Page last updated: 2024-09-03

celastrol and rotenone

celastrol has been researched along with rotenone in 4 studies

Compound Research Comparison

Studies
(celastrol)
Trials
(celastrol)
Recent Studies (post-2010)
(celastrol)
Studies
(rotenone)
Trials
(rotenone)
Recent Studies (post-2010) (rotenone)
88517414,40761,648

Protein Interaction Comparison

ProteinTaxonomycelastrol (IC50)rotenone (IC50)
Bile salt export pumpHomo sapiens (human)8
NADH-ubiquinone oxidoreductase chain 1Bos taurus (cattle)0.015
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialBos taurus (cattle)0.0051
Cytochrome P450 2C19Homo sapiens (human)3.6486
5-hydroxytryptamine receptor 6Homo sapiens (human)0.87
Acyl carrier protein, mitochondrialBos taurus (cattle)0.0051

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Jantas, D; Konieczny, J; Kuśmierczyk, J; Lasoń, W; Lenda, T; Lorenc-Koci, E; Roman, A1
Deng, YN; Liu, J; Qu, QM; Shi, J1
Choi, BS; Kim, H; Kim, S; Kim, SJ; Lee, HJ; Park, SE; Sapkota, K1

Other Studies

4 other study(ies) available for celastrol and rotenone

ArticleYear
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
The extent of neurodegeneration and neuroprotection in two chemical in vitro models related to Parkinson's disease is critically dependent on cell culture conditions.
    Neurotoxicity research, 2013, Volume: 24, Issue:1

    Topics: Acetylcysteine; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Drug Interactions; Humans; Nerve Degeneration; Neuroprotective Agents; Parkinson Disease; Pentacyclic Triterpenes; Rotenone; Time Factors; Tretinoin; Triterpenes

2013
Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy.
    Neurochemistry international, 2013, Volume: 63, Issue:1

    Topics: Apoptosis; Autophagy; Cell Line, Tumor; Humans; Neuroblastoma; Pentacyclic Triterpenes; Rotenone; Triterpenes

2013
Celastrol from 'Thunder God Vine' protects SH-SY5Y cells through the preservation of mitochondrial function and inhibition of p38 MAPK in a rotenone model of Parkinson's disease.
    Neurochemical research, 2014, Volume: 39, Issue:1

    Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Membrane Potential, Mitochondrial; Neuroprotective Agents; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Pentacyclic Triterpenes; Rotenone; Triterpenes

2014