celastrol has been researched along with celastrol methyl ester in 14 studies
| Studies (celastrol) | Trials (celastrol) | Recent Studies (post-2010) (celastrol) | Studies (celastrol methyl ester) | Trials (celastrol methyl ester) | Recent Studies (post-2010) (celastrol methyl ester) |
|---|---|---|---|---|---|
| 885 | 1 | 741 | 39 | 0 | 27 |
| Protein | Taxonomy | celastrol (IC50) | celastrol methyl ester (IC50) |
|---|---|---|---|
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | 5.5 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 5.5 | |
| Monoglyceride lipase | Rattus norvegicus (Norway rat) | 0.093 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 5 (35.71) | 2.80 |
| Authors | Studies |
|---|---|
| Figueiredo, JN; Räz, B; Séquin, U | 1 |
| Chan, WK; Chang, MN; He, W; Huang, FC; Moriarty, KJ; Yu, KT; Zhang, DC; Zilberstein, A | 1 |
| Bastow, KF; Chang, FR; Chen, IH; Cragg, GM; Hayashi, K; Lee, KH; Liaw, CC; Nakanishi, Y; Nozaki, H; Wu, YC | 1 |
| Hirasawa, Y; Morita, H; Muto, A; Sekita, S; Shirota, O; Yoshida, T | 1 |
| Chang, JS; Kim, YM; Lee, JY; Lee, WS; Park, KH; Park, SJ; Rho, MC; Ryu, YB; Seo, WD | 1 |
| Jiang, J; Sun, H; Wang, Y; Xu, L; Yu, P; Zhang, G | 1 |
| Bao, QC; Jiang, D; Jiang, F; Jin, YH; Wang, HJ; Wang, L; Xu, XL; You, QD; Zhang, Q | 1 |
| Chen, Y; Shan, WG; Wang, HG; Wang, JW; Wen, YT; Wu, R; Ying, YM; Zhan, ZJ; Zhang, LW | 1 |
| Chen, Z; Hu, C; Huang, Z; Kang, Q; Li, M; Li, X; Li, Z; Lian, B; Peng, S; Su, Y; Yan, S; Yu, H; Zeng, Z; Zhang, D; Zhang, XK; Zhu, Y | 1 |
| Feng, JH; He, QW; Hu, XL; Huang, XF; Jiang, ZZ; Long, H; Wang, H; Ye, WC; Zhang, XQ | 1 |
| Chen, J; Gao, K; Huang, F; Tepe, JJ; Wang, R; Wei, GW | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Feng, W; Li, X; Mou, Y; Wang, X; Wang, Y; Zhang, Y | 1 |
| Ahmad, F; Al-Tamimi, M; Alam, M; Anver, R; Buddenkotte, J; Khan, AQ; M Mateo, J; Raza, SS; Steinhoff, M; Uddin, S | 1 |
1 review(s) available for celastrol and celastrol methyl ester
| Article | Year |
|---|---|
The multifaceted mechanisms of pristimerin in the treatment of tumors state-of-the-art.
Topics: Carcinoma, Squamous Cell; Humans; Male; Mouth Neoplasms; Pentacyclic Triterpenes; Triterpenes; Tumor Microenvironment | 2022 |
13 other study(ies) available for celastrol and celastrol methyl ester
| Article | Year |
|---|---|
Novel quinone methides from Salacia kraussii with in vitro antimalarial activity.
Topics: Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Erythrocytes; Humans; In Vitro Techniques; Malaria; Mice; Molecular Sequence Data; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Quinones; South Africa; Tumor Cells, Cultured | 1998 |
Novel cytokine release inhibitors. Part I: Triterpenes.
Topics: Animals; Cytokines; Humans; In Vitro Techniques; Inflammation; Molecular Structure; Rats; Triterpenes | 1998 |
Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Celastraceae; Drug Screening Assays, Antitumor; Female; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Ovarian Neoplasms; Plants, Medicinal; Sesquiterpenes; Tanzania; Tumor Cells, Cultured | 2003 |
Antimitotic quinoid triterpenes from Maytenus chuchuhuasca.
Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Maytenus; Molecular Structure; Pentacyclic Triterpenes; Plants, Medicinal; Triterpenes; Tubulin | 2008 |
SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii.
Topics: Antiviral Agents; Benzoquinones; Models, Molecular; Plant Extracts; Severe acute respiratory syndrome-related coronavirus; Tripterygium; Triterpenes | 2010 |
Synthesis and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; HSP70 Heat-Shock Proteins; Molecular Conformation; Neuroprotective Agents; PC12 Cells; Pentacyclic Triterpenes; Rats; Stereoisomerism; Structure-Activity Relationship; tert-Butylhydroperoxide; Triterpenes | 2010 |
Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Chaperonins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HSP90 Heat-Shock Proteins; Humans; Models, Molecular; Molecular Structure; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes | 2016 |
Synthesis of 3- and 29-substituted celastrol derivatives and structure-activity relationship studies of their cytotoxic activities.
Topics: A549 Cells; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Design; Drug Screening Assays, Antitumor; Esterification; Humans; Mice, Nude; Neoplasms; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes | 2017 |
SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Drug Design; Hep G2 Cells; Humans; Molecular Docking Simulation; Molecular Structure; Nuclear Receptor Subfamily 4, Group A, Member 1; Pentacyclic Triterpenes; Protein Binding; Sequestosome-1 Protein; Structure-Activity Relationship; TNF Receptor-Associated Factor 2; Triterpenes; Zebrafish | 2019 |
Synthesis and Biological Evaluation of Celastrol Derivatives as Potential Immunosuppressive Agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cytokines; Drug Screening Assays, Antitumor; Humans; Immunosuppressive Agents; Male; Mice; Mice, Inbred BALB C; Pentacyclic Triterpenes; Signal Transduction; T-Lymphocytes; ZAP-70 Protein-Tyrosine Kinase | 2020 |
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
Topics: Antiviral Agents; Coronavirus 3C Proteases; Humans; Protease Inhibitors | 2021 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Pristimerin mediated anticancer effects and sensitization of human skin cancer cells through modulation of MAPK signaling pathways.
Topics: Carcinoma, Squamous Cell; Humans; MAP Kinase Signaling System; Reactive Oxygen Species; Skin Neoplasms | 2022 |