cefsulodin and apalcillin

cefsulodin has been researched along with apalcillin* in 2 studies

Other Studies

2 other study(ies) available for cefsulodin and apalcillin

ArticleYear
Susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1985, Volume: 4, Issue:6

    Since the discovery of carbenicillin in 1970, several groups of beta-lactam agents with remarkable activity against P. aeruginosa are actually available among penicillins such as ticarcillin, azlocillin, piperacillin, apalcillin and among cephalosporins: cefoperazone, cefsulodin as well as new structures including monobactams (aztreonam) and carbapenems with imipenem. An attempt to establish hierarchy in terms of weight for weight activity, particularly against susceptible isolates is made. The most active antimicrobial agents are: imipenem, apalcillin, ceftazidime, cefsulodin, piperacillin and azlocillin. The bactericidal activity is reported for virtually all of them but more accurate techniques such as time-killing curves are needed to make comparisons, because some discrepancies were reported. Nevertheless, among several factors affecting their inhibitory and bactericidal activities, some of them appeared predominant: inoculum effect and beta-lactamases. The different behavior of beta-lactam antibiotics may be in relation with other mechanisms such as impermeability. A few surveys on the resistance mechanism indicated that impermeability can be prevalent, instead beta-lactamases. But in any case, the enzyme distribution showed carbenicillinases (PSE-1, PSE-4) and OXA were observed with a high prevalence among ticarcillin-resistant isolates and more recently cephalosporinases. These drugs acted synergistically with all of the aminoglycosides in vitro against P. aeruginosa isolates and also in animal models of infection. If the synergism appeared to play a major role in the therapy of P. aeruginosa infections, these new beta-lactam antibiotics offer the possibility of other approaches to combination therapy.

    Topics: Ampicillin; Anti-Bacterial Agents; Azlocillin; beta-Lactamases; Cefsulodin; Ceftazidime; Hydrolysis; Imipenem; Microbial Sensitivity Tests; Monobactams; Naphthyridines; Penicillin Resistance; Piperacillin; Pseudomonas aeruginosa; Thienamycins; Ticarcillin

1985
A turbidimetric study of the responses of selected strains of Pseudomonas aeruginosa to eight antipseudomonal beta-lactam antibiotics.
    The Journal of infectious diseases, 1982, Volume: 145, Issue:1

    Turbidimetric and morphologic responses to eight antipseudomonal beta-lactam antibiotics were compared for selected strains of Pseudomonas aeruginosa with different susceptibilities to carbenicillin. In conventional minimal inhibitory concentration tests, all of the newer antibiotics appeared more active than carbenicillin, and apalcillin and cefsulodin had the greatest overall activity. However, in turbidimetric tests the activity of apalcillin and three other N-acyl penicillins (azlocillin, mezlocillin, and piperacillin) was inferior to that of carbenicillin and the other agents. The N-acyl penicillins were also all susceptible to intrinsic pseudomonal beta-lactamase, so that dense bacterial populations inactivated these antibiotics in concentrations of greater 128 micrograms/ml during overnight incubation. Against carbenicillin-resistant strains, carbenicillin, ticarcillin, and sulbenicillin were the least active antibiotics, and cefsulodin had the best overall activity. Turbidimetric monitoring highlights the problems of interpreting the results of conventional minimal inhibitory concentration tests, particularly when large inocula are involved.

    Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactams; Carbenicillin; Cefsulodin; Cephalosporins; Mezlocillin; Naphthyridines; Nephelometry and Turbidimetry; Penicillin Resistance; Penicillins; Piperacillin; Pseudomonas aeruginosa; Sulbenicillin; Ticarcillin

1982