Compounds > celastrol
Page last updated: 2024-09-03

celastrol and cyclosporine

celastrol has been researched along with cyclosporine in 5 studies

Compound Research Comparison

Studies
(celastrol)		Trials
(celastrol)		Recent Studies (post-2010)
(celastrol)		Studies
(cyclosporine)		Trials
(cyclosporine)		Recent Studies (post-2010) (cyclosporine)
885174119014
88517413772170
885174130,5473,8026,558

Protein Interaction Comparison

ProteinTaxonomycelastrol (IC50)cyclosporine (IC50)
ATP-binding cassette sub-family C member 3Homo sapiens (human)0.6315
Bile salt export pumpRattus norvegicus (Norway rat)0.6
Bile salt export pumpHomo sapiens (human)3.5
Interleukin-2Mus musculus (house mouse)0.005
ATP-dependent translocase ABCB1Mus musculus (house mouse)0.7
ATP-dependent translocase ABCB1Homo sapiens (human)1.6792
Cytochrome P450 3A4Homo sapiens (human)3.734
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 25.82
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A5Homo sapiens (human)2.06
ATP-dependent translocase ABCB1Mus musculus (house mouse)4.8
Substance-K receptorHomo sapiens (human)4.139
Peptidyl-prolyl cis-trans isomerase BHomo sapiens (human)0.0088
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A7Homo sapiens (human)2.06
Cytochrome P450 2C19Homo sapiens (human)7
Multidrug resistance-associated protein 1 Homo sapiens (human)3.5082
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)9.34
Peptidyl-prolyl cis-trans isomerase A Homo sapiens (human)0.0252
Peptidyl-prolyl cis-trans isomerase FKBP4Homo sapiens (human)0.016
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformHomo sapiens (human)0.183
Peptidyl-prolyl cis-trans isomerase DHomo sapiens (human)0.0036
Sodium/bile acid cotransporterHomo sapiens (human)1
Reverse transcriptase/RNaseH Human immunodeficiency virus 10.455
Cytochrome P450 3A43 Homo sapiens (human)2.06
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Mus musculus (house mouse)0.57
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)4.3
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.95

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's2 (40.00)2.80

Authors

AuthorsStudies
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Dong, G; Liu, N; Sheng, C; Tu, J; Wang, Y1
Feng, JH; He, QW; Hu, XL; Huang, XF; Jiang, ZZ; Long, H; Wang, H; Ye, WC; Zhang, XQ1
Fukazawa, T; Kubo, T; Kunieda, T; Naora, Y1

Reviews

1 review(s) available for celastrol and cyclosporine

ArticleYear
Emerging New Targets for the Treatment of Resistant Fungal Infections.
    Journal of medicinal chemistry, 2018, 07-12, Volume: 61, Issue:13

    Topics: Antifungal Agents; Drug Resistance, Fungal; Humans; Molecular Targeted Therapy; Mycoses

2018

Other Studies

4 other study(ies) available for celastrol and cyclosporine

ArticleYear
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
Synthesis and Biological Evaluation of Celastrol Derivatives as Potential Immunosuppressive Agents.
    Journal of natural products, 2020, 09-25, Volume: 83, Issue:9

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cytokines; Drug Screening Assays, Antitumor; Humans; Immunosuppressive Agents; Male; Mice; Mice, Inbred BALB C; Pentacyclic Triterpenes; Signal Transduction; T-Lymphocytes; ZAP-70 Protein-Tyrosine Kinase

2020
Suppression of the immune response potentiates tadpole tail regeneration during the refractory period.
    Development (Cambridge, England), 2009, Volume: 136, Issue:14

    Topics: Animals; Base Sequence; Chemokines; Cyclosporine; Gene Expression Profiling; Immunosuppressive Agents; Larva; Oligodeoxyribonucleotides, Antisense; Pentacyclic Triterpenes; Proto-Oncogene Proteins; Regeneration; T-Lymphocytes, Regulatory; Tacrolimus; Tail; Time Factors; Trans-Activators; Triterpenes; Xenopus laevis; Xenopus Proteins

2009