celastrol has been researched along with novobiocin in 4 studies
| Studies (celastrol) | Trials (celastrol) | Recent Studies (post-2010) (celastrol) | Studies (novobiocin) | Trials (novobiocin) | Recent Studies (post-2010) (novobiocin) |
|---|---|---|---|---|---|
| 885 | 1 | 741 | 2,271 | 15 | 290 |
| Protein | Taxonomy | celastrol (IC50) | novobiocin (IC50) |
|---|---|---|---|
| DNA gyrase subunit B | Mycolicibacterium smegmatis MC2 155 | 0.046 | |
| DNA gyrase subunit B | Staphylococcus aureus | 0.0474 | |
| DNA gyrase subunit B | Streptococcus pneumoniae TIGR4 | 0.037 | |
| DNA gyrase subunit A | Escherichia coli K-12 | 0.1441 | |
| DNA gyrase subunit B | Escherichia coli K-12 | 0.1537 | |
| DNA topoisomerase 4 subunit B | Staphylococcus aureus | 7.9 | |
| DNA gyrase subunit B | Mycolicibacterium smegmatis | 0.161 | |
| DNA gyrase subunit A | Staphylococcus aureus | 0.0383 | |
| DNA gyrase subunit B | Mycobacterium tuberculosis H37Rv | 0.0446 | |
| DNA gyrase subunit A | Mycobacterium tuberculosis H37Rv | 0.1315 | |
| DNA topoisomerase | Streptococcus pneumoniae | 2.03 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ansar, S; Blagg, BS; Lu, Y; Michaelis, ML | 1 |
| Blagg, BS; Brandt, GE; Dixit, A; Donnelly, AC; Lu, Y; Matts, RL; Mollapour, M; Neckers, L; Verkhivker, G; Wang, S | 1 |
| Blagg, BS; Davenport, J; Krumm, B; Manjarrez, JR; Matts, RL; Peterson, L | 1 |
| Li, L; Wang, L; Xu, XL; You, QD | 1 |
1 review(s) available for celastrol and novobiocin
| Article | Year |
|---|---|
Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.
Topics: Animals; Antineoplastic Agents; Autoimmune Diseases; Benzoquinones; Forecasting; HSP90 Heat-Shock Proteins; Humans; Immunosuppressive Agents; Lactams, Macrocyclic; Molecular Chaperones; Neoplasms; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary | 2020 |
3 other study(ies) available for celastrol and novobiocin
| Article | Year |
|---|---|
Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line.
Topics: Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; HSP90 Heat-Shock Proteins; Humans; Models, Neurological; Neurons; Neuroprotective Agents; Novobiocin | 2009 |
A systematic protocol for the characterization of Hsp90 modulators.
Topics: Benzoquinones; Cell Line, Tumor; Chromatography, Affinity; HSP90 Heat-Shock Proteins; Humans; Hydrolysis; Immunoprecipitation; Lactams, Macrocyclic; Models, Molecular; Novobiocin; Pentacyclic Triterpenes; Triterpenes | 2011 |
Gambogic acid, a natural product inhibitor of Hsp90.
Topics: Benzoquinones; Biological Products; Cell Cycle Proteins; Chaperonins; Crystallography, X-Ray; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Lactams, Macrocyclic; Pentacyclic Triterpenes; Protein Conformation; Stereoisomerism; Triterpenes; Xanthones | 2011 |