Compounds > celastrol
Page last updated: 2024-09-03

celastrol and luteolin

celastrol has been researched along with luteolin in 3 studies

Compound Research Comparison

Studies
(celastrol)		Trials
(celastrol)		Recent Studies (post-2010)
(celastrol)		Studies
(luteolin)		Trials
(luteolin)		Recent Studies (post-2010) (luteolin)
88517412,402151,648

Protein Interaction Comparison

ProteinTaxonomycelastrol (IC50)luteolin (IC50)
Chain A, Casein kinase II subunit alphaZea mays0.35
Chain A, Casein kinase II subunit alphaZea mays0.35
Chain A, Casein Kinase Ii Subunit AlphaZea mays0.35
integrase, partialHuman immunodeficiency virus 11.059
lens epithelium-derived growth factor p75Homo sapiens (human)1.059
Aldo-keto reductase family 1 member B10Homo sapiens (human)9.2
G2/mitotic-specific cyclin-B2Homo sapiens (human)6.2
Poly [ADP-ribose] polymerase tankyrase-1Homo sapiens (human)2.3994
TransthyretinHomo sapiens (human)6.4
Interstitial collagenaseHomo sapiens (human)3.03
Cytochrome P450 1A1Homo sapiens (human)1.249
Amyloid-beta precursor proteinHomo sapiens (human)6.4
Cytochrome P450 1A2Homo sapiens (human)3.37
Prostaglandin G/H synthase 1Ovis aries (sheep)3.2
Cyclin-dependent kinase 1Homo sapiens (human)6.2
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.54
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)3.2
72 kDa type IV collagenaseHomo sapiens (human)3.61
Poly [ADP-ribose] polymerase 1Homo sapiens (human)4.2329
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)1.6
SialidaseClostridium perfringens4.3
Serine/threonine-protein kinase pim-1Homo sapiens (human)1.6
G2/mitotic-specific cyclin-B1Homo sapiens (human)6.2
Matrix metalloproteinase-9Homo sapiens (human)5.62
Aldo-keto reductase family 1 member B1Homo sapiens (human)1.9
G2/mitotic-specific cyclin-BMarthasterias glacialis (spiny starfish)3.6
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)5
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5.162
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)3.6
Casein kinase II subunit alpha'Homo sapiens (human)0.8333
Amine oxidase [flavin-containing] AHomo sapiens (human)4.9
Dipeptidyl peptidase 4Homo sapiens (human)0.12
Proteasome subunit beta type-5Homo sapiens (human)1.4
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1Homo sapiens (human)8.2
Prostaglandin G/H synthase 2Homo sapiens (human)3.2
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.83
Macrophage metalloelastaseHomo sapiens (human)0.98
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.66
1-deoxy-D-xylulose 5-phosphate reductoisomeraseEscherichia coli K-123.4
Xanthine dehydrogenase/oxidaseHomo sapiens (human)4.175
Glycogen synthase kinase-3 alphaHomo sapiens (human)0.8
Glycogen synthase kinase-3 betaHomo sapiens (human)0.8
Mitogen-activated protein kinase 10Homo sapiens (human)2.3
Casein kinase II subunit betaHomo sapiens (human)0.8333
Casein kinase II subunit alphaHomo sapiens (human)0.75
Cyclin-dependent kinase 6Homo sapiens (human)3.6
Cyclin-dependent-like kinase 5 Homo sapiens (human)3.65
Cyclin homologHerpesvirus saimiri (strain 11)3.6
Lactoylglutathione lyaseHomo sapiens (human)7.7
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)3.65
Mitogen-activated protein kinase 14Homo sapiens (human)2.3
Cytochrome P450 1B1Homo sapiens (human)0.2195
Integrase Human immunodeficiency virus 14.675
Casein kinase II subunit alpha 3Homo sapiens (human)0.5
Inositol polyphosphate multikinaseHomo sapiens (human)5.5
Histone-lysine N-methyltransferase SETD7Homo sapiens (human)6.08
G2/mitotic-specific cyclin-B3Homo sapiens (human)6.2
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)2
3-oxoacyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)4
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)Plasmodium falciparum (malaria parasite P. falciparum)5
Aurora kinase BHomo sapiens (human)3.88
MAP kinase-interacting serine/threonine-protein kinase 1Homo sapiens (human)0.179
Cyclin-dependent kinase 1Oryzias latipes (Japanese medaka)3.6
Poly [ADP-ribose] polymerase tankyrase-2Homo sapiens (human)1.0858
MAP kinase-interacting serine/threonine-protein kinase 2Homo sapiens (human)0.579
NADPH oxidase 4Homo sapiens (human)0.85
Inositol hexakisphosphate kinase 2Homo sapiens (human)1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)8.9
DNA topoisomerase 1Rattus norvegicus (Norway rat)2.83
M1-family alanyl aminopeptidasePlasmodium falciparum 3D722.86
large T antigenBetapolyomavirus macacae11.9

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Cuong, TD; Hung, TM; Lee, JS; Min, BS; Weon, KY; Woo, MH1
Chen, J; Gao, K; Huang, F; Tepe, JJ; Wang, R; Wei, GW1

Other Studies

3 other study(ies) available for celastrol and luteolin

ArticleYear
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
Anti-inflammatory activity of phenolic compounds from the whole plant of Scutellaria indica.
    Bioorganic & medicinal chemistry letters, 2015, Mar-01, Volume: 25, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Flavonoids; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Phenols; Plant Extracts; Scutellaria

2015
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
    Journal of medicinal chemistry, 2021, 12-09, Volume: 64, Issue:23

    Topics: Antiviral Agents; Coronavirus 3C Proteases; Humans; Protease Inhibitors

2021