cathepsin-g and epigallocatechin-gallate

cathepsin-g has been researched along with epigallocatechin-gallate* in 1 studies

Other Studies

1 other study(ies) available for cathepsin-g and epigallocatechin-gallate

ArticleYear
(-)Epigallocatechin-3-gallate inhibits leukocyte elastase: potential of the phyto-factor in hindering inflammation, emphysema, and invasion.
    Journal of leukocyte biology, 2002, Volume: 71, Issue:1

    Flavanol (-)epigallocatechin-3-gallate is shown to be a potent natural inhibitor of leukocyte elastase that may be used to reduce elastase-mediated progression to emphysema and tumor invasion. This phyto-factor, abundant in green tea, exerts a dose-dependent, noncompetitive inhibition of leukocyte elastase at a noncytotoxic concentration and is effective in neutrophil culture. This inhibition shows an IC(50) of 0.4 microM, 30 times higher than the alpha1-protease inhibitor but lower than other known natural and synthetic elastase inhibitors. The flavanol inhibits leukocyte elastase at concentrations of 50, 150, and 2500 times lower than that effective on gelatinases (MMP-2 and MMP-9), thrombin, and cathepsin G, respectively, and also blocks elastase-mediated activation of MMP-9.

    Topics: Catechin; Cathepsin G; Cathepsins; Cells, Cultured; Dose-Response Relationship, Drug; Emphysema; Enzyme Activation; Enzyme Inhibitors; Gelatinases; Humans; Inflammation; Leukocyte Elastase; Neutrophils; Phytotherapy; Serine Endopeptidases; Thrombin

2002