cefoxitin and 5-methoxysalicylic-acid

Lymphatic uptake of sodium cefoxitin after injection into rectal connective tissue was greater than after injection into the femoral muscle of rats. Coadministration with sodium 5-methoxysalicylate enhanced lymphatic drug uptake at both sites. This enhancement may be an indirect result of 5-methoxysalicylate's suppression of vascular permeation of the cefoxitin. An adjuvant-induced increase in lymphatic fluid flow may also be partially involved in the enhancement of cefoxitin lymphatic transport.

Topics: Animals; Biological Transport, Active; Cefoxitin; Connective Tissue; Hydroxybenzoate Ethers; Lymphatic System; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Rectum; Salicylates; Time Factors

Uptake of sodium cefoxitin, D-phenylalanine and insulin into human red blood cells was significantly enhanced by the presence of salicylate and 5-methoxysalicylate in the medium. The mechanism of adjuvant action appeared to depend on an affinity between the adjuvant and the protein fraction in the erythrocyte membrane. The inhibitory effect of DIDS and phlorizin on the salicylate-enhanced uptake of these compounds strongly suggests that the ability of salicylate to permeate the membrane may be essential for it to act as an adjuvant.

Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4-Chloromercuribenzenesulfonate; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Cefoxitin; Cell Membrane Permeability; Erythrocyte Membrane; Humans; Hydroxybenzoate Ethers; Hydroxybenzoates; In Vitro Techniques; Insulin; Phenylalanine; Phlorhizin; Salicylates; Salicylic Acid

Topics: Adjuvants, Pharmaceutic; Animals; Calcium Chloride; Cefmetazole; Cefoxitin; Cephalosporins; Cephamycins; Edetic Acid; Hydroxybenzoate Ethers; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Rats; Salicylates; Salicylic Acid; Time Factors