnis, KS; Peters, JM; Rigas, B; Sorg, JM; Williams, JL | 1 |
| Chang, JK; Ho, ML; Li, CJ; Liao, HJ; Wang, CK; Wang, GJ | 1 |
| Choi, KH; Chung, MW; Kim, KB; Kim, SH; Lee, HJ; Oh, HY; Oh, JS; Um, SY | 1 |
| Ehrlich, K; Peskar, BA; Peskar, BM; Schuligoi, R | 1 |
| Chang, JK; Chou, CH; Ho, ML; Li, CJ; Wang, GJ | 1 |
| Allena, M; Ferrante, E; Lisotto, C; Nappi, G; Rossi, P; Tassorelli, C | 1 |
| Arai, Y; Ishihara, T; Kimoto, A; Mizushima, T; Okamoto, Y; Otsuka, M; Suemasu, S; Tanaka, K; Yamakawa, N; Yokomizo, K | 1 |
| Aronoff, DM; Carlos, D; Faccioli, LH; Lourenço, EV; Machado, ER; Ramos, SG; Silva, EV; Sorgi, CA; Souza, GE; Ueta, MT | 1 |
| Cetin, A; Cetin, M; Guvenal, T; Timuroglu, Y; Yanar, O | 1 |
| Cho, YB; Hur, J; Jung, I; Jung, KC; Kang, JY; Kang, M; Kim, KS; Kim, SH; Lee, JD; Lee, JH; Park, DS; Yoo, MC | 1 |
| Case, N; Rubin, J; Sen, B; Styner, M; Xie, Z | 1 |
| Bakhle, YS; Camêlo, VM; de Francischi, JN; Dos Reis, WG; Paiva-Lima, P; Rezende, RM | 1 |
| Abd El Razik, HA; Bekhit, AA; Bistawroos, AA; El-Mallah, A; Mohy El-Din, MM; Nour El-Din, NA; Senbel, AM | 1 |
| Fomenko, IS; Panasyuk, NB; Sklyarov, AY | 1 |
| Brzozowski, T; Konturek, SJ; Kwiecien, S; Mazurkiewicz-Janik, M; Pajdo, R; Pawlik, M; Pawlik, WW; Ptak-Belowska, A; Sliwowski, Z | 1 |
| An, H; Jiang, DM; Luo, XJ; Ou, YS; Quan, ZX; Tan, C; Tang, K | 1 |
| Ansari, MS; Crews, BC; Ghebreselasie, K; Huda, I; Kingsley, PJ; Marnett, LJ; Reese, J; Tantawy, MN; Uddin, MJ | 1 |
| Halmos, B; Li, G; Merchan, JR; Wang, A; Wang, X; Zhang, Z | 1 |
| Cannon, DM; Heiner, JP; Illgen, RL; Kozak, KR; Kruser, TJ; Platta, CS | 1 |
| Avril, S; Bronger, H; Cerny, C; Kiechle, M; Kraeft, S; Schmitt, M; Schwarz-Boeger, U; Stöckel, A | 1 |
| Cantwell, MM; Hughes, CM; Murray, LJ; Parsons, C; Reid, J | 1 |
| Andersson, M; Lönnroth, C; Lundholm, K; Nordgren, S | 1 |
| Chan, C; Chiang, PC; Chou, KJ; Cui, Y; Hart, R; Ran, Y; Sambrone, A | 1 |
| Bandyopadhyay, SK; Chatterjee, A; Chatterjee, S; Chattopadhyay, S; Das, S; Saha, A | 1 |
| An, H; Jiang, D; Luo, X; Ou, Y; Quan, Z; Tan, C; Tang, K | 1 |
| Asano, K; Ito, Y; Kim, S; Matsukawa, N; Yamamoto, K; Yamatodani, A | 1 |
| Harirforoosh, S; Pettit, WL; Wyatt, JE | 1 |
| Huang, D; Li, H; Liu, B; Luo, W; Zhang, Y; Zhou, Y; Zhu, N | 1 |
| Akutsu, M; Ito, K; Kawashima, M; Kondoh, T; Ogura, N | 1 |
| Chandra, C; Chandy, SJ; Danda, D; Iliyas, MM; Mathew, AJ | 1 |
| Dong, L; Jurban, BJ; Sharma, NP; Smith, WL | 1 |
| Cai, KQ; Smedberg, J; Smith, ER; Xu, XX; Yang, WL; Yeasky, T | 1 |
| Krisch, M; Pogna, EA; Rodríguez-Tinoco, C; Rodríguez-Viejo, J; Scopigno, T | 1 |
| Altman, R; Daniels, S; Young, CL | 1 |
| Amirheidari, B; Ghahremani, MH; Mandegary, A; Seyedabadi, M; Sharif, E; Torshabi, M | 1 |
| Arimitsu, J; Hagihara, K; Hiyama, S; Iijima, H; Inoue, T; Kawai, S; Mukai, A; Nishida, T; Ogata, A; Shinzaki, S; Shiraishi, E; Takehara, T; Tsujii, M | 1 |
| Li, S; Liu, Y; Wang, Z | 1 |
| Ahmed, SB; Beaudin, AE; Hanly, PJ; Nicholl, DD; Poulin, MJ; Pun, M; Slater, DM; Steinback, CD; Wynne-Edwards, KE; Yang, C | 1 |
| Shi, W; Wu, J; Xiao, H; Xue, F; Zhao, H | 1 |
| Andersson, M; Asting, AG; Lönnroth, C; Lundholm, K; Nordgren, S | 1 |
| Bastos-Pereira, AL; Fraga, D; Leite, MC; Zampronio, AR | 1 |
| Aguilar, MI; Benítez, WV; Bye, R; Calzada, F; Colín, A; Ríos-Gómez, R | 1 |
| Ali, RM; El-Gowelli, HM; El-Mas, MM; Helmy, MW | 1 |
| Meschede, AK; Schebb, NH; Willenberg, I | 1 |
| Chen, H; Chen, L; Cheng, B; Jiang, C | 1 |
| Abdel-Gaber, SA; Abdelrahman, AM; Amin, EF; Ibrahim, MA; Ibrahim, SA; Mohammed, RK | 1 |
| Ahmed, SB; Anderson, TJ; Beaudin, AE; Hanly, PJ; Poulin, MJ; Pun, M; Waltz, X; Wynne-Edwards, KE | 1 |
| Andrews, GP; Brennan, CM; Healy, AM; Holm, R; Jones, DS; Knopp, MM; Kozyra, A; Löbmann, K; Olesen, NE; Paluch, K; Rades, T; Tajber, L; Tian, Y | 1 |
| Girgenti, MJ; Newton, SS; Sathyanesan, M; Warner-Schmidt, J | 1 |
| Gueler, F; Jang, MS; Meschede, AK; Schebb, NH; Shushakova, N; Willenberg, I | 1 |
| Matteson, EL; Thongprayoon, C; Ungprasert, P | 1 |
| Doods, H; Gould, SA; Lamla, T; Pekcec, A | 1 |
| McKenna, GB; Mehta, M; Ragoonanan, V; Suryanarayanan, R | 1 |
| Arantes, EC; Faccioli, LH; Hori, JI; Paula-Silva, FW; Serezani, CH; Sorgi, CA; Zamboni, DS; Zoccal, KF | 1 |
| Adamski, J; Brzozowski, T; Kwiecien, S; Magierowska, K; Magierowski, M; Mazur-Bialy, AI; Pajdo, R; Sliwowski, Z; Surmiak, M | 1 |
| Choi, KH; Chung, MW; Lee, HJ; Park, JH; Um, SY | 1 |
| Agrawal, R; Assaiya, A; Banerjee, T; Jain, N; Kumar, A; Manivannan, E; Mufti, I; Parmar, HS; Tiwari, S | 1 |
| Bastos-Pereira, AL; Dreifuss, AA; Fraga, D; Zampronio, AR | 1 |
| Izadi, G; Sepehri, G; Shamsi Meymandi, M; Zamiri, Z | 1 |
| Azouz, AA; Bakr, RB; Ghoneim, AA | 1 |
| Arnez, MFM; Faccioli, LH; Paula-Silva, FWG; Petean, IBF; Ribeiro-Santos, FR; Silva, GGD; Silva, LABD | 1 |
| Abdelall, EKA; Abdellatif, KRA; Fadaly, WAA; Labib, MB; Zidan, TH | 1 |
| Ibi, K; Imai, K; Kihara, T; Nejishima, H; Ogawa, H; Senshu, M; Takeda, Y; Yonezawa, Y | 1 |
| Hajhashemi, V; Mesripour, A; Shahnooshi, S | 1 |
| Guo, Y; Huang, C; Li, J; Li, Z; Shi, W; Xu, T; Zhang, Y; Zheng, Y | 1 |
| Abraham, D; Al-Jaber, M; Bakhamis, A; Bashah, M; Clapp, LH; Mohamed-Ali, V; Orie, NN; Raees, A | 1 |
| Elsahar, AE; Faggal, SI; Kamal, AM; Mohamed, KO; Shabaan, MA | 1 |
| Diwan, A; Imran, M; Khan, A; Thabet, HK | 1 |
| Abuo-Rahma, GEA; Allam, RM; El Subbagh, HI; El-Gamal, DA; Marzouk, AA; Mohamed, MFA; Moustafa, AH; Nafady, A | 1 |
| da Cruz-Filho, IJ; da Silva, TG; de Almeida, SMV; de Lima, MCA; de Melo, CML; de Miranda, MDS; de Oliveira, JF; Gomes, FOS; Jacob, ÍTT; Moreira, DRM; Peixoto, CA | 1 |
| Brox, R; Hackstein, H | 1 |
| Goto, K; Hiramoto, K; Maruyama, K; Ooi, K; Tanaka, S | 1 |
| Bahra, A; Farag, M | 1 |
| El-Nassan, HB; Fahim, SH; Mahmoud, ST; Mikhail, DS | 1 |
| Almeida-Junior, LA; Arnez, MFM; de Carvalho, FK; de Queiroz, AM; Duarte, ACA; Faccioli, LH; Gonçalves, JL; Paula-Silva, FWG | 1 |
| Blake, L; Carvalho, B; Carver, AL; Desai, N; Murdoch, I; O'Carroll, JE; Onwochei, DN; Sultan, P | 1 |
| Arnous, A; Foderà, V; Kabedev, A; Leng, D; Löbmann, K; Sener, Z; Zhao, M; Zhuo, X | 1 |
16 review(s) available for celecoxib and indomethacin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Recently reported biological activities of pyrazole compounds.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Antineoplastic Agents; Antiviral Agents; Humans; Pyrazoles | 2017 |
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.
Topics: Aldehyde Reductase; Alkaline Phosphatase; Cholinesterases; Coumarins; Drug Design; Enzymes; Glucosidases; Humans; Molecular Docking Simulation; Monoamine Oxidase | 2018 |
Anti-inflammatory activity of triazine derivatives: A systematic review.
Topics: Animals; Anti-Inflammatory Agents; Humans; Inflammation; Structure-Activity Relationship; Triazines | 2019 |
Role of sulphur-heterocycles in medicinal chemistry: An update.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antihypertensive Agents; Antineoplastic Agents; Chemistry, Pharmaceutical; Heterocyclic Compounds; Humans; Hypoglycemic Agents; Sulfur | 2019 |
Contemporary advances of cyclic molecules proposed for inflammation.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Humans; Inflammation; Molecular Structure; Structure-Activity Relationship | 2021 |
Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Controlled Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etodolac; Gene Expression; Humans; Ibuprofen; Indomethacin; Isoenzymes; Meloxicam; Membrane Proteins; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thiazines; Thiazoles | 1999 |
[Neutrophil-endothelium interaction].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cell Adhesion; Cell Adhesion Molecules; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelium, Vascular; Gastric Mucosa; Humans; Indomethacin; Isoenzymes; Membrane Proteins; Microcirculation; Neutrophils; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2002 |
[Interactions of nonsteroid anti-inflammatory drugs with inhibitors of angiotensin-converting enzyme in patients with rheumatic diseases (a review)].
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Captopril; Celecoxib; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Hemodynamics; Humans; Hypertension; Indomethacin; Middle Aged; Osteoarthritis; Placebos; Pyrazoles; Randomized Controlled Trials as Topic; Rheumatic Diseases; Sulfonamides | 2003 |
Possible glutamatergic and lipid signalling mechanisms in ECT-induced retrograde amnesia: experimental evidence for involvement of COX-2, and review of literature.
Topics: Amnesia, Retrograde; Animals; Avoidance Learning; Celecoxib; Conditioning, Classical; Cyclooxygenase 2; Electroconvulsive Therapy; Glutamine; Hippocampus; Indomethacin; Kynurenic Acid; Lipid Peroxidation; Long-Term Potentiation; Male; Mental Recall; Pyrazoles; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sulfonamides; Up-Regulation | 2008 |
Pharmacological treatment of heterotopic ossification following hip and acetabular surgery.
Topics: Acetabulum; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Celecoxib; Diclofenac; Humans; Indomethacin; Naproxen; Ossification, Heterotopic; Postoperative Complications; Pyrazoles; Sulfonamides | 2008 |
Focus on therapy: hemicrania continua and new daily persistent headache.
Topics: Amines; Analgesics; Celecoxib; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Headache; Headache Disorders; Humans; Indomethacin; Pyrazoles; Sulfonamides; Topiramate; Treatment Outcome | 2010 |
Non-steroidal anti-inflammatory drugs for the treatment of cancer cachexia: a systematic review.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cachexia; Celecoxib; Cyclooxygenase 2 Inhibitors; Humans; Ibuprofen; Indomethacin; Neoplasms; Pyrazoles; Quality of Life; Sulfonamides; Treatment Outcome | 2013 |
Pharmacogenetics of nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Aspirin; Celecoxib; Cytochrome P-450 CYP2C9; Diclofenac; Humans; Ibuprofen; Indomethacin; Pharmacogenetics; Pyrazoles; Sulfonamides | 2012 |
Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Observational Studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cerebral Hemorrhage; Diclofenac; Humans; Ibuprofen; Incidence; Indomethacin; Lactones; Meloxicam; Naproxen; Observational Studies as Topic; Odds Ratio; Piroxicam; Proportional Hazards Models; Stroke; Sulfones; Thiazines; Thiazoles | 2016 |
Comparison of different nonsteroidal anti-inflammatory drugs for cesarean section: a systematic review and network meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cesarean Section; Diclofenac; Female; Humans; Indomethacin; Ketorolac; Network Meta-Analysis; Pain; Pregnancy | 2023 |
17 trial(s) available for celecoxib and indomethacin
| Article | Year |
|---|---|
A prospective randomized safety trial of celecoxib for treatment of preterm labor.
Topics: Adolescent; Adult; Celecoxib; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Prospective Studies; Pyrazoles; Sulfonamides; Tocolytic Agents | 2002 |
Effect of COX-2-specific inhibition on fracture-healing in the rat femur.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Celecoxib; Cyclooxygenase Inhibitors; Femoral Fractures; Fracture Healing; Indomethacin; Male; Pyrazoles; Radiography; Rats; Rats, Wistar; Sulfonamides | 2004 |
Celecoxib versus indomethacin in the prevention of heterotopic ossification after total hip arthroplasty.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Celecoxib; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Male; Middle Aged; Ossification, Heterotopic; Prospective Studies; Pyrazoles; Sulfonamides | 2004 |
[Treatment of osteoarthritis of the knee joint. Efficacy and tolerance to acemetacin slow release in comparison to celecoxib].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Confidence Intervals; Data Interpretation, Statistical; Delayed-Action Preparations; Double-Blind Method; Female; Follow-Up Studies; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Pyrazoles; Sulfonamides; Time Factors | 2004 |
Early vasodilator response to anodal current application in human is not impaired by cyclooxygenase-2 blockade.
Topics: Adult; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Electric Stimulation; Electrodes; Humans; Indomethacin; Iontophoresis; Laser-Doppler Flowmetry; Male; Membrane Proteins; Microcirculation; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Skin; Sulfonamides; Vasodilation | 2005 |
Physiological effects of indomethacin and celecobix: an S-transform laser Doppler flowmetry signal analysis.
Topics: Administration, Oral; Adult; Algorithms; Anti-Inflammatory Agents; Blood Flow Velocity; Celecoxib; Diagnosis, Computer-Assisted; Female; Humans; Indomethacin; Laser-Doppler Flowmetry; Male; Pyrazoles; Signal Processing, Computer-Assisted; Single-Blind Method; Skin; Sulfonamides; Treatment Outcome | 2005 |
Effects of indomethacin and celecoxib on renal function in athletes.
Topics: Adult; Body Water; Celecoxib; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Exercise Test; Glomerular Filtration Rate; Humans; Indomethacin; Kidney; Male; Middle Aged; Pyrazoles; Sports; Sulfonamides | 2005 |
The renal effects of the addition of low-dose aspirin to COX-2 selective and nonselective antiinflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Blood Pressure; Celecoxib; Clinical Chemistry Tests; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Indomethacin; Kidney; Kidney Function Tests; Middle Aged; Pyrazoles; Sulfonamides | 2006 |
Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Indomethacin; Male; New York City; Pyrazoles; Rats; Rats, Sprague-Dawley; Rotator Cuff; Sulfonamides; Tendon Injuries; Treatment Outcome; Wound Healing | 2006 |
Effects of specific COX-2-inhibition on renin release and renal and systemic prostanoid synthesis in healthy volunteers.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aldosterone; Body Weight; Celecoxib; Creatinine; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Diuretics; Female; Furosemide; Humans; Indomethacin; Kidney; Potassium; Prostaglandins; Pyrazoles; Renin; Sodium; Sulfonamides; Thromboxane B2 | 2005 |
Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis.
Topics: Acetylcholine; Adult; Algorithms; Ascorbic Acid; Celecoxib; Cyclooxygenase 2; Endothelium, Vascular; Female; Forearm; Hashimoto Disease; Humans; Indomethacin; Inflammation; Male; Membrane Proteins; Middle Aged; Nitric Oxide; Nitroprusside; Oxidative Stress; Pyrazoles; Regional Blood Flow; Sulfonamides; Vascular Diseases; Vasculitis; Vasodilation | 2006 |
Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Movement; Colorectal Neoplasms; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dendritic Cells; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HLA-D Antigens; Humans; Indomethacin; Lymphocyte Subsets; Lymphocytes, Tumor-Infiltrating; Macrophages; Male; Middle Aged; Neoplasm Proteins; Omeprazole; Premedication; Preoperative Care; Pyrazoles; Sulfonamides | 2008 |
The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Knee; Cartilage, Articular; Celecoxib; Cyclooxygenase 2 Inhibitors; Dinoprostone; Female; Humans; Indomethacin; Interleukin-1beta; Male; Matrix Metalloproteinases; Middle Aged; Nitric Oxide; Osteoarthritis, Knee; Proteoglycans; Pyrazoles; Sulfonamides; Synovial Membrane; Tumor Necrosis Factor-alpha | 2009 |
Indomethacin submicron particle capsules provide effective pain relief in patients with acute pain: a phase 3 study.
Topics: Acute Pain; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Celecoxib; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Hallux Valgus; Humans; Indomethacin; Male; Middle Aged; Pain, Postoperative; Pyrazoles; Sulfonamides; Visual Analog Scale; Young Adult | 2013 |
Amelioration of small bowel injury by switching from nonselective nonsteroidal anti-inflammatory drugs to celecoxib in rheumatoid arthritis patients: a pilot study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Capsule Endoscopy; Celecoxib; Cytokines; Diclofenac; Drug Substitution; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Middle Aged; Phenylpropionates; Pilot Projects; Prospective Studies; Pyrazoles; Severity of Illness Index; Single-Blind Method; Sulfonamides | 2014 |
Cyclooxygenases 1 and 2 differentially regulate blood pressure and cerebrovascular responses to acute and chronic intermittent hypoxia: implications for sleep apnea.
Topics: Adult; Blood Pressure; Celecoxib; Cerebrovascular Circulation; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Double-Blind Method; Epoprostenol; Female; Heart Rate; Humans; Hypoxia; Indomethacin; Male; Middle Aged; Pyrazoles; Sleep Apnea, Obstructive; Sulfonamides; Thromboxane A2 | 2014 |
Human intermittent hypoxia-induced respiratory plasticity is not caused by inflammation.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cross-Over Studies; Double-Blind Method; Healthy Volunteers; Humans; Hypercapnia; Hypoxia; Indomethacin; Inflammation; Interleukin-1beta; Male; Sleep Apnea, Obstructive; Tumor Necrosis Factor-alpha | 2015 |
266 other study(ies) available for celecoxib and indomethacin
| Article | Year |
|---|---|
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Carrageenan; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Hyperalgesia; Isoenzymes; Magnetic Resonance Spectroscopy; Male; Membrane Proteins; Molecular Structure; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides | 1997 |
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
Topics: Administration, Oral; Animals; Biological Availability; CHO Cells; Cricetinae; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Humans; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Sulfones | 1999 |
SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor.
Topics: Administration, Oral; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Macaca mulatta; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Saimiri; Structure-Activity Relationship; U937 Cells | 1999 |
A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CHO Cells; Cricetinae; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Furans; Isoenzymes; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship | 1999 |
Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.
Topics: Animals; Biological Availability; CHO Cells; Cricetinae; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Furans; Humans; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats | 1999 |
Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase Inhibitors; Fever; Humans; Magnetic Resonance Spectroscopy; Male; Oxazoles; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Structure-Activity Relationship | 2000 |
Novel antiarthritic agents with 1,2-isothiazolidine-1,1-dioxide (gamma-sultam) skeleton: cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Blood Platelets; Cyclic S-Oxides; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Female; Gastric Mucosa; Humans; Interleukin-1; Isoenzymes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Structure-Activity Relationship; Synovial Membrane; Thiazoles | 2000 |
Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors.
Topics: Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation; Isoenzymes; Prostaglandin-Endoperoxide Synthases; Pyrroles; Structure-Activity Relationship | 2000 |
1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Heterocyclic Compounds, 3-Ring; Humans; In Vitro Techniques; Indoles; Isoenzymes; Macrophages, Peritoneal; Membrane Proteins; Mice; Prostaglandin-Endoperoxide Synthases; Stomach; Structure-Activity Relationship | 2000 |
2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors.
Topics: Animals; Arthritis, Experimental; Combinatorial Chemistry Techniques; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Foot Diseases; Furans; Inhibitory Concentration 50; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2001 |
Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Edema; Enzyme Inhibitors; Exudates and Transudates; Humans; Isoenzymes; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrimidines; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Stomach; Structure-Activity Relationship | 2001 |
Naphthalene derivatives: A new series of selective cyclooxygenase-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Inflammation; Isoenzymes; Naphthalenes; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship | 2001 |
Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Blood Platelets; Celecoxib; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Humans; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Lactones; Membrane Proteins; Models, Chemical; Models, Molecular; Monocytes; Prostaglandin-Endoperoxide Synthases; Protein Binding; Protein Conformation; Pyrazoles; Sulfonamides; Sulfones | 2002 |
4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1)
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Benzenesulfonates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fluorine; Humans; Inhibitory Concentration 50; Isoenzymes; Membrane Proteins; Models, Chemical; Oxazoles; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Temperature | 2002 |
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Cell Membrane; Diffusion; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Humans; Insecta; Multidrug Resistance-Associated Proteins; Prostaglandins; Prostaglandins A; Prostaglandins F; Ribosomal Proteins; RNA Interference; RNA, Small Interfering; Thromboxane B2; Time Factors | 2003 |
Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Binding Sites; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Imidazoles; Inflammation; Isoenzymes; Male; Membrane Proteins; Models, Molecular; Pain Measurement; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides | 2003 |
Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonamides; Binding Sites; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Humans; Inhibitory Concentration 50; Isoenzymes; Male; Membrane Proteins; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Sheep; Sodium; Spodoptera; Structure-Activity Relationship; Sulfonamides | 2003 |
In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives.
Topics: Adult; Animals; Arthritis, Experimental; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Furans; Humans; In Vitro Techniques; Isoenzymes; Macrophages, Peritoneal; Male; Membrane Proteins; Mice; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship | 2004 |
Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors.
Topics: Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2004 |
2,3-diarylpyran-4-ones: a new series of selective cyclooxygenase-2 inhibitors.
Topics: Animals; Cyclooxygenase Inhibitors; Male; Pyrans; Rats; Rats, Sprague-Dawley | 2004 |
1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors.
Topics: Acetates; Animals; Binding Sites; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Esters; Membrane Proteins; Mice; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Pyrroles | 2005 |
Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides.
Topics: Azo Compounds; Blood Cells; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Molecular Structure; Structure-Activity Relationship; Sulfonamides | 2006 |
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Drug Design; Edema; Fungi; Granuloma; Humans; Male; Microbial Sensitivity Tests; Pyrazoles; Rats; Thiadiazoles; Thiazoles; Ulcer | 2008 |
Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors.
Topics: Animals; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Design; Drug Synergism; Female; Gastric Mucosa; Humans; Hydroxamic Acids; Indomethacin; Male; Nitric Oxide Donors; Pyrazoles; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship; Sulfonamides | 2007 |
New celecoxib derivatives as anti-inflammatory agents.
Topics: Acetic Acid; Animals; Carrageenan; Celecoxib; Chronic Disease; Crystallization; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Edema; Ethanol; Gastric Mucosa; Hyperalgesia; Male; Pyrazoles; Rats; Rats, Wistar; Recombinant Proteins; Stereoisomerism; Stomach Ulcer; Sulfonamides | 2008 |
Novel anti-inflammatory agents based on pyridazinone scaffold; design, synthesis and in vivo activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Design; Edema; Ligands; Male; Models, Molecular; Molecular Structure; Pyridazines; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Synthesis of some pyrazolyl benzenesulfonamide derivatives as dual anti-inflammatory antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Benzenesulfonamides; Candida albicans; Cyclooxygenase 2 Inhibitors; Drug Evaluation, Preclinical; Escherichia coli; Humans; Rats; Staphylococcus aureus; Sulfonamides | 2009 |
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Topics: Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Cyclooxygenase 1; Cyclooxygenase 2; Drug Design; Enzyme Activation; Enzyme Inhibitors; Humans; Inflammation; Inhibitory Concentration 50; Intramolecular Oxidoreductases; Lipoxygenase Inhibitors; Models, Chemical; Prostaglandin-E Synthases; Pyrimidines | 2008 |
Synthesis, pharmacological evaluation and docking studies of new sulindac analogues.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Membrane Permeability; Computer Simulation; Cyclooxygenase 1; Cyclooxygenase 2; Drug Design; Humans; Prodrugs; Protein Binding; Structure-Activity Relationship; Sulindac | 2009 |
Inhibition of iNOS and COX-2 in human whole blood ex vivo and monocyte-macrophage J774 cells by a new group of aminothiopyrimidone derivatives.
Topics: Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Enzyme Inhibitors; Humans; Leukocytes; Lipopolysaccharides; Macrophages; Monocytes; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrimidines; Pyrimidinones; Sulfonamides | 2009 |
Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.
Topics: Animals; Anti-Inflammatory Agents; Carboxylic Acids; Cell Line, Tumor; Edema; Enzyme Inhibitors; Humans; Indoles; Inhibitory Concentration 50; Intramolecular Oxidoreductases; Magnetic Resonance Spectroscopy; Male; Mice; Microsomes; Pleurisy; Prostaglandin-E Synthases; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents.
Topics: Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Edema; Granuloma; HL-60 Cells; Humans; Neuroprotective Agents; Rats; Thiazolidinediones | 2010 |
Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Carbolines; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase Inhibitors; Humans; Indomethacin; Lipoxygenase Inhibitors; Male; Prostatic Neoplasms; Structure-Activity Relationship | 2010 |
Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Ear; Edema; Female; Freund's Adjuvant; Hydrazones; Male; Mice; Pain; Peritonitis; Pyrazines; Rats; Rats, Wistar; Zymosan | 2010 |
Synthesis and biological evaluation of novel pyrazole compounds.
Topics: Anti-Inflammatory Agents; Binding Sites; Catalytic Domain; Celecoxib; Cell Line; Computer Simulation; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Models, Molecular; Pyrazoles; Sulfonamides | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Synthesis and biological evaluation of some thiazolylpyrazole derivatives as dual anti-inflammatory antimicrobial agents.
Topics: Animals; Anti-Bacterial Agents; Candida albicans; Carrageenan; Catalytic Domain; Cotton Fiber; Cyclooxygenase 1; Cyclooxygenase 2; Edema; Escherichia coli; Granuloma; Humans; Male; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Pyrazoles; Rats; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2010 |
Bioactive compounds from the fern Lepisorus contortus.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Aromatase Inhibitors; Caffeic Acids; Cyclooxygenase Inhibitors; Drug Screening Assays, Antitumor; Flavonoids; Glycosides; Humans; Inhibitory Concentration 50; Kaempferols; Mice; Molecular Structure; NF-kappa B; Nitric Oxide; Polypodiaceae; Quercetin; Tumor Necrosis Factor-alpha | 2011 |
Synthesis, biological evaluation and molecular docking studies of stellatin derivatives as cyclooxygenase (COX-1, COX-2) inhibitors and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Catalytic Domain; Coumarins; Cyclooxygenase Inhibitors; Isocoumarins; Mice; Models, Molecular | 2011 |
Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase.
Topics: Animals; Cyclooxygenase 2; Enzyme Inhibitors; Epoxide Hydrolases; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Pyrazoles; Rats; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Urea | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Benzene Derivatives; Binding Sites; Caproates; Cells, Cultured; Cyclooxygenase Inhibitors; Humans; Intramolecular Oxidoreductases; Ligands; Lipoxygenase Inhibitors; Microsomes; Models, Molecular; Prostaglandin-E Synthases; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship | 2011 |
Analogue-based design, synthesis and molecular docking analysis of 2,3-diaryl quinazolinones as non-ulcerogenic anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Design; Edema; Female; Foot; Male; Models, Molecular; Quinazolinones; Rats; Rats, Wistar; Sheep; Stomach Ulcer | 2011 |
Fragment-based design, docking, synthesis, biological evaluation and structure-activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Design; Edema; Female; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Models, Molecular; Structure-Activity Relationship; Thiazolidines | 2012 |
Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Screening Assays, Antitumor; Female; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Sheep; Stereoisomerism; Structure-Activity Relationship; Sulindac | 2012 |
Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: their anti-inflammatory and anti-nociceptive activities.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzothiazoles; Click Chemistry; Cyclooxygenase Inhibitors; Edema; Female; Humans; Male; Models, Molecular; Nociception; Rats; Rats, Wistar; Triazoles | 2012 |
N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.
Topics: Animals; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Design; Humans; Indoles; Indomethacin; Kinetics; Models, Molecular; Recombinant Proteins; Schiff Bases; Sheep; Solutions; Structure-Activity Relationship | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.
Topics: Arachidonate 5-Lipoxygenase; Carboxylic Acids; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Lipoxygenase Inhibitors; Protein Binding; Structure-Activity Relationship; Thiophenes | 2012 |
Indole based cyclooxygenase inhibitors: synthesis, biological evaluation, docking and NMR screening.
Topics: Animals; Chemistry Techniques, Synthetic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Humans; Indoles; Magnetic Resonance Spectroscopy; Molecular Docking Simulation; Protein Conformation | 2012 |
New pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines: synthesis, 2D-QSAR, anti-inflammatory, analgesic and ulcerogenicity studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Chemistry Techniques, Synthetic; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Female; Male; Mice; Pyrimidines; Quantitative Structure-Activity Relationship; Rats; Substrate Specificity; Ulcer | 2012 |
Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors.
Topics: Amides; Benzopyrans; Coumarins; Crystallography, X-Ray; Cyclooxygenase Inhibitors; Enzyme Activation; Molecular Structure; Propane; Protein Binding | 2012 |
Analogue-based design, synthesis and docking of non-steroidal anti-inflammatory agents. Part 2: methyl sulfanyl/methyl sulfonyl substituted 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-ones.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Design; Edema; Molecular Docking Simulation; Quinazolinones; Random Allocation; Rats; Structure-Activity Relationship | 2012 |
Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors.
Topics: Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Design; Male; Pyrazoles; Random Allocation; Rats; Rats, Wistar; Sulfonamides | 2013 |
Rotenoids from Boerhaavia diffusa as potential anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Female; Flavonoids; India; Molecular Structure; Nyctaginaceae; Plant Roots; Rats; Rats, Sprague-Dawley; Rotenone | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.
Topics: Animals; Arachidonate 5-Lipoxygenase; Binding Sites; Drug Design; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Intramolecular Oxidoreductases; Lipoxygenase Inhibitors; Male; Mice; Microsomes; Models, Molecular; Peritonitis; Prostaglandin-E Synthases; Protein Conformation; Pyrimidines; Structure-Activity Relationship; Thiazoles; Zymosan | 2013 |
Synthesis of novel 1,2,3-triazole based benzoxazolinones: their TNF-α based molecular docking with in-vivo anti-inflammatory, antinociceptive activities and ulcerogenic risk evaluation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Edema; Epithelial Cells; Gastric Mucosa; Humans; Models, Molecular; Molecular Structure; Rats; Risk Factors; Structure-Activity Relationship; Triazoles; Tumor Necrosis Factor-alpha | 2013 |
Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Design; Female; Male; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2014 |
Synthesis, docking simulation, biological evaluations and 3D-QSAR study of 5-Aryl-6-(4-methylsulfonyl)-3-(metylthio)-1,2,4-triazine as selective cyclooxygenase-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Edema; Male; Mice; Molecular Docking Simulation; Molecular Structure; Quantitative Structure-Activity Relationship; Rats; Triazines | 2014 |
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles.
Topics: Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Design; Gas Chromatography-Mass Spectrometry; Humans; Inhibitory Concentration 50; Isoxazoles; Magnetic Resonance Spectroscopy; Molecular Docking Simulation; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship | 2014 |
1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.
Topics: Animals; Anisoles; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Hydrazines; Male; Models, Molecular; Molecular Structure; Rats; Stomach Ulcer; Structure-Activity Relationship; Triazoles | 2014 |
Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: identification of a lead for anti-inflammatory drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chromones; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Indoles; Mice; Models, Molecular; Molecular Structure; Pain; Pain Measurement; Pyrazoles; Structure-Activity Relationship | 2014 |
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
Topics: Animals; Anti-Inflammatory Agents; Chrysanthemum; Cyclooxygenase 2; Cytokines; Dinoprostone; Down-Regulation; Edema; I-kappa B Proteins; Interleukin-1beta; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; Models, Animal; Molecular Structure; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Phytotherapy; Signal Transduction; Terpenes; Tumor Necrosis Factor-alpha | 2014 |
Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors.
Topics: Absorption, Physicochemical; Animals; Anthraquinones; Catalytic Domain; Chemistry Techniques, Synthetic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Inhibitory Concentration 50; Molecular Docking Simulation; Naphthalenes; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2014 |
Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1.
Topics: Animals; Anti-Inflammatory Agents; Boswellia; Characidae; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Inhibitory Concentration 50; Intramolecular Oxidoreductases; Lipoxygenase Inhibitors; Molecular Structure; Pentacyclic Triterpenes; Prostaglandin Antagonists; Prostaglandin-E Synthases; Resins, Plant; Structure-Activity Relationship; Tetracycline; Triterpenes | 2014 |
Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase.
Topics: Arachidonate 5-Lipoxygenase; Dose-Response Relationship, Drug; Drug Design; Humans; Indoles; Lipoxygenase Inhibitors; Molecular Structure; Structure-Activity Relationship | 2014 |
Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Synthetic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Male; Molecular Docking Simulation; Protein Conformation; Quantitative Structure-Activity Relationship; Rats; Stomach Ulcer; Substrate Specificity; Triazoles | 2014 |
Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Imidazoles; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship | 2014 |
Synthesis, biological evaluation and docking analysis of 3-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-ones as potential cyclooxygenase-2 (COX-2) inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Coumarins; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Edema; Molecular Docking Simulation; Molecular Structure; Pyrazoles; Rats; Sheep; Structure-Activity Relationship | 2014 |
Synthesis of novel pyrazole–thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors.
Topics: Binding Sites; Cell Line; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Pyrazoles; Structure-Activity Relationship; Thiadiazoles | 2014 |
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.
Topics: Animals; Anti-Inflammatory Agents; Catalytic Domain; Crystallography, X-Ray; Cyclooxygenase 2 Inhibitors; Hyperalgesia; Indoles; Inhibitory Concentration 50; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Molecular Structure; Peptidomimetics | 2015 |
Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties.
Topics: Brain; Caco-2 Cells; Catalytic Domain; Contrast Media; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Isomerism; Molecular Conformation; Molecular Dynamics Simulation; Protein Binding; Sulfonamides | 2015 |
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Inhibitory Concentration 50; Protein Binding; Pyrazoles; Rats; Structure-Activity Relationship; Ulcer | 2015 |
Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent.
Topics: Animals; Anti-Inflammatory Agents; Calorimetry; Carbon-13 Magnetic Resonance Spectroscopy; Cyclooxygenase 2 Inhibitors; Drug Design; Female; Humans; Male; Mice; Peptides; Proton Magnetic Resonance Spectroscopy; Quantitative Structure-Activity Relationship; Spectrometry, Mass, Electrospray Ionization | 2016 |
Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Arachidonate 5-Lipoxygenase; Catalytic Domain; Cell Line, Tumor; Chemistry Techniques, Synthetic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Indoles; Lipoxygenase Inhibitors; Molecular Docking Simulation; Schiff Bases | 2016 |
Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Design; Edema; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Mice; Models, Molecular; Molecular Structure; Rats; Rats, Wistar; Structure-Activity Relationship; Triazines; Ulcer | 2016 |
Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids.
Topics: Analgesics; Animals; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Pain; Pain Threshold; Rats; Transient Receptor Potential Channels | 2017 |
Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Synthetic; Cyclization; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Male; Molecular Docking Simulation; Protein Conformation; Pyrazoles; Rats; Stereoisomerism; Structure-Activity Relationship; Triazines; Ulcer | 2017 |
Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.
Topics: Antineoplastic Agents; Celecoxib; Cell Cycle; Cell Line; Cell Proliferation; Cell Survival; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Indomethacin; Models, Molecular; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship | 2017 |
Novel 2,4-dichlorophenoxy acetic acid substituted thiazolidin-4-ones as anti-inflammatory agents: Design, synthesis and biological screening.
Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Anti-Inflammatory Agents; Drug Design; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship; Thiazoles; Tumor Necrosis Factor-alpha | 2017 |
Synthesis, molecular docking and biological evaluation of some newer 2-substituted-4-(benzo[d][1,3]dioxol-5-yl)-6-phenylpyridazin-3(2H)-ones as potential anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Edema; Humans; Male; Mice; Molecular Docking Simulation; Pyridazines; Rats, Wistar; Stomach Ulcer | 2017 |
Synthesis, potential anti-inflammatory and analgesic activities study of (S)-N-substituted-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamides.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Isoquinolines; Mice; Molecular Structure; Pain; Stereoisomerism; Structure-Activity Relationship; Xylenes | 2017 |
Synthesis and biological evaluations of new nitric oxide-anti-inflammatory drug hybrids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationship, Drug; Edema; Molecular Docking Simulation; Molecular Structure; Nitric Oxide; Rats; Structure-Activity Relationship; Ulcer | 2017 |
Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.
Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hydroxyprostaglandin Dehydrogenases; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured | 2017 |
Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities.
Topics: Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Discovery; Humans; Indomethacin; Molecular Dynamics Simulation; Molecular Structure; Structure-Activity Relationship | 2017 |
Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 15-Lipoxygenase; Cell Differentiation; Click Chemistry; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Female; Humans; Lipoxygenase Inhibitors; Macrophages; Molecular Docking Simulation; Molecular Structure; Quinazolinones; Rats; Rats, Wistar; Structure-Activity Relationship; Sulfhydryl Compounds; Tumor Cells, Cultured | 2018 |
Synthesis and biological properties of aryl methyl sulfones.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Edema; Humans; Male; Mice; Models, Molecular; Molecular Structure; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship; Sulfones; Thermodynamics | 2018 |
Tailoring the Substitution Pattern on 1,3,5-Triazine for Targeting Cyclooxygenase-2: Discovery and Structure-Activity Relationship of Triazine-4-Aminophenylmorpholin-3-one Hybrids that Reverse Algesia and Inflammation in Swiss Albino Mice.
Topics: Analgesics; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Drug Discovery; Female; Humans; Hyperalgesia; Inflammation; Male; Mice; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Pain; Structure-Activity Relationship; Triazines | 2018 |
Synthesis, in vitro and in vivo biological evaluation, COX-1/2 inhibition and molecular docking study of indole-N-acylhydrazone derivatives.
Topics: Acylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Female; Humans; Hydrazones; Indoles; Mice, Inbred BALB C; Molecular Docking Simulation | 2018 |
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Inflammation; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Neurons; PC12 Cells; Rats; Semicarbazides; Triazoles | 2019 |
Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 15-Lipoxygenase; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Ligands; Molecular Docking Simulation; PPAR gamma; Protein Binding; Thiazolidinediones | 2019 |
Synthesis and biological evaluation of pyridazinone derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Edema; Male; Molecular Docking Simulation; Molecular Structure; Pyridazines; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship | 2019 |
Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonamides; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Male; Molecular Docking Simulation; Molecular Structure; Rats; Structure-Activity Relationship; Sulfonamides; Triazoles | 2019 |
Chalcone derivatives bearing chromen or benzo[f]chromen moieties: Design, synthesis, and evaluations of anti-inflammatory, analgesic, selective COX-2 inhibitory activities.
Topics: Anti-Inflammatory Agents; Chalcones; Cyclooxygenase 2 Inhibitors; Drug Design; Molecular Structure; Structure-Activity Relationship | 2019 |
Cyclic enaminone as new chemotype for selective cyclooxygenase-2 inhibitory, anti-inflammatory, and analgesic activities.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Edema; Heterocyclic Compounds; Humans; Male; Molecular Docking Simulation; Molecular Structure; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2019 |
New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Models, Molecular; Molecular Structure; Oxadiazoles; Protein Kinase Inhibitors; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents.
Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Carrageenan; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Design; Edema; Enzyme Inhibitors; Female; Humans; Male; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Molecular Structure; Pyrrolidines; Structure-Activity Relationship | 2020 |
Discovery of new non-acidic lonazolac analogues with COX-2 selectivity as potent anti-inflammatory agents.
Topics: | 2019 |
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Formaldehyde; Humans; Hyperalgesia; Inflammation; Molecular Docking Simulation; Molecular Structure; Piperidines; Rats; Rats, Wistar; Structure-Activity Relationship; Triazines; Tryptophan | 2020 |
Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arachidonate 5-Lipoxygenase; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Lipoxygenase Inhibitors; Male; Mice; Pyrazoles; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides | 2020 |
Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 15-Lipoxygenase; Benzimidazoles; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Edema; Lipoxygenase Inhibitors; Male; Molecular Structure; Rats; Structure-Activity Relationship; Thiazoles | 2020 |
Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Benzothiazoles; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Free Radical Scavengers; Humans; Inflammation; Mice; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Structure-Activity Relationship | 2020 |
Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.
Topics: Antineoplastic Agents; Arachidonate 15-Lipoxygenase; Carbonic Anhydrases; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Molecular Structure; Structure-Activity Relationship; Triazoles | 2020 |
Cacalol Acetate, a Sesquiterpene from
Topics: Animals; Anti-Inflammatory Agents; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Psacalium; RAW 264.7 Cells; Sesquiterpenes; Signal Transduction | 2020 |
Synthesis and evaluations of selective COX-2 inhibitory effects: Benzo[d]thiazol analogs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Design; Edema; Mice; Structure-Activity Relationship; Thiazoles | 2020 |
Design and synthesis of 7-O-1,2,3-triazole hesperetin derivatives to relieve inflammation of acute liver injury in mice.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Hesperidin; Inflammation; Liver; Mice; Mice, Inbred C57BL; Molecular Structure; Nitric Oxide; RAW 264.7 Cells; Reactive Oxygen Species; Structure-Activity Relationship; Triazoles | 2021 |
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Design; Edema; Female; Humans; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Tartrates | 2021 |
Synthesis and computational studies of novel fused pyrimidinones as a promising scaffold with analgesic, anti-inflammatory and COX inhibitory potential.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Design; Edema; Humans; Male; Mice; Pyrimidinones; Quantitative Structure-Activity Relationship; Rats; Rats, Wistar | 2021 |
Synthetic methodology-enabled discovery of a tunable indole template for COX-1 inhibition and anti-cancer activity.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Indoles; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship | 2022 |
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazoles; Indoles; Ischemic Stroke; Lipopolysaccharides; Mice; Microglia; Neuroprotection; Neuroprotective Agents; Piperazine; Pyrimidines; Rats; Stroke; Tumor Necrosis Factor-alpha | 2022 |
Pharmacological analysis of cyclooxygenase-1 in inflammation.
Topics: Animals; Arthritis, Experimental; Blood Platelets; Carrageenan; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Hyperalgesia; Indomethacin; Inflammation; Isoenzymes; Male; Membrane Proteins; Models, Biological; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides; Thromboxane B2 | 1998 |
Kinetic basis for selective inhibition of cyclo-oxygenases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Ibuprofen; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Male; Membrane Proteins; Mice; Naproxen; Oxygen; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sheep; Structure-Activity Relationship; Sulfonamides; Tetramethylphenylenediamine; Thermodynamics | 1999 |
Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Celecoxib; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Radiation; Feeding Behavior; Indomethacin; Isoenzymes; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Skin Neoplasms; Sulfonamides; Ultraviolet Rays | 1999 |
Cyclooxygenase-2 inhibitors constrict the fetal lamb ductus arteriosus both in vitro and in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Ductus Arteriosus; Epoprostenol; Female; Hemodynamics; In Vitro Techniques; Indomethacin; Isoenzymes; Nitrobenzenes; Nitroprusside; Oxygen; Pregnancy; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Pyrazoles; Sheep; Sulfonamides; Vasoconstriction; Vasodilator Agents | 2000 |
Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis.
Topics: Animals; Blotting, Western; Celecoxib; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hydantoins; Indomethacin; Intramolecular Oxidoreductases; Isoenzymes; Lipocalins; Male; Necrosis; Neutrophils; Peroxidase; Peroxisomes; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Receptors, Prostaglandin; RNA, Messenger; Sulfonamides; Transcription Factors | 2000 |
[Celecoxib vs indomethacin and acute gastric lesions in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Digestive System; Female; Indomethacin; Male; Necrosis; Pyloric Antrum; Pyrazoles; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides | 2000 |
Comparison of the intestinal toxicity of celecoxib, a selective COX-2 inhibitor, and indomethacin in the experimental rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Membrane Permeability; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethacin; Intestinal Mucosa; Intestine, Small; Mitochondria; Prostaglandins E; Pyrazoles; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Sulfonamides | 2000 |
Stimulated release of arachidonic acid from rat liver cells by celecoxib and indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Celecoxib; Cell Line; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dactinomycin; Dexamethasone; Drug Interactions; Glucocorticoids; Indomethacin; Isoenzymes; Liver; Prostaglandin-Endoperoxide Synthases; Protein Synthesis Inhibitors; Pyrazoles; Rats; Sulfonamides | 2001 |
Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chromatography, High Pressure Liquid; Confidence Intervals; Cyclooxygenase Inhibitors; Delayed-Action Preparations; Female; Gastric Mucosa; Humans; Indomethacin; Intestinal Mucosa; Lactulose; Male; Mannitol; Meloxicam; Middle Aged; Naproxen; Permeability; Pyrazoles; Statistics, Nonparametric; Sucrose; Sulfonamides; Thiazines; Thiazoles | 2001 |
Nonsteroidal anti-inflammatory drugs for perioperative pain control.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanones; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Etodolac; Humans; Ibuprofen; Indomethacin; Ketorolac; Lactones; Nabumetone; Naproxen; Pain, Postoperative; Piroxicam; Pyrazoles; Sulfonamides; Sulfones; Time Factors | 2001 |
Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors.
Topics: Alitretinoin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Celecoxib; Cell Line; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Drug Synergism; Indomethacin; Kinetics; Liver; Prostaglandin D2; Prostaglandins A; Pyrazoles; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin | 2001 |
Effects of NSAIDs on cryoprobe-induced gastric ulcer healing in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Celecoxib; Cell Division; Cyclooxygenase Inhibitors; Epithelial Cells; Gastric Mucosa; Indomethacin; Male; Nabumetone; Prostaglandins; Pyrazoles; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Sulfonamides; Wound Healing | 2001 |
New cyclooxygenase-2 inhibitors for treatment of experimental autoimmune neuritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Indomethacin; Isoenzymes; Male; Meloxicam; Neuritis, Autoimmune, Experimental; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred Lew; Sciatic Nerve; Sulfonamides; Thiazines; Thiazoles | 2002 |
The role of cyclooxygenase-1 and -2 in the rat formalin test.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Formaldehyde; Indomethacin; Injections, Spinal; Isoenzymes; Male; Membrane Proteins; Neural Conduction; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2002 |
Modulation of inflammatory paw oedema by cysteamine in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Corticotropin-Releasing Hormone; Cystamine; Edema; Formaldehyde; Histamine; Indomethacin; Pyrazoles; Rats; Somatostatin; Substance P; Sulfonamides; Tumor Necrosis Factor-alpha | 2002 |
Anti-implantation effects of indomethacin and celecoxib in rats.
Topics: Animals; Celecoxib; Contraception; Contraceptives, Postcoital; Cyclooxygenase Inhibitors; Decidua; Embryo Implantation; Female; Hormone Antagonists; Indomethacin; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Sulfonamides | 2002 |
Hemicrania continua responds to cyclooxygenase-2 inhibitors.
Topics: Celecoxib; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Lactones; Male; Migraine Disorders; Pyrazoles; Recurrence; Sulfonamides; Sulfones | 2002 |
Effect of cyclooxygenase inhibitors in postoperative ileus: an experimental study.
Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Indomethacin; Intestinal Obstruction; Male; Postoperative Complications; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2002 |
The effect of cyclooxygenase-2 inhibitors on spinal fusion.
Topics: Administration, Oral; Animals; Biopsy, Needle; Celecoxib; Confidence Intervals; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Immunohistochemistry; Indomethacin; Lumbar Vertebrae; Male; Odds Ratio; Osteogenesis; Pyrazoles; Rabbits; Radiography; Random Allocation; Reference Values; Sodium Chloride; Spinal Fusion; Sulfonamides; Wound Healing | 2002 |
Ulcerogenic influence of selective cyclooxygenase-2 inhibitors in the rat stomach with adjuvant-induced arthritis.
Topics: Animals; Arthritis, Experimental; Capillary Permeability; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Immunohistochemistry; Indomethacin; Isoenzymes; Lactones; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Stomach Ulcer; Sulfonamides; Sulfones | 2002 |
Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation.
Topics: Animals; Carrageenan; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Hindlimb; Hyperalgesia; Indomethacin; Inflammation; Isoenzymes; Lactones; Male; Pain Threshold; Piroxicam; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Sulfonamides; Sulfones | 2002 |
Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Edema; Indomethacin; Inflammation; Interleukin-1; Isoenzymes; Lactones; Male; Nitric Oxide; Peroxidase; Pleurisy; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Sulfones; Thromboxane B2; Tumor Necrosis Factor-alpha | 2002 |
The anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline in the rat.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Celecoxib; Dexamethasone; Dose-Response Relationship, Drug; Edema; Indomethacin; Inflammation; Male; Pentoxifylline; Phosphodiesterase Inhibitors; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2003 |
Does the release of arachidonic acid from cells play a role in cancer chemoprevention?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Arachidonic Acid; Catechin; Celecoxib; Cholecalciferol; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Epoprostenol; Humans; Indomethacin; Isoenzymes; Kidney; Liver; Membrane Proteins; Neoplasms; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Retinoids; Sulfonamides; Tetradecanoylphorbol Acetate | 2003 |
Effects of valeryl salicylate, a COX-1 inhibitor, on models of acute inflammation in mice.
Topics: Acute Disease; Animals; Arachidonic Acid; Carrageenan; Celecoxib; Croton Oil; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ear, External; Edema; Foot; Indomethacin; Inflammation; Irritants; Isoenzymes; Male; Membrane Proteins; Mice; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Salicylates; Sulfonamides | 2003 |
Indomethacin and celecoxib improve tendon healing in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cross-Sectional Studies; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Indomethacin; Pyrazoles; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Sulfonamides; Tendon Injuries; Wound Healing | 2003 |
Inhibition of angiotensin II activity enhanced the antitumor effect of cyclooxygenase-2 inhibitors via insulin-like growth factor I receptor pathway.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Cell Division; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Synergism; Enalapril; Humans; Indomethacin; Isoenzymes; Male; Membrane Proteins; Mice; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrazoles; Receptor, IGF Type 1; Sulfonamides | 2003 |
Selective inhibition of cyclooxygenase 2 induces p27kip1 and skp2 in oral squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Celecoxib; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p27; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Indomethacin; Isoenzymes; Membrane Proteins; Mouth Neoplasms; Prostaglandin-Endoperoxide Synthases; Pyrazoles; S-Phase Kinase-Associated Proteins; Sulfonamides; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2003 |
Pharmacological characterisation of a rat model of incisional pain.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Evaluation, Preclinical; Etoricoxib; Foot; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Hyperalgesia; Indomethacin; Male; Morphine; Muscle, Skeletal; Naproxen; Nociceptors; Pain Threshold; Pain, Postoperative; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sulfonamides; Sulfones; Time Factors; Weight-Bearing | 2004 |
Studies on the anti-inflammatory effect of fluoxetine in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carrageenan; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Edema; Fluoxetine; Foot; Imipramine; Indomethacin; Inflammation; Lactones; Melatonin; Pyrazoles; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Sulfonamides; Sulfones; Time Factors; Trazodone | 2004 |
Comparison of nonselective cyclo-oxygenase (COX) inhibitor and selective COX-2 inhibitors on preimplantation loss, postimplantation loss and duration of gestation: an experimental study.
Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Embryonic Development; Female; Gestational Age; Indomethacin; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Sulfonamides | 2004 |
Chemoprevention of gastric cancer by celecoxib in rats.
Topics: Analysis of Variance; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Administration Schedule; Indomethacin; Isoenzymes; Male; Methylnitronitrosoguanidine; Models, Animal; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Sodium Chloride; Stomach Neoplasms; Sulfonamides | 2004 |
Differential effects of selective COX-2 inhibitors on cell cycle regulation and proliferation of glioblastoma cell lines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Cycle; Cell Division; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Glioblastoma; Humans; Indomethacin; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones; Sulindac | 2004 |
Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats.
Topics: Animals; Arachidonic Acids; Atenolol; Behavior, Animal; Biogenic Amines; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Captopril; Celecoxib; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Facial Pain; Formaldehyde; Guanethidine; Hindlimb; Indomethacin; Injections, Subcutaneous; Interleukin-6; Interleukin-8; Lip; Male; Meloxicam; Nociceptors; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Sulfonamides; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha; Tyramine | 2004 |
Gastric effects of the selective cyclooxygenase-2 inhibitor, celecoxib, in the rat.
Topics: Animals; Aspirin; Carrageenan; Celecoxib; Consciousness; Cyclooxygenase Inhibitors; Edema; Gastric Mucosa; Indomethacin; Male; Pyrazoles; Rats; Rats, Wistar; Sulfonamides | 2004 |
Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis.
Topics: Activating Transcription Factor 4; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blotting, Northern; Celecoxib; Cell Line; Cell Survival; Cells, Cultured; Diclofenac; DNA-Binding Proteins; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation; Gastric Mucosa; Genes, Reporter; Guinea Pigs; Heat-Shock Proteins; Hydrogen Peroxide; Ibuprofen; Immunoblotting; Indomethacin; Luciferases; Macrophages; Microscopy, Fluorescence; Molecular Chaperones; Plasmids; Pyrazoles; Regulatory Factor X Transcription Factors; RNA, Messenger; Sulfonamides; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; X-Box Binding Protein 1 | 2004 |
Aggravation of inflammatory bowel disease by cyclooxygenase-2 inhibitors in rats.
Topics: Animals; Celecoxib; Colon; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Female; Indomethacin; Inflammatory Bowel Diseases; Male; Muscle Contraction; Oxidative Stress; Peroxidase; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Sulfonamides | 2004 |
Celecoxib inhibits angiogenesis by inducing endothelial cell apoptosis in human pancreatic tumor xenografts.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial Cells; Fibroblast Growth Factor 2; Group IV Phospholipases A2; Humans; Indomethacin; Interleukin-8; Male; Membrane Proteins; Mice; Mice, Nude; Neovascularization, Pathologic; Pancreatic Neoplasms; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2004 |
The effects of selective and nonselective cyclooxygenase inhibitors on endothelin-1-induced fever in rats.
Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Endothelin-1; Fever; Indomethacin; Injections, Intraperitoneal; Injections, Intraventricular; Intubation, Gastrointestinal; Lipopolysaccharides; Male; Organic Chemicals; Pyrazoles; Rats; Rats, Wistar; Sulfonamides | 2005 |
Different cell kinetic changes in rat stomach cancer after treatment with celecoxib or indomethacin: implications on chemoprevention.
Topics: Adenocarcinoma; Animals; Apoptosis; Celecoxib; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Epithelial Cells; Indomethacin; Isoenzymes; Male; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Stomach Neoplasms; Sulfonamides | 2005 |
Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Celecoxib; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diet; Disease Models, Animal; Esophageal Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hyperplasia; Indomethacin; Isoenzymes; Male; Mutagens; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Tongue Neoplasms; Up-Regulation; Zinc | 2005 |
Celecoxib inhibits ureteral contractility and prostanoid release.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Celecoxib; Cyclooxygenase Inhibitors; Depression, Chemical; Dimethyl Sulfoxide; Dinoprost; Dinoprostone; Gas Chromatography-Mass Spectrometry; Humans; Indomethacin; Muscle Contraction; Nitrobenzenes; Prostaglandin Antagonists; Prostaglandin D2; Prostaglandins; Pyrazoles; Secretory Rate; Sulfonamides; Sus scrofa; Thromboxane A2; Tumor Necrosis Factor-alpha; Ureter; Ureteral Obstruction | 2005 |
Suppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma; Carcinoma, Squamous Cell; Celecoxib; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethacin; Male; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Muscle, Skeletal; Neoplasm Recurrence, Local; Neoplasm Seeding; Neoplasm Transplantation; Peroxidases; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2005 |
Development and pharmacological characterization of a rat model of osteoarthritis pain.
Topics: Alkylating Agents; Analgesics, Opioid; Animals; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, Animal; Hindlimb; Indomethacin; Injections, Intra-Articular; Iodoacetates; Male; Morphine; Osteoarthritis, Knee; Pain; Papain; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Weight-Bearing | 2005 |
Post-training intrahippocampal infusion of the COX-2 inhibitor celecoxib impaired spatial memory retention in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Hippocampus; Indomethacin; Male; Maze Learning; Memory; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Retention, Psychology; Sulfonamides; Swimming; Time Factors | 2005 |
Inhibitory avoidance memory retention in the elevated T-maze is impaired after perivascular manipulation of the common carotid arteries.
Topics: Animals; Avoidance Learning; Carotid Arteries; Carotid Stenosis; Celecoxib; Indomethacin; Male; Maze Learning; Pyrazoles; Rats; Retention, Psychology; Sulfonamides; Time Factors | 2005 |
Cyclooxygenase inhibitors modulate NK activities that control metastatic disease.
Topics: Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytotoxicity, Immunologic; Down-Regulation; Female; Histocompatibility Antigens Class I; Indomethacin; Interferon-gamma; Killer Cells, Natural; Mammary Neoplasms, Experimental; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, SCID; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2005 |
Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors.
Topics: Animals; Celecoxib; Colitis; Cyclooxygenase Inhibitors; Gastric Mucosa; Gastrointestinal Tract; Indomethacin; Male; Pyrazoles; Rats; Rats, Wistar; Reperfusion Injury; Sulfonamides | 2005 |
CC 05, a novel anti-inflammatory compound, exerts its effect by inhibition of cyclooxygenase-2 activity.
Topics: Animals; Anti-Inflammatory Agents; Baculoviridae; Benzenesulfonamides; Carrageenan; Celecoxib; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Edema; Indomethacin; Inflammation; Inhibitory Concentration 50; Male; Pyrazoles; Rats; Rats, Sprague-Dawley; Spodoptera; Sulfonamides | 2005 |
Modification of eicosanoid profile in human blood treated by dual COX/LOX inhibitors.
Topics: Arachidonic Acid; Calcimycin; Celecoxib; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Eicosanoids; Humans; Hydroxyurea; Indomethacin; Inhibitory Concentration 50; Lipopolysaccharides; Lipoxygenase Inhibitors; Pyrazoles; Sulfonamides | 2005 |
Effects of cyclooxygenase-1 and -2 inhibition on gastric acid secretion and cardiovascular functions in rats.
Topics: Animals; Blood Pressure; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Gastric Acid; Heart Rate; Hemodynamics; Indomethacin; Male; Pentagastrin; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Vagotomy | 2006 |
Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2.
Topics: Aspirin; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Celecoxib; Cell Line; Cerebrospinal Fluid Proteins; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indomethacin; Ionophores; Lactones; Meloxicam; Naproxen; Organ Specificity; Organic Chemicals; Protein Binding; Pyrazoles; Sodium Salicylate; Sulfonamides; Sulfones; Synovial Fluid; Thiazines; Thiazoles; Thromboxane A2 | 2006 |
Celecoxib inhibits nitric oxide production in chondrocytes of ligament-damaged osteoarthritic rat joints.
Topics: Animals; Anterior Cruciate Ligament; Celecoxib; Cells, Cultured; Chondrocytes; Cyclooxygenase Inhibitors; Dinoprostone; Indomethacin; Interleukin-1alpha; Knee Joint; Male; Nitric Oxide; Osteoarthritis; Pyrazoles; Rats; Rats, Wistar; Sulfonamides | 2006 |
Nonsteroidal anti-inflammatory drug use in ankylosing spondylitis--a population-based survey.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cohort Studies; Cross-Sectional Studies; Diclofenac; Female; Humans; Indomethacin; Male; Middle Aged; Naproxen; Pain; Pain Measurement; Patient Satisfaction; Pyrazoles; Retreatment; Spondylitis, Ankylosing; Sulfonamides; Surveys and Questionnaires; Treatment Outcome | 2006 |
Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atrasentan; Bosentan; Carrageenan; Celecoxib; Cold Temperature; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelin-1; Endothelins; Grooming; Hyperalgesia; Indomethacin; Male; Maxillary Nerve; Nerve Compression Syndromes; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Pyrazoles; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Trigeminal Neuralgia | 2006 |
Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Arthritis; Biological Availability; Blood Platelets; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Indomethacin; Male; Mice; Mice, Knockout; Nitric Oxide; Pyrazoles; Sulfonamides; Vasoconstriction | 2006 |
Inhibition of the cyclooxygenase pathway attenuates morphine-induced conditioned place preference in mice.
Topics: Analgesics, Opioid; Animals; Celecoxib; Conditioning, Operant; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Indomethacin; Male; Mice; Morphine; Pyrazoles; Sulfonamides | 2006 |
Inhibition of prostaglandin F(2alpha) by selective cyclooxygenase 2 inhibitors accounts for reduced rat leukocyte migration.
Topics: Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Female; Indomethacin; Injections, Intraperitoneal; Lactones; Lipopolysaccharides; Neutrophil Infiltration; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones; Time Factors | 2005 |
Intestinal effects of nonselective and selective cyclooxygenase inhibitors in the rat.
Topics: Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enterobacteriaceae; Ibuprofen; Indomethacin; Intestinal Mucosa; Intestine, Small; Lipid Peroxidation; Male; Mucins; Peroxidase; Pyrazoles; Rats; Rats, Wistar; Sulfonamides | 2006 |
Contributions of histamine, prostanoids, and neurokinins to edema elicited by edema toxin from Bacillus anthracis.
Topics: Animals; Antigens, Bacterial; Aprepitant; Bacillus anthracis; Bacterial Toxins; Capillary Permeability; Celecoxib; Cell Degranulation; Cell Line; Disease Models, Animal; Edema; Enzyme Inhibitors; Histamine; Histamine H1 Antagonists; Humans; Indomethacin; Injections, Intradermal; Mast Cells; Morpholines; Neurokinin-1 Receptor Antagonists; Prostaglandin Antagonists; Prostaglandins; Pyrazoles; Pyrilamine; Rabbits; Substance P; Sulfonamides; Tachykinins | 2007 |
Cyclooxygenase-2 inhibition increases gastric tone and delays gastric emptying in rats.
Topics: Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Gastric Emptying; Gastric Mucosa; Indomethacin; Isoxazoles; Ketorolac; Lactones; Male; Muscle, Smooth; Pyrazoles; Rats; Rats, Wistar; Stomach; Sulfonamides; Sulfones | 2007 |
A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice.
Topics: Adenoma; Aging; Animals; Blotting, Western; Celecoxib; Cell Transformation, Neoplastic; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Epithelium; Female; Gene Dosage; Heterozygote; Homozygote; Humans; Inbreeding; Indomethacin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovarian Neoplasms; Ovary; Phenotype; Pyrazoles; Sulfonamides | 2007 |
Risk of congestive heart failure with nonsteroidal antiinflammatory drugs and selective Cyclooxygenase 2 inhibitors: a class effect?
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Celecoxib; Cyclooxygenase 2 Inhibitors; Female; Heart Failure; Humans; Indomethacin; Lactones; Logistic Models; Male; Odds Ratio; Patient Readmission; Pyrazoles; Risk Assessment; Sulfonamides; Sulfones | 2007 |
Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats.
Topics: Animals; Cardiovascular Diseases; Celecoxib; Colitis, Ulcerative; Colon; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Gene Expression; Indomethacin; Male; Peroxidase; Plasma Substitutes; Pyrazoles; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrophotometry; Sulfonamides; Treatment Outcome | 2007 |
[Effects of selective cyclooxygenase-2 inhibitor on proliferation and apoptosis of human bladder cancer cell line T24].
Topics: Apoptosis; bcl-2-Associated X Protein; Celecoxib; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Flow Cytometry; Humans; Indomethacin; Inhibitory Concentration 50; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Urinary Bladder Neoplasms | 2007 |
Celecoxib prevents juxta-articular osteopenia and growth plate destruction adjacent to inflamed joints in rats with collagen-induced arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Bone Density; Bone Diseases, Metabolic; Celecoxib; Dexamethasone; Growth Plate; Hindlimb; Indomethacin; Male; Pyrazoles; Rats; Rats, Inbred Lew; Sulfonamides | 2007 |
Survivin is a downstream target and effector of sulindac-sensitive oncogenic Stat3 signalling in head and neck cancer.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Celecoxib; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2 Inhibitors; Cysteine Proteinase Inhibitors; Down-Regulation; Enzyme Inhibitors; Humans; Immunohistochemistry; Indomethacin; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Pyrazoles; Signal Transduction; STAT3 Transcription Factor; Sulfonamides; Sulindac; Survivin; Tongue Neoplasms; Tumor Cells, Cultured | 2007 |
Alterations in spontaneous contractions of rat ileum and jejunum after peritonitis.
Topics: Animals; Celecoxib; Guanidines; Ileum; In Vitro Techniques; Indomethacin; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Peritonitis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Sulfonamides | 2008 |
The effects of prostaglandin inhibition on whole-body ischemia-reperfusion in swine.
Topics: Animals; Cardiopulmonary Resuscitation; Celecoxib; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Epoprostenol; Heart; Heart Arrest, Induced; Heart Massage; Indomethacin; Myocardium; Prostaglandins; Pyrazoles; Regional Blood Flow; Reperfusion Injury; Sulfonamides; Swine; Troponin I | 2008 |
Prostaglandin inhibition and ischemia: where are the data?
Topics: Animals; Cardiopulmonary Resuscitation; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, Animal; Heart Arrest, Induced; Indomethacin; Pyrazoles; Reperfusion Injury; Sulfonamides; Troponin I | 2008 |
Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G.
Topics: Apoptosis; Celecoxib; Cell Adhesion Molecules; Cell Proliferation; Colonic Neoplasms; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclin D1; Cyclooxygenase Inhibitors; Enzyme Activation; Humans; Indomethacin; Lactones; Meclofenamic Acid; Microfilament Proteins; Mitogen-Activated Protein Kinase 8; Phosphoproteins; Phosphorylation; Pyrazoles; Sulfonamides; Sulfones; Tumor Cells, Cultured | 2008 |
Intracellular effects of NSAIDs/ASA in oxidatively stressed human lens epithelial cells in culture.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cell Size; Cells, Cultured; Diclofenac; Epithelial Cells; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Indomethacin; Intracellular Membranes; Lens, Crystalline; Membrane Potential, Mitochondrial; Mitochondria; Oxidants; Oxidative Stress; Peroxides; Pyrazoles; Reactive Oxygen Species; Sulfonamides; Superoxides | 2008 |
Inhibition of mouse osteoblast proliferation and prostaglandin E2 synthesis by Ulmus davidiana Planch (Ulmaceae).
Topics: Actins; Animals; Celecoxib; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Immunoenzyme Techniques; Immunohistochemistry; Indomethacin; Mice; Mice, Inbred BALB C; Osteoblasts; Plant Bark; Plant Extracts; Proliferating Cell Nuclear Antigen; Prostaglandin Antagonists; Pyrazoles; Sulfonamides; Ulmus | 2008 |
Applying blood-brain barrier in vitro models to study the influence of drugs on endothelial cells--effects of selected COX-inhibitors.
Topics: Animals; Blood-Brain Barrier; Celecoxib; Cell Line; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Humans; Indomethacin; Intercellular Adhesion Molecule-1; Membrane Proteins; Occludin; Phosphoproteins; Pyrazoles; Rats; Sulfonamides; Vascular Cell Adhesion Molecule-1; von Willebrand Factor; Zonula Occludens-1 Protein | 2008 |
Effects of nonselective and selective cyclooxygenase inhibitors on small intestinal motility in the horse.
Topics: Animals; Celecoxib; Clonixin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Gastrointestinal Motility; Histocytochemistry; Horses; In Vitro Techniques; Indomethacin; Intestine, Small; Male; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides | 2009 |
Cyclooxygenase inhibitors down regulate P-glycoprotein in human colorectal Caco-2 cell line.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Caco-2 Cells; Celecoxib; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Naproxen; Neoplasm Proteins; Pyrazoles; Reproducibility of Results; RNA, Messenger; Sulfonamides; Time Factors | 2008 |
In vitro and in vivo inhibitory effect evaluation of cyclooxygenase-2 inhibitors, antisense cyclooxygenase-2 cDNA, and their combination on the growth of human bladder cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Celecoxib; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; DNA, Antisense; DNA, Complementary; Gene Expression Regulation, Enzymologic; Humans; Indomethacin; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Pyrazoles; Sulfonamides; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2009 |
Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling.
Topics: Antineoplastic Agents; Blotting, Western; Caspase 9; Celecoxib; Cell Death; Cell Line, Tumor; Chromones; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Forkhead Transcription Factors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indomethacin; Morpholines; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Signal Transduction; Stomach Neoplasms; Sulfonamides; Time Factors | 2009 |
Differential involvement of cyclooxygenase isoforms in neutrophil migration in vivo and in vitro.
Topics: Animals; Celecoxib; Cell Adhesion; Cell Movement; Cell Separation; Chemotaxis, Leukocyte; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Data Interpretation, Statistical; Endothelium, Vascular; Female; Indomethacin; Isoenzymes; Male; Mice; Neutrophil Infiltration; Neutrophils; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2008 |
Nifedipine enhances the relaxant effects of cyclo-oxygenase inhibitors on the bovine ciliary muscle.
Topics: Animals; Calcium Channel Blockers; Cattle; Celecoxib; Ciliary Body; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Furans; Indomethacin; Muscle Relaxation; Nifedipine; Pyrazoles; Sulfonamides | 2008 |
Mechanisms involved in the rat peritoneal leukocyte migration induced by a Kunitz-type inhibitor isolated from Dimorphandra mollis seeds.
Topics: Analysis of Variance; Animals; Benzoquinones; Celecoxib; Cell Movement; Dexamethasone; Fabaceae; Indomethacin; Inflammation; Leukocytes; Male; NG-Nitroarginine Methyl Ester; Peptides; Peritoneal Lavage; Piperidines; Plant Proteins; Pyrazoles; Quinuclidines; Rats; Rats, Wistar; Seeds; Sulfonamides | 2009 |
The effect of selective cyclooxygenase-2 inhibitor on human osteoclast precursors to influence osteoclastogenesis in vitro.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Celecoxib; Cell Growth Processes; Cell Survival; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Humans; Indomethacin; Isoxazoles; Macrophage Colony-Stimulating Factor; Osteoclasts; Pyrazoles; RANK Ligand; Stem Cells; Sulfonamides; Time Factors | 2009 |
Role of systemic and local administration of selective inhibitors of cyclo-oxygenase 1 and 2 in an experimental model of periodontal disease in rats.
Topics: Alveolar Bone Loss; Animals; Arachidonic Acid; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethacin; Male; Periodontal Attachment Loss; Periodontal Ligament; Periodontitis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2009 |
Bartter's syndrome with type 2 diabetes mellitus.
Topics: Adult; Bartter Syndrome; Celecoxib; Diabetes Mellitus, Type 2; Female; Humans; Indomethacin; Pyrazoles; Sulfonamides | 2009 |
Inflammatory mediators released following application of irritants on the rat injured incisors. The effect of treatment with anti-inflammatory drugs.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Capsaicin; Celecoxib; Dexamethasone; Dinoprostone; Endotoxins; Incisor; Indomethacin; Inflammation Mediators; Irritants; Morphine; Nerve Growth Factor; Pyrazoles; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sulfonamides | 2009 |
Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Blotting, Western; Celecoxib; Colonic Neoplasms; Colonic Polyps; Disease Models, Animal; Female; Genes, APC; Humans; Indomethacin; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; PPAR delta; PPAR-beta; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfonamides; Tumor Cells, Cultured | 2009 |
Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts.
Topics: Annexin A5; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Celecoxib; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Dexamethasone; Diclofenac; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Indomethacin; Ketorolac; L-Lactate Dehydrogenase; Osteoblasts; Piroxicam; Propidium; Pyrazoles; RNA, Messenger; Sulfonamides; Thymidine | 2009 |
Pattern recognition analysis for the prediction of adverse effects by nonsteroidal anti-inflammatory drugs using 1H NMR-based metabolomics in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibitors; Ibuprofen; Indomethacin; Least-Squares Analysis; Magnetic Resonance Spectroscopy; Male; Metabolomics; Pattern Recognition, Automated; Predictive Value of Tests; Pyrazoles; Rats; Rats, Sprague-Dawley; Stomach; Sulfonamides | 2009 |
Role of lipoxygenases and the lipoxin A(4)/annexin 1 receptor in ischemia-reperfusion-induced gastric mucosal damage in rats.
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Animals; Annexins; Anti-Ulcer Agents; Celecoxib; Cyclooxygenase Inhibitors; Dexamethasone; Drug Synergism; Flavanones; Fluorenes; Gastric Mucosa; Glucocorticoids; Indoles; Indomethacin; Lipoxygenase; Lipoxygenase Inhibitors; Male; Oligopeptides; Phenyl Ethers; Prostaglandin Antagonists; Pyrazoles; Rats; Rats, Wistar; Receptors, Formyl Peptide; Receptors, Lipoxin; Reperfusion Injury; Sulfonamides | 2009 |
The PI3K/Akt/FOXO3a/p27Kip1 signaling contributes to anti-inflammatory drug-suppressed proliferation of human osteoblasts.
Topics: Anti-Inflammatory Agents; Celecoxib; Cell Proliferation; Cells, Cultured; Chromones; Cyclin-Dependent Kinase Inhibitor p27; Dextroamphetamine; Epidermal Growth Factor; Female; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Indomethacin; Male; Morpholines; Osteoblasts; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Pyrazoles; Sulfonamides | 2010 |
Low direct cytotoxicity of loxoprofen on gastric mucosal cells.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Celecoxib; Cell Line, Tumor; Dose-Response Relationship, Drug; Gastric Mucosa; Guinea Pigs; Humans; Indomethacin; Necrosis; Permeability; Phenylpropionates; Pyrazoles; Stomach Neoplasms; Sulfonamides | 2010 |
Cyclooxygenase-derived mediators regulate the immunological control of Strongyloides venezuelensis infection.
Topics: Animals; Ascitic Fluid; Blood; Bronchoalveolar Lavage Fluid; Celecoxib; Dinoprostone; Duodenum; Enzyme Inhibitors; Eosinophils; Ibuprofen; Indomethacin; Leukocytes, Mononuclear; Lung; Male; Mice; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Strongyloides; Strongyloidiasis; Sulfonamides; Th1 Cells; Th2 Cells | 2010 |
Effects of selective and non-selective cyclooxygenase (COX) inhibitors on postoperative adhesion formation in a rat uterine horn model.
Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Female; Indomethacin; Postoperative Complications; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Tissue Adhesions; Uterus | 2010 |
The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo.
Topics: Analgesics; Anemarrhena; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillary Permeability; Carrageenan; Celecoxib; Croton Oil; Disease Models, Animal; Edema; Flowers; Hot Temperature; Indomethacin; Iodoacetates; Lonicera; Mice; Mice, Inbred ICR; Osteoarthritis; Pain; Pain Measurement; Phytotherapy; Plant Extracts; Plant Roots; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfonamides | 2010 |
Indomethacin promotes adipogenesis of mesenchymal stem cells through a cyclooxygenase independent mechanism.
Topics: Adipogenesis; Animals; beta Catenin; CCAAT-Enhancer-Binding Protein-beta; Celecoxib; Cell Line; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Indomethacin; Ligands; Mesenchymal Stem Cells; Mice; PPAR gamma; Pyrazoles; Response Elements; Sulfonamides; Transcriptional Activation | 2010 |
Celecoxib induces tolerance in a model of peripheral inflammatory pain in rats.
Topics: Analgesics; Analysis of Variance; Animals; Celecoxib; Dinoprostone; Hyperalgesia; Indomethacin; Inflammation; Morphine; Pain Threshold; Physical Stimulation; Pyrazoles; Rats; Sulfonamides | 2010 |
A novel COX-2 inhibitor pyrazole derivative proven effective as an anti-inflammatory and analgesic drug.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzenesulfonamides; Carrageenan; Celecoxib; Chronic Disease; Cyclooxygenase 2 Inhibitors; Drug Evaluation, Preclinical; Edema; Female; Formaldehyde; Hyperalgesia; Indomethacin; Inflammation; Male; Mice; Pyrazoles; Rats; Sulfonamides; Ulcer | 2011 |
Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in development of experimental ulcerative colitis.
Topics: Acetic Acid; Animals; Antioxidants; Arachidonate 5-Lipoxygenase; Arginine; Benzoquinones; Celecoxib; Colitis, Ulcerative; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Female; Guanidines; Indomethacin; Intestine, Large; Leukotriene B4; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Pyrazoles; Rats; Sulfonamides | 2011 |
Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Esophagitis, Peptic; Esophagus; Gastric Acid; Humans; Indomethacin; Male; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Pyrazoles; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides | 2011 |
The effects of NSAIDs on types I, II, and III collagen metabolism in a rat osteoarthritis model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Celecoxib; Chondrocytes; Collagen Type I; Collagen Type II; Collagen Type III; Disease Models, Animal; Ibuprofen; Immunohistochemistry; Indomethacin; Osteoarthritis; Proteoglycans; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Time Factors | 2012 |
Fluorinated COX-2 inhibitors as agents in PET imaging of inflammation and cancer.
Topics: Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Female; Halogenation; Humans; Indomethacin; Inflammation; Male; Mice; Mice, Nude; Molecular Imaging; Neoplasms; Positron-Emission Tomography; Pyrazoles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Sulfonamides; Tumor Cells, Cultured | 2011 |
Combined histone deacetylase and cyclooxygenase inhibition achieves enhanced antiangiogenic effects in lung cancer cells.
Topics: Angiogenesis Inhibitors; Celecoxib; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Synergism; Epithelial Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Hydroxyprostaglandin Dehydrogenases; Indomethacin; Lung Neoplasms; Pyrazoles; Sulfonamides; Vorinostat | 2013 |
Low rates of heterotopic ossification after resurfacing hip arthroplasty with use of prophylactic radiotherapy in select patients.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Arthroplasty, Replacement, Hip; Celecoxib; Female; Follow-Up Studies; Humans; Incidence; Indomethacin; Male; Middle Aged; Ossification, Heterotopic; Osteoarthritis, Hip; Pyrazoles; Radiotherapy; Risk Factors; Sulfonamides; Treatment Outcome | 2012 |
Modulation of CXCR3 ligand secretion by prostaglandin E2 and cyclooxygenase inhibitors in human breast cancer.
Topics: Aspirin; Breast Neoplasms; Celecoxib; Cell Line, Tumor; Cell Survival; Chemokine CXCL10; Chemokine CXCL9; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; Indomethacin; Interferon-gamma; Pyrazoles; Sulfonamides; Tumor Microenvironment; Tumor Necrosis Factor-alpha | 2012 |
Downregulation of Prominin 1/CD133 expression in colorectal cancer by NSAIDs following short-term preoperative treatment.
Topics: AC133 Antigen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Biomarkers, Tumor; Carcinoma; Celecoxib; Colorectal Neoplasms; Combined Modality Therapy; Dinoprostone; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Indomethacin; Male; Middle Aged; Peptides; Pyrazoles; Randomized Controlled Trials as Topic; Real-Time Polymerase Chain Reaction; Statistics, Nonparametric; Sulfonamides; Transcription, Genetic | 2012 |
Evaluation of drug load and polymer by using a 96-well plate vacuum dry system for amorphous solid dispersion drug delivery.
Topics: Acetaminophen; Celecoxib; Chemistry, Pharmaceutical; Crystallization; Drug Carriers; Drug Stability; Equipment Design; Griseofulvin; High-Throughput Screening Assays; Hypromellose Derivatives; Indomethacin; Kinetics; Methylcellulose; Miniaturization; Pharmaceutical Preparations; Polymers; Povidone; Pyrazoles; Quality Control; Reproducibility of Results; Solubility; Solvents; Sulfonamides; Technology, Pharmaceutical; Vacuum; Water | 2012 |
Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation.
Topics: Animals; Blotting, Western; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Dose-Response Relationship, Drug; Ellagic Acid; Enzyme-Linked Immunosorbent Assay; Gastric Mucosa; Indomethacin; Intercellular Signaling Peptides and Proteins; Male; Mice; Molecular Structure; Nitrobenzenes; Peroxidase; Pyrazoles; Stomach Ulcer; Sulfonamides; Time Factors; Up-Regulation; Wound Healing | 2012 |
Selective COX-2 inhibitor ameliorates osteoarthritis by repressing apoptosis of chondrocyte.
Topics: Animals; Apoptosis; Cartilage, Articular; Celecoxib; Chondrocytes; Collagen Type II; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Humans; Ibuprofen; Indomethacin; Osteoarthritis; Pyrazoles; Rats; Rats, Wistar; Sulfonamides | 2012 |
Involvement of hypothalamic cyclooxygenase-2, interleukin-1β and melanocortin in the development of docetaxel-induced anorexia in rats.
Topics: Animals; Anorexia; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Docetaxel; Hypothalamus; Indomethacin; Interleukin-1beta; Male; Neoplasms; Nitrobenzenes; Pro-Opiomelanocortin; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Taxoids | 2012 |
Effect of celecoxib on cyclooxygenase-1-mediated prostacyclin synthesis and endothelium-dependent contraction in mouse arteries.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Endothelium, Vascular; Epoprostenol; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred C57BL; Phenylephrine; Pyrazoles; Sulfonamides; Vasoconstriction | 2013 |
The anti-inflammatory effect of cyclooxygenase inhibitors in fibroblast-like synoviocytes from the human temporomandibular joint results from the suppression of PGE2 production.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Culture Techniques; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Female; Fibroblasts; Humans; Indomethacin; Interleukin-1beta; Interleukin-6; Male; Pyrazoles; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Sulfonamides; Synovial Membrane; Synovitis; Temporomandibular Joint Disorders; Young Adult | 2013 |
How safe is Celecoxib for Asian-Indian patients with rheumatic diseases?
Topics: Adult; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Drug Substitution; Female; Humans; Hypertension; India; Indomethacin; Male; Naproxen; Pyrazoles; Retrospective Studies; Rheumatic Diseases; Sulfonamides; Tertiary Care Centers | 2013 |
Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.
Topics: Acetylation; Amino Acid Sequence; Amino Acid Substitution; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Flurbiprofen; Guanidine; Heme; Humans; Indomethacin; Kinetics; Models, Biological; Mutant Proteins; Mutation; Naproxen; Oxygen; Palmitic Acid; Peroxidase; Protein Multimerization; Pyrazoles; Substrate Specificity; Sulfonamides | 2013 |
Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice.
Topics: Aging; Animals; Celecoxib; Crosses, Genetic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Indomethacin; Membrane Proteins; Menopause; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Ovarian Follicle; Primary Ovarian Insufficiency; Pyrazoles; Random Allocation; Sexual Development; Sulfonamides | 2013 |
Acoustic-like dynamics of amorphous drugs in the THz regime.
Topics: Celecoxib; Indomethacin; Molecular Conformation; Pyrazoles; Radiation Dosage; Sound; Sulfonamides; Terahertz Radiation | 2013 |
Indomethacin-enhanced anticancer effect of arsenic trioxide in A549 cell line: involvement of apoptosis and phospho-ERK and p38 MAPK pathways.
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-2-Associated X Protein; Caspase 3; Celecoxib; Cell Proliferation; Cyclooxygenase 2; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Lung Neoplasms; MAP Kinase Signaling System; Oxides; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrazoles; RNA, Messenger; Sulfonamides; Time Factors | 2013 |
The role of cyclooxygenase in multiplication and reactivation of HSV-1 in vestibular ganglion neurons.
Topics: Animals; Celecoxib; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Herpesvirus 1, Human; Indomethacin; Neurons; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Vestibular Nerve | 2014 |
[Effects of selective and non-selective cyclooxygenase 2 inhibitors on heterotopic ossification in rat model with Achilles tenotomy].
Topics: Achilles Tendon; Animals; Bone Morphogenetic Protein 2; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Immunohistochemistry; Indomethacin; Male; Ossification, Heterotopic; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfonamides; Tenotomy | 2014 |
Preoperative low dose NSAID treatment influences the genes for stemness, growth, invasion and metastasis in colorectal cancer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biomarkers, Tumor; Celecoxib; Colorectal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Male; MicroRNAs; Neoplasm Metastasis; Octamer Transcription Factor-3; Prognosis; Pyrazoles; SOXB1 Transcription Factors; Sulfonamides | 2014 |
Central mediators involved in the febrile response induced by polyinosinic-polycytidylic acid: lack of involvement of endothelins and substance P.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Body Temperature; Celecoxib; Central Nervous System; Cytokines; Dinoprostone; Endothelin B Receptor Antagonists; Fever; Indomethacin; Interferon Inducers; Male; Oligopeptides; Peptides; Piperidines; Poly I-C; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Tropanes | 2015 |
Evaluation of the diuretic activity in two Mexican medicinal species: Selaginella nothohybrida and Selaginella lepidophylla and its effects with ciclooxigenases inhibitors.
Topics: Animals; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Diuretics; Indomethacin; Male; Mexico; Mice; Naproxen; Plant Extracts; Plants, Medicinal; Potassium; Selaginellaceae; Sodium | 2015 |
Celecoxib, but not indomethacin, ameliorates the hypertensive and perivascular fibrotic actions of cyclosporine in rats: role of endothelin signaling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Celecoxib; Cyclosporine; Cytoprotection; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Fibrosis; Heart Rate; Hypertension; Indomethacin; Male; Pyrazoles; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Renal Artery; Signal Transduction; Sulfonamides; Vascular Remodeling | 2015 |
Determining cyclooxygenase-2 activity in three different test systems utilizing online-solid phase extraction-liquid chromatography-mass spectrometry for parallel quantification of prostaglandin E(2), D(2) and thromboxane B(2).
Topics: Celecoxib; Cell Line; Chromatography, Liquid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dexamethasone; Dinoprostone; Humans; Indomethacin; Lipopolysaccharides; Monocytes; Prostaglandin D2; Pyrazoles; Recombinant Proteins; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Sulfonamides; Tandem Mass Spectrometry; Thromboxane B2 | 2015 |
Cyclic mechanical stretching induces autophagic cell death in tenofibroblasts through activation of prostaglandin E2 production.
Topics: Adolescent; Adult; Autophagy; Celecoxib; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Dinoprostone; Fibroblasts; Humans; Indomethacin; Male; Patellar Ligament; Signal Transduction; Stress, Mechanical | 2015 |
Effect of selective versus non-selective cyclooxygenase inhibitors on ischemia-reperfusion-induced hepatic injury in rats.
Topics: Alanine Transaminase; Animals; Caspase 3; Celecoxib; Cyclooxygenase 2 Inhibitors; Gene Expression Regulation; Indomethacin; Liver; Liver Diseases; Male; Malondialdehyde; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Oxidoreductases; Pyrazoles; Rats; Reperfusion Injury; Sulfonamides; Tumor Necrosis Factor-alpha | 2015 |
Comparative Study of Different Methods for the Prediction of Drug-Polymer Solubility.
Topics: Acetaminophen; Calorimetry, Differential Scanning; Celecoxib; Chemistry, Pharmaceutical; Chloramphenicol; Crystallization; Drug Stability; Felodipine; Indomethacin; Polymers; Povidone; Pyrrolidinones; Solubility; Thermodynamics; Vinyl Compounds | 2015 |
Indomethacin induced gene regulation in the rat hippocampus.
Topics: Animals; Astrocytes; Celecoxib; Cyclooxygenase 2; Gene Expression Regulation; GTP-Binding Proteins; Hippocampus; Immunohistochemistry; In Situ Hybridization; Indomethacin; Nitric Oxide Synthase Type III; Protein Glutamine gamma Glutamyltransferase 2; Protein Transport; Rats; Transglutaminases | 2015 |
Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity.
Topics: Animals; Anti-Inflammatory Agents; Apigenin; Celecoxib; Cell Line, Tumor; Cells, Cultured; Cyclooxygenase 2; Enzyme Activation; Genistein; Humans; Indomethacin; Lipopolysaccharides; Male; Mice, Inbred C57BL; Monocytes; Polyphenols; Real-Time Polymerase Chain Reaction; Resveratrol; Stilbenes | 2015 |
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Gabapentin; gamma-Aminobutyric Acid; Ibuprofen; Indomethacin; Inflammation; Male; Morphine; Motor Activity; Nerve Growth Factor; Pain; Rats, Wistar; Tramadol | 2016 |
Correlation between Molecular Mobility and Physical Stability in Pharmaceutical Glasses.
Topics: Calorimetry, Differential Scanning; Celecoxib; Crystallization; Dielectric Spectroscopy; Glass; Indomethacin | 2016 |
Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality.
Topics: Animals; Arachidonate 5-Lipoxygenase; Blotting, Western; Carrier Proteins; Celecoxib; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dinoprostone; In Vitro Techniques; Indoles; Indomethacin; Inflammasomes; Interleukin-1beta; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Macrophages, Peritoneal; Mice; Mice, Knockout; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphoproteins; Prostaglandin Antagonists; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Reverse Transcriptase Polymerase Chain Reaction; Scorpion Stings; Scorpion Venoms; Scorpions; Xanthones | 2016 |
The Protective Role of Carbon Monoxide (CO) Produced by Heme Oxygenases and Derived from the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO).
Topics: Animals; Carbon Monoxide; Celecoxib; Cyclooxygenase 2; Gastric Mucosa; Heme Oxygenase (Decyclizing); Hemin; Hypoxia-Inducible Factor 1, alpha Subunit; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitroarginine; Organometallic Compounds; Protoporphyrins; Pyrazoles; Rats; Rats, Wistar; RNA, Messenger; Stress, Physiological | 2016 |
(1)H-Nuclear magnetic resonance-based metabolic profiling of nonsteroidal anti-inflammatory drug-induced adverse effects in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Gastric Mucosa; Ibuprofen; Indomethacin; Least-Squares Analysis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Metabolomics; Piroxicam; Rats; Rats, Sprague-Dawley | 2016 |
Inhibition of Aβ(1-42)Oligomerization, Fibrillization and Acetylcholinesterase Activity by Some Anti-Inflammatory Drugs: An in vitro Study.
Topics: Acetylcholinesterase; Amyloid; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Butylated Hydroxyanisole; Celecoxib; Dexamethasone; Diclofenac; Indomethacin; Methylene Blue; Nitric Oxide; Peptide Fragments; Piroxicam; Rivastigmine; Singlet Oxygen | 2017 |
Central mediators of the zymosan-induced febrile response.
Topics: Animals; Body Temperature; Celecoxib; Dinoprostone; Fever; Indomethacin; Infusions, Intraventricular; Injections, Intra-Articular; Injections, Intraperitoneal; Male; Oligopeptides; Peptide Fragments; Piperidines; Rats; Somatostatin; Tropanes; Zymosan | 2017 |
Evidence for antinociceptive effects of combined administration of vitamin E and celecoxib in tail-flick and formalin test in male rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Formaldehyde; Indomethacin; Male; Pain; Pain Measurement; Rats; Rats, Wistar; Vitamin E | 2019 |
Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo[4,5-d]pyrimidine scaffold.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Edema; Formaldehyde; Indomethacin; Male; Molecular Docking Simulation; Molecular Structure; Rats; Rats, Wistar; Sheep; Structure-Activity Relationship; Thiazoles; Ulcer | 2019 |
Periapical bone response to bacterial lipopolysaccharide is shifted upon cyclooxygenase blockage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dental Pulp Cavity; Escherichia coli; Gene Expression; Indomethacin; Lipopolysaccharides; Male; Mice, Inbred C57BL; Osteogenesis; Periapical Tissue; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Up-Regulation | 2019 |
Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Catalytic Domain; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Gastric Mucosa; Humans; Indomethacin; Inflammation; Molecular Docking Simulation; Protein Binding; Rats; Tolmetin | 2019 |
Olive-Derived Hydroxytyrosol Shows Anti-inflammatory Effect without Gastric Damage in Rats.
Topics: Animals; Aspirin; Carrageenan; Celecoxib; Cyclooxygenase 2 Inhibitors; Dinoprostone; Edema; Gastric Mucosa; Indomethacin; Male; Olea; Phenylethyl Alcohol; Rats, Sprague-Dawley; Stomach; Stomach Ulcer | 2019 |
Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Depression; Disease Models, Animal; Exercise Test; Ibuprofen; Indomethacin; Interferon-alpha; Male; Mice | 2019 |
Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-
Topics: Animals; Celecoxib; Cyclooxygenase 2; Gene Expression Regulation; Hesperidin; Humans; Hydrophobic and Hydrophilic Interactions; Indomethacin; Inflammation; Interleukin-1beta; Interleukin-6; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Signal Transduction; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2019 |
Altered cyclooxygenase-1 and enhanced thromboxane receptor activities underlie attenuated endothelial dilatory capacity of omental arteries in obesity.
Topics: Adipose Tissue; Adult; Apamin; Arteries; Celecoxib; Charybdotoxin; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Endothelial Cells; Endothelium, Vascular; Female; Gastroepiploic Artery; Humans; Indomethacin; Male; Middle Aged; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Obesity, Morbid; Omentum; Receptors, Thromboxane; Vasodilation | 2019 |
Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Carrageenan; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Indomethacin; Lipoxygenase Inhibitors; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Pyrazolones; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Ulcer | 2020 |
Synthesis of novel N-substitutedphenyl-6-oxo-3-phenylpyridazine derivatives as cyclooxygenase-2 inhibitors.
Topics: Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Female; Indomethacin; Male; Molecular Docking Simulation; Molecular Structure; Pyridazines; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship | 2020 |
Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Dinoprostone; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Humans; Indomethacin; Lipopolysaccharides; Male; Mice; Molecular Docking Simulation; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Oximes; Rats; RAW 264.7 Cells | 2020 |
Anti-inflammatory activity of novel thiosemicarbazone compounds indole-based as COX inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Indoles; Indomethacin; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Thiosemicarbazones | 2021 |
Physiologically relevant aspirin concentrations trigger immunostimulatory cytokine production by human leukocytes.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Cytokines; Dinoprostone; Gene Expression Regulation; Humans; Indomethacin; Inflammation; Interleukin-10; Interleukin-1beta; Interleukin-6; Leukocytes; Male; Middle Aged; Toll-Like Receptors; Young Adult | 2021 |
Indomethacin, a Non-steroidal Anti-inflammatory Drug, Induces Skin Dryness via PPARγ in Mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Indomethacin; Mice; PPAR gamma | 2022 |
Etoricoxib and celecoxib sensitive indomethacin-responsive headache disorders.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Etoricoxib; Headache; Headache Disorders; Humans; Indomethacin | 2022 |
Nonacidic thiophene-based derivatives as potential analgesic and design, synthesis, biological evaluation, and metabolic stability study.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chromatography, Liquid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Humans; Indomethacin; Rats; Tandem Mass Spectrometry; Thiophenes | 2022 |
Enamel biomineralization under the effects of indomethacin and celecoxib non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomineralization; Celecoxib; Core Binding Factor Alpha 1 Subunit; Cyclooxygenase 2; Indomethacin; Male; Mice; Minerals; X-Ray Microtomography | 2022 |
Mechanisms of Drug Solubility Enhancement Induced by β-Lactoglobulin-Based Amorphous Solid Dispersions.
Topics: Carvedilol; Celecoxib; Drug Compounding; Drug Liberation; Indomethacin; Lactoglobulins; Solubility | 2023 |