celastrol has been researched along with gambogic acid in 6 studies
| Studies (celastrol) | Trials (celastrol) | Recent Studies (post-2010) (celastrol) | Studies (gambogic acid) | Trials (gambogic acid) | Recent Studies (post-2010) (gambogic acid) |
|---|---|---|---|---|---|
| 885 | 1 | 741 | 348 | 1 | 260 |
| Protein | Taxonomy | celastrol (IC50) | gambogic acid (IC50) |
|---|---|---|---|
| Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens (human) | 3.07 | |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | 0.47 | |
| Regulator of G-protein signaling 17 | Homo sapiens (human) | 10 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Blagg, BS; Davenport, J; Krumm, B; Manjarrez, JR; Matts, RL; Peterson, L | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Bodle, CR; Doorn, JA; Hayes, MP; Henry, MD; Houtman, JCD; James, MA; Mackie, DI; Miller, MR; Roman, DL; Schamp, JH | 1 |
| Abdeen, S; Chapman, E; Chitre, S; Hoang, QQ; Johnson, SM; Park, Y; Ray, AM; Salim, N; Sivinski, J; Stevens, M; Washburn, A | 1 |
| Chen, W; Duan, W; He, D; Xu, Q; Yan, M; Ye, D; Zhang, P; Zhang, Z; Zhong, L; Zhou, X | 1 |
| Cui, J; Gong, T; Hu, Q; Huang, J; Liu, X; Lu, W; Ma, H; Pu, J; Wang, W; Wu, Y | 1 |
6 other study(ies) available for celastrol and gambogic acid
| Article | Year |
|---|---|
Gambogic acid, a natural product inhibitor of Hsp90.
Topics: Benzoquinones; Biological Products; Cell Cycle Proteins; Chaperonins; Crystallography, X-Ray; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Lactams, Macrocyclic; Pentacyclic Triterpenes; Protein Conformation; Stereoisomerism; Triterpenes; Xanthones | 2011 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines.
Topics: Benzophenanthridines; Biological Products; Cytostatic Agents; Cytotoxins; GTP-Binding Protein Regulators; Humans; Isoquinolines; Lung Neoplasms; Male; Molecular Structure; Pentacyclic Triterpenes; Prostatic Neoplasms; Triterpenes | 2017 |
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules.
Topics: Biological Products; Chaperonin 10; Chaperonin 60; Escherichia coli; Humans; Inhibitory Concentration 50; Protein Folding; Rafoxanide; Salicylanilides; Suramin | 2019 |
The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Humans; Mouth Neoplasms; NF-kappa B; Pentacyclic Triterpenes; Signal Transduction; Triterpenes; Xanthones | 2009 |
A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERĪ± mutants in breast cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Dose-Response Relationship, Drug; Estrogen Receptor alpha; Female; HEK293 Cells; Humans; MCF-7 Cells; Mice, Inbred BALB C; Mice, Nude; Mutation; Pentacyclic Triterpenes; Protein Structure, Secondary; Xanthones | 2021 |