Page last updated: 2024-09-03

celastrol and paclitaxel

celastrol has been researched along with paclitaxel in 10 studies

Compound Research Comparison

Studies
(celastrol)
Trials
(celastrol)
Recent Studies (post-2010)
(celastrol)
Studies
(paclitaxel)
Trials
(paclitaxel)
Recent Studies (post-2010) (paclitaxel)
885174131,8745,72915,395

Protein Interaction Comparison

ProteinTaxonomycelastrol (IC50)paclitaxel (IC50)
Integrin beta-3Homo sapiens (human)0.034
Integrin alpha-V Homo sapiens (human)0.034
ATP-dependent translocase ABCB1Homo sapiens (human)2.598
Botulinum neurotoxin type A Clostridium botulinum5.2
UDP-glucuronosyltransferase 2B7Homo sapiens (human)4.9
UDP-glucuronosyltransferase 1-6Homo sapiens (human)4.9
Substance-K receptorHomo sapiens (human)6.125
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)4.9
UDP-glucuronosyltransferase 1A4Homo sapiens (human)4.9
UDP-glucuronosyltransferase 2B10 Homo sapiens (human)4.9
Delta-type opioid receptorHomo sapiens (human)4.202
Tyrosine-protein kinase MerHomo sapiens (human)4.9
Tubulin beta-3 chainHomo sapiens (human)0.0082
Beta-tubulin Leishmania donovani1
Nucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)7.9433
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)0.26
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.28

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's9 (90.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bastow, KF; Chang, FR; Chen, IH; Cragg, GM; Hayashi, K; Lee, KH; Liaw, CC; Nakanishi, Y; Nozaki, H; Wu, YC1
Han, AR; Kang, GY; Lee, D; Lee, YS; Nam, JW; Seo, EK1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Abdeen, S; Chapman, E; Chitre, S; Hoang, QQ; Johnson, SM; Park, Y; Ray, AM; Salim, N; Sivinski, J; Stevens, M; Washburn, A1
Ding, F; Ding, J; Li, N; Li, X; Liu, R; Liu, W; Ning, Y; Ren, S; Wang, H; Zheng, H1
An, S; Byun, JY; Chung, HY; Eum, DY; Kim, MJ; Lee, JH; Lee, SJ; Park, KH; Seo, WD; Suh, Y; Yoon, CH1
Chai, Y; Fan, G; Hu, Y; Liu, H; Qi, Y1
Jeoung, D; Kim, H; Kim, Y1
Choi, MG; Ihm, SH; Kang, JG; Kim, CS; Kim, SH; Lee, SJ; Yoo, HJ1
Cha, EY; Lee, JS; Lee, MS; Lee, Y; Na, J; Park, JB; Sul, JY1

Other Studies

10 other study(ies) available for celastrol and paclitaxel

ArticleYear
Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii.
    Journal of natural products, 2003, Volume: 66, Issue:11

    Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Celastraceae; Drug Screening Assays, Antitumor; Female; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Ovarian Neoplasms; Plants, Medicinal; Sesquiterpenes; Tanzania; Tumor Cells, Cultured

2003
Diarylheptanoids from the seeds of Alpinia katsumadai as heat shock factor 1 inducers.
    Journal of natural products, 2011, Oct-28, Volume: 74, Issue:10

    Topics: Alpinia; Diarylheptanoids; DNA-Binding Proteins; Heat Shock Transcription Factors; HSP70 Heat-Shock Proteins; Molecular Structure; Republic of Korea; Seeds; Transcription Factors

2011
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules.
    Bioorganic & medicinal chemistry letters, 2019, 05-01, Volume: 29, Issue:9

    Topics: Biological Products; Chaperonin 10; Chaperonin 60; Escherichia coli; Humans; Inhibitory Concentration 50; Protein Folding; Rafoxanide; Salicylanilides; Suramin

2019
Synthesis and biological evaluation of celastrol derivatives as anti-ovarian cancer stem cell agents.
    European journal of medicinal chemistry, 2019, Oct-01, Volume: 179

    Topics: Antineoplastic Agents; Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Molecular Structure; Neoplastic Stem Cells; Ovarian Neoplasms; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes; Wound Healing

2019
Triterpenoid pristimerin synergizes with taxol to induce cervical cancer cell death through reactive oxygen species-mediated mitochondrial dysfunction.
    Anti-cancer drugs, 2011, Volume: 22, Issue:8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; bcl-2-Associated X Protein; Cell Death; Drug Synergism; Female; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Paclitaxel; Pentacyclic Triterpenes; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; Triterpenes; Up-Regulation; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

2011
Effects of celastrol on human cervical cancer cells as revealed by ion-trap gas chromatography-mass spectrometry based metabolic profiling.
    Biochimica et biophysica acta, 2013, Volume: 1830, Issue:3

    Topics: Analysis of Variance; Annexin A5; Antineoplastic Agents, Phytogenic; Caspase 3; Cell Proliferation; Cell Survival; Cisplatin; Doxorubicin; Enzyme Activation; Female; Gas Chromatography-Mass Spectrometry; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Metabolome; Paclitaxel; Pentacyclic Triterpenes; Triterpenes; Uterine Cervical Neoplasms

2013
Tubulin Beta3 Serves as a Target of HDAC3 and Mediates Resistance to Microtubule-Targeting Drugs.
    Molecules and cells, 2015, Volume: 38, Issue:8

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression; Histone Deacetylase 6; Histone Deacetylases; Humans; Microtubules; Paclitaxel; Pentacyclic Triterpenes; Promoter Regions, Genetic; Triterpenes; Tubulin

2015
Cytotoxic effect of celastrol alone or in combination with paclitaxel on anaplastic thyroid carcinoma cells.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017, Volume: 39, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; NF-kappa B; Oncogene Protein v-akt; Paclitaxel; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Thyroid Carcinoma, Anaplastic; Triterpenes

2017
Combination of pristimerin and paclitaxel additively induces autophagy in human breast cancer cells via ERK1/2 regulation.
    Molecular medicine reports, 2018, Volume: 18, Issue:5

    Topics: Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Synergism; Female; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Paclitaxel; Pentacyclic Triterpenes; Triterpenes

2018