Compounds > celastrol
Page last updated: 2024-09-03

celastrol and verapamil

celastrol has been researched along with verapamil in 4 studies

Compound Research Comparison

Studies
(celastrol)		Trials
(celastrol)		Recent Studies (post-2010)
(celastrol)		Studies
(verapamil)		Trials
(verapamil)		Recent Studies (post-2010) (verapamil)
885174117,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomycelastrol (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Chen, X; Coghi, P; Efferth, T; Ip, CK; Kadioglu, O; Law, BYK; Liu, L; Ng, JPL; Qiu, AC; Saeed, MEM; Wong, VKW1
Dong, C; Gao, Y; Liu, H; Peng, J; Xu, C; Xu, S1
Gao, X; Liu, S; Wang, Y; Zhang, Y1
Srinivas, NR1

Other Studies

4 other study(ies) available for celastrol and verapamil

ArticleYear
Synthesis, computational docking and biological evaluation of celastrol derivatives as dual inhibitors of SERCA and P-glycoprotein in cancer therapy.
    European journal of medicinal chemistry, 2021, Nov-15, Volume: 224

    Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Pentacyclic Triterpenes; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Structure-Activity Relationship

2021
Absorption and metabolism characteristics of pristimerin as determined by a sensitive and reliable LC-MS/MS method.
    Fitoterapia, 2015, Volume: 106

    Topics: Animals; Biological Availability; Caco-2 Cells; Chromatography, Liquid; Half-Life; Humans; Male; Microsomes, Liver; Pentacyclic Triterpenes; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Triterpenes; Verapamil

2015
Influence of verapamil on pharmacokinetics of pristimerin in rats.
    Biomedical chromatography : BMC, 2016, Volume: 30, Issue:6

    Topics: Animals; Area Under Curve; Caco-2 Cells; Calcium Channel Blockers; Chromatography, Liquid; Drug Interactions; Humans; Limit of Detection; Male; Mass Spectrometry; Pentacyclic Triterpenes; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Triterpenes; Verapamil

2016
Verapamil and pristimerin pharmacokinetic drug-drug interaction study in rats - perspectives.
    Biomedical chromatography : BMC, 2016, Volume: 30, Issue:12

    Topics: Animals; Chromatography, Liquid; Drug Interactions; Pentacyclic Triterpenes; Rats; Tandem Mass Spectrometry; Triterpenes; Verapamil

2016