celastrol has been researched along with withaferin a in 7 studies
| Studies (celastrol) | Trials (celastrol) | Recent Studies (post-2010) (celastrol) | Studies (withaferin a) | Trials (withaferin a) | Recent Studies (post-2010) (withaferin a) |
|---|---|---|---|---|---|
| 885 | 1 | 741 | 590 | 22 | 454 |
| Protein | Taxonomy | celastrol (IC50) | withaferin a (IC50) |
|---|---|---|---|
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 0.585 | |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | 0.047 | |
| Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (human) | 0.047 | |
| Transcription factor p65 | Homo sapiens (human) | 0.047 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 3 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Cowley, MA; De Angelis, M; Dodd, GT; Geerlof, A; Kyriakou, E; Lenhart, D; Messias, AC; Pfluger, PT; Pfuhlmann, K; Plettenburg, O; Sattler, M; Schmidt, S; Schramm, KW; Schriever, SC; Simonds, SE; Tiganis, T; Tschöp, MH | 1 |
| Li, L; Wang, L; Xu, XL; You, QD | 1 |
| Chang, YH; Hung, HY | 1 |
| Heikkila, JJ; Khamis, I; Khan, S; Music, E | 1 |
| Chen, X; Cheng, X; Deshmukh, RR; Dou, QP; Ji, W; Long, J; Lu, L; Shi, W; Zeng, G; Zhang, Y | 1 |
| Choi, JW; Feng, X; Ibi, D; Lee, J; Liu, J; Mucka, P; Ozcan, U; Salazar Hernández, MA | 1 |
| Akter, R; Bibi, P; Hassan, SSU; Mubin, S; Najda, A; Rahman, MH; Saeeda, S; Shah, M; Wesołowska, S | 1 |
3 review(s) available for celastrol and withaferin a
| Article | Year |
|---|---|
Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.
Topics: Animals; Antineoplastic Agents; Autoimmune Diseases; Benzoquinones; Forecasting; HSP90 Heat-Shock Proteins; Humans; Immunosuppressive Agents; Lactams, Macrocyclic; Molecular Chaperones; Neoplasms; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary | 2020 |
Recent advances in natural anti-obesity compounds and derivatives based on in vivo evidence: A mini-review.
Topics: Animals; Anti-Obesity Agents; Drug Discovery; Obesity; Phytochemicals | 2022 |
Potential Role of Natural Products to Combat Radiotherapy and Their Future Perspectives.
Topics: Berberine; Biological Products; Curcumin; Emodin; Genistein; Humans; Neoplasms; Pentacyclic Triterpenes; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy; Resveratrol; Sesquiterpenes; Triterpenes; Ursolic Acid; Vitamin D; Withanolides | 2021 |
4 other study(ies) available for celastrol and withaferin a
| Article | Year |
|---|---|
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.
Topics: Allosteric Site; Animals; Anti-Obesity Agents; Catalytic Domain; Diet, High-Fat; Hypothalamus; Magnetic Resonance Spectroscopy; Male; Mice, Transgenic; Obesity; Pentacyclic Triterpenes; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 2; Structure-Activity Relationship; Triterpenes; Weight Loss | 2018 |
Accumulation of heme oxygenase-1 (HSP32) in Xenopus laevis A6 kidney epithelial cells treated with sodium arsenite, cadmium chloride or proteasomal inhibitors.
Topics: Animals; Arsenites; Cadmium Chloride; Cell Line; Cytoplasmic Structures; Enzyme Induction; Heme Oxygenase-1; Hot Temperature; HSP30 Heat-Shock Proteins; Immunohistochemistry; Kidney; Leupeptins; Pentacyclic Triterpenes; Proteasome Inhibitors; Protein Transport; Sodium Compounds; Toxicity Tests, Acute; Triterpenes; Water Pollutants, Chemical; Withanolides; Xenopus laevis; Xenopus Proteins | 2014 |
Tumor necrosis factor-α sensitizes breast cancer cells to natural products with proteasome-inhibitory activity leading to apoptosis.
Topics: Apoptosis; Biological Products; Blotting, Western; Breast Neoplasms; Caspase 3; Caspase 9; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Microscopy, Fluorescence; Pentacyclic Triterpenes; Proteasome Endopeptidase Complex; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor RelA; Triterpenes; Tumor Necrosis Factor-alpha; Withanolides; X-Linked Inhibitor of Apoptosis Protein | 2014 |
Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice.
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Diabetes Mellitus, Type 2; Diet, High-Fat; Fatty Liver; Fluorescent Antibody Technique; Glucose Tolerance Test; Hypothalamus; Immunohistochemistry; Leptin; Liver; Mice; Mice, Obese; Obesity; Pentacyclic Triterpenes; Real-Time Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor; Triterpenes; Withanolides | 2016 |