celastrol has been researched along with triptolide in 21 studies
| Studies (celastrol) | Trials (celastrol) | Recent Studies (post-2010) (celastrol) | Studies (triptolide) | Trials (triptolide) | Recent Studies (post-2010) (triptolide) |
|---|---|---|---|---|---|
| 885 | 1 | 741 | 1,158 | 6 | 820 |
| Protein | Taxonomy | celastrol (IC50) | triptolide (IC50) |
|---|---|---|---|
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 0.04 | |
| Proteinase-activated receptor 2 | Homo sapiens (human) | 0.0185 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 11 (52.38) | 24.3611 |
| 2020's | 6 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Cen, S; He, Y; Hu, L; Li, Q; Li, X; Liu, Y; Wu, M; Zhou, J | 1 |
| Huang, YL; Sun, CF; Xu, QN; Ye, M; Zhou, D; Zhou, YX | 1 |
| Corson, TW; Crews, CM | 1 |
| Chen, XH; Jin, MC; OuYang, XK | 1 |
| But, PP; Ge, W; He, MF; Jiang, R; Liu, L; Shaw, PC; Wu, LW | 1 |
| Dou, QP; Liu, J; Yang, H | 1 |
| Liu, Z; Ma, L; Zhou, GB | 1 |
| Fang, W; Lam, CW; Peng, F; Wan, C; Xu, H; Yang, X; Yi, T; Zhang, C | 1 |
| Chen, S; Cui, H; Huang, H; Luo, H; Wu, X; Yang, A; Yang, J; Yang, W; Zhang, L | 1 |
| Chen, MW; Chen, Y; Cheng, KJ; Jiang, QW; Lv, M; Mei, XL; Qin, WM; Qiu, JG; Shi, Z; Wei, MN; Wei, X; Xue, YQ; Yang, Y; Zhang, WJ; Zhang, X; Zheng, DW | 1 |
| Bai, Y; Duan, JA; Guo, S; Ji, T; Qian, D; Shen, F; Su, S; Wang, T; Wang, Y; Yan, H | 1 |
| Ding, B; Prabhu, S; Thakkar, A; Wahid, MA; Wang, J; Wang, Z; Xie, C | 1 |
| Gao, W; Hu, T; Huang, L; Lu, Y; Ma, B; Su, P; Wang, J; Zhang, R; Zhang, Y; Zhao, Y; Zhou, J | 1 |
| Hao, J; Li, J | 1 |
| Gao, W; Hu, TY; Huang, LQ; Tong, YR; Wang, JD; Zhang, YF; Zhao, YJ | 1 |
| Dai, E; Song, X; Zhang, Y | 1 |
| Cheng, Y; Dai, M; Li, F; Ma, X; Peng, W; Wang, C; Zhang, T; Zhao, Q | 1 |
| Cai, BL; Huang, F; Lin, N; Mao, X; Su, XH; Wang, JR; Wang, KX; Wu, AG; Zhang, YG | 1 |
| Chen, X; Li, M; Liu, C; Luo, Q; Qiu, F; Sun, X; Tao, Y | 1 |
| Dai, L; He, GN; Song, J | 1 |
| Cheng, Y; Dai, M; Gonzalez, FJ; Huang, J; Li, F; Lin, L; Lin, Q; Liu, A; Peng, W; Rao, Q; Wu, ZE; Zhang, B; Zhang, T; Zhao, J; Zhao, Q | 1 |
5 review(s) available for celastrol and triptolide
| Article | Year |
|---|---|
Targeting tumor proteasome with traditional Chinese medicine.
Topics: Animals; Antineoplastic Agents, Phytogenic; Benzyl Compounds; Curcumin; Diterpenes; Drug Delivery Systems; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Epoxy Compounds; Humans; Medicine, Chinese Traditional; Molecular Structure; Naphthoquinones; Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Phenols; Proteasome Endopeptidase Complex; Signal Transduction; Triterpenes | 2010 |
The main anticancer bullets of the Chinese medicinal herb, thunder god vine.
Topics: Animals; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Humans; Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Signal Transduction; Tripterygium; Triterpenes | 2011 |
Treatment of Neurodegenerative Diseases with Bioactive Components of
Topics: Alzheimer Disease; Animals; Diterpenes; Epoxy Compounds; Humans; Medicine, Chinese Traditional; Molecular Conformation; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Pentacyclic Triterpenes; Phenanthrenes; Phytotherapy; Tripterygium; Triterpenes | 2019 |
Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review).
Topics: Arthritis, Rheumatoid; Chemokines; Cyclooxygenase 2; Diterpenes; Epoxy Compounds; Humans; NF-kappa B; Pentacyclic Triterpenes; Phenanthrenes; Signal Transduction; Toll-Like Receptor 4; Tripterygium; Triterpenes | 2020 |
A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes.
Topics: Diterpenes; Epoxy Compounds; Humans; Neoplasms; Phenanthrenes; Triterpenes | 2023 |
16 other study(ies) available for celastrol and triptolide
| Article | Year |
|---|---|
Identification of Triptophenolide from
Topics: | 2016 |
[Several monomes from Tripterygium wilfordii inhibit proliferation of glioma cells in vitro].
Topics: Antineoplastic Agents; Cell Division; Diterpenes; Epoxy Compounds; Glioma; Humans; Inhibitory Concentration 50; Molecular Structure; Pentacyclic Triterpenes; Phenanthrenes; Plant Extracts; Tripterygium; Triterpenes; Tumor Cells, Cultured | 2002 |
Molecular understanding and modern application of traditional medicines: triumphs and trials.
Topics: Animals; Artemisinins; Capsaicin; Curcumin; Diterpenes; Drug Approval; Drug Evaluation, Preclinical; Epoxy Compounds; Humans; Medicine, Traditional; Pentacyclic Triterpenes; Phenanthrenes; Plant Preparations; Technology, Pharmaceutical; Triterpenes | 2007 |
Simultaneous determination of triptolide, tripdiolide and tripterine in human urine by high-performance liquid chromatography coupled with ion trap atmospheric-pressure chemical ionization mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Diterpenes; Epoxy Compounds; Humans; Hydrocortisone; Linear Models; Models, Chemical; Pentacyclic Triterpenes; Phenanthrenes; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2009 |
Antiangiogenic activity of Tripterygium wilfordii and its terpenoids.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Diterpenes; Drugs, Chinese Herbal; Embryo, Nonmammalian; Epoxy Compounds; Neovascularization, Physiologic; Pentacyclic Triterpenes; Phenanthrenes; Plant Roots; Reverse Transcriptase Polymerase Chain Reaction; Terpenes; Tripterygium; Triterpenes; Zebrafish | 2009 |
Biological activity and safety of Tripterygium extract prepared by sodium carbonate extraction.
Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Carbonates; Cell Line; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Female; Humans; Inflammation; Lactones; Male; Mice; Pentacyclic Triterpenes; Phenanthrenes; Phytotherapy; Pyridines; Rats; Tripterygium; Triterpenes | 2012 |
Simultaneous determination of triptolide, tripterifordin, celastrol and nine sesquiterpene alkaloids in Tripterygium preparations using high-performance liquid chromatography-triple quadrupole mass spectrometry.
Topics: Alkaloids; Chromatography, High Pressure Liquid; Diterpenes; Epoxy Compounds; Pentacyclic Triterpenes; Phenanthrenes; Sesquiterpenes; Tandem Mass Spectrometry; Tripterygium; Triterpenes | 2016 |
Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Epoxy Compounds; G2 Phase Cell Cycle Checkpoints; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Mice, Inbred BALB C; Mice, Nude; Molecular Chaperones; Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Phytotherapy; Plant Extracts; Plants, Medicinal; Reactive Oxygen Species; Time Factors; Transfection; Tripterygium; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Comparative analysis of four terpenoids in root and cortex of Tripterygium wilfordii Radix by different drying methods.
Topics: China; Desiccation; Diterpenes; Epoxy Compounds; Molecular Structure; Pentacyclic Triterpenes; Phenanthrenes; Plant Roots; Terpenes; Tripterygium; Triterpenes | 2016 |
Triptolide and celastrol loaded silk fibroin nanoparticles show synergistic effect against human pancreatic cancer cells.
Topics: Cell Line, Tumor; Diterpenes; Drug Synergism; Epoxy Compounds; Fibroins; Humans; Nanoparticles; Pancreatic Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Triterpenes | 2017 |
Overexpression and RNAi-mediated downregulation of TwIDI regulates triptolide and celastrol accumulation in Tripterygium wilfordii.
Topics: Biosynthetic Pathways; Carbon-Carbon Double Bond Isomerases; Diterpenes; Down-Regulation; Epoxy Compounds; Gene Expression Regulation, Plant; Hemiterpenes; Pentacyclic Triterpenes; Phenanthrenes; Phylogeny; Plant Proteins; RNA Interference; Tripterygium; Triterpenes; Up-Regulation | 2018 |
Differential expression of the TwHMGS gene and its effect on triptolide biosynthesis in Tripterygium wilfordii.
Topics: Acetyl Coenzyme A; Amino Acid Sequence; Biosynthetic Pathways; Catalytic Domain; Diterpenes; Epoxy Compounds; Gene Expression Regulation, Plant; Hydroxymethylglutaryl-CoA Synthase; Models, Molecular; Pentacyclic Triterpenes; Phenanthrenes; Plant Proteins; RNA Interference; Terpenes; Tripterygium; Triterpenes | 2019 |
Metabolomics reveals the role of PPARα in Tripterygium Wilfordii-induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentacyclic Triterpenes; Phenanthrenes; Plant Extracts; PPAR alpha; Tablets; Tripterygium | 2022 |
[In vitro "benefit-risk" evaluation and network regulation mechanism of Colquhounia Root Tablets and its key material basis].
Topics: Animals; Arthritis, Rheumatoid; Cytokines; Diabetic Nephropathies; Drugs, Chinese Herbal; Glomerulonephritis, Membranous; Humans; Mice; Molecular Docking Simulation; Tablets | 2022 |
Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Mice; RNA, Messenger; Tripterygium; Tumor Necrosis Factor-alpha; Zebrafish | 2023 |
Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii.
Topics: Animals; Gastrointestinal Hemorrhage; Mice; Mice, Knockout; Molecular Docking Simulation; Tripterygium; Triterpenes | 2023 |