cdp 840 has been researched along with rolipram in 16 studies
| Studies (cdp 840) | Trials (cdp 840) | Recent Studies (post-2010) (cdp 840) | Studies (rolipram) | Trials (rolipram) | Recent Studies (post-2010) (rolipram) |
|---|---|---|---|---|---|
| 18 | 0 | 3 | 1,604 | 17 | 401 |
| 18 | 0 | 3 | 26 | 0 | 15 |
| 17 | 1 | 0 | 1,604 | 17 | 401 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 9 (56.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andresen, CJ; Cheng, JB; Cohan, VL; Decker, C; DiCapua, FM; Duplantier, AJ; Johnson, KL; Kraus, KG; Turner, CR; UmLand, JP; Watson, JW; Wester, RT; Williams, AS; Williams, JA | 1 |
| Djuric, S; Hanney, B; He, W; Huang, FC; Liang, G; Mason, J; Miller, B; Souness, J | 1 |
| Djuric, SW; Huang, FC; Hulme, C; Poli, GB; Souness, JE | 1 |
| Huang, Z; Laliberté, F; Liu, S; Macdonald, D; Masson, P; Perrier, H; Rasori, R; Robichaud, A | 1 |
| Boss, H; Couwenberg, D; Goubitz, K; Hatzelmann, A; Schenk, H; Sterk, GJ; Timmerman, H; Van der Mey, M | 1 |
| Jabaris, SS; Kodimuthali, A; Pal, M | 1 |
| Boss, H; Hatzelmann, A; Sterk, GJ; Timmerman, H; Van der Laan, IJ; Van der Mey, M | 1 |
| Alexander, R; Allen, R; Blease, K; Bloxham, D; Boyd, E; Catterall, C; Eaton, M; Gozzard, N; Head, J; Higgs, G; Holbrook, M; Howat, D; Hughes, B; Hughes, P; James, T; Kingaby, R; Lisle, H; Lumb, S; Merriman, M; Owens, R; Perry, M; Russell, A; Smith, B; Wales, M; Warrellow, G | 1 |
| Gozzard, N; Higgs, G; Holbrook, M; Hughes, B; James, T | 1 |
| Allen, R; Baldock, D; Crabbe, T; Daniel, T; Higgs, GA; Howat, D; Huang, Z; Hughes, B; Laliberte, F; Lumb, S; Merriman, M; O'Connell, J; Owens, RJ; Perry, MJ; Russell, A; Walker, C; Walls, J | 1 |
| Cooper, N; Gristwood, RW; Hellewell, PG; Macari, DM; Miotla, JM; Teixeira, MM; Warneck, J; Wills, RE | 1 |
| Egging, EA; Gullikson, GW; Hammerbeck, DM; Hupperts, AM; Johnson, DD; McGurran, SM; Radziszewski, PL | 1 |
| Cunningham, FM; Lees, P; Page, CP; Rickards, KJ | 1 |
| Allen, JM; Banner, KH; Doherty, A; Jones, NA; Landells, LJ; O'Connor, BJ; Page, CP; Spina, D; Szilagy, CM | 1 |
| Alexander, RP; Allen, RA; Barnes, D; Boyce, B; Boyd, EC; Brown, JA; Cannell, A; Eaton, MA; Gozzard, N; Head, JC; Higgs, G; Hughes, B; Hutchinson, B; Leonard, J; Mason, B; Millican, A; Morphy, R; Perry, M; Porter, JR; Reuberson, JT; Taylor, RJ; Turner, P; Wales, M; Warrellow, GJ; Zomaya, A | 1 |
| Akuta, K; Hirose, R; Ichimura, M; Manabe, H; Nonaka, H; Ohshima, E; Sato, S; Yanagawa, K | 1 |
1 review(s) available for cdp 840 and rolipram
| Article | Year |
|---|---|
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
Topics: Asthma; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive | 2008 |
15 other study(ies) available for cdp 840 and rolipram
| Article | Year |
|---|---|
7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase.
Topics: Airway Obstruction; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Cell Count; Cell Line; Cyclic AMP; Cytokines; Dihydropyridines; Drug Evaluation, Preclinical; Eosinophils; Guinea Pigs; Humans; In Vitro Techniques; Isoenzymes; Macaca fascicularis; Molecular Conformation; Neutrophils; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazoles; Pyrrolidinones; Rolipram; Structure-Activity Relationship | 1998 |
Novel cyclic compounds as potent phosphodiesterase 4 inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Brain; Cyclic Nucleotide Phosphodiesterases, Type 4; Dogs; Endotoxemia; Female; Guinea Pigs; In Vitro Techniques; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Models, Molecular; Phosphodiesterase Inhibitors; Pyridines; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; Vomiting | 1998 |
Quaternary substituted PDE4 inhibitors I: the synthesis and in vitro evaluation of a novel series of oxindoles.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cyclic Nucleotide Phosphodiesterases, Type 4; Indoles; Phosphodiesterase Inhibitors; Pyridines; Structure-Activity Relationship | 1998 |
Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl)methyl]quinoline (APIIMQ).
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Asthmatic Agents; Azides; Bronchoconstriction; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Inhibitors; Ferrets; Guinea Pigs; Humans; Photoaffinity Labels; Quinolines; Recombinant Fusion Proteins; Tumor Necrosis Factor-alpha; Vomiting | 2000 |
Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra- and cis-hexahydrophthalazinones.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adamantane; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Crystallography, X-Ray; Cyclic Nucleotide Phosphodiesterases, Type 4; Edema; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Mice; Molecular Conformation; Neutrophils; Phthalazines; Stereoisomerism; Structure-Activity Relationship | 2002 |
Novel selective PDE4 inhibitors. 3. In vivo antiinflammatory activity of a new series of N-substituted cis-tetra- and cis-hexahydrophthalazinones.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adamantane; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cycloheptanes; Edema; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lipopolysaccharides; Luminescent Measurements; Mice; Phthalazines; Reactive Oxygen Species; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2002 |
The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Airway Resistance; Analysis of Variance; Animals; Asthma; Benzamides; Bronchoconstriction; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilia; Guinea Pigs; Humans; Interleukin-5; Isoenzymes; Lung; Male; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridines; Pyrrolidinones; Rabbits; Rats; Rolipram | 1996 |
Inhibition of bronchospasm and ozone-induced airway hyperresponsiveness in the guinea-pig by CDP840, a novel phosphodiesterase type 4 inhibitor.
Topics: Analysis of Variance; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Carbachol; Cricetinae; Disease Models, Animal; Enzyme Inhibitors; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle Relaxation; Parasympathomimetics; Phosphodiesterase Inhibitors; Pyridines; Pyrrolidinones; Rolipram; Trachea; Vagus Nerve | 1996 |
CDP840: a novel inhibitor of PDE-4.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Brain; Catalysis; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Humans; Male; Mice; Phosphodiesterase Inhibitors; Protein Binding; Pyridines; Pyrrolidinones; Rolipram; Tritium | 1998 |
A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Benzamides; Cell Movement; Cyclic Nucleotide Phosphodiesterases, Type 4; Dermatitis; Eosinophils; Female; Guinea Pigs; Humans; Macrophages; Male; Neutrophils; Phosphodiesterase Inhibitors; Pyridines; Pyrrolidinones; Rolipram; Skin | 1999 |
Effects of several glucocorticosteroids and PDE4 inhibitors on increases in total lung eosinophil peroxidase (EPO) levels following either systemic or intratracheal administration in sephadex- or ovalbumin-induced inflammatory models.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Androstadienes; Animals; Asthma; Beclomethasone; Benzamides; Budesonide; Cyclic Nucleotide Phosphodiesterases, Type 4; Dexamethasone; Dextrans; Disease Models, Animal; Enzyme Inhibitors; Eosinophil Peroxidase; Eosinophils; Fluticasone; Glucocorticoids; Guinea Pigs; Inflammation; Lung; Male; Ovalbumin; Peroxidases; Pyridines; Rats; Rats, Sprague-Dawley; Rolipram | 2000 |
Phosphodiesterase activity in neutrophils from horses with chronic obstructive pulmonary disease.
Topics: Animals; Dose-Response Relationship, Immunologic; Guanidines; Horse Diseases; Horses; Isoenzymes; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Disease, Chronic Obstructive; Pyridazines; Pyridines; Rolipram | 2000 |
Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adolescent; Adult; Allergens; Asthma; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Division; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Leukocytes, Mononuclear; Male; Phosphodiesterase Inhibitors; Phytohemagglutinins; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Rolipram; Theophylline | 2001 |
CDP840. A prototype of a novel class of orally active anti-inflammatory phosphodiesterase 4 inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchoconstriction; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Ferrets; Guinea Pigs; Humans; Inhibitory Concentration 50; Phosphodiesterase Inhibitors; Pyridines; Rats; Rolipram; Saccharomyces cerevisiae; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2002 |
Correlation between emetic effect of phosphodiesterase 4 inhibitors and their occupation of the high-affinity rolipram binding site in Suncus murinus brain.
Topics: Animals; Benzamides; Binding Sites; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Kinetics; Male; Molecular Structure; Naphthyridines; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rolipram; Shrews; Tritium; Vomiting; Xanthines | 2007 |