celastrol has been researched along with chloroquine in 3 studies
| Studies (celastrol) | Trials (celastrol) | Recent Studies (post-2010) (celastrol) | Studies (chloroquine) | Trials (chloroquine) | Recent Studies (post-2010) (chloroquine) |
|---|---|---|---|---|---|
| 885 | 1 | 741 | 16,405 | 763 | 4,029 |
| Protein | Taxonomy | celastrol (IC50) | chloroquine (IC50) |
|---|---|---|---|
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | 43 | |
| Spike glycoprotein | Betacoronavirus England 1 | 5.47 | |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | 5.47 | |
| Transmembrane protease serine 2 | Homo sapiens (human) | 5.47 | |
| Dihydrofolate reductase | Bos taurus (cattle) | 0.0301 | |
| Amyloid-beta precursor protein | Homo sapiens (human) | 7 | |
| Histidine-rich protein PFHRP-II | Plasmodium falciparum (malaria parasite P. falciparum) | 0.2383 | |
| Procathepsin L | Homo sapiens (human) | 5.47 | |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | 5.47 | |
| Replicase polyprotein 1ab | Human coronavirus 229E | 5.47 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | 5.47 | |
| Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 | 3.58 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 6.375 | |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | 1.5 | |
| Serine/threonine-protein kinase mTOR | Homo sapiens (human) | 0.27 | |
| Beta-secretase 1 | Homo sapiens (human) | 7 | |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | 5.47 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 2.503 | |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | 6.235 | |
| Cysteine proteinase falcipain 2a | Plasmodium falciparum (malaria parasite P. falciparum) | 0.02 | |
| Cysteine proteinase falcipain 2a | Plasmodium falciparum (malaria parasite P. falciparum) | 0.2 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Figueiredo, JN; Räz, B; Séquin, U | 1 |
| de Vera, IMS; Kamenecka, TM; Khan, P; Kojetin, DJ; Lin, H; Munoz-Tello, P | 1 |
| Nazim, UM; Park, SY; Yin, H | 1 |
3 other study(ies) available for celastrol and chloroquine
| Article | Year |
|---|---|
Novel quinone methides from Salacia kraussii with in vitro antimalarial activity.
Topics: Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Erythrocytes; Humans; In Vitro Techniques; Malaria; Mice; Molecular Sequence Data; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Quinones; South Africa; Tumor Cells, Cultured | 1998 |
Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
Topics: Amodiaquine; Animals; Cell Line; Chloroquine; Humans; Ligands; Nuclear Magnetic Resonance, Biomolecular; Nuclear Receptor Subfamily 4, Group A, Member 2; Phenylacetates; Protein Binding; Rats; Small Molecule Libraries; Transcription, Genetic | 2020 |
Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species.
Topics: A549 Cells; Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Caspase 8; Cell Line, Tumor; Chloroquine; Drug Combinations; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Mitochondria; Pentacyclic Triterpenes; Reactive Oxygen Species; Sequestosome-1 Protein; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Triterpenes | 2019 |