Page last updated: 2024-09-03

celastrol and triptolide

celastrol has been researched along with triptolide in 21 studies

Compound Research Comparison

Studies
(celastrol)
Trials
(celastrol)
Recent Studies (post-2010)
(celastrol)
Studies
(triptolide)
Trials
(triptolide)
Recent Studies (post-2010) (triptolide)
88517411,1586820

Protein Interaction Comparison

ProteinTaxonomycelastrol (IC50)triptolide (IC50)
Prostaglandin G/H synthase 2Homo sapiens (human)0.04
Proteinase-activated receptor 2Homo sapiens (human)0.0185

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (19.05)29.6817
2010's11 (52.38)24.3611
2020's6 (28.57)2.80

Authors

AuthorsStudies
Cen, S; He, Y; Hu, L; Li, Q; Li, X; Liu, Y; Wu, M; Zhou, J1
Huang, YL; Sun, CF; Xu, QN; Ye, M; Zhou, D; Zhou, YX1
Corson, TW; Crews, CM1
Chen, XH; Jin, MC; OuYang, XK1
But, PP; Ge, W; He, MF; Jiang, R; Liu, L; Shaw, PC; Wu, LW1
Dou, QP; Liu, J; Yang, H1
Liu, Z; Ma, L; Zhou, GB1
Fang, W; Lam, CW; Peng, F; Wan, C; Xu, H; Yang, X; Yi, T; Zhang, C1
Chen, S; Cui, H; Huang, H; Luo, H; Wu, X; Yang, A; Yang, J; Yang, W; Zhang, L1
Chen, MW; Chen, Y; Cheng, KJ; Jiang, QW; Lv, M; Mei, XL; Qin, WM; Qiu, JG; Shi, Z; Wei, MN; Wei, X; Xue, YQ; Yang, Y; Zhang, WJ; Zhang, X; Zheng, DW1
Bai, Y; Duan, JA; Guo, S; Ji, T; Qian, D; Shen, F; Su, S; Wang, T; Wang, Y; Yan, H1
Ding, B; Prabhu, S; Thakkar, A; Wahid, MA; Wang, J; Wang, Z; Xie, C1
Gao, W; Hu, T; Huang, L; Lu, Y; Ma, B; Su, P; Wang, J; Zhang, R; Zhang, Y; Zhao, Y; Zhou, J1
Hao, J; Li, J1
Gao, W; Hu, TY; Huang, LQ; Tong, YR; Wang, JD; Zhang, YF; Zhao, YJ1
Dai, E; Song, X; Zhang, Y1
Cheng, Y; Dai, M; Li, F; Ma, X; Peng, W; Wang, C; Zhang, T; Zhao, Q1
Cai, BL; Huang, F; Lin, N; Mao, X; Su, XH; Wang, JR; Wang, KX; Wu, AG; Zhang, YG1
Chen, X; Li, M; Liu, C; Luo, Q; Qiu, F; Sun, X; Tao, Y1
Dai, L; He, GN; Song, J1
Cheng, Y; Dai, M; Gonzalez, FJ; Huang, J; Li, F; Lin, L; Lin, Q; Liu, A; Peng, W; Rao, Q; Wu, ZE; Zhang, B; Zhang, T; Zhao, J; Zhao, Q1

Reviews

5 review(s) available for celastrol and triptolide

ArticleYear
Targeting tumor proteasome with traditional Chinese medicine.
    Current drug discovery technologies, 2010, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Benzyl Compounds; Curcumin; Diterpenes; Drug Delivery Systems; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Epoxy Compounds; Humans; Medicine, Chinese Traditional; Molecular Structure; Naphthoquinones; Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Phenols; Proteasome Endopeptidase Complex; Signal Transduction; Triterpenes

2010
The main anticancer bullets of the Chinese medicinal herb, thunder god vine.
    Molecules (Basel, Switzerland), 2011, Jun-23, Volume: 16, Issue:6

    Topics: Animals; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Humans; Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Signal Transduction; Tripterygium; Triterpenes

2011
Treatment of Neurodegenerative Diseases with Bioactive Components of
    The American journal of Chinese medicine, 2019, Volume: 47, Issue:4

    Topics: Alzheimer Disease; Animals; Diterpenes; Epoxy Compounds; Humans; Medicine, Chinese Traditional; Molecular Conformation; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Pentacyclic Triterpenes; Phenanthrenes; Phytotherapy; Tripterygium; Triterpenes

2019
Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review).
    Molecular medicine reports, 2020, Volume: 21, Issue:6

    Topics: Arthritis, Rheumatoid; Chemokines; Cyclooxygenase 2; Diterpenes; Epoxy Compounds; Humans; NF-kappa B; Pentacyclic Triterpenes; Phenanthrenes; Signal Transduction; Toll-Like Receptor 4; Tripterygium; Triterpenes

2020
A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 162

    Topics: Diterpenes; Epoxy Compounds; Humans; Neoplasms; Phenanthrenes; Triterpenes

2023

Other Studies

16 other study(ies) available for celastrol and triptolide

ArticleYear
Identification of Triptophenolide from
    ACS medicinal chemistry letters, 2016, Dec-08, Volume: 7, Issue:12

    Topics:

2016
[Several monomes from Tripterygium wilfordii inhibit proliferation of glioma cells in vitro].
    Ai zheng = Aizheng = Chinese journal of cancer, 2002, Volume: 21, Issue:10

    Topics: Antineoplastic Agents; Cell Division; Diterpenes; Epoxy Compounds; Glioma; Humans; Inhibitory Concentration 50; Molecular Structure; Pentacyclic Triterpenes; Phenanthrenes; Plant Extracts; Tripterygium; Triterpenes; Tumor Cells, Cultured

2002
Molecular understanding and modern application of traditional medicines: triumphs and trials.
    Cell, 2007, Sep-07, Volume: 130, Issue:5

    Topics: Animals; Artemisinins; Capsaicin; Curcumin; Diterpenes; Drug Approval; Drug Evaluation, Preclinical; Epoxy Compounds; Humans; Medicine, Traditional; Pentacyclic Triterpenes; Phenanthrenes; Plant Preparations; Technology, Pharmaceutical; Triterpenes

2007
Simultaneous determination of triptolide, tripdiolide and tripterine in human urine by high-performance liquid chromatography coupled with ion trap atmospheric-pressure chemical ionization mass spectrometry.
    Biomedical chromatography : BMC, 2009, Volume: 23, Issue:3

    Topics: Chromatography, High Pressure Liquid; Diterpenes; Epoxy Compounds; Humans; Hydrocortisone; Linear Models; Models, Chemical; Pentacyclic Triterpenes; Phenanthrenes; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Triterpenes

2009
Antiangiogenic activity of Tripterygium wilfordii and its terpenoids.
    Journal of ethnopharmacology, 2009, Jan-12, Volume: 121, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Diterpenes; Drugs, Chinese Herbal; Embryo, Nonmammalian; Epoxy Compounds; Neovascularization, Physiologic; Pentacyclic Triterpenes; Phenanthrenes; Plant Roots; Reverse Transcriptase Polymerase Chain Reaction; Terpenes; Tripterygium; Triterpenes; Zebrafish

2009
Biological activity and safety of Tripterygium extract prepared by sodium carbonate extraction.
    Molecules (Basel, Switzerland), 2012, Sep-17, Volume: 17, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Carbonates; Cell Line; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Female; Humans; Inflammation; Lactones; Male; Mice; Pentacyclic Triterpenes; Phenanthrenes; Phytotherapy; Pyridines; Rats; Tripterygium; Triterpenes

2012
Simultaneous determination of triptolide, tripterifordin, celastrol and nine sesquiterpene alkaloids in Tripterygium preparations using high-performance liquid chromatography-triple quadrupole mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2016, Jan-05, Volume: 117

    Topics: Alkaloids; Chromatography, High Pressure Liquid; Diterpenes; Epoxy Compounds; Pentacyclic Triterpenes; Phenanthrenes; Sesquiterpenes; Tandem Mass Spectrometry; Tripterygium; Triterpenes

2016
Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine.
    Oncotarget, 2015, Oct-20, Volume: 6, Issue:32

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Epoxy Compounds; G2 Phase Cell Cycle Checkpoints; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Mice, Inbred BALB C; Mice, Nude; Molecular Chaperones; Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Phytotherapy; Plant Extracts; Plants, Medicinal; Reactive Oxygen Species; Time Factors; Transfection; Tripterygium; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays

2015
Comparative analysis of four terpenoids in root and cortex of Tripterygium wilfordii Radix by different drying methods.
    BMC complementary and alternative medicine, 2016, Nov-23, Volume: 16, Issue:1

    Topics: China; Desiccation; Diterpenes; Epoxy Compounds; Molecular Structure; Pentacyclic Triterpenes; Phenanthrenes; Plant Roots; Terpenes; Tripterygium; Triterpenes

2016
Triptolide and celastrol loaded silk fibroin nanoparticles show synergistic effect against human pancreatic cancer cells.
    Nanoscale, 2017, Aug-17, Volume: 9, Issue:32

    Topics: Cell Line, Tumor; Diterpenes; Drug Synergism; Epoxy Compounds; Fibroins; Humans; Nanoparticles; Pancreatic Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Triterpenes

2017
Overexpression and RNAi-mediated downregulation of TwIDI regulates triptolide and celastrol accumulation in Tripterygium wilfordii.
    Gene, 2018, Dec-30, Volume: 679

    Topics: Biosynthetic Pathways; Carbon-Carbon Double Bond Isomerases; Diterpenes; Down-Regulation; Epoxy Compounds; Gene Expression Regulation, Plant; Hemiterpenes; Pentacyclic Triterpenes; Phenanthrenes; Phylogeny; Plant Proteins; RNA Interference; Tripterygium; Triterpenes; Up-Regulation

2018
Differential expression of the TwHMGS gene and its effect on triptolide biosynthesis in Tripterygium wilfordii.
    Chinese journal of natural medicines, 2019, Volume: 17, Issue:8

    Topics: Acetyl Coenzyme A; Amino Acid Sequence; Biosynthetic Pathways; Catalytic Domain; Diterpenes; Epoxy Compounds; Gene Expression Regulation, Plant; Hydroxymethylglutaryl-CoA Synthase; Models, Molecular; Pentacyclic Triterpenes; Phenanthrenes; Plant Proteins; RNA Interference; Terpenes; Tripterygium; Triterpenes

2019
Metabolomics reveals the role of PPARα in Tripterygium Wilfordii-induced liver injury.
    Journal of ethnopharmacology, 2022, May-10, Volume: 289

    Topics: Animals; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentacyclic Triterpenes; Phenanthrenes; Plant Extracts; PPAR alpha; Tablets; Tripterygium

2022
[In vitro "benefit-risk" evaluation and network regulation mechanism of Colquhounia Root Tablets and its key material basis].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:23

    Topics: Animals; Arthritis, Rheumatoid; Cytokines; Diabetic Nephropathies; Drugs, Chinese Herbal; Glomerulonephritis, Membranous; Humans; Mice; Molecular Docking Simulation; Tablets

2022
Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns.
    BMC complementary medicine and therapies, 2023, Jan-10, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Mice; RNA, Messenger; Tripterygium; Tumor Necrosis Factor-alpha; Zebrafish

2023
Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 121

    Topics: Animals; Gastrointestinal Hemorrhage; Mice; Mice, Knockout; Molecular Docking Simulation; Tripterygium; Triterpenes

2023