caseins has been researched along with valyl-prolyl-proline in 22 studies
| Studies (caseins) | Trials (caseins) | Recent Studies (post-2010) (caseins) | Studies (valyl-prolyl-proline) | Trials (valyl-prolyl-proline) | Recent Studies (post-2010) (valyl-prolyl-proline) |
|---|---|---|---|---|---|
| 16,863 | 561 | 4,170 | 85 | 24 | 40 |
| Protein | Taxonomy | caseins (IC50) | valyl-prolyl-proline (IC50) |
|---|---|---|---|
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 9 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (50.00) | 29.6817 |
| 2010's | 11 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gotou, T; Kajimoto, O; Kajimoto, Y; Matsuura, K; Mizuno, S; Nishimura, S; Yabune, M; Yamamoto, N | 1 |
| Bernard, BK; Maeno, M; Mennear, JH; Nakamura, Y | 1 |
| Bernard, BK; Matsuura, K; Mennear, JH; Mizuno, S | 1 |
| Bernard, BK; Maeno, M; Matsuura, K; Mennear, JH | 1 |
| Bernard, BK; Maeno, M; Mennear, JH; Mizuno, S | 1 |
| Hirota, T; Kajimoto, Y; Kawagishi, R; Kitakaze, M; Mizuno, S; Nakamura, Y; Ohki, K | 1 |
| Enjoh, M; Ohki, K; Ohsawa, K; Satsu, H; Shimizu, M; Takano, T | 1 |
| de Leeuw, PW; Koning, MM; Kroon, AA; Rennenberg, RM; van der Zander, K | 1 |
| Mizutani, J; Nakamura, T; Sasaki, K; Takazawa, K; Yamamoto, N | 1 |
| Aihara, K; Ishii, H; Yoshida, M | 1 |
| Jakala, P; Korpela, R; Lehtinen, R; Pere, E; Turpeinen, A; Vapaatalo, H | 1 |
| Groop, PH; Jauhiainen, T; Kautiainen, H; Korpela, R; Rönnback, M; Vapaatalo, H; Wuolle, K | 1 |
| Jauhiainen, T; Kankuri, E; Kerojoki, O; Korpela, R; Kovanen, PT; Lehtinen, R; Lindstedt, K; Vapaatalo, H | 1 |
| Bacchelli, S; Borghi, C; Cicero, AF; Grandi, E; Melegari, C; Rosticci, M; Strocchi, E; Veronesi, M | 1 |
| Fukuhara, I; Ishida, Y; Kaneko, K; Shibata, Y; Takehara, I; Yano, Y | 1 |
| Mizutani, J; Nakamura, T; Ohki, K; Takazawa, K; Takeshi, M; Yamada, K; Yamamoto, N | 1 |
| Ehlers, PI; Kivimäki, AS; Korpela, R; Turpeinen, AM; Vapaatalo, H | 1 |
| Bacchelli, S; Borghi, C; Cicero, AF; Gerocarni, B; Rosticci, M; Strocchi, E; Veronesi, M | 1 |
| Bacchelli, S; Borghi, C; Cicero, AF; Ferroni, A; Rosticci, M; Strocchi, E; Veronesi, M | 1 |
| Hatanaka, M; Nakamura, Y; Wakai, T; Yamaguchi, N; Yamamoto, N | 1 |
| Aihara, K; Osaka, M; Yoshida, M | 1 |
| Martini, S; Rutella, GS; Solieri, L; Tagliazucchi, D | 1 |
10 trial(s) available for caseins and valyl-prolyl-proline
| Article | Year |
|---|---|
Antihypertensive effect of casein hydrolysate in a placebo-controlled study in subjects with high-normal blood pressure and mild hypertension.
Topics: Administration, Oral; Adult; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aspergillus oryzae; Blood Pressure; Body Mass Index; Body Weight; Caseins; Dietary Supplements; Female; Humans; Hypertension; Male; Oligopeptides; Single-Blind Method | 2005 |
Casein hydrolysate containing the antihypertensive tripeptides Val-Pro-Pro and Ile-Pro-Pro improves vascular endothelial function independent of blood pressure-lowering effects: contribution of the inhibitory action of angiotensin-converting enzyme.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Blood Pressure; Caseins; Cross-Over Studies; Endothelium, Vascular; Forearm; Humans; Hypertension; Male; Middle Aged; Oligopeptides | 2007 |
Dose-dependent lowering of blood pressure by dairy peptides in mildly hypertensive subjects.
Topics: Aged; Beverages; Blood Pressure Determination; Blood Pressure Monitoring, Ambulatory; Caseins; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Office Visits; Oligopeptides; Powders; Reproducibility of Results; Yogurt | 2009 |
Beneficial potential of casein hydrolysate containing Val-Pro-Pro and Ile-Pro-Pro on central blood pressure and hemodynamic index: a preliminary study.
Topics: Adult; Blood Pressure; Caseins; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Oligopeptides | 2009 |
Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects.
Topics: Adult; Animals; Antihypertensive Agents; Blood Pressure; Caseins; Double-Blind Method; Endothelium, Vascular; Female; Fermentation; Food Microbiology; Humans; Hypertension; Lactobacillus helveticus; Male; Middle Aged; Milk; Oligopeptides; Radial Artery | 2010 |
Hemodynamic effects of lactotripeptides from casein hydrolysate in Mediterranean normotensive subjects and patients with high-normal blood pressure: a randomized, double-blind, crossover clinical trial.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiovascular Diseases; Caseins; Circadian Rhythm; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Hemodynamics; Humans; Hypertension; Male; Mediterranean Region; Middle Aged; Oligopeptides; Severity of Illness Index; Young Adult | 2010 |
Effect of an excess intake of casein hydrolysate containing Val-Pro-Pro and Ile-Pro-Pro in subjects with normal blood pressure, high-normal blood pressure, or mild hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Body Mass Index; Body Weight; Caseins; Double-Blind Method; Female; Humans; Hypertension; Japan; Male; Middle Aged; Oligopeptides; Peptidyl-Dipeptidase A; Placebos; Tablets | 2011 |
Casein hydrolysate containing Val-Pro-Pro and Ile-Pro-Pro improves central blood pressure and arterial stiffness in hypertensive subjects: a randomized, double-blind, placebo-controlled trial.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Ankle Brachial Index; Antihypertensive Agents; Blood Pressure; Caseins; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Oligopeptides; Vascular Stiffness | 2011 |
Lactotripeptides effect on office and 24-h ambulatory blood pressure, blood pressure stress response, pulse wave velocity and cardiac output in patients with high-normal blood pressure or first-degree hypertension: a randomized double-blind clinical trial
Topics: Adult; Aged; Blood Flow Velocity; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiac Output; Caseins; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Oligopeptides; Pulsatile Flow; Stress, Physiological | 2011 |
Predictors of the short-term effect of isoleucine-proline-proline/valine-proline-proline lactotripeptides from casein on office and ambulatory blood pressure in subjects with pharmacologically untreated high-normal blood pressure or first-degree hypertens
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiovascular Diseases; Caseins; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Office Visits; Oligopeptides; Predictive Value of Tests; Time Factors; Treatment Outcome | 2012 |
12 other study(ies) available for caseins and valyl-prolyl-proline
| Article | Year |
|---|---|
Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): III. Single- and/or repeated-dose toxicity of tripeptides-containing Lactobacillus helveticus-fermented milk powder and casein hydrolysa
Topics: Administration, Oral; Animals; Body Weight; Caseins; Cultured Milk Products; Dose-Response Relationship, Drug; Female; Hematocrit; Hemoglobins; Humans; Lactobacillus helveticus; Male; Oligopeptides; Organ Size; Powders; Rats; Rats, Sprague-Dawley; Sex Factors; Time Factors; Toxicity Tests; Urinalysis | 2005 |
Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): V. A 13-week toxicity study of tripeptides-containing casein hydrolysate in male and female rats.
Topics: Administration, Oral; Animals; Caseins; Cataract; Chlorides; Dose-Response Relationship, Drug; Eating; Female; Hematologic Tests; Kidney; Male; Oligopeptides; Organ Size; Powders; Rats; Rats, Sprague-Dawley; Sex Factors; Time Factors; Toxicity Tests; Urobilinogen; Uterus; Weight Gain | 2005 |
Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): VII. Micronucleus test of tripeptides-containing casein hydrolysate and Lactobacillus helveticus-fermented milk powders in rats and mice
Topics: Administration, Oral; Animals; Aspergillus oryzae; Bone Marrow Cells; Caseins; Cultured Milk Products; Cyclophosphamide; Dose-Response Relationship, Drug; Erythroblasts; Lactobacillus helveticus; Male; Mice; Mice, Inbred ICR; Micronucleus Tests; Mitomycin; Oligopeptides; Peptide Hydrolases; Powders; Rats; Rats, Sprague-Dawley; Toxicity Tests | 2005 |
Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): VIII. Assessment of cytotoxicity and clastogenicity of tripeptides-containing casein hydrolysate and Lactobacillus helveticus-fermented
Topics: Animals; Benzo(a)pyrene; Caseins; Cell Proliferation; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Cultured Milk Products; Dose-Response Relationship, Drug; Lactobacillus helveticus; Lung; Male; Microsomes, Liver; Mitomycin; Mutagenicity Tests; Oligopeptides; Powders; Rats; Rats, Sprague-Dawley | 2005 |
Producibility and digestibility of antihypertensive beta-casein tripeptides, Val-Pro-Pro and Ile-Pro-Pro, in the gastrointestinal tract: analyses using an in vitro model of mammalian gastrointestinal digestion.
Topics: Amino Acid Sequence; Animals; Antihypertensive Agents; Caco-2 Cells; Caseins; Digestion; Drug Stability; Fermentation; Gastrointestinal Tract; Humans; Milk; Oligopeptides; Peptide Fragments | 2008 |
Casein-derived tripeptide, Val-Pro-Pro (VPP), modulates monocyte adhesion to vascular endothelium.
Topics: Caseins; Cell Adhesion; Cell Line; Endothelium, Vascular; Flow Cytometry; Humans; MAP Kinase Kinase 4; Monocytes; Oligopeptides; Phosphorylation; Tetradecanoylphorbol Acetate | 2009 |
Cardiovascular activity of milk casein-derived tripeptides and plant sterols in spontaneously hypertensive rats.
Topics: Acetylcholinesterase; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Caseins; Cholesterol; Cultured Milk Products; Hypertension; Lactobacillus helveticus; Male; Oligopeptides; Phytosterols; Random Allocation; Rats; Rats, Inbred SHR; Time Factors | 2009 |
Effects of milk casein-derived tripeptides Ile-Pro-Pro, Val-Pro-Pro, and Leu-Pro-Pro on enzymes processing vasoactive precursors in vitro.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arginase; Caseins; Cathepsin G; Chymases; Enzymes; Humans; Oligopeptides; Peptidyl-Dipeptidase A | 2010 |
High blood pressure-lowering and vasoprotective effects of milk products in experimental hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Caseins; Cultured Milk Products; Endothelium, Vascular; Gene Expression; Hypertension; Male; Nitric Oxide; Oligonucleotide Array Sequence Analysis; Oligopeptides; Peptidyl-Dipeptidase A; Phytosterols; Phytotherapy; Plant Extracts; Rats; Rats, Inbred Strains; Signal Transduction | 2011 |
Repressive processing of antihypertensive peptides, Val-Pro-Pro and Ile-Pro-Pro, in Lactobacillus helveticus fermented milk by added peptides.
Topics: Amino Acids; Animals; Antihypertensive Agents; Caseins; Endopeptidases; Fermentation; Gene Expression Regulation, Bacterial; Lactobacillus helveticus; Milk; Oligonucleotide Array Sequence Analysis; Oligopeptides; Peptides; Proteolysis; Transcriptome | 2012 |
Oral administration of the milk casein-derived tripeptide Val-Pro-Pro attenuates high-fat diet-induced adipose tissue inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caseins; Cattle; CD18 Antigens; Chemokine CCL2; Diet, High-Fat; Dietary Supplements; Gene Expression Regulation; Interleukin-6; Intra-Abdominal Fat; Macrophages; Male; Mice; Mice, Inbred C57BL; Monocytes; Obesity; Oligopeptides; Panniculitis; Peptide Fragments | 2014 |
Release of the Antihypertensive Tripeptides Valine-Proline-Proline and Isoleucine-Proline-Proline from Bovine Milk Caseins during in Vitro Gastrointestinal Digestion.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Caseins; Cattle; Digestion; Gastrointestinal Tract; Humans; Kinetics; Models, Biological; Oligopeptides | 2016 |