celastrol has been researched along with fluorouracil in 6 studies
| Studies (celastrol) | Trials (celastrol) | Recent Studies (post-2010) (celastrol) | Studies (fluorouracil) | Trials (fluorouracil) | Recent Studies (post-2010) (fluorouracil) |
|---|---|---|---|---|---|
| 885 | 1 | 741 | 45,562 | 9,307 | 14,663 |
| Protein | Taxonomy | celastrol (IC50) | fluorouracil (IC50) |
|---|---|---|---|
| Epidermal growth factor receptor | Homo sapiens (human) | 0.32 | |
| Thymidylate synthase | Mus musculus (house mouse) | 1.58 | |
| Aromatase | Homo sapiens (human) | 0.63 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, J; Liu, XH; Shi, JB; Tang, WJ; Tong, X; Wang, J | 1 |
| Alho, DPS; Figueiredo, SAC; Gonçalves, BMF; Leal, AS; Mendes, VIS; Salvador, JAR; Silvestre, SM; Valdeira, AS | 1 |
| Huang, R; Huang, X; Ji, M; Jin, L; Wang, H; Zhang, B | 1 |
| Deng, H; Guo, HY; Jin, X; Li, X; Quan, ZS; Shang, FF; Shen, QK; Wang, JY; Xu, Q | 1 |
| Feng, Y; Fu, X; Li, Z; Lin, F; Lv, J; Mao, Q; Mou, Y; Wang, S; Yang, Y; Zhang, B; Zhang, L; Zhang, P; Zhao, J | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
1 review(s) available for celastrol and fluorouracil
| Article | Year |
|---|---|
Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.
Topics: Animals; Antineoplastic Agents; Chemistry Techniques, Synthetic; Humans; Indolequinones; Neoplasms; Oleanolic Acid; Structure-Activity Relationship; Triterpenes | 2017 |
5 other study(ies) available for celastrol and fluorouracil
| Article | Year |
|---|---|
Design and synthesis of celastrol derivatives as anticancer agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Neoplasms; Pentacyclic Triterpenes; Structure-Activity Relationship; Telomerase; Triterpenes; Tumor Cells, Cultured | 2015 |
Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance.
Topics: Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chaperonins; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glycyrrhetinic Acid; HSP90 Heat-Shock Proteins; Humans; Molecular Structure; Structure-Activity Relationship | 2018 |
Design, synthesis of novel celastrol derivatives and study on their antitumor growth through HIF-1α pathway.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Structure; Pentacyclic Triterpenes; Solubility; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |
Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Oxazoles; Pentacyclic Triterpenes; Pyrazines; Structure-Activity Relationship; Zebrafish | 2022 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |