cefixime and cephalexin

cefixime has been researched along with cephalexin in 40 studies

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199015 (37.50)18.7374
1990's10 (25.00)18.2507
2000's9 (22.50)29.6817
2010's5 (12.50)24.3611
2020's1 (2.50)2.80

Authors

AuthorsStudies
Inui, K; Saito, H; Yamamoto, M1
Iseki, K; Kondo, Y; Miyazaki, K; Shiroto, H; Sugawara, M; Uchino, J1
Allen, SD; Erwin, ME; Gerlach, EH; Jones, RN; Koontz, FP; Murray, PR; Pfaller, MA; Washington, JA1
Kim, H; Kim, WJ; Ko, KY; Oh, J1
Kalbfleisch, JH; Roberson, D; Sarubbi, F; Verghese, A1
Nies, BA1
Dorow, P1
Barry, AL; Jones, RN1
Lin, SR; Peng, CF1
Chin, NX; Neu, HC1
Baba, S; Itoh, Y; Kawamura, S; Kinoshita, H; Kobayashi, K; Mori, Y; Onishi, S; Shimada, J; Suzuki, K; Ueda, R1
Ayers, LW; Barry, AL; Fuchs, PC; Gavan, TL; Gerlach, EH; Jones, RN; Thornsberry, C1
Ayers, LW; Barry, AL; Fuchs, PC; Gavan, TL; Gerlach, EH; Jones, RN1
Edelstein, MA; Finegold, SM; Gee, R; Ingram-Drake, L; MacDonald, K; Reinhardt, J; Wexler, H1
Faulkner, RD; Hiltke, MF; McAteer, JA; Silber, BM1
Blatter, MM; Bluestone, CD; Fall, P; Kenna, MA; Kurs-Lasky, M; Reisinger, KS; Stephenson, J; Wucher, FP1
Fujishita, Y; Kaizu, M; Kojo, H; Matsumoto, Y; Shigi, Y1
Goto, S; Kamimura, T; Kojo, H; Kuwahara, S; Matsumoto, Y; Mine, Y1
Girbig, F; Gutjahr, U; Kowalewski, S; Kramer, W1
Ogle, JW1
El-Khayam, A; Godfrey, L; Katz, B; Kessler, OJ; Korzets, Z; Pomeranz, A; Wolach, B1
Cadeddu, L; Cadoni, BM; Puxeddu, P1
Barbagallo, S; Catena, E; Crimi, N; Dericoloso, L; Micillo, E; Mistretta, A; Tranchese, D1
Alkharfy, KM; Najjar, TA; Saad, SY1
Bai, AM; Cheng, LY; Hu, YJ; Li, HZ; Li, M; Ouyang, Y; Yang, CZ1
A Ahmed, H; A Mohamed, M; Adel Pashameah, R; F Nassar, H; Y A Alanazi, T; Y Binsaleh, A1
Clauss, W; Daniel, H; Gebert, I; Weber, WM; Weintraut, H; Wenzel, U1
Inui, K; Mukai, M; Saito, H; Terada, T1
Hayashi, K; Higashida, H; Miyamoto, K; Nakanishi, T; Sai, Y; Shiraga, T; Takeda, E; Tamai, I; Terao, T; Tsuji, A1
Carter, AL; Ganapathy, ME; Ganapathy, V; Huang, W; Iseki, K; Leibach, FH; Rajan, DP; Sugawara, M1
Brandsch, M; Luckner, P1
Biegel, A; Brandsch, M; Gebauer, S; Hartrodt, B; Neubert, K; Thondorf, I1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Aldini, G; De Luca, L; Marconi, C; Pedretti, A; Regazzoni, L; Vistoli, G1
Grime, K; Paine, SW1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1

Reviews

1 review(s) available for cefixime and cephalexin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

5 trial(s) available for cefixime and cephalexin

ArticleYear
Antimicrobial activity of RU29246 (HR916 metabolite) compared with four other oral beta-lactams tested against more than 5000 clinical isolates.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:9

    Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Cefaclor; Cefixime; Cefotaxime; Cephalexin; Cephalosporins; Clavulanic Acids; Drug Therapy, Combination; Enterococcus; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Staphylococcus; Streptococcus agalactiae

1991
Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.
    Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:6

    Topics: Acute Disease; Bronchitis; Cefixime; Cefotaxime; Cephalexin; Chronic Disease; Gram-Negative Bacteria; Haemophilus Infections; Haemophilus influenzae; Humans; Moraxella catarrhalis; Pneumococcal Infections; Randomized Controlled Trials as Topic; Respiratory Tract Infections

1990
Safety and efficacy of cefixime versus cefaclor in respiratory tract infections.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Cefaclor; Cefixime; Cefotaxime; Cephalexin; Female; Humans; Male; Middle Aged; Respiratory Tract Infections

1989
[A parallel comparative double blind study of cefixime with cefaclor in the treatment of acute suppurative otitis media in children].
    The Japanese journal of antibiotics, 1987, Volume: 40, Issue:1

    Topics: Acute Disease; Age Factors; Cefaclor; Cefixime; Cefotaxime; Cephalexin; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Humans; Infant; Otitis Media; Otitis Media, Suppurative

1987
Cefixime vs. cefaclor in the treatment of acute otitis media in infants and children.
    The Pediatric infectious disease journal, 1987, Volume: 6, Issue:10

    Topics: Acute Disease; Cefaclor; Cefixime; Cefotaxime; Cephalexin; Child; Child, Preschool; Female; Humans; Infant; Male; Otitis Media with Effusion; Patient Compliance

1987

Other Studies

34 other study(ies) available for cefixime and cephalexin

ArticleYear
Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: specific transport systems in apical and basolateral membranes.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:1

    Topics: Amino Acids; Anti-Infective Agents, Urinary; Biological Transport; Cefixime; Cefotaxime; Cefotiam; Cell Line; Cell Membrane; Cells, Cultured; Cephalexin; Cephradine; Epithelium; Intestinal Mucosa; Intestines

1992
Transport characteristics of ceftibuten, cefixime and cephalexin across human jejunal brush-border membrane.
    The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:12

    Topics: Biological Transport, Active; Cefixime; Cefotaxime; Ceftibuten; Cephalexin; Cephalosporins; Glucose; Humans; Hydrogen; In Vitro Techniques; Jejunum; Microvilli

1991
Synthesis and biological activity of novel 3-(2-propenyl)-cephalosporins. I.
    The Journal of antibiotics, 1991, Volume: 44, Issue:10

    Topics: Absorption; Administration, Oral; Alkenes; Animals; Bacteria; Cefixime; Cefotaxime; Cephalexin; Cephalosporins; Chromatography; Drug Evaluation, Preclinical; Kinetics; Mice; Microbial Sensitivity Tests; Molecular Structure; Rats

1991
Comparative activity of cefixime and cefaclor in an in vitro model simulating human pharmacokinetics.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1989, Volume: 8, Issue:6

    Topics: Cefaclor; Cefixime; Cefotaxime; Cephalexin; Drug Resistance, Microbial; Enterobacteriaceae; Escherichia coli; Humans; Klebsiella pneumoniae; Proteus mirabilis; Streptococcus pyogenes

1989
In vitro evaluation of ceftibuten (7432-S, SCH 39720), a novel orally administered cephalosporin.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1988, Volume: 7, Issue:5

    Topics: Administration, Oral; Cefaclor; Cefixime; Cefotaxime; Ceftibuten; Cefuroxime; Cephalexin; Cephalosporins; Enterobacteriaceae; Haemophilus influenzae; Microbial Sensitivity Tests; Moraxella catarrhalis; Neisseria meningitidis; Streptococcus

1988
In vitro antibacterial activity of cefixime.
    Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences, 1988, Volume: 4, Issue:10

    Topics: Amoxicillin; Ampicillin; Bacteria; Bacterial Infections; Cefaclor; Cefixime; Cefotaxime; Cephalexin; Humans; Microbial Sensitivity Tests

1988
In vitro activity of an oral iminomethoxy aminothiazolyl cephalosporin, R-3746.
    Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:5

    Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; beta-Lactamases; Cefaclor; Cefixime; Cefotaxime; Cefpodoxime; Ceftizoxime; Cefuroxime; Cephalexin; Cephalosporins; Clavulanic Acids; Culture Media; Drug Combinations; Drug Stability; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

1988
In vitro evaluation of cefixime (FK027, FR17027, CL284635): spectrum against recent clinical isolates, comparative antimicrobial activity, beta-lactamase stability, and preliminary susceptibility testing criteria.
    Diagnostic microbiology and infectious disease, 1986, Volume: 5, Issue:2

    Topics: Amoxicillin; beta-Lactamases; Cefaclor; Cefixime; Cefotaxime; Cefuroxime; Cephalexin; Clavulanic Acid; Clavulanic Acids; Enterobacteriaceae; Escherichia coli; In Vitro Techniques; Pseudomonas; Staphylococcus

1986
Antimicrobial activity of Ro 19-5247 (T-2525), a new oral cephalosporin, tested against 7,745 recent clinical isolates.
    Diagnostic microbiology and infectious disease, 1987, Volume: 6, Issue:3

    Topics: Bacteria; Cefixime; Cefmenoxime; Cefotaxime; Cephalexin; Cephaloridine; Cephalosporins; Enterobacteriaceae; Microbial Sensitivity Tests

1987
Bowel flora changes in humans receiving cefixime (CL 284,635) or cefaclor.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:3

    Topics: Bacteria; Cefaclor; Cefixime; Cefotaxime; Cephalexin; Clostridium; Digestive System; Enterobacteriaceae; Feces; Humans; Intestines; Male

1987
Liquid-chromatographic determination of five orally active cephalosporins--cefixime, cefaclor, cefadroxil, cephalexin, and cephradine--in human serum.
    Clinical chemistry, 1987, Volume: 33, Issue:10

    Topics: Cefaclor; Cefadroxil; Cefixime; Cefotaxime; Cephalexin; Cephalosporins; Cephradine; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reference Values

1987
Mechanism of action of the new orally active cephalosporin FK027.
    The Journal of antibiotics, 1984, Volume: 37, Issue:7

    Topics: Amoxicillin; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Carrier Proteins; Cefaclor; Cefixime; Cephalexin; Cephalosporins; Enterobacter; Escherichia coli; Hexosyltransferases; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidyl Transferases; Staphylococcus aureus

1984
In vitro and in vivo antibacterial properties of FK 027, a new orally active cephem antibiotic.
    Antimicrobial agents and chemotherapy, 1984, Volume: 25, Issue:1

    Topics: Amoxicillin; Animals; Bacteria; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; Cefaclor; Cefixime; Cephalexin; Cephalosporins; Mice; Penicillin Resistance

1984
Interaction of the orally active dianionic cephalosporin cefixime with the uptake system for oligopeptides and alpha-amino-beta-lactam antibiotics in rabbit small intestine.
    Biochemical pharmacology, 1993, Aug-03, Volume: 46, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Biological Transport; Cefixime; Cefotaxime; Cephalexin; Drug Interactions; Hot Temperature; Hydrogen-Ion Concentration; Intestine, Small; Oligopeptides; Rabbits

1993
Antimicrobial therapy for ambulatory pediatrics.
    Pediatric annals, 1999, Volume: 28, Issue:7

    Topics: Ambulatory Care; Anti-Bacterial Agents; Anti-Infective Agents; Cefixime; Cefuroxime; Cephalexin; Cephalosporins; Child; Fluoroquinolones; Humans; Macrolides; Otitis Media; Penicillins; Pharyngitis; Pneumonia, Bacterial; Sinusitis; Urinary Tract Infections

1999
A bioassay evaluation of the urinary antibacterial efficacy of low dose prophylactic antibiotics in children with vesicoureteral reflux.
    The Journal of urology, 2000, Volume: 164, Issue:3 Pt 2

    Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Biological Assay; Cefixime; Cephalexin; Child; Child, Preschool; Evaluation Studies as Topic; Female; Humans; Infant; Male; Nalidixic Acid; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Tract Infections; Vesico-Ureteral Reflux

2000
Cefixime: comparative clinical trial on the treatment of upper respiratory tract infection and otitis in adults.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Cefixime; Cephalexin; Controlled Clinical Trials as Topic; Female; Humans; Male; Randomized Controlled Trials as Topic; Respiratory Tract Infections

1989
Cefixime: comparative clinical trial on the treatment of lower respiratory tract infection in adults.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Bronchitis; Bronchopneumonia; Cefixime; Cephalexin; Clinical Trials as Topic; Female; Humans; Male; Pneumonia, Bacterial; Pulmonary Disease, Chronic Obstructive; Respiratory Tract Infections

1989
Mechanism and implication of cephalosporin penetration into oropharyngeal mucosa.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2009, Volume: 15, Issue:2

    Topics: Adult; Area Under Curve; Cefixime; Cephalexin; Haemophilus influenzae; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Moraxella catarrhalis; Mucous Membrane; Oropharynx; Saliva; Streptococcus

2009
Probing the interaction of cephalosporin with bovine serum albumin: A structural and comparative perspective.
    Luminescence : the journal of biological and chemical luminescence, 2018, Volume: 33, Issue:1

    Topics: Animals; Cattle; Cefixime; Cephalexin; Circular Dichroism; Models, Molecular; Molecular Conformation; Molecular Structure; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thermodynamics

2018
Condition optimization of eco-friendly RP-HPLC and MCR methods via Box-Behnken design and six sigma approach for detecting antibiotic residues.
    Scientific reports, 2023, 09-21, Volume: 13, Issue:1

    Topics: Anti-Bacterial Agents; Cefixime; Cephalexin; Chromatography, High Pressure Liquid; Humans; Total Quality Management; Vitelliform Macular Dystrophy

2023
Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:2

    Topics: Animals; Biological Transport; Caco-2 Cells; Carrier Proteins; Cephalosporins; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Oocytes; Peptide Transporter 1; Rabbits; Symporters; Xenopus laevis

1996
Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells.
    The American journal of physiology, 1997, Volume: 273, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Biological Transport; Carrier Proteins; Ceftibuten; Cephalosporins; Cyclacillin; Dipeptides; Hydrogen-Ion Concentration; Kidney; Kinetics; LLC-PK1 Cells; Peptide Transporter 1; Rats; Recombinant Proteins; Structure-Activity Relationship; Symporters; Transfection

1997
The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine.
    The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:8

    Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Carbon Radioisotopes; Carrier Proteins; Dipeptides; Female; Intestinal Absorption; Intestine, Small; Male; Peptide Transporter 1; Rats; Rats, Sprague-Dawley; Symporters; Xenopus laevis

1997
beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter.
    The Journal of biological chemistry, 2000, Jan-21, Volume: 275, Issue:3

    Topics: Acetylcarnitine; Animals; Anti-Bacterial Agents; Carnitine; Carrier Proteins; Cefadroxil; Cefepime; Cephaloridine; Cephalosporins; Dose-Response Relationship, Drug; HeLa Cells; Humans; Kinetics; Membrane Proteins; Nitrogen; Organic Cation Transport Proteins; Rats; Sodium; Solute Carrier Family 22 Member 5; Tumor Cells, Cultured

2000
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2005, Volume: 59, Issue:1

    Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Binding Sites; Caco-2 Cells; Dose-Response Relationship, Drug; Humans; Peptide Transporter 1; Protein Binding; Rats; Symporters

2005
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.
    Journal of medicinal chemistry, 2005, Jun-30, Volume: 48, Issue:13

    Topics: Animals; beta-Lactams; Cell Line, Tumor; Dipeptides; Drug Design; Humans; Mammals; Models, Molecular; Oligopeptides; Peptide Transporter 1; Quantitative Structure-Activity Relationship; Substrate Specificity; Symporters

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping.
    Bioorganic & medicinal chemistry, 2011, Aug-01, Volume: 19, Issue:15

    Topics: Binding Sites; Computer Simulation; Drug Design; Humans; Ligands; Models, Molecular; Peptides; Protein Binding; Structural Homology, Protein; Symporters

2011
Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bile; Body Weight; Dogs; Drug Administration Routes; Humans; Liver; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Organic Anion Transporters; Pharmaceutical Preparations; Protein Binding; Rats; Species Specificity

2013