cefoxitin has been researched along with picric-acid* in 2 studies
2 other study(ies) available for cefoxitin and picric-acid
| Article | Year |
|---|---|
Effect of seven fluoroquinolones on the determination of serum creatinine by the picric acid and enzymatic methods.
To investigate in vitro the interaction of seven fluoroquinolone antibiotics with the determination of serum creatinine by the picric acid and enzymatic methods.. This blind, in vitro study assayed duplicate serum samples for creatinine by the picric acid and enzymatic methods with averaged spiked concentrations of 2.71, 13.56, 27.12, and 108.47 mumol/L of ciprofloxacin, fleroxacin, lomefloxacin, ofloxacin, 1-ofloxacin, sparfloxacin, and temafloxacin. Cefoxitin (in concentrations of 233.9, 1169.6, 1754.4, and 2339.2 mumol/L) was used as a positive control for the picric acid assay.. University-affiliated hospital, Department of Pharmaceutical Services and Clinical Chemistry section of the Department of Pathology.. The serum creatinine samples spiked with the seven substituted fluoroquinolones and cefoxitin were assayed by both the picric acid and enzymatic assays. Statistical analysis compared the spiked samples with blank serum by Student's t-test and concentration ranges were compared by analysis of variance. A statistically significant interference with serum creatinine was p < 0.05.. None of the substituted fluoroquinolones interfered significantly with the determination of serum creatinine by either method. Cefoxitin significantly interfered with the determination of serum creatinine by the picric acid method.. Fluoroquinolones do not interfere with the determination of serum creatinine by either the picric acid or enzymatic method. Topics: Anti-Infective Agents; Cefoxitin; Creatinine; Drug Interactions; Fluoroquinolones; Humans; Indicators and Reagents; Picrates | 1993 |
Analytical interference of drugs in clinical chemistry: II--The interference of three cephalosporins with the determination of serum creatinine concentration by the Jaffé reaction.
It is well known that some cephalosporins interfere with the Jaffé reaction for creatinine measurement. This interference varies according to the thirteen instruments and eighteen methodologies studied. Our study has shown that: the proportion of picric acid, NaOH and serum have only a slight effect on the interference; the addition of a buffer to the NaOH solution increases the interference due to cephalothin and cephaloridine, but lessens that due to cefoxitin; dialysis decreases the interference; in kinetic methods, the choice of times at which readings are made influences the magnitude of the interference; a higher incubation temperature increases the effect of cefoxitin and decreases the effects of cephalothin and cephaloridine; pre-incubation with NaOH decreases the interference due to cefoxitin, but has no significant effect on the interference due to cephalothin or to cephaloridine. Topics: Autoanalysis; Blood Chemical Analysis; Buffers; Cefoxitin; Cephaloridine; Cephalosporins; Cephalothin; Creatinine; Humans; Pharmaceutical Preparations; Picrates; Reaction Time; Sodium Hydroxide; Temperature | 1985 |