celastrol has been researched along with geldanamycin in 7 studies
| Studies (celastrol) | Trials (celastrol) | Recent Studies (post-2010) (celastrol) | Studies (geldanamycin) | Trials (geldanamycin) | Recent Studies (post-2010) (geldanamycin) |
|---|---|---|---|---|---|
| 885 | 1 | 741 | 96 | 0 | 59 |
| 885 | 1 | 741 | 1,167 | 1 | 329 |
| Protein | Taxonomy | celastrol (IC50) | geldanamycin (IC50) |
|---|---|---|---|
| Lysine-specific demethylase 6B | Homo sapiens (human) | 0.4 | |
| Lysine-specific demethylase 4B | Homo sapiens (human) | 0.7 | |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | 3 | |
| ATP-dependent molecular chaperone HSP82 | Saccharomyces cerevisiae S288C | 3.9667 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 0.014 | |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | 0.0917 | |
| Heat shock protein HSP 90-beta | Homo sapiens (human) | 0.098 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.014 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.014 | |
| Breakpoint cluster region protein | Homo sapiens (human) | 3 | |
| Heat shock protein HSP 90 | Oryctolagus cuniculus (rabbit) | 1.141 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 0.074 | |
| Cytochrome P450 3A5 | Homo sapiens (human) | 0.014 | |
| Cytochrome P450 3A7 | Homo sapiens (human) | 0.014 | |
| Lysine-specific demethylase 5A | Homo sapiens (human) | 0.13 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.074 | |
| Endoplasmin | Canis lupus familiaris (dog) | 0.01 | |
| Heat shock protein 75 kDa, mitochondrial | Homo sapiens (human) | 0.661 | |
| Putative heat shock protein HSP 90-alpha A4 | Homo sapiens (human) | 0.14 | |
| Lysine-specific demethylase 4C | Homo sapiens (human) | 0.7 | |
| Cytochrome P450 3A43 | Homo sapiens (human) | 0.014 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Ansar, S; Blagg, BS; Lu, Y; Michaelis, ML | 1 |
| Blagg, BS; Brandt, GE; Dixit, A; Donnelly, AC; Lu, Y; Matts, RL; Mollapour, M; Neckers, L; Verkhivker, G; Wang, S | 1 |
| Blagg, BS; Davenport, J; Krumm, B; Manjarrez, JR; Matts, RL; Peterson, L | 1 |
| Blagg, BS; Halaweish, F; Hall, JA; Kopel, L; Rice, N; Seedarala, S | 1 |
| Huang, R; Huang, X; Ji, M; Jin, L; Wang, H; Zhang, B | 1 |
| Chiosis, G; Clardy, J; Clement, C; Du, J; Golub, TR; Hahn, WC; Hieronymus, H; Lamb, J; Maloney, KN; Nieto, M; Peng, XP; Raj, SM; Rodina, A; Ross, KN; Stegmaier, K | 1 |
| Basilico, N; Bassanini, I; Ferrandi, EE; Gabriele, E; Parapini, S; Sparatore, A; Taramelli, D | 1 |
7 other study(ies) available for celastrol and geldanamycin
| Article | Year |
|---|---|
Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line.
Topics: Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; HSP90 Heat-Shock Proteins; Humans; Models, Neurological; Neurons; Neuroprotective Agents; Novobiocin | 2009 |
A systematic protocol for the characterization of Hsp90 modulators.
Topics: Benzoquinones; Cell Line, Tumor; Chromatography, Affinity; HSP90 Heat-Shock Proteins; Humans; Hydrolysis; Immunoprecipitation; Lactams, Macrocyclic; Models, Molecular; Novobiocin; Pentacyclic Triterpenes; Triterpenes | 2011 |
Gambogic acid, a natural product inhibitor of Hsp90.
Topics: Benzoquinones; Biological Products; Cell Cycle Proteins; Chaperonins; Crystallography, X-Ray; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Lactams, Macrocyclic; Pentacyclic Triterpenes; Protein Conformation; Stereoisomerism; Triterpenes; Xanthones | 2011 |
Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery.
Topics: Benzoquinones; Cucurbitaceae; DNA-Binding Proteins; Heat Shock Transcription Factors; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; MCF-7 Cells; Molecular Chaperones; Molecular Structure; Neoplasms; Transcription Factors; Triterpenes | 2015 |
Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance.
Topics: Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chaperonins; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glycyrrhetinic Acid; HSP90 Heat-Shock Proteins; Humans; Molecular Structure; Structure-Activity Relationship | 2018 |
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.
Topics: Antibiotics, Antineoplastic; Benzoquinones; Biomarkers, Tumor; Cell Culture Techniques; Cell Line; Cell Line, Tumor; Cell Survival; ErbB Receptors; fms-Like Tyrosine Kinase 3; Fusion Proteins, bcr-abl; Gene Expression; Gene Expression Profiling; Genome, Human; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Lactams, Macrocyclic; Limonins; Male; Metribolone; Pentacyclic Triterpenes; Prostatic Neoplasms; Receptors, Androgen; Reproducibility of Results; RNA, Messenger; Triterpenes | 2006 |
Design, Synthesis and In Vitro Investigation of Novel Basic Celastrol Carboxamides as Bio-Inspired Leishmanicidal Agents Endowed with Inhibitory Activity against
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amides; Animals; Antiprotozoal Agents; Benzoquinones; HSP90 Heat-Shock Proteins; Humans; Kinetics; Lactams, Macrocyclic; Leishmania braziliensis; Macrolides; Mice, Inbred C57BL; Pentacyclic Triterpenes; Protein Conformation; THP-1 Cells | 2021 |