casein-kinase-ii and propylene

casein-kinase-ii has been researched along with propylene* in 1 studies

Other Studies

1 other study(ies) available for casein-kinase-ii and propylene

Article	Year
Structure-based identification of novel CK2 inhibitors with a linear 2-propenone scaffold as anti-cancer agents. Biochemical and biophysical research communications, 2019, 04-30, Volume: 512, Issue:2 Protein kinase CK2 has emerged as an attractive cancer therapeutic target. Previous studies have highlighted the challenge of optimizing CK2 ATP-competitive inhibitors that have low druggability due to their polycyclic ring scaffolds. Therefore the development of novel inhibitors with non-polycyclic scaffolds emerges as a promising strategy for drug discovery targeting CK2. In this current study, based on the similar predicted binding poses of the linear 2-propenone scaffold of isoliquiritigenin with that of the polycyclic inhibitor CX-4945, a series of 2-propenone derivatives containing an amine-substituted five-membered heterocycle and a benzoic acid were designed, synthesized and evaluated for their in vitro CK2 inhibition and anti-cancer activity. Compound 8b was found to be the most potent CK2 inhibitor (IC Topics: Alkenes; Antineoplastic Agents; Casein Kinase II; Cell Proliferation; Drug Design; Hep G2 Cells; Humans; Molecular Docking Simulation; Neoplasms; Protein Kinase Inhibitors; Structure-Activity Relationship	2019

Article

Year

Structure-based identification of novel CK2 inhibitors with a linear 2-propenone scaffold as anti-cancer agents.

Biochemical and biophysical research communications, 2019, 04-30, Volume: 512, Issue:2

Protein kinase CK2 has emerged as an attractive cancer therapeutic target. Previous studies have highlighted the challenge of optimizing CK2 ATP-competitive inhibitors that have low druggability due to their polycyclic ring scaffolds. Therefore the development of novel inhibitors with non-polycyclic scaffolds emerges as a promising strategy for drug discovery targeting CK2. In this current study, based on the similar predicted binding poses of the linear 2-propenone scaffold of isoliquiritigenin with that of the polycyclic inhibitor CX-4945, a series of 2-propenone derivatives containing an amine-substituted five-membered heterocycle and a benzoic acid were designed, synthesized and evaluated for their in vitro CK2 inhibition and anti-cancer activity. Compound 8b was found to be the most potent CK2 inhibitor (IC

Topics: Alkenes; Antineoplastic Agents; Casein Kinase II; Cell Proliferation; Drug Design; Hep G2 Cells; Humans; Molecular Docking Simulation; Neoplasms; Protein Kinase Inhibitors; Structure-Activity Relationship

2019