cbp-501 and oxaline

cbp-501 has been researched along with oxaline* in 1 studies

Other Studies

1 other study(ies) available for cbp-501 and oxaline

ArticleYear
Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization.
    Biochimica et biophysica acta, 2004, Jul-23, Volume: 1693, Issue:1

    Oxaline and neoxaline, fungal alkaloids, were found to inhibit cell proliferation and to induce cell cycle arrest at the G(2)/M phase in Jurkat cells. CBP501 (a peptide corresponding to amino acids 211-221 of Cdc25C phosphatase), which inhibits the G(2) checkpoint, did not affect the G(2)/M arrest caused by oxaline, suggesting that oxaline causes M phase arrest but not G(2) phase arrest. The Cdc2 phosphorylation level of oxaline-treated cell lysate was lower than that of the control cells, indicating that oxaline arrests the M phase. Oxaline disrupted cytoplasmic microtubule assembly in 3T3 cells. Furthermore, oxaline inhibited polymerization of microtubule protein and purified tubulin dose-dependently in vitro. In a binding competition assay, oxaline inhibited the binding of [(3)H]colchicine to tubulin, but not that of [(3)H]vinblastine. These results indicate that oxaline inhibits tubulin polymerization, resulting in cell cycle arrest at the M phase.

    Topics: Animals; Aspergillus; cdc25 Phosphatases; Colchicine; Humans; Hydrogen Peroxide; Imidazoles; Mice; Mitosis; Penicillium; Peptide Fragments; Tritium; Tubulin; Tubulin Modulators; Tyrosine

2004