Compounds > celastrol
Page last updated: 2024-09-03

celastrol and gefitinib

celastrol has been researched along with gefitinib in 3 studies

Compound Research Comparison

Studies
(celastrol)		Trials
(celastrol)		Recent Studies (post-2010)
(celastrol)		Studies
(gefitinib)		Trials
(gefitinib)		Recent Studies (post-2010) (gefitinib)
88517415,2315662,919

Protein Interaction Comparison

ProteinTaxonomycelastrol (IC50)gefitinib (IC50)
epidermal growth factor receptor isoform a precursorHomo sapiens (human)0.004
Cyclin-G-associated kinaseHomo sapiens (human)0.42
Multidrug resistance-associated protein 4Homo sapiens (human)4.6
Tyrosine-protein kinase ABL1Homo sapiens (human)1.2
Epidermal growth factor receptorHomo sapiens (human)0.3676
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)0.5699
Cytochrome P450 1A2Homo sapiens (human)0.151
Cytochrome P450 2E1Homo sapiens (human)0.46
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)1.7
Tyrosine-protein kinase HCKHomo sapiens (human)0.11
Quinolone resistance protein NorAStaphylococcus aureus9.7
Cytochrome P450 2C8Homo sapiens (human)0.151
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)1.1
Serine/threonine-protein kinase B-rafHomo sapiens (human)2
Receptor tyrosine-protein kinase erbB-3Homo sapiens (human)0.008
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)0.281
Cytochrome P450 2C19Homo sapiens (human)0.151
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)0.0073
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.9742
Ephrin type-B receptor 4Homo sapiens (human)1
Synaptic vesicular amine transporterRattus norvegicus (Norway rat)0.001
Transcription factor p65Homo sapiens (human)0.055
Receptor tyrosine-protein kinase erbB-4Homo sapiens (human)0.086
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.29

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fan, XX; He, JX; Leung, EL; Li, N; Liu, L; Wu, JL; Zhou, YL1
Coghi, PS; Fan, XX; Law, BY; Leung, CH; Leung, EL; Liu, L; Ma, DL; Mok, SW; Wong, VK; Xu, SW; Zeng, W1
Kim, SY; Lee, C; Lee, YJ1

Other Studies

3 other study(ies) available for celastrol and gefitinib

ArticleYear
Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.
    Molecules (Basel, Switzerland), 2014, Mar-21, Volume: 19, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gefitinib; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mitochondria; Pentacyclic Triterpenes; Protein Kinase Inhibitors; Proteolysis; Quinazolines; Signal Transduction; Triterpenes

2014
Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol.
    International journal of oncology, 2016, Volume: 49, Issue:4

    Topics: Antineoplastic Agents; Autophagy; Blotting, Western; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Flow Cytometry; Gefitinib; Humans; Lung Neoplasms; Pentacyclic Triterpenes; Proteolysis; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Triterpenes; Tumor Cells, Cultured

2016
Axl is a novel target of celastrol that inhibits cell proliferation and migration, and increases the cytotoxicity of gefitinib in EGFR mutant non‑small cell lung cancer cells.
    Molecular medicine reports, 2019, Volume: 19, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Axl Receptor Tyrosine Kinase; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Expression; Humans; Lung Neoplasms; Mutation; Pentacyclic Triterpenes; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Triterpenes

2019